Research Topics
| A K MallaSummaryAffiliation: McGill University Country: Canada Publications
| Collaborators
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Detail Information
Publications
First-episode psychosis: psychopathology, quality of life, and functional outcomeAshok Malla
Department of Psychiatry, McGill University, Douglas Hospital Research Centre, LaSalle, Montreal, Quebec, Canada
Schizophr Bull 31:650-71. 2005..Studies of functional outcome still lack the rigor of operational definitions, choice of specific instruments for measurement, and use of large enough samples to generate meaningful results...- A community intervention for early identification of first episode psychosis: impact on duration of untreated psychosis (DUP) and patient characteristicsAshok Malla
McGill University, Montreal QC, Canada
Soc Psychiatry Psychiatr Epidemiol 40:337-44. 2005.... 
Factors influencing relapse during a 2-year follow-up of first-episode psychosis in a specialized early intervention serviceA Malla
Department of Psychiatry, McGill University, Douglas Mental Health University Institute, 6875 Boulevard LaSalle, Montreal, Quebec, Canada
Psychol Med 38:1585-93. 2008....- First-episode psychosis, early intervention, and outcome: what have we learned?Ashok K Malla
Department of Psychiatry, McGill University, Montreal, Quebec
Can J Psychiatry 50:881-91. 2005..This study's objective was to examine the concept of early intervention and the evidence that currently exists to support such a shift in the delivery of care... - A comparison of two novel antipsychotics in first episode non-affective psychosis: one-year outcome on symptoms, motor side effects and cognitionAshok Malla
Division of Clinical Research, Department of Psychiatry, McGill University, Douglas Hospital Research Centre, 6875 LaSalle Boulevard, Verdun, Quebec, Canada 4H4 1R3
Psychiatry Res 129:159-69. 2004.... - Predictors of rate and time to remission in first-episode psychosis: a two-year outcome studyAshok Malla
Department of Psychiatry, McGill University, Douglas Hospital Research Centre, Montreal, Quebec, Canada
Psychol Med 36:649-58. 2006..The goal of the current study was to examine the role of predictors for rate and time to remission in first-episode psychosis (FEP)... - Determinants of quality of life in first-episode psychosisA K Malla
McGill University, Montreal, Quebec, Canada
Acta Psychiatr Scand 109:46-54. 2004..To assess patient and/or illness characteristics associated with aspects of quality of life (QOL) in first-episode psychosis (FEP)... - A Canadian programme for early intervention in non-affective psychotic disordersAshok Malla
Division of Clinical Research, Douglas Hospital Research Centre, McGill University, 6875 LaSalle Boul, Verdun, Quebec, Canada, H4H 1R3
Aust N Z J Psychiatry 37:407-13. 2003.... - A multisite Canadian study of outcome of first-episode psychosis treated in publicly funded early intervention servicesAshok Malla
Department of Psychiatry, McGill University, Douglas Hospital Research Centre, Montreal, Quebec
Can J Psychiatry 52:563-71. 2007..The aim of this study was to determine 1-year symptomatic outcome and its predictors in patients with FEP treated at 3 different publicly funded sites... - Duration of untreated psychosis is associated with orbital-frontal grey matter volume reductions in first episode psychosisAshok K Malla
Prevention and Early Intervention Program for Psychoses PEPP Montréal, Douglas Mental Health University Institute, Montreal, Canada
Schizophr Res 125:13-20. 2011..Equivocal evidence exists regarding association between longer DUP and neuro-anatomical changes such as, reduced grey matter volume in specific regions in the brain and deficits in neurocognitive functions... - Early intervention in psychosis: specialized intervention and early case identificationA Malla
Douglas Mental Health University Institute, McGill University, Montreal, Quebec, Canada
Encephale 36:S38-45. 2010.... - Premorbid adjustment in first episode schizophrenia and schizoaffective disorders: a comparison of social and academic domainsR M G Norman
Department of Psychiatry, University of Western Ontario, London Health Sciences Centre, Canada
Acta Psychiatr Scand 112:30-9. 2005..In this paper, we examine the correlates of and prognostic significance of social and academic premorbid adjustment in a sample of 113 patients... - Symptoms and cognition as predictors of community functioning: a prospective analysisR M Norman
