M Pollak

Summary

Affiliation: McGill University
Country: Canada

Publications

  1. ncbi request reprint Individualizing interventions for cancer prevention
    Michael Pollak
    Cancer Prevention Centre, McGill University, 3755 Cote Sainte Catherine Road, Montreal, QC, H3T 1E2, Canada
    Recent Results Cancer Res 166:63-9. 2005
  2. ncbi request reprint Circulating levels of insulin-like growth factors, their binding proteins, and breast cancer risk
    Eva S Schernhammer
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 14:699-704. 2005
  3. pmc Metformin and other biguanides in oncology: advancing the research agenda
    Michael Pollak
    3755 Cote Ste Catherine, Montreal, Quebec, Canada H3T 1E2
    Cancer Prev Res (Phila) 3:1060-5. 2010
  4. pmc Insulin-like growth factor-1, insulin-like growth factor binding protein-3 and lobule type in the Nurses' Health Study II
    Megan S Rice
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Ave 3rd Floor, Boston, MA, 02115 USA
    Breast Cancer Res 14:R44. 2012
  5. doi request reprint Targeting oxidative phosphorylation: why, when, and how
    Michael Pollak
    Department of Oncology, McGill University, Montreal, QC H3T1E2, Canada
    Cancer Cell 23:263-4. 2013
  6. doi request reprint Investigating metformin for cancer prevention and treatment: the end of the beginning
    Michael N Pollak
    Department of Oncology, McGill University, Montreal, Quebec, Canada
    Cancer Discov 2:778-90. 2012
  7. doi request reprint Metformin and pancreatic cancer: a clue requiring investigation
    Michael Pollak
    Department of Oncology, Lady Davis Institute for Medical Research of the Jewish General Hospital and McGill University, Montreal, Quebec, Canada
    Clin Cancer Res 18:2723-5. 2012
  8. doi request reprint Metformin reduces endogenous reactive oxygen species and associated DNA damage
    Carolyn Algire
    Division of Experimental Medicine, McGill University and Segal Cancer Centre of Jewish General Hospital, Montreal, Quebec, Canada
    Cancer Prev Res (Phila) 5:536-43. 2012
  9. doi request reprint Metformin and hepatic carcinogenesis
    Michael Pollak
    Lady Davis Research Institute and McGill University, Montreal, Quebec, 3999 Chemin Cote Sainte Catherine, Montreal Quebec H3T 1E2, Canada
    Cancer Prev Res (Phila) 5:500-2. 2012
  10. doi request reprint The insulin and insulin-like growth factor receptor family in neoplasia: an update
    Michael Pollak
    Lady Davis Research Institute and McGill University, Montreal, Quebec H3T1E2, Canada
    Nat Rev Cancer 12:159-69. 2012

Research Grants

Detail Information

Publications77

  1. ncbi request reprint Individualizing interventions for cancer prevention
    Michael Pollak
    Cancer Prevention Centre, McGill University, 3755 Cote Sainte Catherine Road, Montreal, QC, H3T 1E2, Canada
    Recent Results Cancer Res 166:63-9. 2005
    ....
  2. ncbi request reprint Circulating levels of insulin-like growth factors, their binding proteins, and breast cancer risk
    Eva S Schernhammer
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 14:699-704. 2005
    ..Few studies have assessed IGF binding protein-1 (IGFBP-1) or free IGF and breast cancer risk...
  3. pmc Metformin and other biguanides in oncology: advancing the research agenda
    Michael Pollak
    3755 Cote Ste Catherine, Montreal, Quebec, Canada H3T 1E2
    Cancer Prev Res (Phila) 3:1060-5. 2010
    ..Such trials may define important new indications for biguanides in the prevention and/or treatment of many common cancers...
  4. pmc Insulin-like growth factor-1, insulin-like growth factor binding protein-3 and lobule type in the Nurses' Health Study II
    Megan S Rice
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Ave 3rd Floor, Boston, MA, 02115 USA
    Breast Cancer Res 14:R44. 2012
    ..Studies in animal models suggest that insulin-like growth factor-1 (IGF-1) may inhibit involution of lobules in the breast; however, this has not been studied in humans...
