F D Miller

Summary

Affiliation: McGill University
Country: Canada

Publications

  1. ncbi request reprint Evidence that DeltaNp73 promotes neuronal survival by p53-dependent and p53-independent mechanisms
    Anna F Lee
    Department of Developmental Biology, Hospital for Sick Children, Toronto, Ontario, M5G 1X8 Canada
    J Neurosci 24:9174-84. 2004
  2. doi request reprint Developmental axon pruning mediated by BDNF-p75NTR-dependent axon degeneration
    Karun K Singh
    Developmental and Stem Cell Biology, Hospital for Sick Children, 555 University Avenue, Toronto, Canada M5G 1X8
    Nat Neurosci 11:649-58. 2008
  3. ncbi request reprint On Trk for retrograde signaling
    F D Miller
    Center for Neuronal Survival and Brain Tumor Research Center, Montreal Neurological Institute, McGill University, 3801 rue University, H3A 2B4, Montreal, Quebec, Canada
    Neuron 32:767-70. 2001
  4. ncbi request reprint Neurobiology. TRK makes the retrograde
    Freda D Miller
    Centre for Neuronal Survival and Brain Tumor Research Centre, Montreal Neurological Institute, McGill University, 3801 rue University, Montreal, Quebec H3A 2B4, Canada
    Science 295:1471-3. 2002
  5. ncbi request reprint Functionally antagonistic interactions between the TrkA and p75 neurotrophin receptors regulate sympathetic neuron growth and target innervation
    J Kohn
    Centre for Neuronal Survival, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada, H3A 2B4
    J Neurosci 19:5393-408. 1999
  6. ncbi request reprint Isolation of multipotent adult stem cells from the dermis of mammalian skin
    J G Toma
    Center for Neuronal Survival, Montreal Neurological Institute, McGill University, 3801 rue University, Montreal, Quebec, Canada H3A 2B4
    Nat Cell Biol 3:778-84. 2001
  7. pmc TrkA mediates developmental sympathetic neuron survival in vivo by silencing an ongoing p75NTR-mediated death signal
    M Majdan
    Center for Neuronal Survival, Montreal Neurological Institute, McGill University, Montreal, Canada H3A 2B4
    J Cell Biol 155:1275-85. 2001
  8. ncbi request reprint Early induction of Talpha1 alpha-tubulin transcription in neurons of the developing nervous system
    A Gloster
    Centre for Neuronal Survival, Montreal Neurological Institute, McGill University, Quebec, Canada
    J Comp Neurol 405:45-60. 1999
  9. ncbi request reprint An anti-apoptotic role for the p53 family member, p73, during developmental neuron death
    C D Pozniak
    Center for Neuronal Survival, Brain Tumor Research Center, Montreal Neurological Institute, McGill University, Montreal, Canada H3A 2B4
    Science 289:304-6. 2000
  10. ncbi request reprint The TrkB-Shc site signals neuronal survival and local axon growth via MEK and P13-kinase
    J K Atwal
    Center for Neuronal Survival, McGill University, Montreal, Quebec, Canada
    Neuron 27:265-77. 2000

Collaborators

  • B Massie
  • David R Kaplan
  • F McKeon
  • A F Sadikot
  • Karl J L Fernandes
  • Paul W Frankland
  • R Kageyama
  • Toshiyuki Araki
  • JOHN D SWEATT
  • Fanie Barnabe-Heider
  • Gregory S Walsh
  • Karun K Singh
  • Annie Paquin
  • W Bradley Jacobs
  • Andrée S Gauthier
  • Jeff Biernaskie
  • Ian A McKenzie
  • Jean G Toma
  • Jasvinder K Atwal
  • Anna F Lee
  • Catherine Ménard
  • Katarzyna Bartkowska
  • Dan C Lin
  • Andrew P Hibbert
  • J G Toma
