MICHAEL JOSEPH MEANEY

Summary

Affiliation: McGill University
Country: Canada

Publications

  1. ncbi The programming of individual differences in defensive responses and reproductive strategies in the rat through variations in maternal care
    Nicole M Cameron
    McGill Program for the Study of Behavior, Genes and Environment, Department of Psychiatry, Douglas Hospital Research Centre, McGill University, 6875 Boulevard LaSalle, , Que, Canada H4H 1R3
    Neurosci Biobehav Rev 29:843-65. 2005
  2. ncbi Environmental programming of stress responses through DNA methylation: life at the interface between a dynamic environment and a fixed genome
    Michael J Meaney
    McGill Program for the Study of Behavior, Genes and Environment, Department of Pharmacology, McGill University, Douglas Hospital Research Centre, Montreal, Quebec, Canada
    Dialogues Clin Neurosci 7:103-23. 2005
  3. ncbi Stress during gestation alters postpartum maternal care and the development of the offspring in a rodent model
    Frances A Champagne
    McGill Program for the Study of Behavior, Genes and Environment and Developmental Neuroendocrinology Laboratory, Douglas Hospital Research Centre, McGill University, Montreal, Canada
    Biol Psychiatry 59:1227-35. 2006
  4. ncbi Maternal programming of steroid receptor expression and phenotype through DNA methylation in the rat
    Moshe Szyf
    McGill Program for the Study of Behavior, Genes and Environment, McGill University, Montreal, Canada
    Front Neuroendocrinol 26:139-62. 2005
  5. ncbi Reversal of maternal programming of stress responses in adult offspring through methyl supplementation: altering epigenetic marking later in life
    Ian C G Weaver
    Douglas Hospital Research Center, , , Canada
    J Neurosci 25:11045-54. 2005
  6. ncbi Nature, nurture, and the disunity of knowledge
    M J Meaney
    Program for the Study of Behavior, Genes and Environment, Douglas Hospital Research Centre, McGill University, Montreal, Canada H4H 1R3
    Ann N Y Acad Sci 935:50-61. 2001
  7. ncbi Environmental regulation of the neural epigenome
    Judy Sng
    Integrative Neuroscience Program, Singapore Institute for Clinical Sciences, 30 Medial Drive, Singapore
    Epigenomics 1:131-51. 2009
  8. ncbi Maternal care as a model for experience-dependent chromatin plasticity?
    Michael J Meaney
    Douglas Hospital Research Center, 6875 LaSalle Boulevard, Montreal, Quebec H4H 1R3, Canada
    Trends Neurosci 28:456-63. 2005
  9. ncbi Epigenetics and the biological definition of gene x environment interactions
    Michael J Meaney
    McGill University, Montreal, QC, Canada
    Child Dev 81:41-79. 2010
  10. ncbi Epigenetic mechanisms of perinatal programming of hypothalamic-pituitary-adrenal function and health
    Michael J Meaney
    McGill Program for Study of Genes, Environment and Health, McGill University, Montreal, Canada
    Trends Mol Med 13:269-77. 2007

Research Grants

  1. Maternal Programming of Gene Expression Through DNA Methylation
    Michael Meaney; Fiscal Year: 2007
  2. Maternal Programming of Gene Expression Through DNA Methylation
    MICHAEL JOSEPH MEANEY; Fiscal Year: 2010
  3. Individual differences in maternal behavior in the rat
    Michael Meaney; Fiscal Year: 2007
  4. Individual Differences in Mesolimbic Dopamine Systems
    Michael Meaney; Fiscal Year: 2003
  5. INDIVIDUAL DIFFERENCES IN MATERNAL CARE IN THE RAT
    Michael Meaney; Fiscal Year: 2000

Collaborators

Detail Information

Publications78

  1. ncbi The programming of individual differences in defensive responses and reproductive strategies in the rat through variations in maternal care
    Nicole M Cameron
    McGill Program for the Study of Behavior, Genes and Environment, Department of Psychiatry, Douglas Hospital Research Centre, McGill University, 6875 Boulevard LaSalle, , Que, Canada H4H 1R3
    Neurosci Biobehav Rev 29:843-65. 2005
    ..Ultimately, we will need to contend with the reality that neural development, function and health are defined by social and economic influences...
  2. ncbi Environmental programming of stress responses through DNA methylation: life at the interface between a dynamic environment and a fixed genome
    Michael J Meaney
    McGill Program for the Study of Behavior, Genes and Environment, Department of Pharmacology, McGill University, Douglas Hospital Research Centre, Montreal, Quebec, Canada
    Dialogues Clin Neurosci 7:103-23. 2005
    ....