  5. doi request reprint Targeting oxidative phosphorylation: why, when, and how
    Michael Pollak
    Department of Oncology, McGill University, Montreal, QC H3T1E2, Canada
    Cancer Cell 23:263-4. 2013
    ....
  6. doi request reprint Investigating metformin for cancer prevention and treatment: the end of the beginning
    Michael N Pollak
    Department of Oncology, McGill University, Montreal, Quebec, Canada
    Cancer Discov 2:778-90. 2012
    ..Significance: There are tantalizing clues that justify the investigation of antineoplastic activities of biguanides. The complexity of their biologic effects requires further translational research to guide clinical trial design...
  7. doi request reprint Metformin and pancreatic cancer: a clue requiring investigation
    Michael Pollak
    Department of Oncology, Lady Davis Institute for Medical Research of the Jewish General Hospital and McGill University, Montreal, Quebec, Canada
    Clin Cancer Res 18:2723-5. 2012
    ..Therefore, the hypothesis that metformin has antineoplastic activity is receiving increasing attention. However, gaps in knowledge must be addressed before metformin can be "repurposed" for oncologic indications...
  8. doi request reprint Metformin reduces endogenous reactive oxygen species and associated DNA damage
    Carolyn Algire
    Division of Experimental Medicine, McGill University and Segal Cancer Centre of Jewish General Hospital, Montreal, Quebec, Canada
    Cancer Prev Res (Phila) 5:536-43. 2012
    ..Our results reveal previously unrecognized inhibitory effects of metformin on ROS production and somatic cell mutation, providing a novel mechanism for the reduction in cancer risk reported to be associated with exposure to this drug...
  9. doi request reprint Metformin and hepatic carcinogenesis
    Michael Pollak
    Lady Davis Research Institute and McGill University, Montreal, Quebec, 3999 Chemin Cote Sainte Catherine, Montreal Quebec H3T 1E2, Canada
    Cancer Prev Res (Phila) 5:500-2. 2012
    ....
  10. doi request reprint The insulin and insulin-like growth factor receptor family in neoplasia: an update
    Michael Pollak
    Lady Davis Research Institute and McGill University, Montreal, Quebec H3T1E2, Canada
    Nat Rev Cancer 12:159-69. 2012
    ..The insulin and IGFI receptor family is also relevant to the development of PI3K-AKT pathway inhibitors...
  11. doi request reprint The insulin receptor/insulin-like growth factor receptor family as a therapeutic target in oncology
    Michael Pollak
    Department of Oncology, McGill University, Jewish General Hospital, Montreal, Quebec, Canada
    Clin Cancer Res 18:40-50. 2012
    ..Future studies are required, but it will be important to optimize their design rather than simply repeat the approaches taken to date...
  12. pmc Milk consumption and the prepubertal somatotropic axis
    Janet W Rich-Edwards
    Connors Center for Women s Health and Gender Biology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Nutr J 6:28. 2007
    ..We conducted pilot studies in Mongolia and Massachusetts to test the extent to which milk intake raised somatotropic hormone concentrations in prepubertal children...
  13. pmc Intact and total insulin-like growth factor-binding protein-3 (IGFBP-3) levels in relation to breast cancer risk factors: a cross-sectional study
    Caroline Diorio
    McGill University, Breast Cancer Functional Genomics Group and McGill Centre for Bioinformatics, 3775 University Street, Montreal, QC H3A 2B4, Canada
    Breast Cancer Res 10:R42. 2008
    ..Here, we examine the association of breast cancer risk factors with intact and total IGFBP-3 levels...
  14. pmc Celecoxib analogues disrupt Akt signaling, which is commonly activated in primary breast tumours
    Jill E Kucab
    British Columbia Research Institute for Children s and Women s Health, Department of Pediatrics, University of British Columbia, Vancouver, British Columbia, Canada
    Breast Cancer Res 7:R796-807. 2005
    ..We therefore examined the potential of these compounds in the treatment of breast cancer. The analogues were characterized in MDA-MB-453 cells because they overexpress HER-2 and have very high levels of P-Akt...
