A K Malla

Summary

Affiliation: McGill University
Country: Canada

Publications

  1. doi Duration of untreated psychosis is associated with orbital-frontal grey matter volume reductions in first episode psychosis
    Ashok K Malla
    Prevention and Early Intervention Program for Psychoses PEPP Montréal, Douglas Mental Health University Institute, Montreal, Canada
    Schizophr Res 125:13-20. 2011
  2. pmc Identifying persistent negative symptoms in first episode psychosis
    Cindy L Hovington
    Prevention and Early Intervention Program for Psychoses, PEPP Montreal, Douglas Mental Health University Institute, Montreal, Quebec, Canada
    BMC Psychiatry 12:224. 2012
  3. pmc Evidence review and clinical guidance for the use of ziprasidone in Canada
    David M Gardner
    Department of Psychiatry, Dalhousie University, Halifax, NS, Canada
    Ann Gen Psychiatry 12:1. 2013
  4. ncbi Long-acting injectable antipsychotics: recommendations for clinicians
    Ashok Malla
    Department of Psychiatry, McGill University, Montreal, Quebec
    Can J Psychiatry 58:30S-5S. 2013
  5. ncbi A Canadian programme for early intervention in non-affective psychotic disorders
    Ashok Malla
    Division of Clinical Research, Douglas Hospital Research Centre, McGill University, 6875 LaSalle Boul, Verdun, Quebec, Canada, H4H 1R3
    Aust N Z J Psychiatry 37:407-13. 2003
  6. ncbi A community intervention for early identification of first episode psychosis: impact on duration of untreated psychosis (DUP) and patient characteristics
    Ashok Malla
    McGill University, Montreal QC, Canada
    Soc Psychiatry Psychiatr Epidemiol 40:337-44. 2005
  7. ncbi Determinants of quality of life in first-episode psychosis
    A K Malla
    McGill University, Montreal, Quebec, Canada
    Acta Psychiatr Scand 109:46-54. 2004
  8. ncbi First-episode psychosis: psychopathology, quality of life, and functional outcome
    Ashok Malla
    Department of Psychiatry, McGill University, Douglas Hospital Research Centre, LaSalle, Montreal, Quebec, Canada
    Schizophr Bull 31:650-71. 2005
  9. ncbi First-episode psychosis, early intervention, and outcome: what have we learned?
    Ashok K Malla
    Department of Psychiatry, McGill University, Montreal, Quebec
    Can J Psychiatry 50:881-91. 2005
  10. ncbi Predictors of rate and time to remission in first-episode psychosis: a two-year outcome study
    Ashok Malla
    Department of Psychiatry, McGill University, Douglas Hospital Research Centre, Montreal, Quebec, Canada
    Psychol Med 36:649-58. 2006