  3. ncbi Stress during gestation alters postpartum maternal care and the development of the offspring in a rodent model
    Frances A Champagne
    McGill Program for the Study of Behavior, Genes and Environment and Developmental Neuroendocrinology Laboratory, Douglas Hospital Research Centre, McGill University, Montreal, Canada
    Biol Psychiatry 59:1227-35. 2006
    ..Thus, the effects of environmental adversity can be transmitted across generations through a nongenomic mechanism involving maternal care...
  4. ncbi Maternal programming of steroid receptor expression and phenotype through DNA methylation in the rat
    Moshe Szyf
    McGill Program for the Study of Behavior, Genes and Environment, McGill University, Montreal, Canada
    Front Neuroendocrinol 26:139-62. 2005
    ..These findings demonstrate that an epigenomic state of a gene can be established through a behavioral mode of programming and that in spite of the inherent stability of this epigenomic mark, it is dynamic and potentially reversible...
  5. ncbi Reversal of maternal programming of stress responses in adult offspring through methyl supplementation: altering epigenetic marking later in life
    Ian C G Weaver
    Douglas Hospital Research Center, , , Canada
    J Neurosci 25:11045-54. 2005
    ..These results demonstrate that, despite the inherent stability of the epigenomic marks established early in life through behavioral programming, they are potentially reversible in the adult brain...
  6. ncbi Nature, nurture, and the disunity of knowledge
    M J Meaney
    Program for the Study of Behavior, Genes and Environment, Douglas Hospital Research Centre, McGill University, Montreal, Canada H4H 1R3
    Ann N Y Acad Sci 935:50-61. 2001
    ..More sophisticated models reflecting the inevitable interdependence of gene and environment are essential if we are to realize the potential offered by today's technological advances...
  7. ncbi Environmental regulation of the neural epigenome
    Judy Sng
    Integrative Neuroscience Program, Singapore Institute for Clinical Sciences, 30 Medial Drive, Singapore
    Epigenomics 1:131-51. 2009
    ....
  8. ncbi Maternal care as a model for experience-dependent chromatin plasticity?
    Michael J Meaney
    Douglas Hospital Research Center, 6875 LaSalle Boulevard, Montreal, Quebec H4H 1R3, Canada
    Trends Neurosci 28:456-63. 2005
    ..This review discusses the nature of this environmental programming--the mechanism by which it occurs in rats, its long-term implications, and opportunities for its reversal in rodents and ultimately in humans...
  9. ncbi Epigenetics and the biological definition of gene x environment interactions
    Michael J Meaney
    McGill University, Montreal, QC, Canada
    Child Dev 81:41-79. 2010
    ....
  10. ncbi Epigenetic mechanisms of perinatal programming of hypothalamic-pituitary-adrenal function and health
    Michael J Meaney
    McGill Program for Study of Genes, Environment and Health, McGill University, Montreal, Canada
    Trends Mol Med 13:269-77. 2007
    ....
  11. ncbi Epigenetic regulation of the neural transcriptome: the meaning of the marks
    Michael J Meaney
    Sackler Program for Epigenetics and Psychobiology, Douglas Hospital Mental Health University Institute, McGill University, Montreal, Quebec, Canada
    Nat Neurosci 13:1313-8. 2010
    ..Studies in genomic imprinting may serve as an existing model for such approaches...
  12. ncbi Environmental regulation of the development of mesolimbic dopamine systems: a neurobiological mechanism for vulnerability to drug abuse?
    Michael J Meaney
    McGill Centre for the Study of Behavior, Genes and Environment, Douglas Hospital Research Centre, McGill University, 6875 Boul LaSalle, H4H 1R3, Montreal, Que, Canada
    Psychoneuroendocrinology 27:127-38. 2002
    ..These findings raise the possibility that in addition to effects on stress reactivity, early life events might dispose individuals to illness in later life through effects on very specific neurotransmitter systems...
  13. ncbi Maternal programming of defensive responses through sustained effects on gene expression
    Tie Yuan Zhang
    McGill Program for the Study of Behavior, Genes and Environment, McGill University, Canada
    Biol Psychol 73:72-89. 2006
    ....
  14. ncbi Environmental enrichment reverses the effects of maternal separation on stress reactivity
    Darlene D Francis
    Developmental Neuroendocrinology Laboratory, Douglas Hospital Research Centre, Department of Psychiatry, McGill University, , , Canada
    J Neurosci 22:7840-3. 2002
    ..We conclude that environmental enrichment leads to a functional reversal of the effects of maternal separation through compensation for, rather than reversal of, the neural effects of early life adversity...
