Anthony Mittermaier

Summary

Affiliation: McGill University
Country: Canada

Publications

  1. pmc The response of internal dynamics to hydrophobic core mutations in the SH3 domain from the Fyn tyrosine kinase
    Anthony Mittermaier
    Departments of Biochemistry, Chemistry and Medical Genetics, University of Toronto, Toronto, Ontario, Canada M5S 1A8
    Protein Sci 13:1088-99. 2004
  2. ncbi request reprint New tools provide new insights in NMR studies of protein dynamics
    Anthony Mittermaier
    Department of Chemistry, McGill University, Montreal, Quebec H3A 2K6, Canada
    Science 312:224-8. 2006
  3. pmc Side chain burial and hydrophobic core packing in protein folding transition states
    Patrick J Farber
    Department of Chemistry, McGill University, Montreal H3A 2K6, Canada
    Protein Sci 17:644-51. 2008
  4. ncbi request reprint Slow internal dynamics in proteins: application of NMR relaxation dispersion spectroscopy to methyl groups in a cavity mutant of T4 lysozyme
    Frans A A Mulder
    Protein Engineering Network Centres of Excellence and Department of Medical Genetics, University of Toronto, Toronto M5S 1A8, Canada
    J Am Chem Soc 124:1443-51. 2002
  5. ncbi request reprint Effect of deuteration on some structural parameters of methyl groups in proteins as evaluated by residual dipolar couplings
    Anthony Mittermaier
    Department of Biochemistry, University of Toronto, Ontario, Canada
    J Biomol NMR 23:35-45. 2002
  6. doi request reprint Observing biological dynamics at atomic resolution using NMR
    Anthony K Mittermaier
    Department of Chemistry, McGill University, 801 Sherbrooke St W, 322, Montreal, Quebec, Canada, H3A 2K6
    Trends Biochem Sci 34:601-11. 2009
  7. doi request reprint Binding mechanism of an SH3 domain studied by NMR and ITC
    Jean Philippe Demers
    Department of Chemistry, McGill University, 801 Sherbrooke Street West, Montreal, Quebec, Canada, H3A 2K6
    J Am Chem Soc 131:4355-67. 2009
  8. doi request reprint Active site dynamics in NADH oxidase from Thermus thermophilus studied by NMR spin relaxation
    Teresa Miletti
    Department of Chemistry, McGill University, Montreal, QC H3A 2K6, Canada
    J Biomol NMR 51:71-82. 2011
  9. doi request reprint Concerted dynamics link allosteric sites in the PBX homeodomain
    Patrick J Farber
    Department of Chemistry, McGill University, 801 Sherbrooke Street West, Montreal, Quebec, Canada H3A 2K6
    J Mol Biol 405:819-30. 2011
  10. doi request reprint Virtual screening and computational optimization for the discovery of covalent prolyl oligopeptidase inhibitors with activity in human cells
    Stéphane De Cesco
    Department of Chemistry, McGill University, 801 Sherbrooke Street West, Montreal, Québec H3A 0B8, Canada
    J Med Chem 55:6306-15. 2012