  • Jean Francois Lavoie
  • Sylvain Nadeau
  • M Majdan
  • Benjamin G Neel
  • Celia Quevedo
  • C D Pozniak
  • Sara C Shalin
  • Alan C Peterson
  • Paul Hein
  • J Kohn
  • Patrizia Zanassi
  • H Nicholas Marsh
  • S X Bamji
  • Christine D Pozniak
  • Andrew R Vaillant
  • Petra I Lorenzo
  • Kirmo Wartiovaara
  • J K Atwal
  • R Aloyz
  • A Gloster
  • M A Alonso-Vanegas
  • Bianca M Kramer
  • Elizabeth J Hong
  • Michael E Greenberg
  • Katya J Park
  • H El-Bizri
  • C G Causing
  • Yuanyun Xie
  • Jason R Plemel
  • Jie Liu
  • Joseph S Sparling
  • Casey P Shannon
  • Wolfram Tetzlaff
  • Olivia Furstoss
  • Richard Chan
  • Bianca M R Kramer
  • Natalie E Brewer
  • R S Slack
  • Rajiv Midha
  • Alex Bell
  • Joseph R Testa
  • D J Belliveau
  • Mark L Grimes
  • Michael Sendtner
  • Christian Porsche
  • Lynne Lesauteur
  • Darius Bagli
  • Josee Wong
  • Judi Kohn
  • Julie A Wasylnka
  • Olivia Furtoss
  • Alea A Mills
  • Daniel Ho
  • William M Keyes
  • Carol J Thiele
  • Gregory Govoni
  • Ute Zirrgiebel
  • Jean Pierre Julien
  • Daniel K Ho
  • Katya J Honsa
  • Nina Orike
  • Marc Tessier-Lavigne
  • Maya Kozlowski
  • Olga Zoueva
  • Catherine I Dubreuil

Detail Information

Publications48

  1. ncbi request reprint Evidence that DeltaNp73 promotes neuronal survival by p53-dependent and p53-independent mechanisms
    Anna F Lee
    Department of Developmental Biology, Hospital for Sick Children, Toronto, Ontario, M5G 1X8 Canada
    J Neurosci 24:9174-84. 2004
    ..Thus, DeltaNp73 promotes neuronal survival via p53-dependent and -independent mechanisms, and it does so at multiple points, including some of the most proximal events that occur after NGF withdrawal...
  2. doi request reprint Developmental axon pruning mediated by BDNF-p75NTR-dependent axon degeneration
    Karun K Singh
    Developmental and Stem Cell Biology, Hospital for Sick Children, 555 University Avenue, Toronto, Canada M5G 1X8
    Nat Neurosci 11:649-58. 2008
    ..These data provide a mechanism that explains how active axons can eliminate less-active, competing axons during developmental pruning by directly promoting p75NTR-mediated axonal degeneration...
  3. ncbi request reprint On Trk for retrograde signaling
    F D Miller
    Center for Neuronal Survival and Brain Tumor Research Center, Montreal Neurological Institute, McGill University, 3801 rue University, H3A 2B4, Montreal, Quebec, Canada
    Neuron 32:767-70. 2001
    ....
  4. ncbi request reprint Neurobiology. TRK makes the retrograde
    Freda D Miller
    Centre for Neuronal Survival and Brain Tumor Research Centre, Montreal Neurological Institute, McGill University, 3801 rue University, Montreal, Quebec H3A 2B4, Canada
    Science 295:1471-3. 2002
  5. ncbi request reprint Functionally antagonistic interactions between the TrkA and p75 neurotrophin receptors regulate sympathetic neuron growth and target innervation
    J Kohn
    Centre for Neuronal Survival, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada, H3A 2B4
    J Neurosci 19:5393-408. 1999
    ....
  6. ncbi request reprint Isolation of multipotent adult stem cells from the dermis of mammalian skin
    J G Toma
    Center for Neuronal Survival, Montreal Neurological Institute, McGill University, 3801 rue University, Montreal, Quebec, Canada H3A 2B4
    Nat Cell Biol 3:778-84. 2001
    ....
