M Pai

Summary

Affiliation: McGill University
Country: Canada

Publications

  1. ncbi New tools and emerging technologies for the diagnosis of tuberculosis: part II. Active tuberculosis and drug resistance
    Madhukar Pai
    University of California, Berkeley and San Francisco, Berkeley Division of Epidemiology, 140, Warren Hall, Berkeley, CA 94720, USA
    Expert Rev Mol Diagn 6:423-32. 2006
  2. pmc Commercial nucleic-acid amplification tests for diagnosis of pulmonary tuberculosis in respiratory specimens: meta-analysis and meta-regression
    Daphne I Ling
    Division of Epidemiology, School of Public Health, University of California, Berkeley, California, USA
    PLoS ONE 3:e1536. 2008
  3. pmc T-cell assays for tuberculosis infection: deriving cut-offs for conversions using reproducibility data
    Anandharaman Veerapathran
    Department of Biochemistry, Mahatma Gandhi Institute of Medical Sciences, Sevagram, Maharashtra, India
    PLoS ONE 3:e1850. 2008
  4. pmc Quality and reporting of diagnostic accuracy studies in TB, HIV and malaria: evaluation using QUADAS and STARD standards
    Patricia Scolari Fontela
    Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Canada
    PLoS ONE 4:e7753. 2009
  5. pmc Prevalence of abnormal radiological findings in health care workers with latent tuberculosis infection and correlations with T cell immune response
    Rajnish Joshi
    Division of Epidemiology, School of Public Health, University of California at Berkeley, Berkeley, California, United States of America Department of Medicine, Mahatma Gandhi Institute of Medical Sciences, Sevagram, Maharashtra, India
    PLoS ONE 2:e805. 2007
  6. pmc Comparison of LED and conventional fluorescence microscopy for detection of acid fast bacilli in a low-incidence setting
    Jessica Minion
    Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Canada
    PLoS ONE 6:e22495. 2011
  7. pmc Within-subject variability of interferon-g assay results for tuberculosis and boosting effect of tuberculin skin testing: a systematic review
    Richard N van Zyl-Smit
    Lung Infection and Immunity Unit, Division of Pulmonology and UCT Lung Institute, Department of Medicine, University of Cape Town, Cape Town, South Africa
    PLoS ONE 4:e8517. 2009
  8. pmc The BCG World Atlas: A Database of Global BCG Vaccination Policies and Practices
    Alice Zwerling
    Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Canada
    PLoS Med 8:e1001012. 2011
  9. pmc A pilot study of short-duration sputum pretreatment procedures for optimizing smear microscopy for tuberculosis
    Peter Daley
    Department of Medicine, Christian Medical College Vellore, Vellore, India
    PLoS ONE 4:e5626. 2009
  10. pmc Research questions and priorities for tuberculosis: a survey of published systematic reviews and meta-analyses
    Ioana Nicolau
    McGill University, Montreal, Quebec, Canada
    PLoS ONE 7:e42479. 2012

Detail Information

Publications126 found, 100 shown here

  1. ncbi New tools and emerging technologies for the diagnosis of tuberculosis: part II. Active tuberculosis and drug resistance
    Madhukar Pai
    University of California, Berkeley and San Francisco, Berkeley Division of Epidemiology, 140, Warren Hall, Berkeley, CA 94720, USA
    Expert Rev Mol Diagn 6:423-32. 2006
    ..Latent TB is discussed in Part I; 413-422 of this issue...
  2. pmc Commercial nucleic-acid amplification tests for diagnosis of pulmonary tuberculosis in respiratory specimens: meta-analysis and meta-regression
    Daphne I Ling
    Division of Epidemiology, School of Public Health, University of California, Berkeley, California, USA
    PLoS ONE 3:e1536. 2008
    ..We performed a meta-analysis on the accuracy of commercial NAATs to diagnose pulmonary TB and meta-regression to identify factors that are associated with higher accuracy...
  3. pmc T-cell assays for tuberculosis infection: deriving cut-offs for conversions using reproducibility data
    Anandharaman Veerapathran
    Department of Biochemistry, Mahatma Gandhi Institute of Medical Sciences, Sevagram, Maharashtra, India
    PLoS ONE 3:e1850. 2008
    ..A logical start is to determine the within-person variability of T-cell responses during serial testing...
  4. pmc Quality and reporting of diagnostic accuracy studies in TB, HIV and malaria: evaluation using QUADAS and STARD standards
    Patricia Scolari Fontela
    Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Canada
    PLoS ONE 4:e7753. 2009
    ..However, it is unclear whether these tools have been applied to diagnostic studies of infectious diseases. We performed a systematic review on the methodological and reporting quality of diagnostic studies in TB, malaria and HIV...
  5. pmc Prevalence of abnormal radiological findings in health care workers with latent tuberculosis infection and correlations with T cell immune response
    Rajnish Joshi
    Division of Epidemiology, School of Public Health, University of California at Berkeley, Berkeley, California, United States of America Department of Medicine, Mahatma Gandhi Institute of Medical Sciences, Sevagram, Maharashtra, India
    PLoS ONE 2:e805. 2007
    ..We determined radiological lesions in a cohort of HCWs with latent TB infection (LTBI) in India, and determined their association with demographic, occupational and T-cell immune response variables...
