M D McKee

Summary

Affiliation: McGill University
Country: Canada

Publications

  1. pmc Compounded PHOSPHO1/ALPL Deficiencies Reduce Dentin Mineralization
    M D McKee
    Faculty of Dentistry, and Department of Anatomy and Cell Biology, Faculty of Medicine, McGill University, 3640 University Street, Montreal, QC, Canada
    J Dent Res 92:721-7. 2013
  2. ncbi request reprint Hierarchies of extracellular matrix and mineral organization in bone of the craniofacial complex and skeleton
    M D McKee
    Faculty of Dentistry, McGill University, Montreal, QC, Canada
    Cells Tissues Organs 181:176-88. 2005
  3. pmc Enzyme replacement therapy prevents dental defects in a model of hypophosphatasia
    M D McKee
    Faculty of Dentistry, and Department of Anatomy and Cell Biology, McGill University, Strathcona Anatomy and Dentistry Bldg, 3640 University Street, Montreal, Quebec, Canada
    J Dent Res 90:470-6. 2011
  4. doi request reprint Osteopontin and wound healing in bone
    Marc D McKee
    Faculty of Dentistry, McGill University, Montreal, Que, Canada
    Cells Tissues Organs 194:313-9. 2011
  5. doi request reprint Mineralization of dense collagen hydrogel scaffolds by human pulp cells
    B R Coyac
    Faculty of Dentistry, McGill University, Montreal, QC, Canada
    J Dent Res 92:648-54. 2013
  6. ncbi request reprint Matrix Gla protein inhibition of tooth mineralization
    N R Kaipatur
    Faculty of Dentistry, McGill University, 3640 University Street, Montreal, QC, Canada H3A 2B2
    J Dent Res 87:839-44. 2008
  7. doi request reprint Avian eggshell structure and osteopontin
    Y C Chien
    Faculty of Dentistry, McGill University, Montreal, Que, Canada
    Cells Tissues Organs 189:38-43. 2009
  8. doi request reprint In vitro osteogenesis assays: influence of the primary cell source on alkaline phosphatase activity and mineralization
    C D Hoemann
    Department of Chemical Engineering, Ecole Polytechnique, Montreal, QC, H3C 3A7, Canada
    Pathol Biol (Paris) 57:318-23. 2009
  9. doi request reprint Ultrastructure of avian eggshell during resorption following egg fertilization
    Y C Chien
    Faculty of Dentistry, McGill University, Montreal, Quebec, Canada
    J Struct Biol 168:527-38. 2009
  10. ncbi request reprint Chitosan-glycerol phosphate/blood implants elicit hyaline cartilage repair integrated with porous subchondral bone in microdrilled rabbit defects
    C D Hoemann
    Department of Chemical Engineering, Ecole Polytechnique, Montreal, QC, Canada Institute of Biomedical Engineering, Ecole Polytechnique, Montreal, QC, Canada
    Osteoarthritis Cartilage 15:78-89. 2007

