Judes Poirier

Summary

Affiliation: McGill University
Country: Canada

Publications

  1. pmc Pharmacogenetic analysis of the effects of polymorphisms in APOE, IDE and IL1B on a ketone body based therapeutic on cognition in mild to moderate Alzheimer's disease; a randomized, double-blind, placebo-controlled study
    Samuel T Henderson
    Accera Inc, Broomfield, CO 80021, USA
    BMC Med Genet 12:137. 2011
  2. ncbi request reprint Apolipoprotein E, cholesterol transport and synthesis in sporadic Alzheimer's disease
    Judes Poirier
    Centre for Studies in Aging, McGill University, Douglas Hospital, 6825 Lasalle, Verdun, Que, H4H 1R3, Canada
    Neurobiol Aging 26:355-61. 2005
  3. doi request reprint Apolipoprotein E represents a potent gene-based therapeutic target for the treatment of sporadic Alzheimer's disease
    Judes Poirier
    McGill Centre for Studies in Aging and Douglas Mental Health University Institute, Montreal, Quebec, Canada
    Alzheimers Dement 4:S91-7. 2008
  4. doi request reprint Double-blind, vehicle-controlled randomized twelve-month neurodevelopmental toxicity study of common aluminum salts in the rat
    J Poirier
    Douglas Mental Health University Institute, Verdun, QC, H4H 1R3, Canada
    Neuroscience 193:338-62. 2011
  5. ncbi request reprint Apolipoprotein E and cholesterol metabolism in the pathogenesis and treatment of Alzheimer's disease
    Judes Poirier
    McGill Centre for Studies in Aging, Douglas Hospital Research Centre, 6825 LaSalle Blvd, Verdun, Quebec, Canada H4H 1R3
    Trends Mol Med 9:94-101. 2003
  6. ncbi request reprint A polymorphism in lipoprotein lipase affects the severity of Alzheimer's disease pathophysiology
    Jean Francois Blain
    Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada
    Eur J Neurosci 24:1245-51. 2006
  7. doi request reprint Involvement of paraoxonase 1 genetic variants in Alzheimer's disease neuropathology
    Valerie Leduc
    Neuroscience Division, Douglas Mental Health University Institute, Perry Pavilion E 3207 1, 6875 LaSalle Blvd, Verdun, Quebec H4H1R3, Canada
    Eur J Neurosci 30:1823-30. 2009
  8. doi request reprint APOE and cholesterol homeostasis in Alzheimer's disease
    Valerie Leduc
    Douglas Mental Health University Institute, 6875 Lasalle, Montreal Verdun, Quebec, H4H 1R3, Canada
    Trends Mol Med 16:469-77. 2010
  9. ncbi request reprint A role for caveolin-1 in post-injury reactive neuronal plasticity
    Sophie B Gaudreault
    Douglas Hospital Research Center, Neurological Sciences Department, McGill University, Montreal, Canada
    J Neurochem 92:831-9. 2005
  10. ncbi request reprint A deficit in astroglial organization causes the impaired reactive sprouting in human apolipoprotein E4 targeted replacement mice
    Jean Francois Blain
    Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada H4A 2B4
    Neurobiol Dis 21:505-14. 2006

