R B Postuma

Summary

Affiliation: McGill University
Country: Canada

Publications

  1. ncbi request reprint Genetic association study of PINK1 coding polymorphisms in Parkinson's disease
    Justus L Groen
    Centre for Research in Neurodegenerative Diseases, Department of Medicine, University of Toronto, 6 Queen s Park Crescent West, Toronto, Ont, Canada M5S 3H2
    Neurosci Lett 372:226-9. 2004
  2. ncbi request reprint Potential early markers of Parkinson disease in idiopathic REM sleep behavior disorder
    Ronald B Postuma
    Department of Neurology, McGill University, Montreal General Hospital, Montreal, Quebec, Canada
    Neurology 66:845-51. 2006
  3. doi request reprint REM sleep behaviour disorder in Parkinson's disease is associated with specific motor features
    R B Postuma
    Department of Neurology, McGill University, Montreal General Hospital, Montreal, Quebec, Canada
    J Neurol Neurosurg Psychiatry 79:1117-21. 2008
  4. ncbi request reprint Is there seasonal variation in risk of Parkinson's disease?
    Ronald B Postuma
    Department of Neurology, McGill University, Montreal General Hospital, Montreal, Quebec, Canada
    Mov Disord 22:1097-101. 2007
  5. ncbi request reprint Vitamins and entacapone in levodopa-induced hyperhomocysteinemia: a randomized controlled study
    R B Postuma
    Department of Neurology, McGill University, Montreal General Hospital, Montreal, Quebec, Canada
    Neurology 66:1941-3. 2006
  6. ncbi request reprint Does severity of Parkinson's disease vary according to season?
    Ronald B Postuma
    Department of Neurology, McGill University, Montreal General Hospital, Montreal, Quebec, Canada
    Mov Disord 20:476-9. 2005
  7. doi request reprint Manifestations of Parkinson disease differ in association with REM sleep behavior disorder
    Ronald B Postuma
    Department of Neurology, McGill University, Montreal General Hospital, Montreal, Quebec, Canada
    Mov Disord 23:1665-72. 2008
  8. doi request reprint Executive dysfunction and memory impairment in idiopathic REM sleep behavior disorder
    J Massicotte-Marquez
    Centre d Etude du Sommeil et des Rythmes Biologiques, Hopital du Sacre Coeur de Montreal, 5400 Boul Gouin Ouest Montréal, Quebec, Canada
    Neurology 70:1250-7. 2008
  9. doi request reprint Markers of neurodegeneration in idiopathic rapid eye movement sleep behaviour disorder and Parkinson's disease
    R B Postuma
    Department of Neurology, McGill University, Montreal General Hospital, Montreal, Quebec, Canada
    Brain 132:3298-307. 2009
  10. doi request reprint How does parkinsonism start? Prodromal parkinsonism motor changes in idiopathic REM sleep behaviour disorder
    R B Postuma
    Department of Neurology, McGill University, Montreal General Hospital, Montreal, QC H3G 1A4, Canada
    Brain 135:1860-70. 2012

