Keith K Murai

Summary

Affiliation: McGill University
Country: Canada

Publications

  1. pmc Fragile X related protein 1 clusters with ribosomes and messenger RNAs at a subset of dendritic spines in the mouse hippocampus
    Denise Cook
    Department of Neurology and Neurosurgery, The Research Institute of the McGill University Health Centre, Montreal General Hospital, Montreal, Quebec, Canada
    PLoS ONE 6:e26120. 2011
  2. doi request reprint Eph receptors and ephrins in neuron-astrocyte communication at synapses
    Keith K Murai
    Centre for Research in Neuroscience, Department of Neurology and Neurosurgery, McGill University Health Centre, Montreal, Canada
    Glia 59:1567-78. 2011
  3. ncbi request reprint Neuron glial communication at synapses: insights from vertebrates and invertebrates
    Keith K Murai
    Centre for Research in Neuroscience, Department of Neurology and Neurosurgery, McGill University the Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada
    Neuroscientist 13:657-66. 2007
  4. ncbi request reprint Pre-synaptic and post-synaptic localization of EphA4 and EphB2 in adult mouse forebrain
    David Bouvier
    Département de pathologie et biologie cellulaire and Groupe de recherche sur le système nerveux central GRSNC, Universite de Montreal, Montreal, Quebec, Canada
    J Neurochem 106:682-95. 2008
  5. doi request reprint DCC expression by neurons regulates synaptic plasticity in the adult brain
    Katherine E Horn
    Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, QC, H3A 2B4, Canada
    Cell Rep 3:173-85. 2013
  6. ncbi request reprint EphA4 signaling regulates phospholipase Cgamma1 activation, cofilin membrane association, and dendritic spine morphology
    Lei Zhou
    Center for Research in Neuroscience, Department of Neurology and Neurosurgery, The Research Institute of the McGill University Health Center, Montreal, Quebec, Canada H3G 1A4
    J Neurosci 27:5127-38. 2007
  7. doi request reprint Developmental course of EphA4 cellular and subcellular localization in the postnatal rat hippocampus
    Marie Eve Tremblay
    Departement de pathologie et biologie cellulaire, Groupe de Recherche sur le Système Nerveux Central, Universite de Montreal, Montreal, Quebec, Canada
    J Comp Neurol 512:798-813. 2009
  8. doi request reprint Localization of the Diaphanous-related formin Daam1 to neuronal dendrites
    Steven N Salomon
    Center for Research in Neuroscience, McGill University Health Centre Research Institute, McGill University, Montreal, Quebec, Canada
    Neurosci Lett 447:62-7. 2008
  9. doi request reprint EphA4 is localized in clathrin-coated and synaptic vesicles in adult mouse brain
    David Bouvier
    Département de pathologie et biologie cellulaire and Groupe de recherche sur le système nerveux central, Universite de Montreal, Montreal, QC, Canada
    J Neurochem 113:153-65. 2010
  10. doi request reprint Astrocytes control glutamate receptor levels at developing synapses through SPARC-beta-integrin interactions
    Emma V Jones
    Centre for Research in Neuroscience, Department of Neurology and Neurosurgery, The Research Institute of the McGill University Health Centre, Montreal General Hospital, Montreal, Quebec H3G 1A4, Canada
    J Neurosci 31:4154-65. 2011

