Karim Nader

Summary

Affiliation: McGill University
Country: Canada

Publications

  1. doi request reprint Cellular and systems mechanisms of memory strength as a constraint on auditory fear reconsolidation
    Szu Han Wang
    Department of Psychology, McGill University, Montreal, Quebec, Canada
    Nat Neurosci 12:905-12. 2009
  2. doi request reprint Memory reconsolidation: an update
    Karim Nader
    Department of Psychology, McGill University, Montreal, Quebec, Canada
    Ann N Y Acad Sci 1191:27-41. 2010
  3. pmc Recent advances in basic neurosciences and brain disease: from synapses to behavior
    Guo Qiang Bi
    Department of Neurobiology, University of Pittsburgh, Pittsburgh, USA
    Mol Pain 2:38. 2006
  4. doi request reprint A single standard for memory: the case for reconsolidation
    Karim Nader
    Psychology Department, McGill University, 1205 Doctor Penfield Avenue, Montreal, Quebec, H3A 1B1, Canada
    Nat Rev Neurosci 10:224-34. 2009
  5. ncbi request reprint Fading in
    Karim Nader
    Department of Psychology, McGill University, Montreal, Quebec H3A 1B1, Canada
    Learn Mem 13:530-5. 2006
  6. doi request reprint PKMzeta maintains memories by regulating GluR2-dependent AMPA receptor trafficking
    Paola Virginia Migues
    Department of Psychology, McGill University, Montreal, Quebec, Canada
    Nat Neurosci 13:630-4. 2010
  7. doi request reprint Dorsal hippocampus is necessary for novel learning but sufficient for subsequent similar learning
    Szu Han Wang
    Department of Psychology, McGill University, Montreal, Canada H3A 1B1
    Hippocampus 22:2157-70. 2012
  8. ncbi request reprint eIF2alpha phosphorylation bidirectionally regulates the switch from short- to long-term synaptic plasticity and memory
    Mauro Costa-Mattioli
    Department of Biochemistry and McGill Cancer Center, McGill University, Montreal, Quebec, Canada
    Cell 129:195-206. 2007
  9. doi request reprint Control of synaptic plasticity and memory via suppression of poly(A)-binding protein
    Arkady Khoutorsky
    Department of Biochemistry and Rosalind and Morris Goodman Cancer Research Centre, McGill University, Montreal, QC H3A 1A3, Canada
    Neuron 78:298-311. 2013
  10. doi request reprint β-Adrenergic blockade during reactivation reduces the subjective feeling of remembering associated with emotional episodic memories
    Lars Schwabe
    Douglas Mental Health Institute and Department of Psychiatry, McGill University, Montreal, QC H3A 1A1, Canada
    Biol Psychol 92:227-32. 2013