  6. pmc Comparison of LED and conventional fluorescence microscopy for detection of acid fast bacilli in a low-incidence setting
    Jessica Minion
    Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Canada
    PLoS ONE 6:e22495. 2011
    ....
  7. pmc Within-subject variability of interferon-g assay results for tuberculosis and boosting effect of tuberculin skin testing: a systematic review
    Richard N van Zyl-Smit
    Lung Infection and Immunity Unit, Division of Pulmonology and UCT Lung Institute, Department of Medicine, University of Cape Town, Cape Town, South Africa
    PLoS ONE 4:e8517. 2009
    ..However, the effect of a preceding TST on subsequent IGRA results has been reported in studies with apparently conflicting results...
  8. pmc The BCG World Atlas: A Database of Global BCG Vaccination Policies and Practices
    Alice Zwerling
    Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Canada
    PLoS Med 8:e1001012. 2011
    ..Madhu Pai and colleagues introduce the BCG World Atlas, an open access, user friendly Web site for TB clinicians to discern global BCG vaccination policies and practices and improve the care of their patients...
  9. pmc A pilot study of short-duration sputum pretreatment procedures for optimizing smear microscopy for tuberculosis
    Peter Daley
    Department of Medicine, Christian Medical College Vellore, Vellore, India
    PLoS ONE 4:e5626. 2009
    ..We did a pilot study to compare the diagnostic accuracy and incremental yield of two short-duration (<1 hour) sputum pretreatment procedures to optimize direct smears among patients with suspected TB at a referral hospital in India...
  10. pmc Research questions and priorities for tuberculosis: a survey of published systematic reviews and meta-analyses
    Ioana Nicolau
    McGill University, Montreal, Quebec, Canada
    PLoS ONE 7:e42479. 2012
    ..As part of the process of developing the International Roadmap for TB Research, we did a systematic review of published systematic reviews on TB, to identify research priorities that are most frequently suggested in reviews...
  11. pmc Tuberculosis infection among young nursing trainees in South India
    Devasahayam J Christopher
    Department of Pulmonary Medicine, Christian Medical College, Vellore, Tamil Nadu, India
    PLoS ONE 5:e10408. 2010
    ..To better understand the epidemiology of nosocomial TB among nurses, we recruited a cohort of young nursing trainees at Christian Medical College, a large, tertiary medical school hospital in Southern India...
  12. pmc Commercial serological tests for the diagnosis of active pulmonary and extrapulmonary tuberculosis: an updated systematic review and meta-analysis
    Karen R Steingart
    Department of Health Services, University of Washington School of Public Health, Seattle, Washington, United States of America
    PLoS Med 8:e1001062. 2011
    ....
  13. pmc Serological testing versus other strategies for diagnosis of active tuberculosis in India: a cost-effectiveness analysis
    David W Dowdy
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America
    PLoS Med 8:e1001074. 2011
    ..The cost and impact of using serology compared with other diagnostic techniques is unknown...
  14. pmc Point-of-Care Testing for Infectious Diseases: Diversity, Complexity, and Barriers in Low- And Middle-Income Countries
    Nitika Pant Pai
    Division of Clinical Epidemiology, Department of Medicine, McGill University, Montreal, Canada
    PLoS Med 9:e1001306. 2012
    ..Madhukar Pai and colleagues discuss a framework for envisioning how point-of-care testing can be applied to infectious diseases in low- and middle-income countries...
  15. pmc High annual risk of tuberculosis infection among nursing students in South India: a cohort study
    Devasahayam J Christopher
    Christian Medical College, Vellore, India
    PLoS ONE 6:e26199. 2011
    ..Annual tuberculin skin testing (TST) was conducted to assess the annual risk of TB infection (ARTI) in this cohort...
  16. pmc Point-of-care urine tests for smoking status and isoniazid treatment monitoring in adult patients
    Ioana Nicolau
    Department of Epidemiology and Biostatistics, McGill University, Montreal, Canada
    PLoS ONE 7:e45913. 2012
    ....
  17. pmc Repeat IGRA testing in Canadian health workers: conversions or unexplained variability?
    Alice Zwerling
    Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Canada
    PLoS ONE 8:e54748. 2013
    ....
  18. pmc TB screening in Canadian health care workers using interferon-gamma release assays
    Alice Zwerling
    Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Canada
    PLoS ONE 7:e43014. 2012
    ....
  19. doi New tuberculosis technologies: challenges for retooling and scale-up
    M Pai
    Department of Epidemiology and Biostatistics, McGill University, Montreal, Quebec, Canada
    Int J Tuberc Lung Dis 16:1281-90. 2012
    ..They may provide the first opportunities to fully assess the public health impact of new tools...
  20. doi Novel and improved technologies for tuberculosis diagnosis: progress and challenges
    Madhukar Pai
    Department of Epidemiology, Biostatistics and Occupational Health, McGill University, 1020 Pine Avenue West, Montreal, H3A 1A2, Canada
    Clin Chest Med 30:701-16, viii. 2009
    ..This article reviews the existing evidence base on TB diagnostics, describes the progress of new technologies, and ends with a review of cost-effectiveness and modeling studies on the potential effect of new diagnostics in TB control...
  21. doi New and improved tuberculosis diagnostics: evidence, policy, practice, and impact
    Madhukar Pai
    Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Canada
    Curr Opin Pulm Med 16:271-84. 2010
    ....