  15. pmc Redefining prognostic factors for breast cancer: YB-1 is a stronger predictor of relapse and disease-specific survival than estrogen receptor or HER-2 across all tumor subtypes
    Golareh Habibi
    Laboratory for Oncogenomic Research, Departments of Pediatrics and Experimental Medicine, Child and Family Research Institute, University of British Columbia, Vancouver, Canada
    Breast Cancer Res 10:R86. 2008
    ..We therefore investigated whether YB-1 identifies patients at risk for either reduced relapse free survival or decreased r breast cancer specific survival (BCSS) across all tumor subtypes by evaluating 4,049 cases...
  16. pmc Inhibition of insulin-like growth factor-1 receptor signaling enhances growth-inhibitory and proapoptotic effects of gefitinib (Iressa) in human breast cancer cells
    Anne Camirand
    Lady Davis Institute for Medical Research, Department of Oncology, McGill University, Montreal, QC, Canada
    Breast Cancer Res 7:R570-9. 2005
    ....
  17. doi request reprint Insulin analogues and cancer risk: cause for concern or cause célèbre?
    M Pollak
    Department of Medicine, McGill University, Montreal, Canada
    Int J Clin Pract 64:628-36. 2010
    ..There is a need for further population studies and for the development of new laboratory models that are more sophisticated than previous experimental methods employed to assess potential tumour growth-promoting properties of insulins...
  18. doi request reprint Macronutrient intake and cancer: how does dietary restriction influence tumor growth and why should we care?
    Michael Pollak
    Division of Cancer Prevention, Department of Oncology, McGill University and Segal Cancer Centre, Montreal, Quebec, Canada
    Cancer Prev Res (Phila) 2:698-701. 2009
    ..Major challenges include defining the underlying mechanisms and determining the clinical relevance of laboratory models of caloric restriction...
  19. doi request reprint Do cancer cells care if their host is hungry?
    Michael Pollak
    Department of Medicine, McGill University, Montreal, Quebec, Canada
    Cell Metab 9:401-3. 2009
    ..A recent report by Kalaany and Sabatini concerning mechanisms underlying the inhibitory effect of dietary restriction on the growth of certain tumors adds to the evidence that insulin and IGF-I are hormones with relevance to oncology...
  20. ncbi request reprint Energy metabolism, cancer risk, and cancer prevention
    Michael Pollak
    General Jewish Hospital, Medicine and Oncology, Montreal, QC, Canada
    Recent Results Cancer Res 181:51-4. 2009
    ..This topic comprises two distinct fields: energetics at (1) the cellular level and (2) the whole organism level. Both of these have relevance to Cancer Risk and Cancer Prevention...
  21. doi request reprint Insulin and insulin-like growth factor signalling in neoplasia
    Michael Pollak
    Department of Oncology, McGill University, Montreal, Quebec, Canada
    Nat Rev Cancer 8:915-28. 2008
    ..Recent results are encouraging and have justified the expansion of many translational research programmes...
  22. doi request reprint Targeting insulin and insulin-like growth factor signalling in oncology
    Michael Pollak
    Department of Oncology, McGill University, Montreal, Quebec, Canada
    Curr Opin Pharmacol 8:384-92. 2008
    ..Most of these trials will involve assessing activity of rational combinations of IGF-I receptor targeting agents with currently approved drugs...
  23. doi request reprint Loss of function of PTEN alters the relationship between glucose concentration and cell proliferation, increases glycolysis, and sensitizes cells to 2-deoxyglucose
    Marie Jose Blouin
    Department of Oncology, McGill University, Segal Cancer Centre, Jewish General Hospital, Montreal, QC, Canada H3T 1E2
    Cancer Lett 289:246-53. 2010
    ..This demonstrates that the impact of loss of function of PTEN is modified by glucose concentration, and may be relevant to epidemiologic results linking hyperglycemia to cancer risk and cancer mortality...
  24. doi request reprint Insulin, insulin-like growth factors and neoplasia
    Michael Pollak
    Department of Oncology, McGill University, 3755 Chemin Cote Sainte Catherine, Montreal, Quebec, Canada
    Best Pract Res Clin Endocrinol Metab 22:625-38. 2008
    ....
  25. ncbi request reprint Challenges to cancer control by screening
    Michael N Pollak
    Programs of Cancer Prevention and Cancer Genetics, McGill University, Montreal, Quebec, Canada H3T 1E2
    Nat Rev Cancer 3:297-303. 2003
    ..What are these biological issues, and what challenges do clinicians face in screening for common cancers?..