Collaborators

Detail Information

Publications29

  1. pmc Pharmacogenetic analysis of the effects of polymorphisms in APOE, IDE and IL1B on a ketone body based therapeutic on cognition in mild to moderate Alzheimer's disease; a randomized, double-blind, placebo-controlled study
    Samuel T Henderson
    Accera Inc, Broomfield, CO 80021, USA
    BMC Med Genet 12:137. 2011
    ..To examine the effect of genetic variation in APOE, IDE and IL1B on the response to induced ketosis in the Alzheimer's Disease Assessment Scale-Cognitive subscale (ADAS-Cog) in subjects with mild to moderate Alzheimer's disease (AD)...
  2. ncbi request reprint Apolipoprotein E, cholesterol transport and synthesis in sporadic Alzheimer's disease
    Judes Poirier
    Centre for Studies in Aging, McGill University, Douglas Hospital, 6825 Lasalle, Verdun, Que, H4H 1R3, Canada
    Neurobiol Aging 26:355-61. 2005
    ....
  3. doi request reprint Apolipoprotein E represents a potent gene-based therapeutic target for the treatment of sporadic Alzheimer's disease
    Judes Poirier
    McGill Centre for Studies in Aging and Douglas Mental Health University Institute, Montreal, Quebec, Canada
    Alzheimers Dement 4:S91-7. 2008
  4. doi request reprint Double-blind, vehicle-controlled randomized twelve-month neurodevelopmental toxicity study of common aluminum salts in the rat
    J Poirier
    Douglas Mental Health University Institute, Verdun, QC, H4H 1R3, Canada
    Neuroscience 193:338-62. 2011
    ....
  5. ncbi request reprint Apolipoprotein E and cholesterol metabolism in the pathogenesis and treatment of Alzheimer's disease
    Judes Poirier
    McGill Centre for Studies in Aging, Douglas Hospital Research Centre, 6825 LaSalle Blvd, Verdun, Quebec, Canada H4H 1R3
    Trends Mol Med 9:94-101. 2003
    ....
  6. ncbi request reprint A polymorphism in lipoprotein lipase affects the severity of Alzheimer's disease pathophysiology
    Jean Francois Blain
    Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada
    Eur J Neurosci 24:1245-51. 2006
    ....
  7. doi request reprint Involvement of paraoxonase 1 genetic variants in Alzheimer's disease neuropathology
    Valerie Leduc
    Neuroscience Division, Douglas Mental Health University Institute, Perry Pavilion E 3207 1, 6875 LaSalle Blvd, Verdun, Quebec H4H1R3, Canada
    Eur J Neurosci 30:1823-30. 2009
    ..001) and choline acetyltransferase activity (P < 0.05) in, respectively, two of two, five of six, and three of six brain areas. These results suggest an involvement of the PON1 gene in AD etiopathology and responses to treatment...
  8. doi request reprint APOE and cholesterol homeostasis in Alzheimer's disease
    Valerie Leduc
    Douglas Mental Health University Institute, 6875 Lasalle, Montreal Verdun, Quebec, H4H 1R3, Canada
    Trends Mol Med 16:469-77. 2010
    ....
  9. ncbi request reprint A role for caveolin-1 in post-injury reactive neuronal plasticity
    Sophie B Gaudreault
    Douglas Hospital Research Center, Neurological Sciences Department, McGill University, Montreal, Canada
    J Neurochem 92:831-9. 2005
    ..Altogether, these results indicate that caveolin-1 plays an active role in the regulation of injury-induced synaptic and terminal remodeling in the adult CNS...
  10. ncbi request reprint A deficit in astroglial organization causes the impaired reactive sprouting in human apolipoprotein E4 targeted replacement mice
    Jean Francois Blain
    Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada H4A 2B4
    Neurobiol Dis 21:505-14. 2006
    ..ApoE and beta-amyloid (Abeta) 1-40 accumulated at 30 DPL in hE4 mice. These results suggest that the presence of apoE4 delays the astroglial repair process and indirectly compromises synaptic remodeling...
  11. doi request reprint Normalization of gene expression using SYBR green qPCR: a case for paraoxonase 1 and 2 in Alzheimer's disease brains
    Valerie Leduc
    Douglas Mental Health University Institute, Verdun, QC H4H1R3, Canada
    J Neurosci Methods 200:14-9. 2011
    ..The use of a computational method allowing the inclusion of possible confounding factors is thus recommended for the analysis of data...
  12. pmc Motor system alterations in retired former athletes: the role of aging and concussion history
    Louis De Beaumont
    Centre de Recherche en Neuropsychologie et Cognition CERNEC, Universite de Montreal, Montreal, Canada
    BMC Neurol 13:109. 2013
    ..The present study investigated the effects of aging on motor system metabolism and function in former university-level athletes who sustained their last concussion several decades prior to testing...
  13. doi request reprint Altered bidirectional plasticity and reduced implicit motor learning in concussed athletes
    Louis De Beaumont
    Centre de Recherche en Neuropsychologie et Cognition CERNEC, Department of Psychology Université de Montréal, Montreal, Quebec, Canada
    Cereb Cortex 22:112-21. 2012
    ....
  14. ncbi request reprint The apoE receptor apoER2 is involved in the maintenance of efficient synaptic plasticity
    Caroline Petit-Turcotte
    Douglas Hospital Research Center, 6875 LaSalle Blvd, Verdun, Que, Canada H4H 1R3
    Neurobiol Aging 26:195-206. 2005
    ..The results suggest a significant role for apoER2 in signalling various proteins in response to massive deafferentation and may participate in maintaining efficient synaptic plasticity and dendritic remodelling...
  15. ncbi request reprint Cholesterol homeostasis and the pathophysiology of Alzheimer's disease
    Jean Francois Blain
    Douglas Hospital Research Centre, 6875 LaSalle Blvd, Verdun, Quebec, H4H 1R3, Canada
    Expert Rev Neurother 4:823-9. 2004
    ....
  16. doi request reprint Sports concussions and aging: a neuroimaging investigation
    Sebastien Tremblay
    Centre de Recherche en Neuropsychologie et Cognition, University of Montreal, Montreal, Canada