  22. pmc Nosocomial tuberculosis in India
    Madhukar Pai
    Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Quebec, Canada
    Emerg Infect Dis 12:1311-8. 2006
    ..Finally, we outline the critical information needed to effectively address the problem of nosocomial transmission of TB in India...
  23. ncbi Bacteriophage assays for rifampicin resistance detection in Mycobacterium tuberculosis: updated meta-analysis
    J Minion
    Department of Epidemiology, McGill University, Montreal, Quebec, Canada
    Int J Tuberc Lung Dis 14:941-51. 2010
    ..Tests included the commercial FASTPlaque assays, luciferase reporter phage (LRP) assays, and in-house phage amplification tests. Sensitivity and specificity for RMP resistance were the main outcomes...
  24. pmc Sensitivity of a whole-blood interferon-gamma assay among patients with pulmonary tuberculosis and variations in T-cell responses during anti-tuberculosis treatment
    M Pai
    Dept of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, QC, Canada H3A 1A2
    Infection 35:98-103. 2007
    ..Interferon-gamma (IFN-gamma) assays are new tests for tuberculosis (TB) infection, and T-cell responses may be correlated with antigen burden. However, it is unclear if IFN-gamma assays can be used to monitor response to TB treatment...
  25. pmc Evidence-based tuberculosis diagnosis
    Madhukar Pai
    Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Quebec, Canada
    PLoS Med 5:e156. 2008
  26. pmc Serial testing of health care workers for tuberculosis using interferon-gamma assay
    Madhukar Pai
    Division of Epidemiology, School of Public Health, University of California, Berkeley, CA, USA
    Am J Respir Crit Care Med 174:349-55. 2006
    ..Although interferon-gamma (IFN-gamma) assays are promising alternatives to the tuberculin skin test (TST), their serial testing performance is unknown...
  27. pmc T-cell assay conversions and reversions among household contacts of tuberculosis patients in rural India
    M Pai
    Department of Epidemiology and Biostatistics, McGill University, Montreal, Quebec, Canada
    Int J Tuberc Lung Dis 13:84-92. 2009
    ..In a pilot study, we determined conversions and reversions using QuantiFERON-TB Gold In-Tube((R)) (QFT) among household contacts of TB cases, and evaluated the effect of using various definitions and criteria for conversions...
  28. doi Interferon-gamma release assays for tuberculosis screening of healthcare workers: a systematic review
    Alice Zwerling
    McGill University and Montreal Chest Institute, Montreal, Canada
    Thorax 67:62-70. 2012
    ..Further longitudinal research will be required to inform guidelines on serial testing using IGRAs...
  29. pmc Improving the estimation of tuberculosis infection prevalence using T-cell-based assay and mixture models
    M Pai
    Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Canada
    Int J Tuberc Lung Dis 12:895-902. 2008
    ..Highly specific blood-based interferon-gamma release assays (IGRAs) are now available and could enhance the estimation of LTBI prevalence in combination with model-based methods...
  30. pmc Systematic review: T-cell-based assays for the diagnosis of latent tuberculosis infection: an update
    Madhukar Pai
    McGill University and Montreal Chest Institute, Montreal, Quebec, Canada
    Ann Intern Med 149:177-84. 2008
    ..A recent meta-analysis showed that IGRAs have high specificity, even among populations that have received bacille Calmette-Guérin (BCG) vaccination. Sensitivity was suboptimal for TST and IGRAs...
  31. doi New diagnostics for latent and active tuberculosis: state of the art and future prospects
    Madhukar Pai
    Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Quebec, Canada
    Semin Respir Crit Care Med 29:560-8. 2008
    ....
  32. ncbi Lethal interaction: the colliding epidemics of tobacco and tuberculosis
    Madhukar Pai
    Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Canada
    Expert Rev Anti Infect Ther 5:385-91. 2007
    ..Since tobacco control will have multiple health benefits, it is likely to be a highly cost-effective intervention from a societal perspective...
  33. pmc Serial testing for tuberculosis: can we make sense of T cell assay conversions and reversions?
    Madhukar Pai
    Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Quebec, Canada
    PLoS Med 4:e208. 2007
  34. ncbi International standards for tuberculosis care: relevance and implications for laboratory professionals
    M Pai
    Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Quebec, H3A 1A2, Canada
    Indian J Med Microbiol 25:89-92. 2007
    ....
  35. pmc Diagnostic accuracy of the microscopic observation drug susceptibility assay: a pilot study from India
    J S Michael
    Department of Microbiology, Christian Medical College, Vellore, Tamil Nadu, India
    Int J Tuberc Lung Dis 14:482-8. 2010
    ..The microscopic observation drug susceptibility (MODS) assay is a rapid, sensitive, low-cost liquid culture technique...
  36. doi Are interferon-γ release assays useful for diagnosing active tuberculosis in a high-burden setting?
    D I Ling
    Dept of Medicine, Groote Schuur Hospital, Observatory, Cape Town, South Africa
    Eur Respir J 38:649-56. 2011
    ..In a high-burden setting, IGRAs alone do not have value as rule-in or -out tests for active TB. In smear-negative patients, chest radiography had better NPV even in HIV-infected patients...
  37. ncbi Risk of tuberculosis infection and disease associated with work in health care settings
    D Menzies
    Respiratory Epidemiology and Clinical Research Unit, Montreal Chest Institute, McGill University, Montreal, Canada
    Int J Tuberc Lung Dis 11:593-605. 2007
    ..Tuberculosis (TB) in health care workers (HCWs) was not considered a serious problem following the advent of effective antibiotic therapy. Interest was re-stimulated by the occurrence of several major nosocomial outbreaks...