  26. ncbi request reprint Insulin-like growth factor-I receptor signaling and resistance to trastuzumab (Herceptin)
    Y Lu
    Department of Oncology, Jewish General Hospital, and McGill University, Montreal, PQ, Canada
    J Natl Cancer Inst 93:1852-7. 2001
    ..Thus, strategies that target IGF-IR signaling may prevent or delay development of resistance to trastuzumab...
  27. ncbi request reprint Insulin-like growth factors and prostate cancer
    M Pollak
    Jewish General Hospital McGill University, Montreal, Quebec, Canada
    Cancer Metastasis Rev 17:383-90. 1998
    ....
  28. doi request reprint BMS-536924 sensitizes human epithelial ovarian cancer cells to the PARP inhibitor, 3-aminobenzamide
    Marie Claude Beauchamp
    Division of Gynecologic Oncology, Jewish General Hospital, McGill University, Montreal, Quebec, Canada
    Gynecol Oncol 115:193-8. 2009
    ..To evaluate the anti-neoplastic activity of BMS-536924, an IGF-1R inhibitor, in epithelial ovarian cancer and its capacity to potentiate the effect of a PARP inhibitor, 3-aminobenzamide...
  29. ncbi request reprint Insulin-like growth factor physiology and cancer risk
    M Pollak
    Cancer Prevention Research Unit, Lady Davis Research Institute of the Jewish General Hospital and McGill University, Montreal, H3T 1E2, Quebec, Canada
    Eur J Cancer 36:1224-8. 2000
    ..This review summarises key results in this field and provides a hypothesis concerning the mechanism by which IGF physiology influences risk of common epithelial cancers including those of breast, prostate, lung and colon...
  30. ncbi request reprint In vivo progression of LAPC-9 and LNCaP prostate cancer models to androgen independence is associated with increased expression of insulin-like growth factor I (IGF-I) and IGF-I receptor (IGF-IR)
    T Nickerson
    Cancer Prevention Research Unit of the Jewish General Hospital and McGill University, Montreal, Quebec, H3T 1E2 Canada
    Cancer Res 61:6276-80. 2001
    ....
  31. doi request reprint Diet and tumor LKB1 expression interact to determine sensitivity to anti-neoplastic effects of metformin in vivo
    C Algire
    E423 Segal Cancer Centre of the Jewish General Hospital, Departments of Experimental Medicine and Oncology, McGill University, Montreal, Quebec, Canada
    Oncogene 30:1174-82. 2011
    ..These findings predict that any clinical utility of metformin or similar compounds in oncology will be restricted to subpopulations defined by host insulin levels and/or loss of function of LKB1...
  32. ncbi request reprint The question of a link between insulin-like growth factor physiology and neoplasia
    M Pollak
    Cancer Prevention Research Unit, Lady Davis Research Institute of the Jewish General Hospital and McGill University, Montreal, Quebec, Canada
    Growth Horm IGF Res 10:S21-4. 2000
    ..The monitoring of serum IGF-I levels may be advisable to help avoid inadvertent over-treatment, particularly in individuals undergoing long-term GH replacement therapy...
  33. doi request reprint In vitro metformin anti-neoplastic activity in epithelial ovarian cancer
    Walter H Gotlieb
    Division of Gynecologic Oncology, Jewish General Hospital, McGill University, Montreal, Quebec, Canada
    Gynecol Oncol 110:246-50. 2008
    ..Metformin, a commonly used drug in the treatment of type II diabetes, may reduce cancer risk and improve cancer prognosis. We evaluated its effect on epithelial ovarian cancer cell lines...
  34. ncbi request reprint Insulin-like growth factor receptor I targeting in epithelial ovarian cancer
    Walter H Gotlieb
    Division of Gynecologic Oncology, McGill University, Montreal, Quebec, Canada
    Gynecol Oncol 100:389-96. 2006
    ..Preclinical evaluation of the anti-neoplastic activity of an insulin-like growth factor I receptor (IGF-IR) kinase inhibitor in ovarian cancer...