  7. pmc TrkA mediates developmental sympathetic neuron survival in vivo by silencing an ongoing p75NTR-mediated death signal
    M Majdan
    Center for Neuronal Survival, Montreal Neurological Institute, McGill University, Montreal, Canada H3A 2B4
    J Cell Biol 155:1275-85. 2001
    ....
  8. ncbi request reprint Early induction of Talpha1 alpha-tubulin transcription in neurons of the developing nervous system
    A Gloster
    Centre for Neuronal Survival, Montreal Neurological Institute, McGill University, Quebec, Canada
    J Comp Neurol 405:45-60. 1999
    ..This promoter, therefore, provides a valuable tool for genetic manipulation of early developing neurons in transgenic mice...
  9. ncbi request reprint An anti-apoptotic role for the p53 family member, p73, during developmental neuron death
    C D Pozniak
    Center for Neuronal Survival, Brain Tumor Research Center, Montreal Neurological Institute, McGill University, Montreal, Canada H3A 2B4
    Science 289:304-6. 2000
    ..Thus, truncated p73 is an essential anti-apoptotic protein in neurons, serving to counteract the pro-apoptotic function of p53...
  10. ncbi request reprint The TrkB-Shc site signals neuronal survival and local axon growth via MEK and P13-kinase
    J K Atwal
    Center for Neuronal Survival, McGill University, Montreal, Quebec, Canada
    Neuron 27:265-77. 2000
    ..These results indicate that the TrkB-Shc site mediates both neuronal survival and axonal outgrowth by activating the P13-kinase and MEK signaling pathways...
  11. ncbi request reprint Neurotrophin signalling pathways regulating neuronal apoptosis
    F D Miller
    Center for Neuronal Survival, Montreal Neurological Institute, PQ, Canada
    Cell Mol Life Sci 58:1045-53. 2001
    ..In this review, we focus on the proapoptotic actions of the p75 neurotrophin receptor (p75NTR), and on the interplay between Trk and p75NTR that determines neuronal survival...
  12. pmc The p75 neurotrophin receptor mediates neuronal apoptosis and is essential for naturally occurring sympathetic neuron death
    S X Bamji
    Center for Neuronal Survival, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada H3A 2B4
    J Cell Biol 140:911-23. 1998
    ..Together, these data indicate that p75NTR can signal to mediate apoptosis, and that this mechanism is essential for naturally occurring sympathetic neuron death...
  13. ncbi request reprint Characterization of dopaminergic midbrain neurons in a DBH:BDNF transgenic mouse
    M A Alonso-Vanegas
    Department of Neurology and Neurosurgery, Cone Laboratory and Center for Neuronal Survival, Montreal Neurological Institute, McGill University, Montreal, Quebec H3A 2B4, Canada
    J Comp Neurol 413:449-62. 1999
    ..We propose that BDNF rescues dopaminergic neurons from the perinatal period of developmental cell death as a consequence of increased anterograde transport of the neurotrophin via the coeruleonigral projection...
  14. ncbi request reprint Neuronal life and death: an essential role for the p53 family
    F D Miller
    Center for Neuronal Survival, Montreal Neurological Institute, McGill University, 3801 rue University, Montreal, Canada H3A 2B4
    Cell Death Differ 7:880-8. 2000
    ....
  15. pmc A critical temporal requirement for the retinoblastoma protein family during neuronal determination
    R S Slack
    Center for Neuronal Survival, Montreal Neurological Institute, McGill University, 3801 rue University, Montreal, Canada H3A 2B4
    J Cell Biol 140:1497-509. 1998
    ....
  16. ncbi request reprint Signal transduction by the neurotrophin receptors
    D R Kaplan
    Brain Tumor Research Centre, Montreal Neurological Institute, 3801 University Street, Montreal, PQ, Canada, H3A 2B4
    Curr Opin Cell Biol 9:213-21. 1997
    ..These differing responses point to a complex interplay between neurotrophin-stimulated survival, differentiation, and apoptosis pathways...