Detail Information

Publications39

  1. doi request reprint Cellular and systems mechanisms of memory strength as a constraint on auditory fear reconsolidation
    Szu Han Wang
    Department of Psychology, McGill University, Montreal, Quebec, Canada
    Nat Neurosci 12:905-12. 2009
    ..This suggests that one molecular mechanism for mediating boundary conditions is through downregulation of reconsolidation induction mechanisms...
  2. doi request reprint Memory reconsolidation: an update
    Karim Nader
    Department of Psychology, McGill University, Montreal, Quebec, Canada
    Ann N Y Acad Sci 1191:27-41. 2010
    ....
  3. pmc Recent advances in basic neurosciences and brain disease: from synapses to behavior
    Guo Qiang Bi
    Department of Neurobiology, University of Pittsburgh, Pittsburgh, USA
    Mol Pain 2:38. 2006
    ..The second international meeting on Neurons and Brain Disease will be held in Toronto (August 29-31, 2007)...
  4. doi request reprint A single standard for memory: the case for reconsolidation
    Karim Nader
    Psychology Department, McGill University, 1205 Doctor Penfield Avenue, Montreal, Quebec, H3A 1B1, Canada
    Nat Rev Neurosci 10:224-34. 2009
    ....
  5. ncbi request reprint Fading in
    Karim Nader
    Department of Psychology, McGill University, Montreal, Quebec H3A 1B1, Canada
    Learn Mem 13:530-5. 2006
    ..Finally, this review will suggest some strategies for resolving this debate...
  6. doi request reprint PKMzeta maintains memories by regulating GluR2-dependent AMPA receptor trafficking
    Paola Virginia Migues
    Department of Psychology, McGill University, Montreal, Quebec, Canada
    Nat Neurosci 13:630-4. 2010
    ..Together, these findings indicate that PKMzeta maintains long-term memory by regulating the trafficking of GluR2-containing AMPA receptors, the postsynaptic expression of which directly predicts memory retention...
  7. doi request reprint Dorsal hippocampus is necessary for novel learning but sufficient for subsequent similar learning
    Szu Han Wang
    Department of Psychology, McGill University, Montreal, Canada H3A 1B1
    Hippocampus 22:2157-70. 2012
    ..Together, these findings suggest that prior training experiences can change how the hippocampus processes subsequent similar learning...
  8. ncbi request reprint eIF2alpha phosphorylation bidirectionally regulates the switch from short- to long-term synaptic plasticity and memory
    Mauro Costa-Mattioli
    Department of Biochemistry and McGill Cancer Center, McGill University, Montreal, Quebec, Canada
    Cell 129:195-206. 2007
    ..These findings highlight the importance of a single phosphorylation site in eIF2alpha as a key regulator of L-LTP and LTM formation...
  9. doi request reprint Control of synaptic plasticity and memory via suppression of poly(A)-binding protein
    Arkady Khoutorsky
    Department of Biochemistry and Rosalind and Morris Goodman Cancer Research Centre, McGill University, Montreal, QC H3A 1A3, Canada
    Neuron 78:298-311. 2013
    ....
  10. doi request reprint β-Adrenergic blockade during reactivation reduces the subjective feeling of remembering associated with emotional episodic memories
    Lars Schwabe
    Douglas Mental Health Institute and Department of Psychiatry, McGill University, Montreal, QC H3A 1A1, Canada
    Biol Psychol 92:227-32. 2013
    ....
  11. doi request reprint Evidence for the persistence of contextual fear memories following immediate extinction
    Georgina E B Archbold
    Department of Psychology, McGill University, 1205 Dr Penfield Avenue, Montreal, QC, Canada H3A 1B1
    Eur J Neurosci 31:1303-11. 2010
    ..Overall, the results provide little evidence that extinction conducted immediately after conditioning destroys or erases the original memory trace...
  12. doi request reprint Involvement of the anterior cingulate cortex in formation, consolidation, and reconsolidation of recent and remote contextual fear memory
    Einar Ö Einarsson
    Department of Psychology, McGill University, Montreal, Quebec, Canada
    Learn Mem 19:449-52. 2012
    ..Our findings demonstrate for the first time that the ACC plays an important role in reconsolidation of contextual fear memory at recent and remote time points...
  13. doi request reprint Storage or retrieval deficit: the yin and yang of amnesia
    Oliver Hardt
    Department of Psychology, McGill University, Montreal, Quebec, Canada
    Learn Mem 16:224-30. 2009
    ..e., falsifiable, predictions for the absence of memory. Applying this paradigm, we demonstrate here that infusing anisomycin into the dorsal hippocampus induces amnesia by impairing memory storage, not retrieval...
  14. doi request reprint Neural signature of reconsolidation impairments by propranolol in humans
    Lars Schwabe
