Keith K Murai

Summary

Affiliation: McGill University
Country: Canada

Publications

  1. ncbi Eph receptors and ephrins in neuron-astrocyte communication at synapses
    Keith K Murai
    Centre for Research in Neuroscience, Department of Neurology and Neurosurgery, McGill University Health Centre, Montreal, Canada
    Glia 59:1567-78. 2011
  2. ncbi Neuron glial communication at synapses: insights from vertebrates and invertebrates
    Keith K Murai
    Centre for Research in Neuroscience, Department of Neurology and Neurosurgery, McGill University the Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada
    Neuroscientist 13:657-66. 2007
  3. ncbi Pre-synaptic and post-synaptic localization of EphA4 and EphB2 in adult mouse forebrain
    David Bouvier
    Département de pathologie et biologie cellulaire and Groupe de recherche sur le système nerveux central GRSNC, Universite de Montreal, Montreal, Quebec, Canada
    J Neurochem 106:682-95. 2008
  4. ncbi EphA4 signaling regulates phospholipase Cgamma1 activation, cofilin membrane association, and dendritic spine morphology
    Lei Zhou
    Center for Research in Neuroscience, Department of Neurology and Neurosurgery, The Research Institute of the McGill University Health Center, Montreal, Quebec, Canada H3G 1A4
    J Neurosci 27:5127-38. 2007
  5. ncbi Developmental course of EphA4 cellular and subcellular localization in the postnatal rat hippocampus
    Marie Eve Tremblay
    Departement de pathologie et biologie cellulaire, Groupe de Recherche sur le Système Nerveux Central, Universite de Montreal, Montreal, Quebec, Canada
    J Comp Neurol 512:798-813. 2009
  6. ncbi Localization of the Diaphanous-related formin Daam1 to neuronal dendrites
    Steven N Salomon
    Center for Research in Neuroscience, McGill University Health Centre Research Institute, McGill University, Montreal, Quebec, Canada
    Neurosci Lett 447:62-7. 2008
  7. ncbi EphA4 is localized in clathrin-coated and synaptic vesicles in adult mouse brain
    David Bouvier
    Département de pathologie et biologie cellulaire and Groupe de recherche sur le système nerveux central, Universite de Montreal, Montreal, QC, Canada
    J Neurochem 113:153-65. 2010
  8. ncbi Astrocytes control glutamate receptor levels at developing synapses through SPARC-beta-integrin interactions
    Emma V Jones
    Centre for Research in Neuroscience, Department of Neurology and Neurosurgery, The Research Institute of the McGill University Health Centre, Montreal General Hospital, Montreal, Quebec H3G 1A4, Canada
    J Neurosci 31:4154-65. 2011
  9. ncbi Glial glutamate transport modulates dendritic spine head protrusions in the hippocampus
    David Verbich
    Department of Neurology and Neurosurgery, McGill University, Montreal, QC H3G 0B1, Canada
    Glia 60:1067-77. 2012
  10. ncbi A neuron-astrocyte co-culture system to investigate astrocyte-secreted factors in mouse neuronal development
    Emma V Jones
    Centre for Research in Neuroscience, Montreal General Hospital, Montreal, QC, Canada
    Methods Mol Biol 814:341-52. 2012

Collaborators

  • Guy Doucet
  • Sabrina Chierzi
  • Elena Pasquale
  • Donald J van Meyel
  • Danuta Radzioch
  • Laurent Descarries
  • Peter S McPherson
  • Jean Claude Lacaille
  • Emma V Jones
  • Michael Haber
  • Marie Eve Tremblay
  • David Bouvier
  • Lei Zhou
  • Mustapha Riad
  • Denise Cook
  • Yann Bernardinelli
  • Edward A Fon
  • Amadou T Corera
  • David Verbich
  • Aude Panatier
  • Steven N Salomon
  • Marie-Eve Tremblay
  • Melanie Richter
  • Philip K Y Chang
  • George A Prenosil
  • R Anne McKinney
  • Richard Robitaille
  • Edouard W Khandjian
  • Joanne Vallée
  • Tak Pan Wong
  • Luc DesGroseillers
  • Sandra Tremblay
  • Maria del Rayo Sanchez-Carbente
  • Yiu Chung Tse
  • Claude Lachance
  • Chris Salmon
  • David Stellwagen
  • W Todd Farmer
  • Timothy E Kennedy
  • Diane Gingras
  • Katherine E Horn
  • Maryam Fotouhi
  • Martine Girard
  • Elizabeth J Fry
  • Sandrine Vautrin
  • Miguel Chagnon
  • Robert J Dunn
  • Andreas H Zisch
  • Caroline Bourgin
  • Sarah J Martinez
  • Daniel T Pak