  15. ncbi Early environmental regulation of hippocampal glucocorticoid receptor gene expression: characterization of intracellular mediators and potential genomic target sites
    Ian C G Weaver
    McGill Program for the Study of Behavior, Genes and Environment, Douglas Hospital Research Centre, Department of Psychiatry, McGill University, Montreal, Quebec, Canada
    Ann N Y Acad Sci 1024:182-212. 2004
    ..This paper summarizes the evidence in favor of these pathways as well as recent studies describing regulatory targets within the chromatin structure of the promoter region of the rat hippocampal glucocorticoid receptor gene...
  16. ncbi Epigenetic programming by maternal behavior
    Ian C G Weaver
    Douglas Hospital Research Center, 6875 LaSalle Blvd, , , Canada
    Nat Neurosci 7:847-54. 2004
    ..Thus we show that an epigenomic state of a gene can be established through behavioral programming, and it is potentially reversible...
  17. ncbi Epigenetics and the biological basis of gene x environment interactions
    Rosemary C Bagot
    Sackler Program for Epigenetics and Psychobiology, McGill University and Douglas Mental Health University Institute, Montreal, Canada
    J Am Acad Child Adolesc Psychiatry 49:752-71. 2010
    ....
  18. ncbi Serotonin regulates hippocampal glucocorticoid receptor expression via a 5-HT7 receptor
    Patricia Laplante
    Developmental Neuroendocrinology Laboratory, Douglas Hospital Research Center, Departments of Psychiatry and Neurology and Neurosurgery, McGill University, 6875 Boul. LaSalle, Quebec, , Canada H4H 1R3
    Brain Res Dev Brain Res 139:199-203. 2002
    ..The effect of 5-HT or 5-CT was blocked with methiothepin or by a protein kinase A inhibitor, but not pindolol. These results suggest that the effects of 5-HT on hippocampal GR expression is mediated by a 5-HT7 receptor...
  19. ncbi The social environment and the epigenome
    Moshe Szyf
    Department of Pharmacology and Therapeutics, McGill University, and Department of Psychiatry, Douglas Hospital Research Center, Montreal, Quebec, Canada
    Environ Mol Mutagen 49:46-60. 2008
    ..We speculate that exposures to different environmental toxins alters long-established epigenetic programs in the brain as well as other tissues leading to late-onset disease...
  20. ncbi Quality of parental emotional care and calculated risk for coronary heart disease
    Nisha D Almeida
    Department of Epidemiology, Biostatistics and Occupational Health, Douglas Mental Health University Institute, McGill University, Montreal, Quebec, H3A 1A2
    Psychosom Med 72:148-55. 2010
    ..To evaluate associations between perceived quality of parental emotional care and calculated 10-year risk for coronary heart disease (CHD). Little is understood about the role of parental emotional care in contributing to the risk for CHD...
  21. ncbi The Douglas Hospital Longitudinal Study of Normal and Pathological Aging: summary of findings
    Sonia J Lupien
    Laboratory of Human Stress Research, Douglas Hospital Research Centre, Borough of Verdun, and Department of Psychiatry, McGill University, Montreal, Quebec, Canada
    J Psychiatry Neurosci 30:328-34. 2005
    ....
  22. ncbi Non-stress-related factors associated with maternal corticotrophin-releasing hormone (CRH) concentration
    Michael S Kramer
    Departments of Pediatrics, McGill University Faculty of Medicine, and Département de médecine sociale et préventive, Faculte de Medecine de l Universite de Montreal, Montreal, Quebec, Canada
    Paediatr Perinat Epidemiol 24:390-7. 2010
    ..Further studies are indicated both in animal models and human populations to better understand the biochemical and physiological pathways to CRH secretion and their aetiological role, if any, in preterm birth...
  23. ncbi From maternal care to gene expression: DNA methylation and the maternal programming of stress responses
    Ian C G Weaver
    Douglas Hospital Research Centre, McGill University, Montreal, PQ, Canada
    Endocr Res 28:699. 2002
  24. ncbi Deactivation of the limbic system during acute psychosocial stress: evidence from positron emission tomography and functional magnetic resonance imaging studies
    Jens C Pruessner
    Center for Studies on Human Stress, Douglas Hospital Research Center and Montreal Neurological Institute, Department of Psychiatry, McGill University, Montreal, Quebec, Canada
    Biol Psychiatry 63:234-40. 2008
    ..Newly developed paradigms to investigate stress in neuroimaging environments allow the assessment of brain activation changes in association with the perception of and the metabolic response to stress...