  38. doi Microcolony culture techniques for tuberculosis diagnosis: a systematic review
    E Leung
    Respiratory Epidemiology and Clinical Research Unit, Montreal Chest Institute, Montreal, Quebec, Canada
    Int J Tuberc Lung Dis 16:16-23, i-iii. 2012
    ..The microscopic observation drug susceptibility (MODS) assay and the thin-layer agar (TLA) assay are inexpensive, rapid microcolony-based culture methods...
  39. doi Predicting outcomes and drug resistance with standardised treatment of active tuberculosis
    O Oxlade
    McGill University, Respiratory Epidemiology Unit, Montreal Chest Institute, 3650 St Urbain, Room K1 24, Montreal, QC, H2X 2P4, Canada
    Eur Respir J 36:870-7. 2010
    ..We predict substantial public health benefits from changing from the 8-month to the 6-month regimen. However in almost all settings the current standardised retreatment regimen will no longer be adequate...
  40. ncbi Thinking in three dimensions: a web-based algorithm to aid the interpretation of tuberculin skin test results
    D Menzies
    Respiratory Epidemiology and Clinical Research Unit, Montreal Chest Institute, McGill University, Montreal, Canada
    Int J Tuberc Lung Dis 12:498-505. 2008
    ..Accurate interpretation of TST requires consideration of three dimensions-the size of the skin reaction, the positive predictive value (PPV) and risk of disease...
  41. pmc Systematic review and meta-analysis of antigen detection tests for the diagnosis of tuberculosis
    L L Flores
    Division of Pulmonary and Critical Care Medicine, San Francisco General Hospital, University of California, San Francisco, California, USA
    Clin Vaccine Immunol 18:1616-27. 2011
    ..Considering that antigen detection tests could be translated into rapid point-of-care tests, research to improve their performance is urgently needed...
  42. doi GenoType MTBDR assays for the diagnosis of multidrug-resistant tuberculosis: a meta-analysis
    D I Ling
    Dept of Epidemiology, Biostatistics and Occupational Health, McGill University, 1020 Pine Avenue West, Montreal, QC H3A 1A2, Canada
    Eur Respir J 32:1165-74. 2008
    ..While specificity is excellent for isoniazid, sensitivity estimates were modest and variable. Together with data from demonstration projects, the meta-analysis provides evidence for policy making and clinical practice...
  43. ncbi Global tuberculosis trends: a reflection of changes in tuberculosis control or in population health?
    O Oxlade
    Respiratory Epidemiology and Clinical Research Unit, Montreal Chest Institute, McGill University, Montreal, Quebec, Canada
    Int J Tuberc Lung Dis 13:1238-46. 2009
    ..We have analyzed the association between changes in population health and health service indicators, and concomitant changes in TB incidence between 1990 and 2005...
  44. pmc Interferon release does not add discriminatory value to smear-negative HIV-tuberculosis algorithms
    M X Rangaka
    Centre for Infectious Disease and Epidemiology Research School of Health Sciences, University of Cape Town, Observatory, 7925, Cape Town, South Africa
    Eur Respir J 39:163-71. 2012
    ..Evaluation of new TB diagnostics for clinical relevance should follow a multivariable process that goes beyond test accuracy...
  45. pmc Blinded evaluation of commercial urinary lipoarabinomannan for active tuberculosis: a pilot study
    P Daley
    Department of Medicine, Christian Medical College, Vellore, India
    Int J Tuberc Lung Dis 13:989-95. 2009
    ..Urine antigen testing is an attractive strategy for the diagnosis of active tuberculosis (TB), but accuracy data are scarce...
  46. ncbi Alternatives to the tuberculin skin test: interferon-gamma assays in the diagnosis of mycobacterium tuberculosis infection
    M Pai
    Division of Epidemiology, University of California, Berkeley, CA 94720, and Division of Pulmonary and Critical Care Medicine, San Francisco General Hospital, University of California, San Francisco, USA
    Indian J Med Microbiol 23:151-8. 2005
    ..To fully evaluate the utility of IFN-gamma assays in high burden countries such as India, long-term cohort studies are needed to determine the association between positive IFN-gamma results and the subsequent risk of active disease...
  47. pmc Does bleach processing increase the accuracy of sputum smear microscopy for diagnosing pulmonary tuberculosis?
    A Cattamanchi
    Division of Pulmonary and Critical Care Medicine, San Francisco General Hospital, University of California, San Francisco, CA 94110, USA
    J Clin Microbiol 48:2433-9. 2010
    ..Further research should focus on alternative approaches to optimizing smear microscopy, such as light-emitting diode fluorescence microscopy and same-day sputum collection strategies...
  48. ncbi New tools and emerging technologies for the diagnosis of tuberculosis: part I. Latent tuberculosis
    Madhukar Pai
    University of California, Berkeley and San Francisco, Berkeley Division of Epidemiology, 140, Warren Hall, Berkeley, CA 94720, USA
    Expert Rev Mol Diagn 6:413-22. 2006
    ..The review concludes by highlighting areas where evidence is lacking, and provides an agenda for future research. Active TB and drug resistance are discussed in Part II; 423-432 of this issue...