    Cereb Cortex 23:1159-66. 2013
    ..Findings from this study highlight patterns of decline often associated with abnormal aging...
  17. ncbi request reprint Pro-inflammatory cytokines modulate glial apolipoprotein E secretion
    Rosanne Aleong
    Department of Neurology and Neurosurgery, Montreal, Quebec, Canada
    Curr Alzheimer Res 5:33-7. 2008
    ..These results are consistent with the notion that elevated cytokine expression directly modulates immunosuppression and indirectly apoE-mediated neuronal remodeling...
  18. doi request reprint Polymorphisms at the paraoxonase 1 L55M and Q192R loci affect the pathophysiology of Alzheimer's disease: emphasis on the cholinergic system and beta-amyloid levels
    Valerie Leduc
    Douglas Mental Health University Institute, Verdun, Que, Canada
    Neurodegener Dis 5:225-7. 2008
    ..Recent studies have shown that polymorphisms at the PON1 L55M and Q192R loci might affect individual susceptibility to experience-derived and environmental events such as the exposure to inhibitors of cholinesterase (ChEIs)...
  19. doi request reprint Acute and long-term associations between ApoE genetic polymorphism, cortisol levels, and declarative memory performance in older adults
    Alexandra J Fiocco
    Douglas Hospital Research Center, Montreal Verdun, Quebec, Canada H4H 1R3
    Psychoneuroendocrinology 33:625-33. 2008
    ..To date, only one study has reported a relationship between APOE status and cortisol levels, however the relationship was only found to be significant in dementia patients, with a trend observed in healthy controls...
  20. doi request reprint Altered declarative memory in introverted middle-aged adults carrying the BDNF val66met allele
    Louis De Beaumont
    Department of Psychology, University of Quebec at Trois Rivieres, Trois Rivieres, Quebec, Canada Montreal Sacred Heart Hospital Research Centre, Montreal, Quebec, Canada Electronic address
    Behav Brain Res 253:152-6. 2013
    ..Here, we examine the potential relationship between the BDNFMet allele, introversion and declarative memory in middle-age adults...
  21. ncbi request reprint Increased caveolin-1 expression in Alzheimer's disease brain
    Sophie B Gaudreault
    Departments of Psychiatry and Neurology and Neurosurgery, Douglas Hospital Research Centre, McGill University, Montreal, Que, Canada H4A 2B4
    Neurobiol Aging 25:753-9. 2004
    ..These results indicate that caveolin over-expression is linked to alterations of cholesterol distribution in the plasma membrane of brain cells and are consistent with the notion of a deterioration of cholesterol homeostasis in AD...
  22. pmc Function and comorbidities of apolipoprotein e in Alzheimer's disease
    Valerie Leduc
    Department of Psychiatry, Douglas Mental Health University Institute, Perry Pavilion, E 3207 1, 6875 LaSalle Boulevard, Verdun, QC, Canada H4H1R3
    Int J Alzheimers Dis 2011:974361. 2011
    ....
  23. doi request reprint Current and future management of Alzheimer's disease
    Serge Gauthier
    McGill Center for Studies in Aging, Douglas Institute for Mental Health, Montreal, Quebec, Canada
    Alzheimers Dement 4:S48-50. 2008
    ..There are multiple research opportunities for better understanding and treatment of this condition. Ongoing cohort studies developed under Leon Thal's leadership will facilitate this process...
  24. ncbi request reprint Could lipoprotein lipase play a role in Alzheimer's disease?
    Jean Francois Blain
    Douglas Hospital Research Center, Verdun, Quebec, Canada
    ScientificWorldJournal 4:531-5. 2004
    ..This novel role could have implication for Alzheimer's disease treatment...
  25. ncbi request reprint A role for lipoprotein lipase during synaptic remodeling in the adult mouse brain
    Jean Francois Blain
    Department of Anatomy and Physiology, Faculty of Medicine, Laval University, Ste Foy, Quebec, Canada
    Neurobiol Dis 15:510-9. 2004
    ..These results suggest that LPL is involved in the recycling of cholesterol and lipids released from degenerating terminals after a lesion through a syndecan-4-dependent pathway...
  26. ncbi request reprint Non-steroidal anti-inflammatory drugs mediate increased in vitro glial expression of apolipoprotein E protein
    Rosanne Aleong
    Douglas Hospital Research Centre, McGill University, Montreal, Quebec, Canada
    Eur J Neurosci 18:1428-38. 2003
    ..Consequently, NSAID-induced increases in apoE protein may enhance apoE-mediated immunosuppression and compensatory synaptic plasticity, potentially resulting in decreased AD risk and delay of disease onset...
  27. doi request reprint ABCG1 influences the brain cholesterol biosynthetic pathway but does not affect amyloid precursor protein or apolipoprotein E metabolism in vivo
    Braydon L Burgess
    Department of Pathology and Laboratory Medicine, Child and Family Research Institute, University of British Columbia, Vancouver, Canada
    J Lipid Res 49:1254-67. 2008
    ....
  28. ncbi request reprint The absence of ABCA1 decreases soluble ApoE levels but does not diminish amyloid deposition in two murine models of Alzheimer disease
    Veronica Hirsch-Reinshagen
    Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V4Z 5H5, Canada
    J Biol Chem 280:43243-56. 2005
    ..These data suggested that ABCA1-mediated effects on apoE levels and lipidation influenced amyloidogenesis in vivo...
  29. ncbi request reprint Influence of the apolipoprotein E epsilon4 allele on human embryonic development
    Henrik Zetterberg
    Department of Clinical Chemistry and Transfusion Medicine, Sahlgrenska University Hospital, Goteborg University, 41345 Gothenburg, Sweden
    Neurosci Lett 324:189-92. 2002
    ..005), suggesting that epsilon4 may have protective effects during embryogenesis. These protective effects might counterbalance the deleterious age-related effects of the epsilon4 allele in natural selection...