  25. ncbi The transcription factor nerve growth factor-inducible protein a mediates epigenetic programming: altering epigenetic marks by immediate-early genes
    Ian C G Weaver
    Douglas Hospital Research Center, Montreal, Quebec, Canada H4H 1R3
    J Neurosci 27:1756-68. 2007
    ..The data are consistent with the hypothesis that NGFI-A participates in epigenetic programming of GR expression...
  26. ncbi Maternal care and DNA methylation of a glutamic acid decarboxylase 1 promoter in rat hippocampus
    Tie Yuan Zhang
    Sackler Program for Epigenetics and Developmental Psychobiology at McGill University, Douglas Mental Health University Institute, McGill University, Montreal, Quebec H4H 1R3, Canada
    J Neurosci 30:13130-7. 2010
    ..These results suggest that maternal care influences the development of the GABA system by altering GAD1 promoter methylation levels through the maternally induced activation of NGFI-A and its association with the GAD1 promoter...
  27. ncbi Behavioral response to methylphenidate challenge: influence of early life parental care
    Veronika Engert
    Douglas Mental Health University Institute, Department of Psychiatry, McGill University, Montreal, Quebec, Canada H4H 1R3
    Dev Psychobiol 51:408-16. 2009
    ..Activity measures in response to reward and MPH were uninfluenced by parental care. This is the first human study to reveal that the behavioral MPH response interacts with early life parental care experience...
  28. ncbi Epigenetic programming of stress responses through variations in maternal care
    Eric W Fish
    McGill Program for the Study of Behavior, Genes and Environment, Douglas Hospital Research Centre, McGill University, Montreal, Canada
    Ann N Y Acad Sci 1036:167-80. 2004
    ..Given the importance of early life and parent-child interactions to later behavior, prevention and intervention programs should target this critical phase of development...
  29. ncbi Stress pathways to spontaneous preterm birth: the role of stressors, psychological distress, and stress hormones
    Michael S Kramer
    Department of Pediatrics, McGill University Faculty of Medicine, Montreal, Quebec, Canada
    Am J Epidemiol 169:1319-26. 2009
    ..The biologic pathways underlying stress-induced preterm birth remain poorly understood...
  30. ncbi Prenatal maternal stress from a natural disaster predicts dermatoglyphic asymmetry in humans
    Suzanne King
    Douglas Hospital Research Centre, Verdun, Quebec, Canada
    Dev Psychopathol 21:343-53. 2009
    ..56). Prenatal maternal stress during the period of fingerprint development results in greater dermatoglyphic asymmetry in their children, especially in the face of greater maternal distress...
  31. ncbi Maternal care determines rapid effects of stress mediators on synaptic plasticity in adult rat hippocampal dentate gyrus
    Rosemary C Bagot
    SILS CNS, University of Amsterdam, Amsterdam, The Netherlands
    Neurobiol Learn Mem 92:292-300. 2009
    ..We suggest that decreased pup LG during postnatal life may be adaptive in high-threat environments, potentially enhancing hippocampal function in the offspring under conditions of adversity...
  32. ncbi Dopamine release in response to a psychological stress in humans and its relationship to early life maternal care: a positron emission tomography study using [11C]raclopride
    Jens C Pruessner
    McConnell Brain Imaging Center, Montreal Neurological Institute, McGill University, Montreal, Canada H3A 2B4
    J Neurosci 24:2825-31. 2004
    ..These data suggest that aversive stressful events can be associated with mesolimbic dopamine release in humans, and that the method presented here may be useful to study the effects of early life events on neurobiological stress systems...
  33. ncbi Epigenetics and the environmental regulation of the genome and its function
    Tie Yuan Zhang
    Sackler Program for Epigenetics and Psychobiology of McGill University, Douglas Mental Health University Institute and the Singapore Institute for Clinical Sciences, Montreal, Quebec, H4H 1R3 Canada
    Annu Rev Psychol 61:439-66, C1-3. 2010
    ..These studies define a biological basis for the interplay between environmental signals and the genome in the regulation of individual differences in behavior, cognition, and physiology...
  34. ncbi Peripubertal environmental enrichment reverses the effects of maternal care on hippocampal development and glutamate receptor subunit expression
    Timothy W Bredy
    Developmental Neuroendocrinology Laboratory, Genes and Environment, Douglas Hospital Research Center, , Canada H4H 1R3
    Eur J Neurosci 20:1355-62. 2004
    ....
  35. ncbi Epigenetics, behaviour, and health
    Moshe Szyf
    Department of Pharmacology and Therapeutics, McGill University, Montréimeal, QC
    Allergy Asthma Clin Immunol 4:37-49. 2008
    ..In contrast to genetic sequence differences, epigenetic aberrations are potentially reversible, raising the hope for interventions that will be able to reverse deleterious epigenetic programming...