  17. ncbi request reprint Neurotrophin signal transduction in the nervous system
    D R Kaplan
    Brain Tumor Research Center, Montreal Neurological Institute, Montreal, H3A 2B4, Canada
    Curr Opin Neurobiol 10:381-91. 2000
    ..In addition, a number of novel p75NTR-interacting proteins have been identified that transmit growth, survival, and apoptotic signals...
  18. ncbi request reprint TrkA induces apoptosis of neuroblastoma cells and does so via a p53-dependent mechanism
    Jean Francois Lavoie
    Cancer Research Program, Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
    J Biol Chem 280:29199-207. 2005
    ..These results identify apoptosis as a novel biological response of TrkA in NB cells and imply that TrkA is a good prognosis marker for NB due in part to its ability to mediate apoptosis when expressed at sufficient levels...
  19. pmc APPL1 associates with TrkA and GIPC1 and is required for nerve growth factor-mediated signal transduction
    Dan C Lin
    Cancer Research Program, Hospital for Sick Children, 555 University Avenue, Toronto M5G 1X8, Ontario, Canada
    Mol Cell Biol 26:8928-41. 2006
    ..Together, these results indicate that GIPC1 and APPL1 play a role in TrkA function and suggest that a population of endosomes bearing a complex of APPL1, GIPC1, and activated TrkA may transmit NGF signals...
  20. ncbi request reprint Neuronal MEK is important for normal fear conditioning in mice
    Sara C Shalin
    Division of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci Res 75:760-70. 2004
    ..These findings indicate that the MEK1/ERK1/2 cascade within neurons plays an important role in the processes of learning and memory...
  21. pmc SHP-1 negatively regulates neuronal survival by functioning as a TrkA phosphatase
    H Nicholas Marsh
    Brain Tumor Research Centre, Montreal Neurological Institute, McGill University, Quebec, Canada
    J Cell Biol 163:999-1010. 2003
    ....
  22. ncbi request reprint Semaphorin 3F antagonizes neurotrophin-induced phosphatidylinositol 3-kinase and mitogen-activated protein kinase kinase signaling: a mechanism for growth cone collapse
    Jasvinder K Atwal
    The Hospital for Sick Children, Department of Molecular and Medical Genetics, University of Toronto, Toronto, Ontario, Canada M5G 1X8
    J Neurosci 23:7602-9. 2003
    ....
  23. ncbi request reprint Endogenously produced neurotrophins regulate survival and differentiation of cortical progenitors via distinct signaling pathways
    Fanie Barnabe-Heider
    Center for Neuronal Survival and Brain Tumor Research Center, Montreal Neurological Institute, McGill University, Montreal, Canada H3A 2B4
    J Neurosci 23:5149-60. 2003
    ..Thus, neurotrophins made by cortical progenitor cells themselves signal through the TrkB and TrkC receptors to mediate cortical progenitor cell survival and neurogenesis via two distinct downstream signaling pathways...
  24. ncbi request reprint N-myc promotes survival and induces S-phase entry of postmitotic sympathetic neurons
    Kirmo Wartiovaara
    Brain Tumor Research Center and Center for Neuronal Survival, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada H3A 2B4
    J Neurosci 22:815-24. 2002
    ..Thus, N-myc both selectively causes sympathetic neurons to reenter the cell cycle and protects them from apoptosis, potentially contributing to their transformation to NBs...
  25. ncbi request reprint Neurobiology: a move to sort life from death
    David R Kaplan
    Nature 427:798-9. 2004
  26. ncbi request reprint Skin-derived precursors generate myelinating Schwann cells that promote remyelination and functional recovery after contusion spinal cord injury
    Jeff Biernaskie
    Developmental and Stem Cell Biology Group, Hospital for Sick Children, Toronto, Ontario, Canada M5G 1L7
    J Neurosci 27:9545-59. 2007
    ..Thus, SKP-derived SCs provide an accessible, potentially autologous source of cells for transplantation into and treatment of the injured spinal cord...