Department of Psychiatry, London Health Sciences Centre, Ont, Canada
Am J Psychiatry 156:400-5. 1999..In the current study, the authors used symptom and neurocognitive data to predict subsequent level of functioning in the community... - The pathways to mental health care of first-episode psychosis patients: a systematic reviewK K Anderson
Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Quebec, Canada
Psychol Med 40:1585-97. 2010..Studies were included if they used an observational design to assess the pathways to care of patients with first-episode psychosis (FEP)... - Signs and symptoms in the pre-psychotic phase: description and implications for diagnostic trajectoriesS N Iyer
Douglas Mental Health University Institute, Montreal, Quebec, Canada
Psychol Med 38:1147-56. 2008..Our objective was to determine whether factors derived from early signs and symptoms are differentially associated with non-affective versus affective psychosis... - Family history of schizophrenia and the relationship of stress to symptoms: preliminary findingsR M Norman
Department of Psychiatry, University of Western Ontario, Ontario, Canada
Aust N Z J Psychiatry 35:217-23. 2001..In the past this hypothesis has only been tested through manipulations of negative affect in laboratory settings. In this paper we test this hypothesis using longitudinal clinical data... - Preliminary findings from a study of first-episode psychosis in Montreal, Canada and Chennai, India: comparison of outcomesSrividya N Iyer
Prevention and Early Intervention Program for Psychoses PEPP Montréal, Douglas Mental Health University Institute, Wilson Pavilion, 6875 Boulevard LaSalle, Montreal, Quebec H4H 1R3, Canada
Schizophr Res 121:227-33. 2010..Specifically, the aim of this study was to examine whether one year clinical and functional outcomes of first-episode psychosis varied between these two programs... - Neural markers of remission in first-episode schizophrenia: a volumetric neuroimaging study of the hippocampus and amygdalaMichael Bodnar
Brain Imaging Group, Douglas Mental Health University Institute, Montreal, Canada
Schizophr Res 122:72-80. 2010..However, volumetric differences (namely, in the hippocampus) exhibit an ambiguous relationship with long-term outcome. So, we examined the relationship between hippocampus and amygdala volumes and early remission status... - Duration of untreated psychosis: a critical examination of the concept and its importanceR M Norman
Department of Psychiatry, University of Western Ontario, London, Canada
Psychol Med 31:381-400. 2001..CONCLUSIONS: It is important that there should be more thorough investigations of DUP, its correlates, and the extent to which it does mediate any advantages of earlier intervention... - Understanding delay in treatment for first-episode psychosisR M G Norman
Department of Psychiatry, University of Western Ontario, London, Ontario, Canada
Psychol Med 34:255-66. 2004.... - The treatment of negative symptoms: a clinical and methodological studyY D Lapierre
Department of Psychiatry, Royal Ottawa Hospital, Ontario, Canada
Int Clin Psychopharmacol 14:101-12. 1999..In addition, the design of the study provides a methodology that is appropriate to the study of primary negative symptoms in schizophrenia... - Examining adherence to medication and substance use as possible confounds of duration of untreated psychosisRoss M G Norman
Department of Psychiatry, London Health Sciences Centre, University of Western Ontario, 392 South Street, London, Ontario N6A 4G5, Canada
J Nerv Ment Dis 190:331-4. 2002 - Selective abnormal modulation of hippocampal activity during memory formation in first-episode psychosisAmelie M Achim
Brain Imaging Group, Douglas Hospital Research Centre FBC1, 6875 Boul LaSalle, Verdun, QC H4H 1R3, Canada
Arch Gen Psychiatry 64:999-1014. 2007..Memory is one of the cognitive functions most affected in schizophrenia, with deficits observed from the first episode of psychosis (FEP). Previous studies have indicated that some memory processes may be more affected than others... - Social cognitive markers of short-term clinical outcome in first-episode psychosisTina Montreuil
Prevention and Early Intervention Program for Psychoses PEPP Montréal, Douglas Mental Health University Institute, Montreal, Canada
Clin Schizophr Relat Psychoses 4:105-14. 2010.... - Medial temporal lobe activations during associative memory encoding for arbitrary and semantically related object pairsAmelie M Achim