  49. doi Comparative cost and performance of light-emitting diode microscopy in HIV-tuberculosis-co-infected patients
    A Whitelaw
    Division of Medical Microbiology, UCT Lung Institute, University of Cape Town, Cape Town, South Africa
    Eur Respir J 38:1393-7. 2011
    ..63) compared with ZN microscopy (US$2.10). Among HIV-TB-co-infected patients, LED microscopy was cheaper and performed as well as ZN microscopy or MVFM independent of the staining (ZN or auramine O) or processing methods used...
  50. doi Global lung health: the colliding epidemics of tuberculosis, tobacco smoking, HIV and COPD
    R N van Zyl Smit
    Lung Infection and Immunity Unit, Division of Pulmonology and UCT Lung Institute, Dept of Medicine, University of Cape Town, Cape Town, South Africa
    Eur Respir J 35:27-33. 2010
    ..These interactions deserve urgent attention and have major implications for coordinated public health planning and policy recommendations in the developing world...
  51. ncbi Interferon-gamma assays in the immunodiagnosis of tuberculosis: a systematic review
    Madhukar Pai
    Division of Epidemiology, School of Public Health, University of California, Berkeley, CA, USA
    Lancet Infect Dis 4:761-76. 2004
    ..Whether this potential can be realised in practice remains to be confirmed in well designed, long-term studies...
  52. doi Treatment of active tuberculosis in HIV-coinfected patients: a systematic review and meta-analysis
    Faiz A Khan
    Montreal Chest Institute, McGill University Health Centre, Montreal, Canada
    Clin Infect Dis 50:1288-99. 2010
    ..Patients with human immunodeficiency virus (HIV) infection and tuberculosis have an increased risk of death, treatment failure, and relapse...
  53. pmc Tuberculosis among health-care workers in low- and middle-income countries: a systematic review
    Rajnish Joshi
    Division of Epidemiology, School of Public Health, University of California Berkeley, Berkeley, California, United States of America
    PLoS Med 3:e494. 2006
    ..Most health-care facilities in these countries lack resources to prevent nosocomial transmission of tuberculosis (TB)...
  54. doi Tuberculin skin test and QuantiFERON® assay in young children investigated for tuberculosis in South Africa
    S Moyo
    South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine and School of Child and Adolescent Health, University of Cape Town, Cape Town, South Africa
    Int J Tuberc Lung Dis 15:1176-81, i. 2011
    ..Although the literature on interferon-gamma release assays on tuberculosis (TB) in children has increased, data pertaining to young children remain relatively limited...
  55. ncbi Pre-hospital delay in acute myocardial infarction in an urban Indian hospital: a prospective study
    R E Rajagopalan
    Department of Critical Care Medicine, Dr Rangarajan Memorial Hospital, Sundaram Medical Foundation, Shanthi Colony, Anna Nagar, Chennai 600040, Tamil Nadu, India
    Natl Med J India 14:8-12. 2001
    ..Successful treatment of acute myocardial infarction is dependent on early presentation of the patient to the hospital. The factors that contribute to delay in seeking treatment have not been systematically evaluated in the Indian milieu...
  56. doi Diagnosing tuberculosis with urine lipoarabinomannan: systematic review and meta-analysis
    J Minion
    Dept of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, QC, Canada
    Eur Respir J 38:1398-405. 2011
    ..Further studies are needed to evaluate the potential value of the LAM assay in individuals with advanced HIV or for diagnosis of paediatric TB...
  57. ncbi Bacteriophage-based assays for the rapid detection of rifampicin resistance in Mycobacterium tuberculosis: a meta-analysis
    Madhukar Pai
    Division of Epidemiology, School of Public Health, University of California, 140, Warren Hall, Berkeley, CA 94720, USA
    J Infect 51:175-87. 2005
    ..To summarize, using meta-analysis, the accuracy of bacteriophage-based assays for the detection of rifampicin resistance in Mycobacterium tuberculosis...
  58. doi High prevalence of smoking among patients with suspected tuberculosis in South Africa
    L Brunet
    Dept of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, QC, Canada
    Eur Respir J 38:139-46. 2011
    ..Self-reporting is an accurate measure of smoking status. These results suggest the need to actively incorporate tobacco cessation programmes into TB services in South Africa...
  59. doi Methodological and reporting quality of systematic reviews on tuberculosis
    I Nicolau
    Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Quebec, Canada
    Int J Tuberc Lung Dis 17:1160-9. 2013
    ..Systematic reviews are used to inform tuberculosis (TB) guidelines. However, there are no data on whether TB systematic reviews are conducted well and reported transparently...
  60. ncbi Interpretation of Mycobacterium tuberculosis antigen-specific IFN-gamma release assays (T-SPOT.TB) and factors that may modulate test results
    K Dheda
    Division of Pulmonology, Department of Medicine, University of Cape Town, South Africa
    J Infect 55:169-73. 2007
    ..Thus, the utility of IGRAs as a surrogate marker of mycobacterial burden remain unclear...
  61. ncbi False-positive tuberculin skin tests: what is the absolute effect of BCG and non-tuberculous mycobacteria?
    M Farhat
    Respiratory Epidemiology and Clinical Research Unit, Montreal Chest Institute, McGill University, Montreal, Quebec, Canada
    Int J Tuberc Lung Dis 10:1192-204. 2006
    ..However, TST specificity is reduced by bacille Calmette-Guérin (BCG) vaccination and exposure to non-tuberculous mycobacteria (NTM)...