Collaborators

Detail Information

Publications28

  1. ncbi request reprint Genetic association study of PINK1 coding polymorphisms in Parkinson's disease
    Justus L Groen
    Centre for Research in Neurodegenerative Diseases, Department of Medicine, University of Toronto, 6 Queen s Park Crescent West, Toronto, Ont, Canada M5S 3H2
    Neurosci Lett 372:226-9. 2004
    ..19). Nevertheless, it remains to be evaluated whether PINK1 variations contribute to the risk of common late onset sporadic PD...
  2. ncbi request reprint Potential early markers of Parkinson disease in idiopathic REM sleep behavior disorder
    Ronald B Postuma
    Department of Neurology, McGill University, Montreal General Hospital, Montreal, Quebec, Canada
    Neurology 66:845-51. 2006
    ..Several potential early diagnostic markers of PD have been proposed, but they have generally not been tested in presymptomatic PD. The authors hypothesized that these markers may be abnormal in idiopathic RBD...
  3. doi request reprint REM sleep behaviour disorder in Parkinson's disease is associated with specific motor features
    R B Postuma
    Department of Neurology, McGill University, Montreal General Hospital, Montreal, Quebec, Canada
    J Neurol Neurosurg Psychiatry 79:1117-21. 2008
    ..However, it is unclear whether the association of RBD in PD has implications for motor manifestations of the disease...
  4. ncbi request reprint Is there seasonal variation in risk of Parkinson's disease?
    Ronald B Postuma
    Department of Neurology, McGill University, Montreal General Hospital, Montreal, Quebec, Canada
    Mov Disord 22:1097-101. 2007
    ..We found no evidence of systematic seasonal variation in PD incidence by birth date, or of clustering of birth dates during influenza pandemic years in PD patients...
  5. ncbi request reprint Vitamins and entacapone in levodopa-induced hyperhomocysteinemia: a randomized controlled study
    R B Postuma
    Department of Neurology, McGill University, Montreal General Hospital, Montreal, Quebec, Canada
    Neurology 66:1941-3. 2006
    ..Levodopa initiation caused a small elevation in homocysteine. Vitamin therapy, but not entacapone, resulted in a decrease in homocysteine compared to placebo...
  6. ncbi request reprint Does severity of Parkinson's disease vary according to season?
    Ronald B Postuma
    Department of Neurology, McGill University, Montreal General Hospital, Montreal, Quebec, Canada
    Mov Disord 20:476-9. 2005
    ..We found no evidence for seasonal fluctuation in the UPDRS scores, suggesting that, although considerable day-to-day variation may exist in PD, there is little monthly or seasonal variation...
  7. doi request reprint Manifestations of Parkinson disease differ in association with REM sleep behavior disorder
    Ronald B Postuma
    Department of Neurology, McGill University, Montreal General Hospital, Montreal, Quebec, Canada
    Mov Disord 23:1665-72. 2008
    ..These findings suggest that the pathophysiology of RBD and nonmotor manifestations of PD, particularly autonomic dysfunction, are linked...
  8. doi request reprint Executive dysfunction and memory impairment in idiopathic REM sleep behavior disorder
    J Massicotte-Marquez
    Centre d Etude du Sommeil et des Rythmes Biologiques, Hopital du Sacre Coeur de Montreal, 5400 Boul Gouin Ouest Montréal, Quebec, Canada
    Neurology 70:1250-7. 2008
    ..Recent studies showing a slowing of waking EEG in iRBD suggest that iRBD is associated with cognitive impairment...
  9. doi request reprint Markers of neurodegeneration in idiopathic rapid eye movement sleep behaviour disorder and Parkinson's disease
    R B Postuma
    Department of Neurology, McGill University, Montreal General Hospital, Montreal, Quebec, Canada
    Brain 132:3298-307. 2009
    ....
  10. doi request reprint How does parkinsonism start? Prodromal parkinsonism motor changes in idiopathic REM sleep behaviour disorder
    R B Postuma
    Department of Neurology, McGill University, Montreal General Hospital, Montreal, QC H3G 1A4, Canada
    Brain 135:1860-70. 2012
    ..Simple quantitative motor measures may be capable of reliably detecting parkinsonism, even before a clinical diagnosis can be made by experienced movement disorders neurologists...
  11. pmc Quantifying the risk of neurodegenerative disease in idiopathic REM sleep behavior disorder
    R B Postuma
    Department of Neurology, L7 305 Montreal General Hospital, 1650 Cedar Ave, Montreal, Quebec, Canada
    Neurology 72:1296-300. 2009
    ..Obtaining an accurate picture of this risk is essential for counseling patients and for development of potential neuroprotective therapies...
  12. doi request reprint Predicting Parkinson's disease - why, when, and how?
    R B Postuma
    Department of Neurology, McGill University, Montreal General Hospital, Montreal, Quebec, Canada
    Parkinsonism Relat Disord 15:S105-9. 2009
    ..This provides an unprecedented opportunity to test potential predictive markers before clinical disease onset. The results of marker testing in idiopathic RBD with its implications for disease prediction will be detailed...
  13. pmc Severity of REM atonia loss in idiopathic REM sleep behavior disorder predicts Parkinson disease
    R B Postuma
    Department of Neurology, McGill University, Montreal General Hospital, Montreal, Canada
    Neurology 74:239-44. 2010
    ..Since polysomnography is performed in all patients with idiopathic RBD at diagnosis, there is an opportunity to analyze if baseline sleep variables predict eventual neurodegenerative disease...
  14. pmc Environmental risk factors for REM sleep behavior disorder: a multicenter case-control study
    R B Postuma
    Department of Neurology, McGill University, Montreal General Hospital, Montreal, Canada
    Neurology 79:428-34. 2012
    ..Since risk factors have not been defined, we initiated a multicenter case-control study to assess environmental and lifestyle risk factors for REM sleep behavior disorder...