Brain Imaging Group, Douglas Hospital Research Centre, Montreal, Canada
Brain Res 1161:46-55. 2007..Most importantly, this study suggests that associative processing can activate the MTL regardless of the pre-existence of an association between the items of a pair... - Structural neural correlates of impairments in social cognition in first episode psychosisMarie Claude Bertrand
Douglas Hospital Research Centre, Montreal, Quebec, Canada
Soc Neurosci 3:79-88. 2008..We concluded that structural abnormalities within the MSN may account for the social cognitive deficits present in some psychiatric disorders, such as schizophrenia... - Prevalence of psychotic and non-psychotic disorders in relatives of patients with a first episode psychosisKia Faridi
Prevention and Early Intervention Program for Psychosis, Montreal, Quebec, Canada
Schizophr Res 114:57-63. 2009..However, few studies have examined familial psychopathology in probands with a first episode of psychosis (FEP). We systematically evaluated family history in patients experiencing an affective or non-affective FEP... - Can patients at risk for persistent negative symptoms be identified during their first episode of psychosis?Ashok K Malla
McGill University, Montreal, Quebec, Canada
J Nerv Ment Dis 192:455-63. 2004..It may therefore be possible to distinguish a subgroup of FEP patients whose primary negative symptoms are likely to persist on the basis of characteristics shown at initial presentation for treatment... - Changes in cognitive functioning following comprehensive treatment for first episode patients with schizophrenia spectrum disordersLaurel A Townsend
Department of Psychiatry, University of Western Ontario, 392 South Street, London, Ontario, Canada, N6A 4G5
Psychiatry Res 113:69-81. 2002..Neither gender nor duration of untreated psychosis were related to the degree of change in cognitive functioning for this sample. The implications of these findings and the impact of early intervention with this population are discussed... - Negative symptoms in first episode non-affective psychosisAshok K Malla
Department of Psychiatry, University of Western Ontario, Ontario, Canada
Acta Psychiatr Scand 105:431-9. 2002.... - Disrupted integrity of the fornix in first-episode schizophreniaDavid Luck
Brain Imaging Group, Douglas Mental Health University Institute, Verdun, Canada
Schizophr Res 119:61-4. 2010..No significant correlations were found between FA values and clinical and sociodemographic data in FES patients. These findings revealed slight alterations along the fornix in early stage of schizophrenia... - Social cognitive impairments in first episode psychosisMarie Claude Bertrand
Department of Psychology, University of Montreal, 90 Vincent d Indy Avenue, Montreal, Quebec, Canada H2V 2S9
Schizophr Res 95:124-33. 2007..However, most have focused on a single aspect of social cognition, namely "theory of mind" and/or included patients with long standing illness... - An interstitial deletion of the long arm of chromosome 21 in a case of a first episode of psychosisJ Takhar
Department of Psychiatry, University of Western Ontario, London Health Sciences Centre, London, Ontario, Canada
Acta Psychiatr Scand 106:71-4; discussion 74-5. 2002..Identification of susceptibility genes will greatly facilitate investigation of factors that contribute to the disease process and may lead to early intervention and prevention... - An evaluation of a stress management program for individuals with schizophreniaRoss M G Norman
Department of Psychiatry, University of Western Ontario, London, Ontario, Canada
Schizophr Res 58:293-303. 2002..It was concluded that training in stress management may provide patients with skills for coping with acute stressors and reduce the likelihood of subsequent acute exacerbation of symptoms with need for hospitalization... - Early premorbid adjustment as a moderator of the impact of duration of untreated psychosisRoss M G Norman
University of Western Ontario and Prevention and Early Intervention Program for Psychoses, WMCH Building, 392 South Street, London, Ontario, Canada N6A 4G5
Schizophr Res 95:111-4. 2007..Shorter duration of untreated psychosis (DUP) is often correlated with a poorer response to treatment. In this paper we test the hypothesis that the importance of DUP is moderated by early premorbid adjustment... 