  27. ncbi request reprint Analysis of the neurogenic potential of multipotent skin-derived precursors
    Karl J L Fernandes
    Program in Developmental Biology, University of Toronto, Toronto, Canada M5G 1X8 Program in Cancer Research, University of Toronto, Toronto, Canada M5G 1X8
    Exp Neurol 201:32-48. 2006
    ..These findings indicate that SKPs retain latent neurogenic properties after residing in a non-neural tissue, but that additional measures will be necessary to promote their differentiation into electrophysiologically active neurons...
  28. ncbi request reprint Skin-derived precursors generate myelinating Schwann cells for the injured and dysmyelinated nervous system
    Ian A McKenzie
    Department of Developmental Biology, Hospital for Sick Children Research Institute, Toronto, Ontario, Canada M5G 1X8
    J Neurosci 26:6651-60. 2006
    ....
  29. ncbi request reprint The localization, trafficking and retrograde transport of BDNF bound to p75NTR in sympathetic neurons
    Andrew P Hibbert
    Cancer Research and Developmental Biology Programs, Hospital for Sick Children, Toronto, Ontario, and Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada H3A 2B4
    Mol Cell Neurosci 32:387-402. 2006
    ..We postulate that beta-caveolin-1-containing lipid rafts and possibly intracellular endosomes might be compartments to which p75NTR:BDNF complexes are trafficked separately from Trk...
  30. doi request reprint Regenerating your senses: multiple roles for neurogenesis in the adult brain
    Paul W Frankland
    Neurosciences and Mental Health Program, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada M5G1X8
    Nat Neurosci 11:1124-6. 2008
  31. ncbi request reprint To die or not to die: neurons and p63
    Freda D Miller
    Developmental Biology, Hospital for Sick Children, Toronto, Ontario, Canada
    Cell Cycle 6:312-7. 2007
    ..In this review, we will cover the emerging evidence that p63 plays an essential role in regulating neuronal life and death decisions in the nervous system working in concert with its two other family members, p53 and p73...
  32. pmc Control of CNS cell-fate decisions by SHP-2 and its dysregulation in Noonan syndrome
    Andrée S Gauthier
    Developmental Biology Program, Hospital for Sick Children, 555 University Avenue, Toronto, ON M5G 1X8, Canada
    Neuron 54:245-62. 2007
    ....
  33. ncbi request reprint Timing is everything: making neurons versus glia in the developing cortex
    Freda D Miller
    Developmental and Stem Cell Biology, Hospital for Sick Children, Toronto M5G 1X8, Canada
    Neuron 54:357-69. 2007
    ..These studies have defined an intriguing interplay between intrinsic epigenetic status, transcription factors, and environmental cues, all of which work together to establish this fascinating and complex biological timing mechanism...
  34. ncbi request reprint Trk signaling regulates neural precursor cell proliferation and differentiation during cortical development
    Katarzyna Bartkowska
    Developmental and Stem Cell Biology, Hospital for Sick Children, University of Toronto, Toronto, Canada
    Development 134:4369-80. 2007
    ....
  35. ncbi request reprint When a motor goes bad: a kinesin regulates neuronal survival
    David R Kaplan
    Cancer Research and Developmental Biology, Hospital for Sick Children Research Institute, Department of Molecular, University of Toronto, Ontario, Canada M5G 1X8
    Cell 125:224-6. 2006
    ....
  36. ncbi request reprint p63 is an essential proapoptotic protein during neural development
    W Bradley Jacobs
    Cancer Research and Hospital for Sick Children, University of Toronto, Toronto ON, Canada M5G 1X8
    Neuron 48:743-56. 2005
    ..Thus, p63 is essential for developmental neuronal death, likely functioning both on its own, and as an obligate proapoptotic partner for p53...
  37. ncbi request reprint CCAAT/enhancer-binding protein phosphorylation biases cortical precursors to generate neurons rather than astrocytes in vivo
    Annie Paquin
    Developmental Biology, Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada
    J Neurosci 25:10747-58. 2005
    ..Thus, activation of an MEK-C/EBP pathway in cortical precursors in vivo biases them to become neurons and against becoming astrocytes, thereby acting as a growth factor-regulated switch...