Collaborators

Detail Information

Publications29

  1. pmc Fragile X related protein 1 clusters with ribosomes and messenger RNAs at a subset of dendritic spines in the mouse hippocampus
    Denise Cook
    Department of Neurology and Neurosurgery, The Research Institute of the McGill University Health Centre, Montreal General Hospital, Montreal, Quebec, Canada
    PLoS ONE 6:e26120. 2011
    ..Our data indicate that FXR1P is properly positioned to control local protein synthesis in the dendrite and at synapses in the central nervous system...
  2. doi request reprint Eph receptors and ephrins in neuron-astrocyte communication at synapses
    Keith K Murai
    Centre for Research in Neuroscience, Department of Neurology and Neurosurgery, McGill University Health Centre, Montreal, Canada
    Glia 59:1567-78. 2011
    ..This review will focus on the emerging role of Eph receptors and ephrins in neuron-astrocyte interaction at synapses and discuss implications for synaptic plasticity, behavior, and disease...
  3. ncbi request reprint Neuron glial communication at synapses: insights from vertebrates and invertebrates
    Keith K Murai
    Centre for Research in Neuroscience, Department of Neurology and Neurosurgery, McGill University the Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada
    Neuroscientist 13:657-66. 2007
    ..This review highlights selected studies that have revealed structural and functional insights into neuron-glial interactions at synapses in invertebrate and vertebrate model systems...
  4. ncbi request reprint Pre-synaptic and post-synaptic localization of EphA4 and EphB2 in adult mouse forebrain
    David Bouvier
    Département de pathologie et biologie cellulaire and Groupe de recherche sur le système nerveux central GRSNC, Universite de Montreal, Montreal, Quebec, Canada
    J Neurochem 106:682-95. 2008
    ..The localization of EphA4 and EphB2 in multiple compartments of neurons and synaptic junctions suggests that they interact with several distinct scaffolding proteins and play diverse roles at synapses...
  5. doi request reprint DCC expression by neurons regulates synaptic plasticity in the adult brain
    Katherine E Horn
    Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, QC, H3A 2B4, Canada
    Cell Rep 3:173-85. 2013
    ..We demonstrate that enhancing NMDAR function or activating Src rescues LTP in the absence of DCC. We conclude that DCC activation of Src is required for NMDAR-dependent LTP and certain forms of learning and memory...
  6. ncbi request reprint EphA4 signaling regulates phospholipase Cgamma1 activation, cofilin membrane association, and dendritic spine morphology
    Lei Zhou
    Center for Research in Neuroscience, Department of Neurology and Neurosurgery, The Research Institute of the McGill University Health Center, Montreal, Quebec, Canada H3G 1A4
    J Neurosci 27:5127-38. 2007
    ..Because cofilin has been implicated previously in the structural plasticity of spines, this signaling may enable cofilin to depolymerize actin filaments and restructure spines at sites of ephrin-EphA4 contact...
  7. doi request reprint Developmental course of EphA4 cellular and subcellular localization in the postnatal rat hippocampus
    Marie Eve Tremblay
    Departement de pathologie et biologie cellulaire, Groupe de Recherche sur le Système Nerveux Central, Universite de Montreal, Montreal, Quebec, Canada
    J Comp Neurol 512:798-813. 2009
    ....
  8. doi request reprint Localization of the Diaphanous-related formin Daam1 to neuronal dendrites
    Steven N Salomon
    Center for Research in Neuroscience, McGill University Health Centre Research Institute, McGill University, Montreal, Quebec, Canada
    Neurosci Lett 447:62-7. 2008
    ..In addition, viral directed expression of a fluorescently tagged Daam1 fusion protein in hippocampal slices resulted in targeted delivery to the dendrites of pyramidal neurons, leading to a reduction in the density of spines...
  9. doi request reprint EphA4 is localized in clathrin-coated and synaptic vesicles in adult mouse brain
    David Bouvier
    Département de pathologie et biologie cellulaire and Groupe de recherche sur le système nerveux central, Universite de Montreal, Montreal, QC, Canada
    J Neurochem 113:153-65. 2010
    ..This trafficking itinerary may serve to regulate the levels of EphA4 in the synaptic plasma membrane and thereby modulate signaling events that contribute to synaptic plasticity...
  10. doi request reprint Astrocytes control glutamate receptor levels at developing synapses through SPARC-beta-integrin interactions