  35. ncbi request reprint Insulin-like growth factors and neoplasia
    Michael N Pollak
    Department of Oncology, McGill University and Lady Davis Research Institute, 3999 Rue Côte Sainte Catherine, Montreal, Quebec H3T 1E2, Canada
    Nat Rev Cancer 4:505-18. 2004
  36. pmc Reduced mammary gland carcinogenesis in transgenic mice expressing a growth hormone antagonist
    M Pollak
    Cancer Prevention Research Unit of the Jewish General Hospital and McGill University, Montreal, Quebec, H3T 1E2, Canada
    Br J Cancer 85:428-30. 2001
    ....
  37. doi request reprint Metformin and rapamycin have distinct effects on the AKT pathway and proliferation in breast cancer cells
    Mahvash Zakikhani
    Department of Oncology, McGill University, Montreal, QC, Canada
    Breast Cancer Res Treat 123:271-9. 2010
    ..The data are consistent with the observation that maximal induction of apoptosis and inhibition of proliferation are greater for metformin than rapamycin...
  38. doi request reprint Long-term effects of insulin glargine on the risk of breast cancer
    S Suissa
    Center for Clinical Epidemiology, Lady Davis Research Institute, Jewish General Hospital, 3755 Cote Ste Catherine, Montreal, QC, Canada H3T 1E2
    Diabetologia 54:2254-62. 2011
    ..There have been growing concerns regarding the long-term effects of insulin glargine (A21Gly,B31Arg,B32Arg human insulin) on the risk of breast cancer...
  39. pmc Co-targeting IGF-1R and c-kit: synergistic inhibition of proliferation and induction of apoptosis in H 209 small cell lung cancer cells
    A Camirand
    Lady Davis Institute for Medical Research and Department of Oncology, McGill University, , QC, Canada
    Br J Cancer 90:1825-9. 2004
    ....
  40. pmc The potential role of somatostatin analogues in breast cancer treatment
    M Pollak
    Department of Medicine, McGill University, Montreal, Canada
    Yale J Biol Med 70:535-9. 1997
    ..This has led to suggestions to test these agents clinically in the treatment of breast cancer patients, and a program of clinical trials has recently been initiated. This review will describe aspects of research in this area...
  41. doi request reprint The effects of adiponectin and metformin on prostate and colon neoplasia involve activation of AMP-activated protein kinase
    Mahvash Zakikhani
    Department of Oncology, McGill University, Montreal, Quebec, Canada
    Cancer Prev Res (Phila) 1:369-75. 2008
    ....
  42. ncbi request reprint Serum insulin-like growth factor (IGF)-1 and IGF-binding protein-3 do not correlate with Gleason score or quantity of prostate cancer in biopsy samples
    H A Ismail
    Department of Surgery, McGill University, and the Montreal General Hospital Research Institute, Montreal, Quebec, Canada
    BJU Int 92:699-702. 2003
    ..To examine the relationship of serum insulin-like growth factor (IGF)-1 and IGF binding protein-3 (IGFBP-3) with histological cancer characteristics in men undergoing transrectal ultrasonography (TRUS)-guided biopsy...
  43. ncbi request reprint The human insulin-like growth factor-binding protein 4 gene maps to chromosome region 17q12-q21.1 and is close to the gene for hereditary breast-ovarian cancer
    P Tonin
    Department of Medicine, McGill University, Montreal, Canada
    Genomics 18:414-7. 1993
    ..IGFBP4 is, however, one of the closest known centromeric markers for BRCA1; the estimated recombination fraction is 0.015. IGFBP4 and D17S579 together define a 2.8-cM interval that contains BRCA1...
  44. ncbi request reprint Insulin-like growth factors and neoplasia
    Michael N Pollak
    Department of Oncology, McGill University and Lady Davis Research Institute, 3999 Rue Côte Sainte Catherine, Montreal, Quebec, H3T 1E2, Canada
    Novartis Found Symp 262:84-98; discussion 98-107, 265-8. 2004
    ..This has led to the development of novel IGF-I receptor targeting therapies which have impressive antineoplastic activity in experimental systems...
  45. ncbi request reprint Insulin-like growth factor-I and risk of high-grade cervical intraepithelial neoplasia
    Andrea Schaffer
    Department of Epidemiology and Biostatistics, McGill University, Montreal, Quebec, Canada
    Cancer Epidemiol Biomarkers Prev 16:716-22. 2007
    ..In contrast to the previously reported study, our results suggest that levels of IGF-I in young women may be inversely associated with HGCIN, a precursor to cervical cancer...