Detail Information

Publications26

  1. ncbi Eph receptors and ephrins in neuron-astrocyte communication at synapses
    Keith K Murai
    Centre for Research in Neuroscience, Department of Neurology and Neurosurgery, McGill University Health Centre, Montreal, Canada
    Glia 59:1567-78. 2011
    ..This review will focus on the emerging role of Eph receptors and ephrins in neuron-astrocyte interaction at synapses and discuss implications for synaptic plasticity, behavior, and disease...
  2. ncbi Neuron glial communication at synapses: insights from vertebrates and invertebrates
    Keith K Murai
    Centre for Research in Neuroscience, Department of Neurology and Neurosurgery, McGill University the Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada
    Neuroscientist 13:657-66. 2007
    ..This review highlights selected studies that have revealed structural and functional insights into neuron-glial interactions at synapses in invertebrate and vertebrate model systems...
  3. ncbi Pre-synaptic and post-synaptic localization of EphA4 and EphB2 in adult mouse forebrain
    David Bouvier
    Département de pathologie et biologie cellulaire and Groupe de recherche sur le système nerveux central GRSNC, Universite de Montreal, Montreal, Quebec, Canada
    J Neurochem 106:682-95. 2008
    ..The localization of EphA4 and EphB2 in multiple compartments of neurons and synaptic junctions suggests that they interact with several distinct scaffolding proteins and play diverse roles at synapses...
  4. ncbi EphA4 signaling regulates phospholipase Cgamma1 activation, cofilin membrane association, and dendritic spine morphology
    Lei Zhou
    Center for Research in Neuroscience, Department of Neurology and Neurosurgery, The Research Institute of the McGill University Health Center, Montreal, Quebec, Canada H3G 1A4
    J Neurosci 27:5127-38. 2007
    ..Because cofilin has been implicated previously in the structural plasticity of spines, this signaling may enable cofilin to depolymerize actin filaments and restructure spines at sites of ephrin-EphA4 contact...
  5. ncbi Developmental course of EphA4 cellular and subcellular localization in the postnatal rat hippocampus
    Marie Eve Tremblay
    Departement de pathologie et biologie cellulaire, Groupe de Recherche sur le Système Nerveux Central, Universite de Montreal, Montreal, Quebec, Canada
    J Comp Neurol 512:798-813. 2009
    ....
  6. ncbi Localization of the Diaphanous-related formin Daam1 to neuronal dendrites
    Steven N Salomon
    Center for Research in Neuroscience, McGill University Health Centre Research Institute, McGill University, Montreal, Quebec, Canada
    Neurosci Lett 447:62-7. 2008
    ..In addition, viral directed expression of a fluorescently tagged Daam1 fusion protein in hippocampal slices resulted in targeted delivery to the dendrites of pyramidal neurons, leading to a reduction in the density of spines...
  7. ncbi EphA4 is localized in clathrin-coated and synaptic vesicles in adult mouse brain
    David Bouvier
    Département de pathologie et biologie cellulaire and Groupe de recherche sur le système nerveux central, Universite de Montreal, Montreal, QC, Canada
    J Neurochem 113:153-65. 2010
    ..This trafficking itinerary may serve to regulate the levels of EphA4 in the synaptic plasma membrane and thereby modulate signaling events that contribute to synaptic plasticity...
  8. ncbi Astrocytes control glutamate receptor levels at developing synapses through SPARC-beta-integrin interactions
    Emma V Jones
    Centre for Research in Neuroscience, Department of Neurology and Neurosurgery, The Research Institute of the McGill University Health Centre, Montreal General Hospital, Montreal, Quebec H3G 1A4, Canada
    J Neurosci 31:4154-65. 2011
    ..Thus neuron-glial signals control glutamate receptor levels at developing synapses to enable activity-driven modifications of synaptic strength...