    Emma V Jones
    Centre for Research in Neuroscience, Department of Neurology and Neurosurgery, The Research Institute of the McGill University Health Centre, Montreal General Hospital, Montreal, Quebec H3G 1A4, Canada
    J Neurosci 31:4154-65. 2011
    ..Thus neuron-glial signals control glutamate receptor levels at developing synapses to enable activity-driven modifications of synaptic strength...
  11. ncbi request reprint Cooperative astrocyte and dendritic spine dynamics at hippocampal excitatory synapses
    Michael Haber
    Centre for Research in Neuroscience, Department of Neurology and Neurosurgery, The Research Institute of the McGill University Health Centre, Montreal General Hospital, Montreal, Quebec, H3G 1A4, Canada
    J Neurosci 26:8881-91. 2006
    ..Our results suggest that dynamic structural changes in astrocytes help control the degree of neuron-glial communication at hippocampal synapses...
  12. doi request reprint Astrocytes display complex and localized calcium responses to single-neuron stimulation in the hippocampus
    Yann Bernardinelli
    Centre for Research in Neuroscience, Department of Neurology and Neurosurgery, The Research Institute of the McGill University Health Centre, Montreal General Hospital, Montreal, Quebec, Canada, H3G 1A4
    J Neurosci 31:8905-19. 2011
    ..This study provides a new perspective on the dynamic response property of astrocyte ensembles to neuronal activity...
  13. doi request reprint Glial glutamate transport modulates dendritic spine head protrusions in the hippocampus
    David Verbich
    Department of Neurology and Neurosurgery, McGill University, Montreal, QC H3G 0B1, Canada
    Glia 60:1067-77. 2012
    ..Hence, the dynamic changes of both spines and astrocytes can rapidly modify synaptic connectivity...
  14. doi request reprint A neuron-astrocyte co-culture system to investigate astrocyte-secreted factors in mouse neuronal development
    Emma V Jones
    Centre for Research in Neuroscience, Montreal General Hospital, Montreal, QC, Canada
    Methods Mol Biol 814:341-52. 2012
    ..We find this culture system to be a convenient and powerful approach to study the contribution of astrocyte-secreted molecules to neuron development...
  15. pmc EphA signaling promotes actin-based dendritic spine remodeling through slingshot phosphatase
    Lei Zhou
    Centre for Research in Neuroscience, Department of Neurology and Neurosurgery, The Research Institute of the McGill University Health Centre, Montreal General Hospital, Montreal, Quebec, Canada
    J Biol Chem 287:9346-59. 2012
    ..Thus, EphA receptors utilize discrete cellular and molecular pathways to promote actin-based structural plasticity of excitatory synapses...
  16. doi request reprint Astrocytes are endogenous regulators of basal transmission at central synapses
    Aude Panatier
    Departement de Physiologie, Universite de Montreal, PO Box 6128, Station Centre Ville, Montreal, QC H3C 3J7, Canada
    Cell 146:785-98. 2011
    ..Our work uncovers an essential role for astrocytes in the regulation of elementary synaptic communication and provides insight into fundamental aspects of brain function...
  17. doi request reprint Dopamine facilitates dendritic spine formation by cultured striatal medium spiny neurons through both D1 and D2 dopamine receptors
    Caroline Fasano
    Department of Pharmacology, Faculty of Medicine, Universite de Montreal, Montreal, Quebec, Canada
    Neuropharmacology 67:432-43. 2013
    ..These results represent a first step in the understanding of how dopamine neurons promote the structural plasticity of MSNs during the development of basal ganglia circuits...
  18. doi request reprint Subtype-specific oligodendrocyte dynamics in organotypic culture
    Michael Haber
    Centre for Research in Neuroscience, Department of Neurology and Neurosurgery, Research Institute of the McGill University Health Centre, Montreal General Hospital, Montreal, Quebec, Canada
    Glia 57:1000-13. 2009
    ..Our findings provide a detailed characterization of cellular events that help shape oligodendrocyte morphology and likely participate in neuron-glial cell interactions and the process of myelination...
  19. doi request reprint Neuroscience. Axons seek neighborly advice
    Keith K Murai
    Centre for Research in Neuroscience, Department of Neurology and Neurosurgery, McGill University Health Centre, Montreal General Hospital, 1650 Cedar Avenue, Montreal, QC H3G 1A4, Canada
