Research Topics
| Karim NaderSummaryAffiliation: McGill University Country: Canada Publications
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Detail Information
Publications
Memory reconsolidation: an updateKarim Nader
Department of Psychology, McGill University, Montreal, Quebec, Canada
Ann N Y Acad Sci 1191:27-41. 2010....- Cellular and systems mechanisms of memory strength as a constraint on auditory fear reconsolidationSzu Han Wang
Department of Psychology, McGill University, Montreal, Quebec, Canada
Nat Neurosci 12:905-12. 2009..This suggests that one molecular mechanism for mediating boundary conditions is through downregulation of reconsolidation induction mechanisms... 
Recent advances in basic neurosciences and brain disease: from synapses to behaviorGuo Qiang Bi
Department of Neurobiology, University of Pittsburgh, Pittsburgh, USA
Mol Pain 2:38. 2006..The second international meeting on Neurons and Brain Disease will be held in Toronto (August 29-31, 2007)...- A single standard for memory: the case for reconsolidationKarim Nader
Psychology Department, McGill University, 1205 Doctor Penfield Avenue, Montreal, Quebec, H3A 1B1, Canada
Nat Rev Neurosci 10:224-34. 2009.... 
Fading inKarim Nader
Department of Psychology, McGill University, Montreal, Quebec H3A 1B1, Canada
Learn Mem 13:530-5. 2006..Finally, this review will suggest some strategies for resolving this debate...- PKMzeta maintains memories by regulating GluR2-dependent AMPA receptor traffickingPaola Virginia Migues
Department of Psychology, McGill University, Montreal, Quebec, Canada
Nat Neurosci 13:630-4. 2010..Together, these findings indicate that PKMzeta maintains long-term memory by regulating the trafficking of GluR2-containing AMPA receptors, the postsynaptic expression of which directly predicts memory retention... - eIF2alpha phosphorylation bidirectionally regulates the switch from short- to long-term synaptic plasticity and memoryMauro Costa-Mattioli
Department of Biochemistry and McGill Cancer Center, McGill University, Montreal, Quebec, Canada
Cell 129:195-206. 2007..These findings highlight the importance of a single phosphorylation site in eIF2alpha as a key regulator of L-LTP and LTM formation... - Evidence for the persistence of contextual fear memories following immediate extinctionGeorgina E B Archbold
Department of Psychology, McGill University, 1205 Dr Penfield Avenue, Montreal, QC, Canada H3A 1B1
Eur J Neurosci 31:1303-11. 2010..Overall, the results provide little evidence that extinction conducted immediately after conditioning destroys or erases the original memory trace... - Involvement of the anterior cingulate cortex in formation, consolidation, and reconsolidation of recent and remote contextual fear memoryEinar Ö Einarsson
Department of Psychology, McGill University, Montreal, Quebec, Canada
Learn Mem 19:449-52. 2012..Our findings demonstrate for the first time that the ACC plays an important role in reconsolidation of contextual fear memory at recent and remote time points... - Storage or retrieval deficit: the yin and yang of amnesiaOliver Hardt
Department of Psychology, McGill University, Montreal, Quebec, Canada
Learn Mem 16:224-30. 2009..e., falsifiable, predictions for the absence of memory. Applying this paradigm, we demonstrate here that infusing anisomycin into the dorsal hippocampus induces amnesia by impairing memory storage, not retrieval... - Neural signature of reconsolidation impairments by propranolol in humansLars Schwabe
Douglas Mental Health Institute and Department of Psychiatry, McGill University, Montreal, QC, Canada
Biol Psychiatry 71:380-6. 2012..Here, we asked whether a β-adrenergic receptor antagonist might interfere with the reconsolidation of emotional episodic memories and what brain mechanisms are involved in these effects... - A bridge over troubled water: reconsolidation as a link between cognitive and neuroscientific memory research traditionsOliver Hardt
Department of Psychology, McGill University, Montreal, Quebec, H3A 1B1 Canada
Annu Rev Psychol 61:141-67. 2010..We apply concepts developed in neuroscience to phenomena revealed in cognitive psychology to illustrate how these twins separated at birth may be reunited again... - Engagement of the PFC in consolidation and recall of recent spatial memoryWanda C Leon
Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec H3G 1Y6, Canada
Learn Mem 17:297-305. 2010.... - PKMzeta maintains 1-day- and 6-day-old long-term object location but not object identity memory in dorsal hippocampusOliver Hardt
Department of Psychology, McGill University, Montreal, Quebec, Canada
Hippocampus 20:691-5. 2010..These results suggest that the dorsal hippocampus mediates long-term memory for where, but not what things have been encountered, and that PKMzeta maintains this type of spatial knowledge as long as the memory exists... - NMDA receptors are critical for unleashing consolidated auditory fear memoriesCyrinne Ben Mamou
Psychology Department, McGill University, 1205 Dr. Penfield Avenue, Montreal, Quebec H3A 1B1, Canada
Nat Neurosci 9:1237-9. 2006..These findings suggest that NMDA receptors in the amygdala are critical for transforming a memory from a fixed to a labile state... - Consolidation and reconsolidation of incentive learning in the amygdalaSzu Han Wang
University of California, Los Angeles, USA
J Neurosci 25:830-5. 2005.... - Dorsal hippocampus is necessary for novel learning but sufficient for subsequent similar learningSzu Han Wang
Department of Psychology, McGill University, Montreal, Canada H3A 1B1
Hippocampus 22:2157-70. 2012..Together, these findings suggest that prior training experiences can change how the hippocampus processes subsequent similar learning... - Memory traces unboundKarim Nader
Department of Psychology, McGill University, Montreal, Quebec, Canada H3A 1B1
Trends Neurosci 26:65-72. 2003.... - β-Adrenergic blockade during reactivation reduces the subjective feeling of remembering associated with emotional episodic memoriesLars Schwabe
Douglas Mental Health Institute and Department of Psychiatry, McGill University, Montreal, QC H3A 1A1, Canada
Biol Psychol 92:227-32. 2013.... - The role of metaplasticity mechanisms in regulating memory destabilization and reconsolidationPeter S B Finnie
Department of Psychology, McGill University, 1205 Avenue du Docteur Penfield, Montreal, Quebec, Canada H3A 1B1
Neurosci Biobehav Rev 36:1667-707. 2012..Rather, metaplasticity mechanisms may serve to alter the specific reactivation cues necessary to destabilize a memory. This might imply that destabilization mechanisms can differ depending on learning conditions... - Preclinical evaluation of reconsolidation blockade by clonidine as a potential novel treatment for posttraumatic stress disorderKarine Gamache
Department of Psychology, McGill University, Montreal, QC, Canada
Neuropsychopharmacology 37:2789-96. 2012..This study provides important preclinical parameters for future therapeutic strategies involving clonidine to block reconsolidation as a novel treatment for PTSD symptoms... - Translational control of hippocampal synaptic plasticity and memory by the eIF2alpha kinase GCN2Mauro Costa-Mattioli
Department of Biochemistry and McGill Cancer Center, Montreal, Quebec, Canada
Nature 436:1166-73. 2005..Our study provides genetic, physiological, behavioural and molecular evidence that GCN2 regulates synaptic plasticity, as well as learning and memory, through modulation of the ATF4/CREB pathway... - Metyrapone administration reduces the strength of an emotional memory trace in a long-lasting mannerMarie France Marin
Centre for Studies on Human Stress, Mental Health Research Centre Fernand Seguin, Louis H Lafontaine Hospital, Montreal, Quebec, Canada
J Clin Endocrinol Metab 96:E1221-7. 2011..Recent studies have shown that glucocorticoids (GCs) have the capacity to modulate the process of memory retrieval. This suggests that GCs could be an interesting avenue to investigate with regard to reduction of emotional memory... - Autism-related deficits via dysregulated eIF4E-dependent translational controlChristos G Gkogkas
Department of Biochemistry and Goodman Cancer Research Centre, McGill University, Montreal, Quebec H3A 1A3, Canada
Nature 493:371-7. 2013..Thus, translational control by eIF4E regulates the synthesis of neuroligins, maintaining the excitation-to-inhibition balance, and its dysregulation engenders ASD-like phenotypes... - Decay happens: the role of active forgetting in memoryOliver Hardt
McGill University, Department of Psychology, Montreal, Quebec, H3A 1B1, Canada