  46. ncbi request reprint Tumor suppressor activity of the gene encoding mammary-derived growth inhibitor
    H T Huynh
    Lady Davis Research Institute, McGill University, Montreal, Quebec, Canada
    Cancer Res 55:2225-31. 1995
    ....
  47. ncbi request reprint Novel promoter polymorphism in insulin-like growth factor-binding protein-3: correlation with serum levels and interaction with known regulators
    C Deal
    Department of Pediatrics, Universite de Montreal, Quebec, Canada
    J Clin Endocrinol Metab 86:1274-80. 2001
    ..The IGFBP3 promoter region deserves investigation as a locus where polymorphic variation occurs frequently and may influence GH responsiveness, somatic growth, and possibly cancer risk...
  48. ncbi request reprint Association of total insulin-like growth factor-I, insulin-like growth factor binding protein-1 (IGFBP-1), and IGFBP-3 levels with incident coronary events and ischemic stroke
    Robert C Kaplan
    Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York 10461, USA, and Department of Medicine, Lady Davis Research Institute of Jewish General Hospital, Montreal, Quebec, Canada
    J Clin Endocrinol Metab 92:1319-25. 2007
    ..Prior observational studies have demonstrated that the GH/IGF axis is associated with cardiovascular disease. However, this association has not been extensively studied among older adults...
  49. ncbi request reprint Lifestyle correlates of plasma insulin-like growth factor I and insulin-like growth factor binding protein 3 concentrations
    Michelle D Holmes
    Channing Laboratory, Department of Medicine, Harvard Medical School and Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Cancer Epidemiol Biomarkers Prev 11:862-7. 2002
    ..This is the first report of an inverse association of circulating IGF-I levels with parity. This association may represent one mechanism by which parity exerts its protective effect on some cancers...
  50. ncbi request reprint Potential applications for circulating tumor cells expressing the insulin-like growth factor-I receptor
    Johann S de Bono
    Royal Marsden NHS Foundation Trust, London, United Kingdom
    Clin Cancer Res 13:3611-6. 2007
    ..To detect insulin-like growth factor-IR (IGF-IR) on circulating tumor cells (CTC) as a biomarker in the clinical development of a monoclonal human antibody, CP-751,871, targeting IGF-IR...
  51. pmc Fasting insulin levels and cognitive decline in older women without diabetes
    Marieke van Oijen
    Department of Epidemiology Biostatistics and Neurology, Erasmus Medical Center, Rotterdam, The Netherlands
    Neuroepidemiology 30:174-9. 2008
    ..Type 2 diabetes has been associated with an increased risk of dementia. To assess possible independent effects of insulin, we investigated the relation of insulin levels to cognitive decline in nondiabetic women...
  52. ncbi request reprint Body shape throughout life and correlations with IGFs and GH
    Eva S Schernhammer
    Channing Laboratory, Department of Medicine, Harvard Medical School, Brigham and Women s Hospital, 181 Longwood Avenue, Boston 02115, Massachusetts, USA
    Endocr Relat Cancer 14:721-32. 2007
    ..Our results suggest that childhood and adult body size may affect premenopausal breast cancer risk differently than birth weight, through associations with IGF and GH levels...
  53. ncbi request reprint Prediagnostic plasma C-peptide and pancreatic cancer risk in men and women
    Dominique S Michaud
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 16:2101-9. 2007
    ..An association between serum insulin levels and pancreatic cancer risk was reported in a recent study, but the population was composed of heavy smokers and their findings may not be generalizable to nonsmokers...
  54. pmc Common genetic variation in IGF1, IGFBP-1, and IGFBP-3 in relation to mammographic density: a cross-sectional study
    Rulla M Tamimi
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Breast Cancer Res 9:R18. 2007
    ....
  55. ncbi request reprint Soy isoflavones in the treatment of prostate cancer
    Maha Hussain
    Division of Hematology and Oncology, Wayne State University, Detroit, MI 48201, USA
    Nutr Cancer 47:111-7. 2003
    ..00002) and from 0.11 to 0.51 microM (P = 0.00001), respectively. No significant changes were observed in serum levels of testosterone, IGF-1, IGFBP-3, or 5-OHmdU. These data suggest that soy isoflavones may benefit some patients with Pca...
