Affiliation: McGill University
Location: McGill, Canada
- Microevolution of the direct repeat region of Mycobacterium tuberculosis: implications for interpretation of spoligotyping dataR M Warren
MRC Centre for Molecular and Cellular Biology, Department of Medical Biochemistry, Faculty of Health Sciences, Stellenbosch University, Tygerberg 7505, South Africa
J Clin Microbiol 40:4457-65. 2002..tuberculosis. This has important implications for molecular epidemiologic strain tracking and for the application of spoligotype data to phylogenetic analysis of M. tuberculosis isolates...
- Dispersal of Mycobacterium tuberculosis via the Canadian fur tradeCAITLIN S PEPPERELL
Division of Infectious Diseases, Stanford University, Stanford, CA 94305, USA
Proc Natl Acad Sci U S A 108:6526-31. 2011..tuberculosis and the difficulties in global elimination of tuberculosis, as small, widely dispersed pathogen populations are difficult both to detect and to eradicate...
- Clinical response to azithromycin in cystic fibrosis correlates with in vitro effects on Pseudomonas aeruginosa phenotypesDao Nguyen
Children s Hospital and Regional Medical Center, Seattle, Washington, USA
Pediatr Pulmonol 42:533-41. 2007..The in vitro effect of AZM on PLC correlates with FEV(1) response to AZM. This suggests that AZM anti-virulence effects may be predictive of clinical response and play a role in the mechanism of action of AZM in CF patients...
- Evolving stealth: genetic adaptation of Pseudomonas aeruginosa during cystic fibrosis infectionsDao Nguyen
Department of Medicine, University of Washington School of Medicine, 1959 Northeast Pacific Street, Room G-310, Seattle, WA 98195-7242, USA
Proc Natl Acad Sci U S A 103:8305-6. 2006
- Genomic characterization of an endemic Mycobacterium tuberculosis strain: evolutionary and epidemiologic implicationsDao Nguyen
Division of Infectious Diseases and Medical Microbiology, McGil University Health Centre, Montreal, Quebec, Canada
J Clin Microbiol 42:2573-80. 2004..These results provide insight into the evolution of genotypes in endemic strains and the potential for false clustering in molecular epidemiologic studies...
- Diversity of Mycobacterium tuberculosis isolates in an immigrant population: evidence against a founder effectSophie Kulaga
Joint Department of Epidemiology and Biostatistics and Occupational Health, Faculty of Medicine, McGill University, Montreal, Quebec, Canada
Am J Epidemiol 159:507-13. 2004..A mycobacterial "founder effect" is unlikely to account for the high proportion of shared isolates among Haitian-born Montrealers. Recent transmission remains the most likely explanation...
- Tuberculosis in the Inuit community of Quebec, CanadaDao Nguyen
Department of Medicine and Research Institute, McGill University Health Centre, Montreal, Quebec, Canada
Am J Respir Crit Care Med 168:1353-7. 2003..In a resource-rich country such as Canada, these communities illustrate some of the persistent challenges of TB control and elimination...
- Autotransfusion of shed mediastinal blood: a risk factor for mediastinitis after cardiac surgery? Results of a cluster investigationSandra Dial
Department of Critical Care, Sir Mortimer B Davis Jewish General Hospital, McGill University, Montreal, PQ, Canada
Chest 124:1847-51. 2003..After the introduction of autotransfusion of shed mediastinal blood following cardiac surgery, the incidence of mediastinitis increased. The role of autotransfusion in the increased occurrence of this serious complication was examined...
- Active starvation responses mediate antibiotic tolerance in biofilms and nutrient-limited bacteriaDao Nguyen
Departments of Medicine, Microbiology and Immunology, McGill University, Montreal, Quebec, Canada
Science 334:982-6. 2011..Furthermore, inactivating this protective mechanism sensitized biofilms by several orders of magnitude to four different classes of antibiotics and markedly enhanced the efficacy of antibiotic treatment in experimental infections...
- Widespread pyrazinamide-resistant Mycobacterium tuberculosis family in a low-incidence settingDao Nguyen
Department of Medicine, McGill University Health Centre, Montreal, Quebec, Canada
J Clin Microbiol 41:2878-83. 2003..We conclude that a clonally related family of PZA-monoresistant M. tuberculosis isolates in Quebec represents historic rather than recent transmission...