  62. pmc Effect of duration and intermittency of rifampin on tuberculosis treatment outcomes: a systematic review and meta-analysis
    Dick Menzies
    Respiratory and Epidemiology Clinical Research Unit, Montreal Chest Institute and Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Canada
    PLoS Med 6:e1000146. 2009
    ..We conducted a systematic review of treatment regimens for active TB, to assess the effect of duration and intermittency of rifampin use on TB treatment outcomes...
  63. pmc Impact of round-the-clock, rapid oral fluid HIV testing of women in labor in rural India
    Nitika Pant Pai
    Division of Infectious Diseases and Immunodeficiency Service, Montreal Chest Institute, McGill University Health Center, Montreal, Canada
    PLoS Med 5:e92. 2008
    ..In this context, we investigated the impact of introducing round-the-clock, rapid, point-of-care HIV testing and counseling in a busy labor ward at a tertiary care hospital in rural India...
  64. ncbi Rapid diagnosis of drug-resistant TB using line probe assays: from evidence to policy
    Daphne I Ling
    Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Respiratory Epidemiology and Clinical Research Unit, , 1020 Pine Avenue West, Montreal H3A 1A2, Canada
    Expert Rev Respir Med 2:583-8. 2008
    ..Whether molecular tools, such as line probe assays, will actually make a clinical and public-health impact remains to be determined...
  65. doi Immune-based diagnostics for TB in children: what is the evidence?
    Daphne I Ling
    Department of Epidemiology, Biostatistics and Occupational Health, McGill University, 1020 Pine Avenue West, Montreal, Quebec H3A 1A2, Canada
    Paediatr Respir Rev 12:9-15. 2011
    ..Although IGRAs can be used as evidence of TB infection in children, appropriate specimen collection and microbiological confirmation of TB disease should remain a priority...
  66. doi Profile of adults seeking voluntary HIV testing and counseling in rural Central India: results from a hospital-based study
    Nitika Pant Pai
    Division of Infectious Diseases and Immunodeficiency Service, Montreal Chest Institute, Montreal, Canada
    AIDS Care 21:294-300. 2009
    ..It provides baseline data on marginalized, largely unstudied populations that may aid in designing probabilistic community-based surveys in this neglected population...
  67. ncbi T-cell assays for the diagnosis of latent tuberculosis infection: moving the research agenda forward
    Madhukar Pai
    McGill University, Department of Epidemiology, Biostatistics and Occupational Health, Montreal, Quebec, Canada
    Lancet Infect Dis 7:428-38. 2007
    ..Ultimately, if adequately financed, the research findings will inform appropriate use of novel latent tuberculosis infection diagnostics in global tuberculosis control...
  68. pmc Evaluation of diagnostic accuracy, feasibility and client preference for rapid oral fluid-based diagnosis of HIV infection in rural India
    Nitika Pant Pai
    Immunodeficiency Service, Montreal Chest Institute, McGill University Health Center, Montreal, Canada
    PLoS ONE 2:e367. 2007
    ..We report a field evaluation of the diagnostic accuracy, client preference, and feasibility for the oral fluid-based OraQuick Rapid HIV1/2 test in a rural hospital in India...
  69. ncbi Meta-analysis: new tests for the diagnosis of latent tuberculosis infection: areas of uncertainty and recommendations for research
    Dick Menzies
    McGill University, Montreal, Quebec, Canada
    Ann Intern Med 146:340-54. 2007
    ..Until recently, the tuberculin skin test was the only test for detecting latent tuberculosis (TB) infection, but 2 ex vivo interferon-gamma release assays (IGRAs) are now commercially licensed...
  70. ncbi Yield of serial sputum specimen examinations in the diagnosis of pulmonary tuberculosis: a systematic review
    S R Mase
    Division of Pulmonary and Critical Care Medicine, San Francisco General Hospital, University of California, San Francisco, California, USA
    Int J Tuberc Lung Dis 11:485-95. 2007
    ....
  71. doi Guidelines on interferon-γ release assays for tuberculosis infection: concordance, discordance or confusion?
    C M Denkinger
    Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Clin Microbiol Infect 17:806-14. 2011
    ..Future IGRA guidelines must aim to be transparent, evidence-based, periodically updated, and free of financial conflicts and industry involvement...
  72. doi Microscopic-observation drug susceptibility and thin layer agar assays for the detection of drug resistant tuberculosis: a systematic review and meta-analysis
    Jessica Minion
    Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, QC, Canada
    Lancet Infect Dis 10:688-98. 2010
    ..We did a systematic review and meta-analysis to investigate the accuracy of microscopic-observation drug susceptibility (MODS) and thin layer agar (TLA) assays for rapid screening of patients at risk of drug-resistant tuberculosis...
  73. ncbi Initial drug resistance and tuberculosis treatment outcomes: systematic review and meta-analysis
    Woojin Lew
    Montreal Chest Institute, McGill University, Montreal, Quebec, Canada
    Ann Intern Med 149:123-34. 2008
    ..Despite the increasing prevalence of drug-resistant tuberculosis, most low- and middle-income countries use standardized regimens, without assessment of drug susceptibility...