Computed tomography of the brain morphology of patients with first-episode schizophrenic psychosisAshok K Malla
Department of Psychiatry, University of Western Ontario, London Health Sciences Centre, Victoria Campus, 392 South St, London, ON N6A 4G5
J Psychiatry Neurosci 27:350-8. 2002....- One year outcome in first episode psychosis: influence of DUP and other predictorsAshok K Malla
University of Western Ontario and London Health Sciences Centre, WMCH Building, 375 South Street, London, N6A 4G5, Ontario, Canada
Schizophr Res 54:231-42. 2002.... - Removing barriers to treatment of first-episode psychotic disordersDerek J Scholten
Department of Psychiatry, University of Western Ontario, London, Ontario
Can J Psychiatry 48:561-5. 2003.... - Social support and three-year symptom and admission outcomes for first episode psychosisRoss M G Norman
University of Western Ontario and Prevention and Early Intervention Program for Psychoses, London Health Sciences Centre, Room 114A, WMCH Building, 392 South Street, London, Ontario, Canada
Schizophr Res 80:227-34. 2005..The relationship of social support to follow-up symptoms and hospitalization was independent of other potential predictors such as gender, age, premorbid adjustment and duration of untreated illness... - Early signs in schizophrenia spectrum disordersRoss M G Norman
Department of Psychiatry, University of Western Ontario, Room 114A, WMCH Building, 392 South Street, London, Ontario, Canada N6A 4G5
J Nerv Ment Dis 193:17-23. 2005..The latter findings may indicate that patients with more profound indications of affective disturbance or stress have a better prognosis... - Relationship of neuromotor disturbances to psychosis symptoms in first-episode neuroleptic-naive schizophrenia patientsLeonardo Cortese
The University of Western Ontario and Windsor Regional Hospital, Windsor Ontario, Canada
Schizophr Res 75:65-75. 2005.... - Persistent psychoses in first episode patientsRahul Manchanda
Prevention and Early Intervention Program for Psychoses PEPP, London Health Sciences Centre, 392 South Street, London, Ontario, Canada N6A 4G5
Schizophr Res 80:113-6. 2005..Duration of untreated psychoses or untreated illness did not discriminate between the groups... - The significance of family history in first-episode schizophrenia spectrum disorderRoss M G Norman
University of Western Ontario, Prevention and Early Intervention Program for Psychosis, London, Ontario, Canada
J Nerv Ment Dis 195:846-52. 2007..The findings provide evidence that presence of a positive family history in first-episode patients is associated with a more pernicious form of illness... - Delay in treatment for psychosis : its relation to family historyRoss M G Norman
Dept of Psychiatry, University of Western Ontario, London ON, Canada
Soc Psychiatry Psychiatr Epidemiol 42:507-12. 2007..Data were derived from 169 patients who presented for treatment to a first episode psychotic disorders program. Information was collected concerning family history, DUP, DUI and the timing of family recognition of the need for help... - Status of patients with first-episode psychosis after one year of phase-specific community-oriented treatmentAshok K Malla
University of Western Ontario, Victoria Campus, London, Ontario, Canada
Psychiatr Serv 53:458-63. 2002..One-year status is reported for a consecutive sample of patients with nonaffective mostly schizophrenic first-episode psychosis who were receiving treatment in this program... - Duration of untreated psychosis vs. N-acetylaspartate and choline in first episode schizophrenia: a 1H magnetic resonance spectroscopy study at 4.0 TeslaJean Théberge
Department of Medical Biophysics, University of Western Ontario, London, ON, Canada
Psychiatry Res 131:107-14. 2004..Increased choline is associated with longer duration of untreated psychosis and could indicate that psychosis-related membrane alterations precede the appearance of NAA reductions observed by studies of chronic schizophrenia... - Longitudinal grey-matter and glutamatergic losses in first-episode schizophreniaJean Théberge
St Joseph s Health Care, Nuclear Medicine and MR, Room B5 233, 268 Grosvenor Street, London, Ontario N6A 4V2, Canada
Br J Psychiatry 191:325-34. 2007..Progressive volumetric changes in the brains of people with schizophrenia have been attributed to a number of factors...