Collaborators

Detail Information

Publications17

  1. pmc The response of internal dynamics to hydrophobic core mutations in the SH3 domain from the Fyn tyrosine kinase
    Anthony Mittermaier
    Departments of Biochemistry, Chemistry and Medical Genetics, University of Toronto, Toronto, Ontario, Canada M5S 1A8
    Protein Sci 13:1088-99. 2004
    ..These results show that contacts within the hydrophobic core affect many aspects of internal mobility throughout the Fyn SH3 domain...
  2. ncbi request reprint New tools provide new insights in NMR studies of protein dynamics
    Anthony Mittermaier
    Department of Chemistry, McGill University, Montreal, Quebec H3A 2K6, Canada
    Science 312:224-8. 2006
    ..Here, we present a brief overview of some of the new methods, together with applications that illustrate the level of detail at which protein motions can now be observed...
  3. pmc Side chain burial and hydrophobic core packing in protein folding transition states
    Patrick J Farber
    Department of Chemistry, McGill University, Montreal H3A 2K6, Canada
    Protein Sci 17:644-51. 2008
    ..Implications of these results to the design and analysis of protein folding studies are discussed...
  4. ncbi request reprint Slow internal dynamics in proteins: application of NMR relaxation dispersion spectroscopy to methyl groups in a cavity mutant of T4 lysozyme
    Frans A A Mulder
    Protein Engineering Network Centres of Excellence and Department of Medical Genetics, University of Toronto, Toronto M5S 1A8, Canada
    J Am Chem Soc 124:1443-51. 2002
    ..These experiments should be particularly well suited for probing dynamics in high molecular weight systems due to the favorable NMR spectroscopic properties of methyl groups...
  5. ncbi request reprint Effect of deuteration on some structural parameters of methyl groups in proteins as evaluated by residual dipolar couplings
    Anthony Mittermaier
    Department of Biochemistry, University of Toronto, Ontario, Canada
    J Biomol NMR 23:35-45. 2002
    ..4+/-0.2 degrees between CH3, CH2D and CH3, CHD2 isotopomers, respectively. Knowledge of methyl geometry is a prerequisite for the extraction of accurate dynamics parameters from spin relaxation studies involving these groups...
  6. doi request reprint Observing biological dynamics at atomic resolution using NMR
    Anthony K Mittermaier
    Department of Chemistry, McGill University, 801 Sherbrooke St W, 322, Montreal, Quebec, Canada, H3A 2K6
    Trends Biochem Sci 34:601-11. 2009
    ..Applications of these new NMR techniques to the study of fundamental processes such as binding and catalysis have provided new insights into how living systems operate at an atomic level...
  7. doi request reprint Binding mechanism of an SH3 domain studied by NMR and ITC
    Jean Philippe Demers
    Department of Chemistry, McGill University, 801 Sherbrooke Street West, Montreal, Quebec, Canada, H3A 2K6
    J Am Chem Soc 131:4355-67. 2009
    ..The combination of NMR and ITC data sheds light on how the Fyn tyrosine kinase is activated by binding to proline-rich targets, and represents a powerful approach for characterizing transient protein/ligand interactions...
  8. doi request reprint Active site dynamics in NADH oxidase from Thermus thermophilus studied by NMR spin relaxation
    Teresa Miletti
    Department of Chemistry, McGill University, Montreal, QC H3A 2K6, Canada
    J Biomol NMR 51:71-82. 2011
    ..We hypothesize that these motions may facilitate structural rearrangements of the active site that allow NOX to accept both FMN and FAD as cofactors...
  9. doi request reprint Concerted dynamics link allosteric sites in the PBX homeodomain
    Patrick J Farber
    Department of Chemistry, McGill University, 801 Sherbrooke Street West, Montreal, Quebec, Canada H3A 2K6
    J Mol Biol 405:819-30. 2011
    ....
  10. doi request reprint Virtual screening and computational optimization for the discovery of covalent prolyl oligopeptidase inhibitors with activity in human cells
    Stéphane De Cesco
    Department of Chemistry, McGill University, 801 Sherbrooke Street West, Montreal, Québec H3A 0B8, Canada
    J Med Chem 55:6306-15. 2012
    ..This small set of molecules also demonstrated that covalent binding and/or geometrical constraints to the ligand/protein complex may lead to an increase in bioactivity...
  11. doi request reprint Analyzing protein folding cooperativity by differential scanning calorimetry and NMR spectroscopy
    Patrick Farber
    Department of Chemistry, McGill University, 801 Sherbrooke Street West, Montreal, Quebec, Canada H3A 2K6
    J Am Chem Soc 132:6214-22. 2010
    ..This study illustrates the potential of combining calorimetry with NMR dynamics experiments to dissect mechanisms of protein folding...
  12. doi request reprint Platinum(II) phenanthroimidazoles for targeting telomeric G-quadruplexes
    Katherine J Castor
    Department of Chemistry, McGill University, Montreal, QC, Canada
    ChemMedChem 7:85-94. 2012
    ..Preliminary cell studies show that complex 6 is preferentially cytotoxic toward cancer over normal cell lines, indicating its potential use in cancer therapy...
  13. ncbi request reprint The effects of mutations on motions of side-chains in protein L studied by 2H NMR dynamics and scalar couplings
    Oscar Millet
    Protein Engineering Network Center of Excellence, University of Toronto, 1 King s College Circle, Toronto, Ont, Canada M5S 1A8
    J Mol Biol 329:551-63. 2003
    ....
  14. pmc Protein stabilization by specific binding of guanidinium to a functional arginine-binding surface on an SH3 domain
    Arash Zarrine-Afsar
    Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada
    Protein Sci 15:162-70. 2006
    ..Since arginine-mediated interactions are often important in the energetics of protein-protein interactions, our observations could be relevant for the design of small molecule inhibitors of protein-protein interactions...
  15. ncbi request reprint Correlation between 2H NMR side-chain order parameters and sequence conservation in globular proteins
    Anthony Mittermaier
    Protein Engineering Network Centres of Excellence, University of Toronto, Toronto, Ontario, Canada M5S 1A8
    J Am Chem Soc 125:9004-5. 2003
    ..Through examination of an SH3 domain structural alignment, we identify side-chain hydrogen bonding of threonine residues and a specific secondary structural element as potential determinants of protein internal dynamics...
  16. ncbi request reprint Multiple-site exchange in proteins studied with a suite of six NMR relaxation dispersion experiments: an application to the folding of a Fyn SH3 domain mutant
    Dmitry M Korzhnev
    Departments of Medical Genetics, Biochemistry, and Chemistry, The University of Toronto, Toronto, Ontario M5S 1A8, Canada
    J Am Chem Soc 127:15602-11. 2005
    ....
  17. ncbi request reprint Side-chain interactions in the folding pathway of a Fyn SH3 domain mutant studied by relaxation dispersion NMR spectroscopy
    Anthony Mittermaier
    Department of Biochemistry, University of Toronto, 1 King s College Circle, Toronto, Ontario, Canada M5S 1A8
    Biochemistry 44:15430-6. 2005
    ..This work illustrates the power of novel relaxation dispersion experiments in characterizing excited states that are "invisible" in even the most sensitive of NMR experiments...