  74. pmc A commercial line probe assay for the rapid detection of rifampicin resistance in Mycobacterium tuberculosis: a systematic review and meta-analysis
    Maureen Morgan
    Division of Epidemiology, School of Public Health, University of California, Berkeley, USA
    BMC Infect Dis 5:62. 2005
    ..The INNO-LiPA Rif. TB (LiPA) is a commercial line probe assay designed to rapidly detect rifampicin resistance, a marker of MDR-TB. Although LiPA has shown promising results, its overall accuracy has not been systematically evaluated...
  75. ncbi International Standards for Tuberculosis Care: revisiting the cornerstones of tuberculosis care and control
    Elizabeth Fair
    University of California, Francis J Curry National Tuberculosis Center, Division of Pulmonary and Critical Care Medicine, San Francisco General Hospital, San Francisco, CA 94110, USA
    Expert Rev Anti Infect Ther 5:61-5. 2007
    ....
  76. ncbi The socio-cultural challenge in public health interventions: the case of tuberculosis in India
    Bilkis Vissandjee
    School of Nursing, University of Montreal, Montreal, Quebec, Canada
    Int J Public Health 52:199-201. 2007
  77. ncbi Nucleic acid amplification tests for the diagnosis of tuberculous lymphadenitis: a systematic review
    P Daley
    Infectious Disease Training and Research Centre, Christian Medical College, Vellore, India
    Int J Tuberc Lung Dis 11:1166-76. 2007
    ..Conventional diagnostic methods such as smear microscopy and culture are not very accurate for TB lymphadenitis. Nucleic acid amplification tests (NAAT) may offer additional diagnostic benefit...
  78. doi TB diagnostic tests: how do we figure out their costs?
    Hojoon Sohn
    Doctoral Scholar, Department of Epidemiology, Biostatistics and Occupational Health McGill University, 1020 Pine Avenue West, Montreal, QC H3A 1A2, Canada and Consultant, Foundation for Innovative New Diagnostics, Geneva, Switzerland
    Expert Rev Anti Infect Ther 7:723-33. 2009
    ..This, in turn, will facilitate evidence-based adoption and use of new diagnostics, especially in resource-limited settings...
  79. pmc In-house nucleic acid amplification tests for the detection of Mycobacterium tuberculosis in sputum specimens: meta-analysis and meta-regression
    Laura L Flores
    Divisions of Infectious Diseases and Epidemiology, School of Public Health, University of California, Berkeley, CA 94720, USA
    BMC Microbiol 5:55. 2005
    ..Here, we used meta-analytical methods, including meta-regression, to identify factors related to study design and assay protocols that affect test accuracy in order to identify those factors associated with high estimates of accuracy...
  80. ncbi International standards for tuberculosis care
    Philip C Hopewell
    Division of Pulmonary and Critical Care Medicine, San Francisco General Hospital, University of California, San Francisco, CA 94110, USA
    Lancet Infect Dis 6:710-25. 2006
    ....
  81. pmc Advances in the diagnosis and treatment of tuberculosis
    Payam Nahid
    Division of Pulmonary and Critical Care Medicine, San Francisco General Hospital, University of California, San Francisco, 1001 Potrero Avenue, Room 5K1, San Francisco, CA 94110, USA
    Proc Am Thorac Soc 3:103-10. 2006
    ....
  82. pmc Bacteriophage- based tests for the detection of Mycobacterium tuberculosis in clinical specimens: a systematic review and meta- analysis
    Shriprakash Kalantri
    University of California, Berkeley, School of Public Health, 140, Warren Hall, Berkeley, CA 94720, USA
    BMC Infect Dis 5:59. 2005
    ..However, the test lacks sensitivity. Although bacteriophage-based tests for tuberculosis have shown promising results, their overall accuracy has not been systematically evaluated...
  83. ncbi Accuracy and reliability of palpation and percussion for detecting hepatomegaly: a rural hospital-based study
    Rajnish Joshi
    Division of Epidemiology, University of California at Berkeley, Berkeley, CA 94720, USA
    Indian J Gastroenterol 23:171-4. 2004
    ..We compared the accuracy of palpation and percussion in a rural population in central India, using ultrasonography as a reference standard...
  84. pmc A systematic review of commercial serological antibody detection tests for the diagnosis of extrapulmonary tuberculosis
    Karen R Steingart
    Division pf Pulmonary and Critical Care Medicine, San Francisco General Hospital, University of California, USA
    Thorax 62:911-8. 2007
    ..At present, commercial antibody detection tests for extrapulmonary tuberculosis have no role in clinical care or case detection...
  85. ncbi Utilization of recombinant activated factor VII in southern Ontario in 85 patients with and without haemophilia
    K E Webert
    Division of Hematology, Department of Medicine, McMaster University, 1200 Main Street West, Hamilton, Ontario, Canada
    Haemophilia 13:518-26. 2007
    ..The tracking system used in this study is a valuable tool to describe ongoing utilization patterns of rFVIIa...
  86. ncbi Effect of the factor V Leiden mutation on the clinical expression of severe hemophilia A
    D H Lee
    Department of Medicine, Queen s University, Kingston, Ontario, Canada
    Thromb Haemost 83:387-91. 2000
    ....
  87. ncbi Accuracy of physical examination in the diagnosis of hypothyroidism: a cross-sectional, double-blind study
    R Indra
    Department of Medicine, Mahatma Gandhi Institute of Medical Sciences, Sevagram, Wardha 442102, India
    J Postgrad Med 50:7-11; discussion 11. 2004
    ..Conversely, patients with typical signs and symptoms may not have the disease when laboratory tests are performed...