Collaborators

Detail Information

Publications26

  1. pmc Compounded PHOSPHO1/ALPL Deficiencies Reduce Dentin Mineralization
    M D McKee
    Faculty of Dentistry, and Department of Anatomy and Cell Biology, Faculty of Medicine, McGill University, 3640 University Street, Montreal, QC, Canada
    J Dent Res 92:721-7. 2013
    ..Results from this study support prominent non-redundant roles for both PHOSPHO1 and TNAP in dentin mineralization. ..
  2. ncbi request reprint Hierarchies of extracellular matrix and mineral organization in bone of the craniofacial complex and skeleton
    M D McKee
    Faculty of Dentistry, McGill University, Montreal, QC, Canada
    Cells Tissues Organs 181:176-88. 2005
    ..Additional attention is given to recent work on the molecular determinants of mineral induction in bone, and how the mineralization process is subsequently regulated by inhibitory proteins...
  3. pmc Enzyme replacement therapy prevents dental defects in a model of hypophosphatasia
    M D McKee
    Faculty of Dentistry, and Department of Anatomy and Cell Biology, McGill University, Strathcona Anatomy and Dentistry Bldg, 3640 University Street, Montreal, Quebec, Canada
    J Dent Res 90:470-6. 2011
    ....
  4. doi request reprint Osteopontin and wound healing in bone
    Marc D McKee
    Faculty of Dentistry, McGill University, Montreal, Que, Canada
    Cells Tissues Organs 194:313-9. 2011
    ..Such interfacial OPN is thought to contribute to the cell adhesion, cell signaling, and matrix mineralization events required to effectively integrate the new bone into the preexisting bone at the margins of the drill site...
  5. doi request reprint Mineralization of dense collagen hydrogel scaffolds by human pulp cells
    B R Coyac
    Faculty of Dentistry, McGill University, Montreal, QC, Canada
    J Dent Res 92:648-54. 2013
    ..In conclusion, use of a 3D dense collagen scaffold promoted SHED osteo/odontogenic cell differentiation and mineralization...
  6. ncbi request reprint Matrix Gla protein inhibition of tooth mineralization
    N R Kaipatur
    Faculty of Dentistry, McGill University, 3640 University Street, Montreal, QC, Canada H3A 2B2
    J Dent Res 87:839-44. 2008
    ..Acellular cementum was lacking in Col1a1-Mgp teeth, and unmineralized osteodentin formed within the pulp. These results strengthen the view that bone and tooth mineralization is critically regulated by mineralization inhibitors...
  7. doi request reprint Avian eggshell structure and osteopontin
    Y C Chien
    Faculty of Dentistry, McGill University, Montreal, Que, Canada
    Cells Tissues Organs 189:38-43. 2009
    ..Given the potent mineralization- inhibiting function of OPN, we discuss how this protein might regulate eggshell growth rate and inhibit calcification at specific compartmental boundaries to provide eggshell form...
  8. doi request reprint In vitro osteogenesis assays: influence of the primary cell source on alkaline phosphatase activity and mineralization
    C D Hoemann
    Department of Chemical Engineering, Ecole Polytechnique, Montreal, QC, H3C 3A7, Canada
    Pathol Biol (Paris) 57:318-23. 2009
    ....
  9. doi request reprint Ultrastructure of avian eggshell during resorption following egg fertilization
    Y C Chien
    Faculty of Dentistry, McGill University, Montreal, Quebec, Canada
    J Struct Biol 168:527-38. 2009
    ..We propose that this mineral-occluded network regulates how shell mineral is dissolved by providing dissolution channels facilitating calcium release for the embryonic skeleton...
  10. ncbi request reprint Chitosan-glycerol phosphate/blood implants elicit hyaline cartilage repair integrated with porous subchondral bone in microdrilled rabbit defects
    C D Hoemann
    Department of Chemical Engineering, Ecole Polytechnique, Montreal, QC, Canada Institute of Biomedical Engineering, Ecole Polytechnique, Montreal, QC, Canada
    Osteoarthritis Cartilage 15:78-89. 2007
    ....
  11. ncbi request reprint Osteopontin: an interfacial extracellular matrix protein in mineralized tissues
    M D McKee
    Department of Stomatology, Faculty of Dentistry, Universite de Montreal, Quebec, Canada
    Connect Tissue Res 35:197-205. 1996
    ....
  12. doi request reprint Local regulation of tooth mineralization by sphingomyelin phosphodiesterase 3
    Z Khavandgar
    Faculty of Dentistry, McGill University, Montreal, Quebec, Canada
    J Dent Res 92:358-64. 2013
    ..In conclusion, analysis of these data demonstrates that Smpd3 expression in odontoblasts is required for tooth mineralization...
  13. ncbi request reprint Osteopontin
    J Sodek
    MRC Group in Periodontal Physiology, Faculty of Dentistry, University of Toronto, ON, Canada
    Crit Rev Oral Biol Med 11:279-303. 2000
    ..In this review, we discuss the structural features of OPN that relate to its function in the formation, remodeling, and maintenance of bones and teeth...