  36. ncbi Maternal programming of individual differences in defensive responses in the rat
    Tie-Yuan Zhang
    McGill Program for the Study of Behavior, Genes and Environment, Douglas Hospital Research Centre, Department of Psychiatry, McGill University, 6875 Boul. LaSalle, , Canada H4H 1R3
    Ann N Y Acad Sci 1032:85-103. 2004
    ..Together these findings suggest an epigenetic process whereby the experience of the mother alters the nature of the parent-offspring interactions and thus the phenotype of the offspring...
  37. ncbi Maternal influences on the sexual behavior and reproductive success of the female rat
    Nicole M Cameron
    Sackler Program for Developmental Psychobiology and Epigenetics at McGill University, Montreal, Canada
    Horm Behav 54:178-84. 2008
    ..Together with previous studies these findings imply that maternal care can 'program' reproductive strategies in the female rat...
  38. ncbi Diet and the epigenetic (re)programming of phenotypic differences in behavior
    Patrick O McGowan
    Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada
    Brain Res 1237:12-24. 2008
    ..Nutritional restriction during gestation could affect epigenetic programming in the brain. These findings provide evidence for a stable yet dynamic epigenome capable of regulating phenotypic plasticity through epigenetic programming...
  39. ncbi Variations in maternal care in the rat as a mediating influence for the effects of environment on development
    Frances A Champagne
    Developmental Neuroendocrinology Laboratory, Douglas Hospital Research Centre, McGill University, 6875 LaSalle Boulevard, Montreal, Quebec, Canada H4H 1R3
    Physiol Behav 79:359-71. 2003
    ..Overall, these findings indicate considerable, normal variations in licking/grooming in the rat that are a stable, individual characteristic of rat dams...
  40. ncbi Effect of neonatal handling and paternal care on offspring cognitive development in the monogamous California mouse (Peromyscus californicus)
    Timothy W Bredy
    Developmental Neuroendocrinology Laboratory, Douglas Hospital Research Centre, and Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada
    Horm Behav 46:30-8. 2004
    ....
  41. ncbi Environmental programming of phenotypic diversity in female reproductive strategies
    Michael J Meaney
    Developmental Neuroendocrinology Laboratory, Douglas Hospital Research Centre, McGill University, Montreal, QC, Canada H4H 1R3
    Adv Genet 59:173-215. 2007
    ..Thus, the variations in parental care that define the reproductive phenotype of the offspring are influenced by the quality of the environment (i.e., nutrient availability, predation, infection, population density, and so on)...
  42. ncbi Epigenetics and parental effects
    Laurent Kappeler
    Sackler Program for Epigenetics and Psychobiology, Douglas Mental Health University Institute, McGill University, Montreal, Quebec, Canada
    Bioessays 32:818-27. 2010
    ..We suggest that parental regulation of DNA methylation states is thus an ideal candidate mechanism for parental effects on phenotypic variation...
  43. ncbi The influence of natural variations in maternal care on play fighting in the rat
    Carine I Parent
    Department of Psychiatry and Neurology, McGill University, Douglas Mental Health University Institute 6875 LaSalle Blvd, Montreal, Quebec, Canada H4H1R3
    Dev Psychobiol 50:767-76. 2008
    ..These findings identify a possible influence of variations in maternal care on play fighting and suggest that maternal care in the perinatal period influence social interactions during periadolescence...
  44. ncbi Variations in nucleus accumbens dopamine associated with individual differences in maternal behavior in the rat
    Frances A Champagne
    Developmental Neuroendocrinology Laboratory, Douglas Hospital Research Centre, McGill University, Montreal, Quebec H4H 1R3, Canada
    J Neurosci 24:4113-23. 2004
    ..Such differences may serve as neural substrates for individual differences in the motivational component of maternal behavior...
  45. ncbi Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse
    Patrick O McGowan
    Douglas Mental Health University Institute, 6875 LaSalle Boulevard, Montreal, Quebec, H4H 1R3, Canada
    Nat Neurosci 12:342-8. 2009
    ..These findings translate previous results from rat to humans and suggest a common effect of parental care on the epigenetic regulation of hippocampal glucocorticoid receptor expression...
  46. ncbi Promoter-wide hypermethylation of the ribosomal RNA gene promoter in the suicide brain
    Patrick O McGowan
    Department of Psychiatry, Douglas Mental Health University Institute, Montreal, Quebec, Canada
    PLoS ONE 3:e2085. 2008
    ..rRNA genes, that encode ribosomal RNA, are the backbone of the protein synthesis machinery and levels of rRNA gene promoter methylation determine rRNA transcription...