  88. ncbi Survival after cardiopulmonary resuscitation in an urban Indian hospital
    R Rajaram
    Dr Rangarajan Memorial Hospital, Sundaram Medical Foundation, Chennai, Tamil Nadu, India
    Natl Med J India 12:51-5. 1999
    ..Age and aetiology of CR arrest did not influence the outcome...
  89. ncbi Platelets from patients with the Quebec platelet disorder contain and secrete abnormal amounts of urokinase-type plasminogen activator
    W H Kahr
    Departments of Pathology and Molecular Medicine, and Medicine, McMaster University, Hamilton, Ontario, Quebec, Canada
    Blood 98:257-65. 2001
    ..QPD is the only inherited bleeding disorder in humans known to be associated with increased u-PA...
  90. ncbi Risk of tuberculosis from exposure to tobacco smoke: a systematic review and meta-analysis
    Michael N Bates
    School of Public Health, University of California, Berkeley, USA
    Arch Intern Med 167:335-42. 2007
    ..There is no consensus whether tobacco smoking increases risk of tuberculosis (TB) infection, disease, or mortality. Whether this is so has substantial implications for tobacco and TB control policies...
  91. ncbi Sputum processing methods to improve the sensitivity of smear microscopy for tuberculosis: a systematic review
    Karen R Steingart
    Division of Pulmonary and Critical Care Medicine, San Francisco General Hospital, University of California, San Francisco, CA, USA
    Lancet Infect Dis 6:664-74. 2006
    ..Operational studies are needed to determine whether the increased sensitivity provided by processing methods is sufficient to offset their increased cost, complexity, and potential biohazards, and to examine their feasibility...
  92. pmc Performance of purified antigens for serodiagnosis of pulmonary tuberculosis: a meta-analysis
    Karen R Steingart
    Francis J Curry National Tuberculosis Center, University of California, San Francisco, 3180 18th Street, Suite 101, San Francisco, CA 94110 2028, USA
    Clin Vaccine Immunol 16:260-76. 2009
    ..The use of a case-control design with healthy controls for the majority of studies was a limitation of the review. Efforts are needed to improve the methodological quality of tuberculosis diagnostic studies...
  93. ncbi Diagnostic accuracy of nucleic acid amplification tests for tuberculous meningitis: a systematic review and meta-analysis
    Madhukar Pai
    Division of Epidemiology, University of California, Berkeley, CA 94720, USA
    Lancet Infect Dis 3:633-43. 2003
    ..On current evidence, commercial NAA tests show a potential role in confirming tuberculous meningitis diagnosis, although their overall low sensitivity precludes the use of these tests to rule out tuberculous meningitis with certainty...
  94. pmc Fading of auramine-stained mycobacterial smears and implications for external quality assurance
    Jessica Minion
    Department of Epidemiology, McGill University, Montreal, Canada
    J Clin Microbiol 49:2024-6. 2011
    ..We stored auramine-stained slides and reexamined them over time. Slides stored in all environments faded quickly, with significant changes in the proportion of positive slides in as little as 1 week...
  95. ncbi Systematic reviews and meta-analyses: an illustrated, step-by-step guide
    Madhukar Pai
    Berkeley Systematic Reviews Group, Division of Epidemiology, University of California at Berkeley, 140 Warren Hall, Berkeley, CA 94720, USA
    Natl Med J India 17:86-95. 2004
    ..We hope that it will enable clinicians to conduct systematic reviews, generate high-quality evidence, and contribute to the evidence-based medicine movement...
  96. pmc Nucleic acid amplification tests in the diagnosis of tuberculous pleuritis: a systematic review and meta-analysis
    Madhukar Pai
    Division of Epidemiology, School of Public Health University of California, Berkeley 140, Warren Hall, Berkeley, CA 94720, USA
    BMC Infect Dis 4:6. 2004
    ..We conducted a systematic review to determine the accuracy of nucleic acid amplification (NAA) tests in the diagnosis of tuberculous pleuritis...
  97. ncbi Clinical trials in India sponsored by the pharmaceutical industry: a proposal for reforms
    Madhukar Pai
    Division of Epidemiology, School of Public Health, University of California at Berkeley, 94720, USA
    Natl Med J India 15:93-6. 2002
  98. ncbi Fluorescence versus conventional sputum smear microscopy for tuberculosis: a systematic review
    Karen R Steingart
    Division of Pulmonary and Critical Care Medicine, San Francisco General Hospital, University of California, San Francisco, CA, USA
    Lancet Infect Dis 6:570-81. 2006
    ....
  99. pmc A systematic review of commercial serological antibody detection tests for the diagnosis of extrapulmonary tuberculosis
    Karen R Steingart
    Division of Pulmonary and Critical Care Medicine, San Francisco General Hospital, University of California, and Francis J Curry National Tuberculosis Center, San Francisco, California, USA
    Postgrad Med J 83:705-12. 2007
    ..At present, commercial antibody detection tests for extrapulmonary tuberculosis have no role in clinical care or case detection...
  100. ncbi Tuberculosis, vulnerability, and access to quality care
    Philip C Hopewell
    Division of Pulmonary and Critical Care Medicine, Francis J Curry National Tuberculosis Center, San Francisco General Hospital, University of California, San Francisco, CA 94110, USA
    JAMA 293:2790-3. 2005