  9. ncbi Glial glutamate transport modulates dendritic spine head protrusions in the hippocampus
    David Verbich
    Department of Neurology and Neurosurgery, McGill University, Montreal, QC H3G 0B1, Canada
    Glia 60:1067-77. 2012
    ..Hence, the dynamic changes of both spines and astrocytes can rapidly modify synaptic connectivity...
  10. ncbi A neuron-astrocyte co-culture system to investigate astrocyte-secreted factors in mouse neuronal development
    Emma V Jones
    Centre for Research in Neuroscience, Montreal General Hospital, Montreal, QC, Canada
    Methods Mol Biol 814:341-52. 2012
    ..We find this culture system to be a convenient and powerful approach to study the contribution of astrocyte-secreted molecules to neuron development...
  11. ncbi EphA signaling promotes actin-based dendritic spine remodeling through slingshot phosphatase
    Lei Zhou
    Centre for Research in Neuroscience, Department of Neurology and Neurosurgery, The Research Institute of the McGill University Health Centre, Montreal General Hospital, Montreal, Quebec, Canada
    J Biol Chem 287:9346-59. 2012
    ..Thus, EphA receptors utilize discrete cellular and molecular pathways to promote actin-based structural plasticity of excitatory synapses...
  12. ncbi Astrocytes display complex and localized calcium responses to single-neuron stimulation in the hippocampus
    Yann Bernardinelli
    Centre for Research in Neuroscience, Department of Neurology and Neurosurgery, The Research Institute of the McGill University Health Centre, Montreal General Hospital, Montreal, Quebec, Canada, H3G 1A4
    J Neurosci 31:8905-19. 2011
    ..This study provides a new perspective on the dynamic response property of astrocyte ensembles to neuronal activity...
  13. ncbi Astrocytes are endogenous regulators of basal transmission at central synapses
    Aude Panatier
    Departement de Physiologie, Universite de Montreal, PO Box 6128, Station Centre Ville, Montreal, QC H3C 3J7, Canada
    Cell 146:785-98. 2011
    ..Our work uncovers an essential role for astrocytes in the regulation of elementary synaptic communication and provides insight into fundamental aspects of brain function...
  14. ncbi Cooperative astrocyte and dendritic spine dynamics at hippocampal excitatory synapses
    Michael Haber
    Centre for Research in Neuroscience, Department of Neurology and Neurosurgery, The Research Institute of the McGill University Health Centre, Montreal General Hospital, Montreal, Quebec, H3G 1A4, Canada
    J Neurosci 26:8881-91. 2006
    ..Our results suggest that dynamic structural changes in astrocytes help control the degree of neuron-glial communication at hippocampal synapses...
  15. ncbi Fragile X related protein 1 clusters with ribosomes and messenger RNAs at a subset of dendritic spines in the mouse hippocampus
    Denise Cook
    Department of Neurology and Neurosurgery, The Research Institute of the McGill University Health Centre, Montreal General Hospital, Montreal, Quebec, Canada
    PLoS ONE 6:e26120. 2011
    ..Our data indicate that FXR1P is properly positioned to control local protein synthesis in the dendrite and at synapses in the central nervous system...
  16. ncbi Subtype-specific oligodendrocyte dynamics in organotypic culture
    Michael Haber
    Centre for Research in Neuroscience, Department of Neurology and Neurosurgery, Research Institute of the McGill University Health Centre, Montreal General Hospital, Montreal, Quebec, Canada
    Glia 57:1000-13. 2009
    ..Our findings provide a detailed characterization of cellular events that help shape oligodendrocyte morphology and likely participate in neuron-glial cell interactions and the process of myelination...
  17. ncbi Neuroscience. Axons seek neighborly advice
    Keith K Murai
    Centre for Research in Neuroscience, Department of Neurology and Neurosurgery, McGill University Health Centre, Montreal General Hospital, 1650 Cedar Avenue, Montreal, QC H3G 1A4, Canada
