- Loss of the Par3 polarity protein promotes breast tumorigenesis and metastasisLuke Martin McCaffrey
Rosalind and Morris Goodman Cancer Research Centre, Department of Oncology, McGill University, Montreal H3A 1A3, Canada
Cancer Cell 22:601-14. 2012..Importantly, Par3 expression is significantly reduced in human breast cancers, which correlates with active aPKC and Stat3. These data identify Par3 as a regulator of signaling pathways relevant to invasive breast cancer...
- Epithelial organization, cell polarity and tumorigenesisLuke Martin McCaffrey
Department of Oncology, Rosalind and Morris Goodman Cancer Research Centre, McGill University, Montreal, Canada
Trends Cell Biol 21:727-35. 2011..3D ex vivo culture systems can now faithfully recapitulate epithelial organ morphogenesis, providing a powerful approach to study both normal development and the initiating events in carcinogenesis...