    Douglas Mental Health Institute and Department of Psychiatry, McGill University, Montreal, QC, Canada
    Biol Psychiatry 71:380-6. 2012
    ..Here, we asked whether a β-adrenergic receptor antagonist might interfere with the reconsolidation of emotional episodic memories and what brain mechanisms are involved in these effects...
  15. doi request reprint A bridge over troubled water: reconsolidation as a link between cognitive and neuroscientific memory research traditions
    Oliver Hardt
    Department of Psychology, McGill University, Montreal, Quebec, H3A 1B1 Canada
    Annu Rev Psychol 61:141-67. 2010
    ..We apply concepts developed in neuroscience to phenomena revealed in cognitive psychology to illustrate how these twins separated at birth may be reunited again...
  16. pmc Preclinical evaluation of reconsolidation blockade by clonidine as a potential novel treatment for posttraumatic stress disorder
    Karine Gamache
    Department of Psychology, McGill University, Montreal, QC, Canada
    Neuropsychopharmacology 37:2789-96. 2012
    ..This study provides important preclinical parameters for future therapeutic strategies involving clonidine to block reconsolidation as a novel treatment for PTSD symptoms...
  17. ncbi request reprint NMDA receptors are critical for unleashing consolidated auditory fear memories
    Cyrinne Ben Mamou
    Psychology Department, McGill University, 1205 Dr Penfield Avenue, Montreal, Quebec H3A 1B1, Canada
    Nat Neurosci 9:1237-9. 2006
    ..These findings suggest that NMDA receptors in the amygdala are critical for transforming a memory from a fixed to a labile state...
  18. doi request reprint Engagement of the PFC in consolidation and recall of recent spatial memory
    Wanda C Leon
    Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec H3G 1Y6, Canada
    Learn Mem 17:297-305. 2010
    ....
  19. doi request reprint PKMzeta maintains 1-day- and 6-day-old long-term object location but not object identity memory in dorsal hippocampus
    Oliver Hardt
    Department of Psychology, McGill University, Montreal, Quebec, Canada
    Hippocampus 20:691-5. 2010
    ..These results suggest that the dorsal hippocampus mediates long-term memory for where, but not what things have been encountered, and that PKMzeta maintains this type of spatial knowledge as long as the memory exists...
  20. ncbi request reprint Consolidation and reconsolidation of incentive learning in the amygdala
    Szu Han Wang
    University of California, Los Angeles, USA
    J Neurosci 25:830-5. 2005
    ....
  21. ncbi request reprint Memory traces unbound
    Karim Nader
    Department of Psychology, McGill University, Montreal, Quebec, Canada H3A 1B1
    Trends Neurosci 26:65-72. 2003
    ....
  22. doi request reprint Decay happens: the role of active forgetting in memory
    Oliver Hardt
    McGill University, Department of Psychology, Montreal, Quebec, H3A 1B1, Canada
    Trends Cogn Sci 17:111-20. 2013
    ..In areas with efficient pattern separation, such as the hippocampus, interference-driven forgetting will be minimal, and, consequently, decay will cause most forgetting...
  23. doi request reprint The role of metaplasticity mechanisms in regulating memory destabilization and reconsolidation
    Peter S B Finnie
    Department of Psychology, McGill University, 1205 Avenue du Docteur Penfield, Montreal, Quebec, Canada H3A 1B1
    Neurosci Biobehav Rev 36:1667-707. 2012
    ..Rather, metaplasticity mechanisms may serve to alter the specific reactivation cues necessary to destabilize a memory. This might imply that destabilization mechanisms can differ depending on learning conditions...
  24. pmc Translational control of hippocampal synaptic plasticity and memory by the eIF2alpha kinase GCN2
    Mauro Costa-Mattioli
    Department of Biochemistry and McGill Cancer Center, Montreal, Quebec, Canada
    Nature 436:1166-73. 2005
    ..Our study provides genetic, physiological, behavioural and molecular evidence that GCN2 regulates synaptic plasticity, as well as learning and memory, through modulation of the ATF4/CREB pathway...
  25. doi request reprint Metyrapone administration reduces the strength of an emotional memory trace in a long-lasting manner
    Marie France Marin
    Centre for Studies on Human Stress, Mental Health Research Centre Fernand Seguin, Louis H Lafontaine Hospital, Montreal, Quebec, Canada
    J Clin Endocrinol Metab 96:E1221-7. 2011
    ..Recent studies have shown that glucocorticoids (GCs) have the capacity to modulate the process of memory retrieval. This suggests that GCs could be an interesting avenue to investigate with regard to reduction of emotional memory...
  26. doi request reprint Autism-related deficits via dysregulated eIF4E-dependent translational control
    Christos G Gkogkas