    Science 320:185-6. 2008
  18. ncbi Localization of EphA4 in axon terminals and dendritic spines of adult rat hippocampus
    Marie Eve Tremblay
    Département de pathologie et biologie cellulaire and Groupe de recherche sur le système nerveux central, Universite de Montreal, Montreal, Quebec, Canada
    J Comp Neurol 501:691-702. 2007
    ..The dual preferential labeling of EphA4 on pre- or postsynaptic specializations of excitatory synapses in adult rat hippocampus is consistent with roles for this receptor in synaptic plasticity and LTP...
  19. ncbi Activity maintains structural plasticity of mossy fiber terminals in the hippocampus
    Sabrina Chierzi
    Centre for Research in Neuroscience, Department of Neurology and Neurosurgery, The Research Institute of the McGill University Health Centre, Montreal General Hospital, Montreal, QC, Canada H3G 1A4
    Mol Cell Neurosci 50:260-71. 2012
    ....
  20. ncbi Eph receptors, ephrins, and synaptic function
    Keith K Murai
    Centre for Research in Neuroscience, McGill University Health Centre, Montreal General Hospital, Montreal, Canada
    Neuroscientist 10:304-14. 2004
    ..In this review, we discuss how Eph receptors and ephrins are integrated into the molecular machinery that supports synaptic function...
  21. ncbi Restraining stem cell niche plasticity: a new talent of eph receptors
    Keith K Murai
    Centre for Research in Neuroscience, Department of Neurology and Neurosurgery, McGill University Health Centre, Montreal General Hospital, 1650 Cedar Avenue, Montreal, QC, Canada H3G 1A4
    Cell Stem Cell 7:647-8. 2010
    ..Nomura et al. (2010) reveal an unexpected function of Eph signaling in suppressing cell fate plasticity of niche cells in the adult brain...
  22. ncbi New exchanges in eph-dependent growth cone dynamics
    Keith K Murai
    Centre for Research in Neuroscience, Department of Neurology and Neurosurgery, McGill University Health Centre, Montreal General Hospital, 1650 Cedar Avenue, Montreal, Quebec, Canada H3G 1A4
    Neuron 46:161-3. 2005
    ..Two articles in this issue of Neuron (Sahin et al. and Cowan et al.) shed light on how Eph receptors recruit guanine nucleotide exchange factors for Rho family GTPases to modulate growth cone dynamics...
  23. ncbi The EphA4 receptor regulates neuronal morphology through SPAR-mediated inactivation of Rap GTPases
    Melanie Richter
    Burnham Institute for Medical Research, La Jolla, California 92037, USA
    J Neurosci 27:14205-15. 2007
    ..Together, our data implicate SPAR as an important signaling intermediate that links the EphA4 receptor with Rap GTPase function in the regulation of neuronal morphology...
  24. ncbi Control of hippocampal dendritic spine morphology through ephrin-A3/EphA4 signaling
    Keith K Murai
    The Burnham Institute, Neurobiology Program, 10901 North Torrey Pines Road, La Jolla, California 92037, USA
    Nat Neurosci 6:153-60. 2003
    ..Thus, our data support a model in which transient interactions between the ephrin-A3 ligand and the EphA4 receptor regulate the structure of excitatory synaptic connections through neuroglial cross-talk...
  25. ncbi Contactin supports synaptic plasticity associated with hippocampal long-term depression but not potentiation
    Keith K Murai
    The Burnham Institute, Neurobiology Program, La Jolla, CA 92037, USA
    Curr Biol 12:181-90. 2002
    ..The mechanisms that modulate these processes still remain unclear...
  26. ncbi Can Eph receptors stimulate the mind?
    Keith K Murai
    The Burnham Institute, Neurobiology Program, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Neuron 33:159-62. 2002
    ..Three new articles show that the Eph receptors continue to be important in modifying the strength of existing neuronal connections (synapses). They do so in close association with at least one family of ion channels, the NMDA receptors...