  15. ncbi request reprint REM sleep behavior disorder predicts cognitive impairment in Parkinson disease without dementia
    M Vendette
    CRCPC, Centre d Etude du Sommeil et des Rythmes Biologiques, Hopital du Sacre Coeur de Montreal, 5400 Boul Gouin Ouest, Montreal, Quebec, Canada
    Neurology 69:1843-9. 2007
    ..To assess the relationship between the presence of REM sleep behavior disorder (RBD) and the cognitive profile of nondemented patients with Parkinson disease (PD)...
  16. doi request reprint Restless legs syndrome outside the blood-brain barrier--exacerbation by domperidone in Parkinson's disease
    S Riós Romenets
    Department of Neurology, McGill University, Montreal General Hospital, 1650 Cedar Ave, Montreal L 7 312, Quebec H3G1A4, Canada
    Parkinsonism Relat Disord 19:92-4. 2013
    ..After encountering a case of restless legs syndrome that dramatically worsened with domperidone, we assessed whether Parkinson's patients may have exacerbation of restless legs with domperidone...
  17. doi request reprint Clinical prediction of Parkinson's disease: planning for the age of neuroprotection
    R B Postuma
    Department of Neurology, Montreal General Hospital, Montreal, Quebec, Canada
    J Neurol Neurosurg Psychiatry 81:1008-13. 2010
    ....
  18. doi request reprint Doxepin and cognitive behavioural therapy for insomnia in patients with Parkinson's disease -- a randomized study
    S Riós Romenets
    Department of Neurology, McGill University, Montreal General Hospital, Montreal, Quebec, Canada
    Parkinsonism Relat Disord 19:670-5. 2013
    ..No studies have conclusively demonstrated effective insomnia treatments in Parkinson's disease...
  19. doi request reprint Idiopathic REM sleep behavior disorder in the transition to degenerative disease
    Ronald B Postuma
    Department of Neurology, McGill University, Montreal General Hospital, Montreal, Quebec, Canada
    Mov Disord 24:2225-32. 2009
    ..The indistinguishability of dementia and PD in all ancillary measures suggests a single unitary "RBD-then-neurodegeneration" process, the clinical presentation of which depends upon selective neuronal vulnerability...
  20. ncbi request reprint Neural bases of set-shifting deficits in Parkinson's disease
    Oury Monchi
    Montreal Neurological Institute, McGill University, Montreal, Quebec, H3W 1W5, Canada
    J Neurosci 24:702-10. 2004
    ..These results suggest that both nigrostriatal dopamine depletion and intracortical dopamine deficiency may play a role in cognitive deficits in PD, depending on the involvement of the striatum in the task at hand...
  21. doi request reprint Validation of the non-motor symptoms questionnaire (NMS-Quest)
    S Rios Romenets
    Department of Neurology, McGill University, Montreal General Hospital, Montreal, Quebec, Canada
    Parkinsonism Relat Disord 18:54-8. 2012
    ..Recently a 30-item screening Non Motor Symptoms Questionnaire was developed. Although some psychometric properties have been evaluated, sensitivity and specificity of the questionnaire have not been systematically assessed...
  22. doi request reprint Is there a higher risk of restless legs syndrome in peripheral neuropathy?
    Erin Hattan
    Department of Neurology and Neurosurgery, McGill University, Montreal General Hospital, Montreal, Quebec, Canada
    Neurology 72:955-60. 2009
    ..If RLS prevalence is truly increased by neuropathy, this has important implications for RLS pathophysiology...
  23. ncbi request reprint Olfactory deficit in idiopathic rapid eye movements sleep behavior disorder
    Maria Livia Fantini
    Sleep Disorders Center, Department of Neurology, Universita Vita Salute San Raffaele, via Stamira d Ancona n 20, 20127 Milan, Italy
    Brain Res Bull 70:386-90. 2006
    ..Pathological changes in the anterior olfactory nucleus and olfactory loss occur very early in the course of PD and DLB. The aim of the study was to assess olfactory function in a large group of idiopathic RBD patients...
  24. ncbi request reprint Potential early markers of Parkinson's disease in idiopathic rapid-eye-movement sleep behaviour disorder
    Ronald B Postuma
    Lancet Neurol 5:552-3. 2006
  25. ncbi request reprint Homocysteine and levodopa: should Parkinson disease patients receive preventative therapy?
    Ronald B Postuma
    Morton and Gloria Shulman Movement Disorders Center, Toronto Western Hospital, Ontario, Canada
    Neurology 63:886-91. 2004
    ..At present, no controlled prospective studies have evaluated this phenomenon, although they are ongoing...
  26. ncbi request reprint Rapid-eye-movement sleep behaviour disorder and neurodegenerative diseases
    Jean Francois Gagnon
    Centre d Etude du Sommeil et des Rythmes Biologiques, Hopital du Sacre Coeur de Montreal, Quebec, Canada
    Lancet Neurol 5:424-32. 2006
    ..RBD might be a stage in the development of neurodegenerative disorders and increased awareness of this could lead to substantial advances in knowledge of mechanisms, diagnosis, and treatment of neurodegenerative disorders...
  27. ncbi request reprint Update on the pharmacology of REM sleep behavior disorder
    Jean Francois Gagnon
    Centre d Etude du Sommeil et des Rythmes Biologiques, Hopital du Sacre Coeur de Montreal, Institut Universitaire de Geriatrie de Montreal, Montreal, Quebec, Canada
    Neurology 67:742-7. 2006
    ..When these agents are prescribed to patients with neurodegenerative disorders or narcolepsy who are at risk of developing RBD, systematic follow-up may be warranted to detect the emergence of RBD symptoms...
  28. ncbi request reprint Hemiballism: revisiting a classic disorder
    Ronald B Postuma
    Morton and Gloria Shulman Movement Disorders Center, Toronto Western Hospital, Ontario, Toronto, Canada
    Lancet Neurol 2:661-8. 2003
    ..Recent studies have pointed to previously unrecognised causes, particularly non-ketotic hyperosmolar hyperglycaemia and complications of HIV infection, that may account for a substantial proportion of cases of hemiballism...