  38. ncbi request reprint Signaling mechanisms underlying reversible, activity-dependent dendrite formation
    Andrew R Vaillant
    Center for Neuronal Survival, Brain Tumor Research Center, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada H3A 2B4
    Neuron 34:985-98. 2002
    ....
  39. ncbi request reprint An essential role for a MEK-C/EBP pathway during growth factor-regulated cortical neurogenesis
    Catherine Ménard
    Centre for Neuronal Survival and Brain Tumor Research Centre, Montreal Neurological Institute, Montreal, Canada
    Neuron 36:597-610. 2002
    ..Thus, activation of a MEK-C/EBP pathway enhances neurogenesis and inhibits gliogenesis, thereby providing a mechanism whereby growth factors can selectively bias progenitors to become neurons during development...
  40. ncbi request reprint Axon growth inhibition: signals from the p75 neurotrophin receptor
    David R Kaplan
    Nat Neurosci 6:435-6. 2003
  41. ncbi request reprint p73 is required for survival and maintenance of CNS neurons
    Christine D Pozniak
    Centre for Neuronal Survival, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada H3A 2B4
    J Neurosci 22:9800-9. 2002
    ....
  42. ncbi request reprint Neuronal survival and p73/p63/p53: a family affair
    W Bradley Jacobs
    Developmental Biology and Cancer Research, Hospital for Sick Children, Division of Neurosurgery, Department of Surgery, University of Toronto, Toronto, Ontario, Canada
    Neuroscientist 10:443-55. 2004
    ....
  43. ncbi request reprint The invulnerability of adult neurons: a critical role for p73
    Gregory S Walsh
    Developmental Biology and Cancer Research, Hospital for Sick Children, Department of Medical Genetics, University of Toronto, Toronto, Ontario, Canada M5G 1X8
    J Neurosci 24:9638-47. 2004
    ..Thus, one way adult neurons become invulnerable is to enhance endogenous survival pathways, and one critical component of these survival pathways is p73...
  44. ncbi request reprint Activity regulates positive and negative neurotrophin-derived signals to determine axon competition
    Karun K Singh
    Department of Developmental Biology, Institute of Medical Sciences, University of Toronto, Toronto, M5G 1X8, Canada
    Neuron 45:837-45. 2005
    ..Thus, activity regulates both positive and negative neurotrophin-derived signaling cascades to confer a competitive growth advantage on one axon versus another, thereby providing a cellular mechanism for developmental axon selection...
  45. ncbi request reprint Isolation and characterization of multipotent skin-derived precursors from human skin
    Jean G Toma
    Department of Developmental Biology, Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada M5G 1X8
    Stem Cells 23:727-37. 2005
    ..Together, these data indicate that SKPs are an endogenous multipotent precursor cell present in human skin that can be isolated and expanded and differentiate into both neural and mesodermal cell types...
  46. ncbi request reprint A transcriptional role for C/EBP beta in the neuronal response to axonal injury
    Sylvain Nadeau
    Developmental Biology and Neurobiology and Behavior, Hospital for Sick Children, 3203 Black Wing, Toronto, Ontario, Canada M5G 1X5
    Mol Cell Neurosci 29:525-35. 2005
    ..Thus, C/EBPbeta is essential for the neuronal injury response, acting to transcriptionally activate regeneration-associated gene expression...
  47. ncbi request reprint Evidence that embryonic neurons regulate the onset of cortical gliogenesis via cardiotrophin-1
    Fanie Barnabe-Heider
    Developmental Biology, University of Toronto, Toronto M5G 1X8, Canada
    Neuron 48:253-65. 2005
    ....
  48. ncbi request reprint Thyroid hormone-dependent regulation of Talpha1 alpha-tubulin during brain development
    Petra I Lorenzo
    Instituto de Investigaciones Biomedicas Alberto Sols, CSIC, 28029 Madrid, Spain
    Mol Cell Neurosci 19:333-43. 2002
    ..It is concluded that regulation of Talpha1 alpha-tubulin by thyroid hormone is the result of multiple influences including effects on mRNA half life and indirect effects at the promoter level...