  14. ncbi request reprint Transglutaminase crosslinking of SIBLING proteins in teeth
    M T Kaartinen
    Division of Oral Biology, Faculty of Dentistry, McGill University, Strathcona Bldg Room M34, 3640 University Street, Montreal, Quebec, Canada H3A 2B2
    J Dent Res 84:607-12. 2005
    ....
  15. doi request reprint Ultrastructural matrix-mineral relationships in avian eggshell, and effects of osteopontin on calcite growth in vitro
    Y C Chien
    Faculty of Dentistry, McGill University, 3640 University Street, Montreal, Que, Canada H3A 2B2
    J Struct Biol 163:84-99. 2008
    ....
  16. doi request reprint Cohesive behavior of soft biological adhesives: experiments and modeling
    A Khayer Dastjerdi
    Department of Mechanical Engineering, McGill University, 817 Sherbrooke Street West, Montreal, Quebec, Canada H3A 2K6
    Acta Biomater 8:3349-59. 2012
    ..Finally, a simple model is proposed, demonstrating how a bell-shaped cohesive law forms during the failure of the fibrin interface based on an eight-chain model whose structure degrades and changes configuration with stress...
  17. ncbi request reprint Tissue engineering of cartilage using an injectable and adhesive chitosan-based cell-delivery vehicle
    C D Hoemann
    Biomedical and Chemical Engineering, Ecole Polytechnique, Montreal, QC, Canada
    Osteoarthritis Cartilage 13:318-29. 2005
    ..To regenerate damaged cartilage, cell-assisted repair is thus viewed as a promising therapy, despite being limited by the lack of a suitable technique to deliver and retain chondrogenic cells at the defect site...
  18. ncbi request reprint Cartilage formation and calcification in arteries of mice lacking matrix Gla protein
    S El-Maadawy
    Department of Anatomy and Cell Biology, McGill University, Montreal, Canada
    Connect Tissue Res 44:272-8. 2003
    ..These data provide evidence that the absence of Mgp, and/or calcification of the ECM, in the arterial media can trigger chondrocyte differentiation and cartilage formation in blood vessels...
  19. pmc DMP1 and MEPE expression are elevated in osteocytes after mechanical loading in vivo: theoretical role in controlling mineral quality in the perilacunar matrix
    S E Harris
    University of Texas Health Science Center at San Antonio, TX 78229, USA
    J Musculoskelet Neuronal Interact 7:313-5. 2007
  20. ncbi request reprint Ovocalyxin-32, a novel chicken eggshell matrix protein. isolation, amino acid sequencing, cloning, and immunocytochemical localization
    J Gautron
    Station de Recherches Avicoles, Institut National de la Recherche Agronomique, Nouzilly, 37380 France
    J Biol Chem 276:39243-52. 2001
    ..Ovocalyxin-32 is therefore identified as a novel protein synthesized in the distal oviduct where hen eggshell formation occurs...
  21. ncbi request reprint Osteopontin deficiency increases mineral content and mineral crystallinity in mouse bone
    A L Boskey
    Hospital for Special Surgery, New York, NY 10021, USA
    Calcif Tissue Int 71:145-54. 2002
    ....
  22. ncbi request reprint Phosphate regulation of vascular smooth muscle cell calcification
    S Jono
    Department of Bioengineering, University of Washington, Seattle, WA 98195, USA
    Circ Res 87:E10-7. 2000
    ..The full text of this article is available at http://www.circresaha.org...
  23. ncbi request reprint Molecular cloning and ultrastructural localization of the core protein of an eggshell matrix proteoglycan, ovocleidin-116
    M T Hincke
    Department of Cellular Medicine, University of Ottawa, Ottawa, Ontario K1H 8M5, Canada
    J Biol Chem 274:32915-23. 1999
    ..Ovocleidin-116 thus is a candidate molecule for the regulation of calcite growth during eggshell calcification...
  24. ncbi request reprint Mice lacking osteopontin show normal development and bone structure but display altered osteoclast formation in vitro
    S R Rittling
    Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, New Jersey, USA
    J Bone Miner Res 13:1101-11. 1998
    ..These results suggest that OPN is not essential for normal mouse development and osteogenesis, but can modulate osteoclast differentiation...
  25. ncbi request reprint Purification of ovocalyxin-32, a novel chicken eggshell matrix protein
    M T Hincke
    Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Canada
    Connect Tissue Res 44:16-9. 2003
    ..The timing of OCX-32 secretion into the uterine fluid suggests that it may play a role in the termination of mineral deposition...
  26. ncbi request reprint Spontaneous calcification of arteries and cartilage in mice lacking matrix GLA protein
    G Luo
    Department of Molecular Genetics, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Nature 386:78-81. 1997
    ..These results indicate that ECM calcification must be actively inhibited in soft tissues. To our knowledge, Mgp is the first inhibitor of calcification of arteries and cartilage to be characterized in vivo...