  56. ncbi request reprint Polymorphic variation at the -202 locus in IGFBP3: Influence on serum levels of insulin-like growth factors, interaction with plasma retinol and vitamin D and breast cancer risk
    Eva S Schernhammer
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Int J Cancer 107:60-4. 2003
    ..Our data do not demonstrate a significant influence of this locus on breast cancer risk, but we cannot exclude a minor influence or an influence confined to subgroups...
  57. ncbi request reprint Re: Italian randomized trial among women with hysterectomy: tamoxifen and hormone-dependent breast cancer in high-risk women
    Rupa Narasimhadevara
    J Natl Cancer Inst 95:917; author reply 918-9. 2003
  58. ncbi request reprint Dinucleotide repeat in the insulin-like growth factor-I gene is not related to risk of colorectal adenoma
    Edward Giovannucci
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cancer Epidemiol Biomarkers Prev 11:1509-10. 2002
  59. ncbi request reprint Glioma risk in relation to serum levels of insulin-like growth factors
    Stefan Lonn
    Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Room 7053, 6120 Executive Boulevard, Bethesda, MD 20892 7238, USA
    Cancer Epidemiol Biomarkers Prev 16:844-6. 2007
    ..3; 95% confidence interval, 0.1-0.7). The results encourage future research on IGFs in relation to brain tumors in larger studies...
  60. ncbi request reprint Dietary correlates of plasma insulin-like growth factor I and insulin-like growth factor binding protein 3 concentrations
    Michelle D Holmes
    Channing Laboratory, Department of Medicine, Harvard Medical School and Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Cancer Epidemiol Biomarkers Prev 11:852-61. 2002
    ..We conclude that higher energy, protein, and milk intakes were associated with higher levels of IGF-I. These associations raise the possibility that diet could affect cancer risk through influencing IGF-I level...
  61. ncbi request reprint A sequence repeat in the insulin-like growth factor-1 gene and risk of breast cancer
    Stacey A Missmer
    Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115 5804, USA
    Int J Cancer 100:332-6. 2002
    ..Although a modest association cannot be excluded, our data do not support an important relation between this IGF-1 gene polymorphism and breast cancer risk...
  62. ncbi request reprint Insulin-like growth factors and ovarian cancer risk: a nested case-control study in three cohorts
    Shelley S Tworoger
    Channing Laboratory, Department of Medicine, Harvard School of Public Health, 3rd Floor, 181 Longwood Avenue, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 16:1691-5. 2007
    ..Overall, our results do not support a positive association between IGF-related proteins and ovarian cancer risk. (Cancer Epidemiol Biomarkers Prev 2007;16(8):1691-5)...
  63. ncbi request reprint A prospective study of C-peptide, insulin-like growth factor-I, insulin-like growth factor binding protein-1, and the risk of colorectal cancer in women
    Esther K Wei
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 3rd Floor, 181 Longwood Avenue, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 14:850-5. 2005
    ..Although altering IGF-I levels may not be practical, the growing burden of obesity and consequently hyperinsulinemia, which seems increasingly important for colon cancer, may be a target for effective prevention...
  64. ncbi request reprint Plasma insulin-like growth factor-1 and binding protein-3 and subsequent risk of prostate cancer in the PSA era
    Elizabeth A Platz
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health and the Brady Urological Institute and the Kimmel Comprehensive Cancer Center, Baltimore, MD 21205, USA
    Cancer Causes Control 16:255-62. 2005
    ..We prospectively investigated the associations of plasma IGF-1 and IGFBP-3 concentrations with prostate cancer detected in the PSA era...
  65. ncbi request reprint Racial differences in premenopausal endogenous hormones
    Simone P Pinheiro
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 14:2147-53. 2005
    ..Further research is needed to explore differences across racial groups and the link between endogenous hormones and breast cancer risk...
  66. doi request reprint Hormonal profile of diabetic men and the potential link to prostate cancer
    Jocelyn S Kasper
    Department of Nutrition, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
    Cancer Causes Control 19:703-10. 2008
    ..To investigate potential biological mechanisms, hormonal profiles of diabetic men and non-diabetic controls were compared...