    Science 320:185-6. 2008
  20. ncbi request reprint Localization of EphA4 in axon terminals and dendritic spines of adult rat hippocampus
    Marie Eve Tremblay
    Département de pathologie et biologie cellulaire and Groupe de recherche sur le système nerveux central, Universite de Montreal, Montreal, Quebec, Canada
    J Comp Neurol 501:691-702. 2007
    ..The dual preferential labeling of EphA4 on pre- or postsynaptic specializations of excitatory synapses in adult rat hippocampus is consistent with roles for this receptor in synaptic plasticity and LTP...
  21. doi request reprint Activity maintains structural plasticity of mossy fiber terminals in the hippocampus
    Sabrina Chierzi
    Centre for Research in Neuroscience, Department of Neurology and Neurosurgery, The Research Institute of the McGill University Health Centre, Montreal General Hospital, Montreal, QC, Canada H3G 1A4
    Mol Cell Neurosci 50:260-71. 2012
    ....
  22. ncbi request reprint Eph receptors, ephrins, and synaptic function
    Keith K Murai
    Centre for Research in Neuroscience, McGill University Health Centre, Montreal General Hospital, Montreal, Canada
    Neuroscientist 10:304-14. 2004
    ..In this review, we discuss how Eph receptors and ephrins are integrated into the molecular machinery that supports synaptic function...
  23. doi request reprint Increasing our understanding of human cognition through the study of Fragile X Syndrome
    Denise Cook
    Department of Neurology and Neurosurgery, Centre for Research in Neuroscience, The Research Institute of the McGill University Health Centre, Montreal General Hospital, Montreal, Quebec, Canada
    Dev Neurobiol 74:147-77. 2014
    ..The study of FXS and its underlying single genetic cause offers an invaluable opportunity to study how a single gene influences brain development and behavior...
  24. pmc Restraining stem cell niche plasticity: a new talent of eph receptors
    Keith K Murai
    Centre for Research in Neuroscience, Department of Neurology and Neurosurgery, McGill University Health Centre, Montreal General Hospital, 1650 Cedar Avenue, Montreal, QC, Canada H3G 1A4
    Cell Stem Cell 7:647-8. 2010
    ..Nomura et al. (2010) reveal an unexpected function of Eph signaling in suppressing cell fate plasticity of niche cells in the adult brain...
  25. ncbi request reprint New exchanges in eph-dependent growth cone dynamics
    Keith K Murai
    Centre for Research in Neuroscience, Department of Neurology and Neurosurgery, McGill University Health Centre, Montreal General Hospital, 1650 Cedar Avenue, Montreal, Quebec, Canada H3G 1A4
    Neuron 46:161-3. 2005
    ..Two articles in this issue of Neuron (Sahin et al. and Cowan et al.) shed light on how Eph receptors recruit guanine nucleotide exchange factors for Rho family GTPases to modulate growth cone dynamics...
  26. ncbi request reprint The EphA4 receptor regulates neuronal morphology through SPAR-mediated inactivation of Rap GTPases
    Melanie Richter
    Burnham Institute for Medical Research, La Jolla, California 92037, USA
    J Neurosci 27:14205-15. 2007
    ..Together, our data implicate SPAR as an important signaling intermediate that links the EphA4 receptor with Rap GTPase function in the regulation of neuronal morphology...
  27. ncbi request reprint Control of hippocampal dendritic spine morphology through ephrin-A3/EphA4 signaling
    Keith K Murai
    The Burnham Institute, Neurobiology Program, 10901 North Torrey Pines Road, La Jolla, California 92037, USA
    Nat Neurosci 6:153-60. 2003
    ..Thus, our data support a model in which transient interactions between the ephrin-A3 ligand and the EphA4 receptor regulate the structure of excitatory synaptic connections through neuroglial cross-talk...
  28. ncbi request reprint Contactin supports synaptic plasticity associated with hippocampal long-term depression but not potentiation
    Keith K Murai
    The Burnham Institute, Neurobiology Program, La Jolla, CA 92037, USA
    Curr Biol 12:181-90. 2002
    ..The mechanisms that modulate these processes still remain unclear...
  29. ncbi request reprint Can Eph receptors stimulate the mind?
    Keith K Murai
    The Burnham Institute, Neurobiology Program, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Neuron 33:159-62. 2002
    ..Three new articles show that the Eph receptors continue to be important in modifying the strength of existing neuronal connections (synapses). They do so in close association with at least one family of ion channels, the NMDA receptors...