Trends Cogn Sci 17:111-20. 2013..In areas with efficient pattern separation, such as the hippocampus, interference-driven forgetting will be minimal, and, consequently, decay will cause most forgetting... - Effect of post-retrieval propranolol on psychophysiologic responding during subsequent script-driven traumatic imagery in post-traumatic stress disorderAlain Brunet
Department of Psychiatry, McGill University and Douglas Hospital Research Center, Montreal, QC, Canada
J Psychiatr Res 42:503-6. 2008.... - Cellular and systems reconsolidation in the hippocampusJacek Debiec
Department of Psychiatry, Jagiellonian University Collegium Medicum, 31-501, Cracow, Poland
Neuron 36:527-38. 2002..Thus, hippocampal memories can undergo reconsolidation at both the cellular and systems levels... - A-kinase anchoring proteins in amygdala are involved in auditory fear memoryMarta A P Moita
W. M. Keck Foundation Laboratory of Neurobiology, Center for Neural Science, New York University, New York 10003, USA
Nat Neurosci 5:837-8. 2002.... - Functional organization of adult motor cortex is dependent upon continued protein synthesisJeffrey A Kleim
Canadian Centre for Behavioural Neuroscience, Department of Psychology and Neuroscience, University of Lethbridge, 4401 University Drive, Lethbridge, Alberta T1K 3M4, Canada
Neuron 40:167-76. 2003..We propose that the circuitry of adult motor cortex is perpetually labile and requires continued protein synthesis in order to maintain its functional organization... - Characterization of fear memory reconsolidationSevil Duvarci
W. M. Keck Foundation Laboratory of Neurobiology, Center for Neural Science, New York University, New York, New York 10003, USA
J Neurosci 24:9269-75. 2004..Second, we show that application of reminder shock does not result in the reinstatement of the memory. These findings support the idea that reactivation of consolidated memories initiates a second time-dependent memory formation process... - Activation of extracellular signal-regulated kinase- mitogen-activated protein kinase cascade in the amygdala is required for memory reconsolidation of auditory fear conditioningSevil Duvarci
W.M. Keck Foundation Laboratory of Neurobiology, Center for Neural Science, New York University, NY, USA
Eur J Neurosci 21:283-9. 2005..Our data show that activation of ERK-MAPK signalling pathway and protein synthesis in the LA are required for reconsolidation of auditory fear memories... - Directly reactivated, but not indirectly reactivated, memories undergo reconsolidation in the amygdalaJacek Debiec
WM Keck Foundation Laboratory of Neurobiology, Center for Neural Science, New York University, Room 809, NY 10003, USA
Proc Natl Acad Sci U S A 103:3428-33. 2006.... - Extinction is not a sufficient condition to prevent fear memories from undergoing reconsolidation in the basolateral amygdalaSevil Duvarci
W.M. Keck Foundation Laboratory of Neurobiology, Center for Neural Science, New York University, NY, USA
Eur J Neurosci 24:249-60. 2006..Therefore, under these conditions, extinction is not a boundary condition on reconsolidation of fear memories in the basolateral amygdala... - Ambiguity and anxiety: when a glass half full is emptyKarim Nader
Nat Neurosci 10:807-8. 2007 - Response to Alberini: right answer, wrong questionKarim Nader
Trends Neurosci 28:346-7. 2005 - Neuroscience: re-recording human memoriesKarim Nader
Nature 425:571-2. 2003 - NMDA receptor blockade in intact adult cortex increases trafficking of NR2A subunits into spines, postsynaptic densities, and axon terminalsChiye Aoki
Center for Neural Science, New York University, Rm 809, 4 Washington Pl, New York, NY 10003, USA
Brain Res 963:139-49. 2003.... - Motivational state determines the functional role of the mesolimbic dopamine system in the mediation of opiate reward processesSteven R Laviolette
Department of Anatomy and Cell Biology, Neurobiology Research Group, University of Toronto, Medical Sciences Building, Toronto, Ont, Canada
Behav Brain Res 129:17-29. 2002..p.) before conditioning in a state of withdrawal, also blocks the aversive effects of opiate withdrawal. We propose that the aversive motivational effects of opiate withdrawal may be mediated by a specific dopaminergic neuronal signal...