  47. ncbi Maternal programming of sexual behavior and hypothalamic-pituitary-gonadal function in the female rat
    Nicole Cameron
    Sackler Program for Epigenetics and Psychobiology, McGill University, Montreal, Canada
    PLoS ONE 3:e2210. 2008
    ....
  48. ncbi Psychological stressors as a model of maternal adversity: diurnal modulation of corticosterone responses and changes in maternal behavior
    Marion Leonhardt
    CIHR program in Maternal Adversity, Vulnerability and Neurodevelopment MAVAN Douglas Hospital Research Center, Department of Psychiatry, McGill University, Montreal, Quebec, Canada H4H 1R3
    Horm Behav 51:77-88. 2007
    ..The combination of forced foraging, wet bedding and strobe light might represent a novel model of mild maternal adversity using "purely" psychological stressors...
  49. ncbi Oxytocin-dopamine interactions mediate variations in maternal behavior in the rat
    Dara K Shahrokh
    Sackler Program for Epigenetics and Psychobiology at McGill University, Douglas Mental Health University Institute, McGill University, Montreal, Canada
    Endocrinology 151:2276-86. 2010
    ....
  50. ncbi Maternal care influences neuronal survival in the hippocampus of the rat
    Timothy W Bredy
    Developmental Neuroendocrinology Laboratory and McGill Program for the Study of Behaviour, Genes and Environment, Douglas Hospital Research Centre, 6875 Boul. LaSalle Blvd, , Canada, H4H 1R3
    Eur J Neurosci 18:2903-9. 2003
    ..These findings emphasize the importance of early maternal care for hippocampal development...
  51. ncbi Maternal programming of defensive responses through sustained effects on gene expression
    Josie Diorio
    McGill Program for the Study of Behaviour, Genes and Environment, Douglas Hospital Research Centre, Department of Psychiatry, McGill University, Montreal, Que
    J Psychiatry Neurosci 32:275-84. 2007
    ....
  52. ncbi Variations in maternal care alter GABA(A) receptor subunit expression in brain regions associated with fear
    Christian Caldji
    Developmental Neuroendocrinology Laboratory, Douglas Hospital Research Centre, McGill University, , Canada H4H 1R3
    Neuropsychopharmacology 28:1950-9. 2003
    ....
  53. ncbi Maternal care effects on the hippocampal transcriptome and anxiety-mediated behaviors in the offspring that are reversible in adulthood
    Ian C G Weaver
    Douglas Hospital Research Center, Montreal, QC, Canada
    Proc Natl Acad Sci U S A 103:3480-5. 2006
    ..These results suggest that early-life experience has a stable and broad effect on the hippocampal transcriptome and anxiety-mediated behavior, which is potentially reversible in adulthood...
  54. ncbi Maternal care associated with methylation of the estrogen receptor-alpha1b promoter and estrogen receptor-alpha expression in the medial preoptic area of female offspring
    Frances A Champagne
    Douglas Hospital Research Center, , , Canada H4H 1R3
    Endocrinology 147:2909-15. 2006
    ....
  55. ncbi Regional-specific global cytosine methylation and DNA methyltransferase expression in the adult rat hippocampus
    Shelley E Brown
    Department of Pharmacology and Therapeutics, McGill University, 3655 Sir William Oslar Promenade, and Douglas Hospital Research Center, Montreal, Quebec H3G 1Y6, Canada
    Neurosci Lett 440:49-53. 2008
    ....
  56. ncbi Maternal behavior regulates benzodiazepine/GABAA receptor subunit expression in brain regions associated with fear in BALB/c and C57BL/6 mice
    Christian Caldji
    Developmental Neuroendocrinology Laboratory, Douglas Hospital Research Centre, McGill University, Montreal, Canada
    Neuropsychopharmacology 29:1344-52. 2004
    ..Such findings may reflect a mammalian example of an indirect genetic effect mediated by maternal care...
  57. ncbi Natural variations in maternal care are associated with estrogen receptor alpha expression and estrogen sensitivity in the medial preoptic area
    Frances A Champagne
    Developmental Neuroendocrinology Laboratory, Douglas Hospital Research Centre, McGill University, 6875 LaSalle Boulevard, Montreal, Canada H4H 1R3
    Endocrinology 144:4720-4. 2003
    ..These findings suggest that natural variations in maternal care are associated with differences in ER alpha expression in the MPOA and that such differences are transmitted from the mother to her female offspring...
  58. ncbi Maternal behavior regulates long-term hippocampal expression of BAX and apoptosis in the offspring
    Ian C G Weaver
    Developmental Neuroendocrinology Laboratory, Douglas Hospital Research Center and Program for the Study of Behavior, Genes, and Environment, McGill University, Montreal, Canada
    J Neurochem 82:998-1002. 2002
    ..In conclusion, we propose that hippocampal neurons in the offspring of low-level LG mothers may be more vulnerable to loss through apoptosis...