    Department of Biochemistry and Goodman Cancer Research Centre, McGill University, Montreal, Quebec H3A 1A3, Canada
    Nature 493:371-7. 2013
    ..Thus, translational control by eIF4E regulates the synthesis of neuroligins, maintaining the excitation-to-inhibition balance, and its dysregulation engenders ASD-like phenotypes...
  27. ncbi request reprint Effect of post-retrieval propranolol on psychophysiologic responding during subsequent script-driven traumatic imagery in post-traumatic stress disorder
    Alain Brunet
    Department of Psychiatry, McGill University and Douglas Hospital Research Center, Montreal, QC, Canada
    J Psychiatr Res 42:503-6. 2008
    ....
  28. pmc Directly reactivated, but not indirectly reactivated, memories undergo reconsolidation in the amygdala
    Jacek Debiec
    WM Keck Foundation Laboratory of Neurobiology, Center for Neural Science, New York University, Room 809, NY 10003, USA
    Proc Natl Acad Sci U S A 103:3428-33. 2006
    ....
  29. ncbi request reprint Cellular and systems reconsolidation in the hippocampus
    Jacek Debiec
    Department of Psychiatry, Jagiellonian University Collegium Medicum, 31 501, Cracow, Poland
    Neuron 36:527-38. 2002
    ..Thus, hippocampal memories can undergo reconsolidation at both the cellular and systems levels...
  30. ncbi request reprint Extinction is not a sufficient condition to prevent fear memories from undergoing reconsolidation in the basolateral amygdala
    Sevil Duvarci
    W M Keck Foundation Laboratory of Neurobiology, Center for Neural Science, New York University, NY, USA
    Eur J Neurosci 24:249-60. 2006
    ..Therefore, under these conditions, extinction is not a boundary condition on reconsolidation of fear memories in the basolateral amygdala...
  31. ncbi request reprint Characterization of fear memory reconsolidation
    Sevil Duvarci
    W M Keck Foundation Laboratory of Neurobiology, Center for Neural Science, New York University, New York, New York 10003, USA
    J Neurosci 24:9269-75. 2004
    ..Second, we show that application of reminder shock does not result in the reinstatement of the memory. These findings support the idea that reactivation of consolidated memories initiates a second time-dependent memory formation process...
  32. ncbi request reprint Functional organization of adult motor cortex is dependent upon continued protein synthesis
    Jeffrey A Kleim
    Canadian Centre for Behavioural Neuroscience, Department of Psychology and Neuroscience, University of Lethbridge, 4401 University Drive, Lethbridge, Alberta T1K 3M4, Canada
    Neuron 40:167-76. 2003
    ..We propose that the circuitry of adult motor cortex is perpetually labile and requires continued protein synthesis in order to maintain its functional organization...
  33. ncbi request reprint A-kinase anchoring proteins in amygdala are involved in auditory fear memory
    Marta A P Moita
    W M Keck Foundation Laboratory of Neurobiology, Center for Neural Science, New York University, New York 10003, USA
    Nat Neurosci 5:837-8. 2002
    ....
  34. ncbi request reprint Activation of extracellular signal-regulated kinase- mitogen-activated protein kinase cascade in the amygdala is required for memory reconsolidation of auditory fear conditioning
    Sevil Duvarci
    W M Keck Foundation Laboratory of Neurobiology, Center for Neural Science, New York University, NY, USA
    Eur J Neurosci 21:283-9. 2005
    ..Our data show that activation of ERK-MAPK signalling pathway and protein synthesis in the LA are required for reconsolidation of auditory fear memories...
  35. ncbi request reprint Ambiguity and anxiety: when a glass half full is empty
    Karim Nader
    Nat Neurosci 10:807-8. 2007
  36. ncbi request reprint Response to Alberini: right answer, wrong question
    Karim Nader
    Trends Neurosci 28:346-7. 2005
  37. ncbi request reprint Neuroscience: re-recording human memories
    Karim Nader
    Nature 425:571-2. 2003
  38. ncbi request reprint NMDA receptor blockade in intact adult cortex increases trafficking of NR2A subunits into spines, postsynaptic densities, and axon terminals
    Chiye Aoki
    Center for Neural Science, New York University, Rm 809, 4 Washington Pl, New York, NY 10003, USA
    Brain Res 963:139-49. 2003
    ....
  39. ncbi request reprint Motivational state determines the functional role of the mesolimbic dopamine system in the mediation of opiate reward processes
    Steven R Laviolette
    Department of Anatomy and Cell Biology, Neurobiology Research Group, University of Toronto, Medical Sciences Building, Toronto, Ont, Canada
    Behav Brain Res 129:17-29. 2002
    ..p.) before conditioning in a state of withdrawal, also blocks the aversive effects of opiate withdrawal. We propose that the aversive motivational effects of opiate withdrawal may be mediated by a specific dopaminergic neuronal signal...