  67. doi request reprint Total insulinlike growth factor 1 and insulinlike growth factor binding protein levels, functional status, and mortality in older adults
    Robert C Kaplan
    Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Am Geriatr Soc 56:652-60. 2008
    ..To assess the association between total insulinlike growth factor (IGF)-1, IGF binding protein-1 (IGFBP-1), and IGFBP-3 levels and functioning and mortality in older adults...
  68. pmc High insulinlike growth factor binding protein 1 level predicts incident congestive heart failure in the elderly
    Robert C Kaplan
    Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Am Heart J 155:1006-12. 2008
    ..We investigated the association between fasting plasma levels of IGF-I, IGFBP-1, IGFBP-3, and insulin and risk of incident CHF in the prospective Cardiovascular Health Study...
  69. pmc Plasma C-peptide levels and rates of cognitive decline in older, community-dwelling women without diabetes
    Olivia I Okereke
    Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
    Psychoneuroendocrinology 33:455-61. 2008
    ....
  70. ncbi request reprint No association between serum insulin-like growth factor (IGF)-I, IGF-binding protein-3, and lung cancer risk
    Jiyoung Ahn
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, EPS 3044, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Cancer Epidemiol Biomarkers Prev 15:2010-2. 2006
  71. ncbi request reprint Obesity, diabetes, and risk of prostate cancer: results from the prostate cancer prevention trial
    Zhihong Gong
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North M4 B402, Seattle, WA 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 15:1977-83. 2006
    ..Obesity increases the risk of high-grade but decreases the risk of low-grade prostate cancer, and this relationship is independent of the lower risk for prostate cancer among men with diabetes...
  72. ncbi request reprint Insulin-like growth factor-I, its binding proteins (IGFBP-1 and IGFBP-3), and growth hormone and breast cancer risk in The Nurses Health Study II
    Eva S Schernhammer
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, Massachusetts 02115, USA
    Endocr Relat Cancer 13:583-92. 2006
    ..In conclusion, circulating IGF-I, IGFBP-1, IGFBP-3, and GH levels appear to have no important association with breast cancer risk in a large cohort of premenopausal women...
  73. ncbi request reprint Reproducibility of plasma steroid hormones, prolactin, and insulin-like growth factor levels among premenopausal women over a 2- to 3-year period
    Stacey A Missmer
    Channing Laboratory, Brigham and Women s Hospital, 181 Longwood Avenue, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 15:972-8. 2006
    ..For estrone and estradiol, where ICCs were relatively low, it is important to use reproducibility data such as those to correct for measurement error in epidemiologic studies...
  74. ncbi request reprint Dietary feeding of silibinin inhibits prostate tumor growth and progression in transgenic adenocarcinoma of the mouse prostate model
    Komal Raina
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Cancer Res 67:11083-91. 2007
    ....
  75. ncbi request reprint Plasma IGF-I levels and cognitive performance in older women
    Olivia Okereke
    Division of Aging, Department of Medicine, Brigham and Women s Hospital, and Harvard Medical School, 3rd Floor, 181 Longwood Avenue, Boston, MA 02115, USA
    Neurobiol Aging 28:135-42. 2007
    ..Emerging biologic and epidemiologic evidence suggests benefits of insulin-like growth factor-I (IGF-I) in cognitive aging...
  76. ncbi request reprint Diabetes mellitus and cancer risk in a population-based case-control study among men from Montreal, Canada
    Marie Claude Rousseau
    INRS Institut Armand Frappier, Universite du Quebec, Laval QC, Canada
    Int J Cancer 118:2105-9. 2006
    ..In conclusion, diabetes was associated with an increased risk of liver cancer among men, but with no other cancer type including pancreatic cancer...
  77. ncbi request reprint Specimen processing time and measurement of total insulin-like growth factor-I (IGF-I), free IGF-I, and IGF binding protein-3 (IGFBP-3)
    Tiffany G Harris
    Albert Einstein College of Medicine, Bronx, NY, USA
    Growth Horm IGF Res 16:86-92. 2006
    ..However, little is known regarding the effects of blood specimen processing time on measured levels of total and free IGF-I, and on IGFBP-3, the major binding protein...

Research Grants2

  1. Silibinin in Prostate Cancer Chemoprevention & Treatment
    Michael Pollak; Fiscal Year: 2004
    ..The work is justified by the favorable toxicity profile of silibinin, together with prior positive laboratory studies reported by our group and other investigators. ..