  59. ncbi The effects of pH on DNA methylation state: In vitro and post-mortem brain studies
    Carl Ernst
    McGill Group for Suicide Studies, McGill University, Montreal, Canada
    J Neurosci Methods 174:123-5. 2008
    ..No correlation was found between DNA methylation state and pH. These results suggest that DNA methylation state is stable in post-mortem brain...
  60. ncbi Glucocorticoid programming
    Jonathan R Seckl
    Endocrinology Unit, University of Edinburgh, Molecular Medicine Centre, Western General Hospital, Edinburgh, EH4 2XU, UK
    Ann N Y Acad Sci 1032:63-84. 2004
    ..Overall, the data suggest that either pharmacological or physiological exposure to excess glucocorticoids prenatally programs pathologies in adult life...
  61. ncbi Maternal care and hippocampal plasticity: evidence for experience-dependent structural plasticity, altered synaptic functioning, and differential responsiveness to glucocorticoids and stress
    Danielle L Champagne
    Swammerdam Institute for Life Sciences Center for Neuroscience, University of Amsterdam, 1098 SM Amsterdam, The Netherlands
    J Neurosci 28:6037-45. 2008
    ....
  62. ncbi Neurobehavioral basis of the impaired nurturing in mice lacking the immediate early gene FosB
    Kumi O Kuroda
    Kuroda Research Unit for Affiliative Social Behavior, RIKEN Brain Science Institute, Saitama 351 0198, Japan
    Brain Res 1211:57-71. 2008
    ..These results suggest that FosB (-/-) mice have broader neurobehavioral dysfunctions, with which the nurturing defect might share the common mechanism...
  63. ncbi Chronic treatment with the antidepressant amitriptyline prevents impairments in water maze learning in aging rats
    Joyce L W Yau
    Centre for the Study of the Ageing Brain, Molecular Medicine Centre, Western General Hospital, Edinburgh EH4 2XU, United Kingdom
    J Neurosci 22:1436-42. 2002
    ..These data suggest that long-term treatment with amitriptyline decreases the prevalence of cognitive impairment in aged rats and that this may, in part, be a consequence of reduced plasma corticosterone levels and reduced anxiety...
  64. ncbi Testosterone-dependent variations in plasma and intrapituitary corticosteroid binding globulin and stress hypothalamic-pituitary-adrenal activity in the male rat
    Victor Viau
    Department of Anatomy and Cell Biology, University of British Columbia, Vancouver, Canada
    J Endocrinol 181:223-31. 2004
    ..This could permit greater access of corticosterone to its receptors and enhance glucocorticoid feedback regulation of ACTH release and/or proopiomelanocortin processing...
  65. ncbi Long-term consequences of neonatal rearing on central corticotropin-releasing factor systems in adult male rat offspring
    Paul M Plotsky
    Stress Neurobiology Laboratory, Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 1639 Pierce Drive, Atlanta, GA 30322, USA
    Neuropsychopharmacology 30:2192-204. 2005
    ....
  66. ncbi Neurodevelopmental sequelae of postnatal maternal care in rodents: clinical and research implications of molecular insights
    Arie Kaffman
    Abraham Ribicoff Labs, Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06598, USA
    J Child Psychol Psychiatry 48:224-44. 2007
    ..Finally, the relevance of findings reported in rodents to those noted in non-human primates and humans are assessed and the research and clinical implications of these observations for future work are explored...
  67. ncbi Influence of early postnatal rearing conditions on mesocorticolimbic dopamine and behavioural responses to psychostimulants and stressors in adult rats
    Wayne G Brake
    Department of Psychology, University of California Santa Barbara, CA 93106, USA
    Eur J Neurosci 19:1863-74. 2004
    ....
  68. ncbi Maternal care modulates the relationship between prenatal risk and hippocampal volume in women but not in men
    Claudia Buss
    University of Trier, Department for Theoretical and Clinical Psychobiology, 54290 Trier, Germany
    J Neurosci 27:2592-5. 2007
    ..The results suggest that the postnatal environment modulates the neurodevelopmental consequences of prenatal risk and that this effect is sex-specific...
  69. ncbi Effect of resource availability on biparental care, and offspring neural and behavioral development in the California mouse (Peromyscus californicus)
    Timothy W Bredy
    Department of Psychiatry and Biobehavioral Sciences, UCLA, Los Angeles, CA 90095, USA
    Eur J Neurosci 25:567-75. 2007
    ..Together, the results suggest that resource availability affects biparental investment strategies, with subsequent effects on hippocampal development and novel object recognition in the offspring...
  70. ncbi Amygdala kindling decreases insulin-like growth factor-I receptor binding sites in the rat hippocampus
    Lisa E Kalynchuk
    Department of Psychology, Dalhousie University, Halifax, Nova Scotia B3H 4J1, Canada
    Brain Res 935:118-23. 2002
    ..These results, in keeping with the established neurotrophic effects of IGF-I, suggest a potential role for this growth factor in mediating the structural alterations associated with kindling...
  71. ncbi Prenatal dexamethasone exposure induces changes in nonhuman primate offspring cardiometabolic and hypothalamic-pituitary-adrenal axis function
    Annick de Vries
    Endocrinology Unit, University of Edinburgh, The Queen s Medical Research Institute, Edinburgh, United Kingdom
    J Clin Invest 117:1058-67. 2007
    ..The data are compatible with the extrapolation of the glucocorticoid programming hypothesis to primates and indicate that repeated glucocorticoid therapy and perhaps chronic stress in humans may have long-term effects...
  72. ncbi Serotonin receptor binding and mRNA expression in the hippocampus of fearful amygdala-kindled rats
    Lisa E Kalynchuk
    Department of Psychology, University of Saskatchewan, 9 Campus Drive, Saskatoon, Sask, Canada S7N 5A5
    Neurosci Lett 396:38-43. 2006
    ..These results suggest that alterations in 5-HT1A receptors in the dentate gyrus may play a role in the expression of kindled fear...
  73. ncbi Maternal separation leads to persistent reductions in pain sensitivity in female rats
    Shelley A Weaver
    War Related Illness and Injury Study Center, Department of Veterans Affairs, New Jersey Health Care System, East Orange, New Jersey 07018, USA
    J Pain 8:962-9. 2007
    ..Clinically, early life history may play an important role in pain symptoms and responses to opioid analgesics...
  74. ncbi ERK-FosB signaling in dorsal MPOA neurons plays a major role in the initiation of parental behavior in mice
    Kumi O Kuroda
    Laboratory for Molecular Dynamics of Mental Disorder, RIKEN Brain Science Institute, Saitama 351 0198, Japan
    Mol Cell Neurosci 36:121-31. 2007
    ..Furthermore, induction of SPRY1 and Rad was impaired in MPOAd of nonparental FosB-knockout mice. These results suggest the pivotal role of ERK-FosB signaling in the initiation of parental care...
  75. ncbi Amygdala kindling increases fear responses and decreases glucocorticoid receptor mRNA expression in hippocampal regions
    Lisa E Kalynchuk
    Department of Psychology and Neuroscience Institute, Dalhousie University, 1355 Oxford Street, B3H 4J1, Halifax, Nova Scotia, Canada
    Prog Neuropsychopharmacol Biol Psychiatry 27:1225-34. 2003
    ..These results suggest that alterations in GR mRNA expression in hippocampal regions may play a role in the development of kindling-induced fear...
  76. ncbi Transgenerational effects of social environment on variations in maternal care and behavioral response to novelty
    Frances A Champagne
    Columbia University, Department of Psychology, New York, NY 10027, USA
    Behav Neurosci 121:1353-63. 2007
    ....
  77. ncbi Preliminary evidence of altered sensitivity to benzodiazepines as a function of maternal care in the rat
    Eva Fries
    Department of Clinical and Theoretical Psychobiology, University of Trier, Germany
    Ann N Y Acad Sci 1032:320-3. 2004
    ....
  78. ncbi Glucocorticoid "programming" and PTSD risk
    Jonathan R Seckl
    Endocrinology Unit, Centre for Cardiovascular Science, Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
    Ann N Y Acad Sci 1071:351-78. 2006
    ....

Research Grants15

  1. Maternal Programming of Gene Expression Through DNA Methylation
    Michael Meaney; Fiscal Year: 2007
    ....
  2. Maternal Programming of Gene Expression Through DNA Methylation
    MICHAEL JOSEPH MEANEY; Fiscal Year: 2010
    ..abstract_text> ..
  3. Individual differences in maternal behavior in the rat
    Michael Meaney; Fiscal Year: 2007
    ..abstract_text> ..
  4. Individual Differences in Mesolimbic Dopamine Systems
    Michael Meaney; Fiscal Year: 2003
    ..We feel that these studies will provide us with an understanding of the way in which early environmental events might contribute to the development of individual differences in neural systems that mediate drug-seeking behavior. ..
  5. INDIVIDUAL DIFFERENCES IN MATERNAL CARE IN THE RAT
    Michael Meaney; Fiscal Year: 2000
    ....