Collaborators

Detail Information

Publications50

  1. doi Duration of untreated psychosis is associated with orbital-frontal grey matter volume reductions in first episode psychosis
    Ashok K Malla
    Prevention and Early Intervention Program for Psychoses PEPP Montréal, Douglas Mental Health University Institute, Montreal, Canada
    Schizophr Res 125:13-20. 2011
    ..Equivocal evidence exists regarding association between longer DUP and neuro-anatomical changes such as, reduced grey matter volume in specific regions in the brain and deficits in neurocognitive functions...
  2. pmc Identifying persistent negative symptoms in first episode psychosis
    Cindy L Hovington
    Prevention and Early Intervention Program for Psychoses, PEPP Montreal, Douglas Mental Health University Institute, Montreal, Quebec, Canada
    BMC Psychiatry 12:224. 2012
    ..We also contrasted those definitions to the Proxy for the Deficit Syndrome (PDS) to identify deficit syndrome (DS) in the same FEP cohort...
  3. pmc Evidence review and clinical guidance for the use of ziprasidone in Canada
    David M Gardner
    Department of Psychiatry, Dalhousie University, Halifax, NS, Canada
    Ann Gen Psychiatry 12:1. 2013
    ..Key challenges in practice include the need for dosing on a full stomach and managing its early onset adverse effect of restlessness. Addressing these issues are critical to its long-term success...
  4. ncbi Long-acting injectable antipsychotics: recommendations for clinicians
    Ashok Malla
    Department of Psychiatry, McGill University, Montreal, Quebec
    Can J Psychiatry 58:30S-5S. 2013
    ..It is recommended that LAIs should be considered as a treatment option for psychotic disorders across all phases, including the first 2 to 5 critical years. ..
  5. ncbi A Canadian programme for early intervention in non-affective psychotic disorders
    Ashok Malla
    Division of Clinical Research, Douglas Hospital Research Centre, McGill University, 6875 LaSalle Boul, Verdun, Quebec, Canada, H4H 1R3
    Aust N Z J Psychiatry 37:407-13. 2003
    ....
  6. ncbi A community intervention for early identification of first episode psychosis: impact on duration of untreated psychosis (DUP) and patient characteristics
    Ashok Malla
    McGill University, Montreal QC, Canada
    Soc Psychiatry Psychiatr Epidemiol 40:337-44. 2005
    ....
  7. ncbi Determinants of quality of life in first-episode psychosis
    A K Malla
    McGill University, Montreal, Quebec, Canada
    Acta Psychiatr Scand 109:46-54. 2004
    ..To assess patient and/or illness characteristics associated with aspects of quality of life (QOL) in first-episode psychosis (FEP)...
  8. ncbi First-episode psychosis: psychopathology, quality of life, and functional outcome
    Ashok Malla
    Department of Psychiatry, McGill University, Douglas Hospital Research Centre, LaSalle, Montreal, Quebec, Canada
    Schizophr Bull 31:650-71. 2005
    ..Studies of functional outcome still lack the rigor of operational definitions, choice of specific instruments for measurement, and use of large enough samples to generate meaningful results...
  9. ncbi First-episode psychosis, early intervention, and outcome: what have we learned?
    Ashok K Malla
    Department of Psychiatry, McGill University, Montreal, Quebec
    Can J Psychiatry 50:881-91. 2005
    ..This study's objective was to examine the concept of early intervention and the evidence that currently exists to support such a shift in the delivery of care...
  10. ncbi Predictors of rate and time to remission in first-episode psychosis: a two-year outcome study
    Ashok Malla
    Department of Psychiatry, McGill University, Douglas Hospital Research Centre, Montreal, Quebec, Canada
    Psychol Med 36:649-58. 2006
    ..The goal of the current study was to examine the role of predictors for rate and time to remission in first-episode psychosis (FEP)...
  11. ncbi A multisite Canadian study of outcome of first-episode psychosis treated in publicly funded early intervention services
    Ashok Malla
    Department of Psychiatry, McGill University, Douglas Hospital Research Centre, Montreal, Quebec
    Can J Psychiatry 52:563-71. 2007
    ..The aim of this study was to determine 1-year symptomatic outcome and its predictors in patients with FEP treated at 3 different publicly funded sites...
  12. doi Factors influencing relapse during a 2-year follow-up of first-episode psychosis in a specialized early intervention service
    A Malla
    Department of Psychiatry, McGill University, Douglas Mental Health University Institute, 6875 Boulevard LaSalle, Montreal, Quebec, Canada
    Psychol Med 38:1585-93. 2008
    ....
  13. doi Early intervention in psychosis: specialized intervention and early case identification
    A Malla
    Douglas Mental Health University Institute, McGill University, Montreal, Quebec, Canada
    Encephale 36:S38-45. 2010
    ....
  14. ncbi A comparison of two novel antipsychotics in first episode non-affective psychosis: one-year outcome on symptoms, motor side effects and cognition
    Ashok Malla
    Division of Clinical Research, Department of Psychiatry, McGill University, Douglas Hospital Research Centre, 6875 LaSalle Boulevard, Verdun, Quebec, Canada 4H4 1R3
    Psychiatry Res 129:159-69. 2004
    ....
  15. ncbi Premorbid adjustment in first episode schizophrenia and schizoaffective disorders: a comparison of social and academic domains
    R M G Norman
    Department of Psychiatry, University of Western Ontario, London Health Sciences Centre, Canada
    Acta Psychiatr Scand 112:30-9. 2005
    ..In this paper, we examine the correlates of and prognostic significance of social and academic premorbid adjustment in a sample of 113 patients...
  16. ncbi Symptoms and cognition as predictors of community functioning: a prospective analysis
    R M Norman
    Department of Psychiatry, London Health Sciences Centre, Ont, Canada
    Am J Psychiatry 156:400-5. 1999
    ..In the current study, the authors used symptom and neurocognitive data to predict subsequent level of functioning in the community...
  17. doi The pathways to mental health care of first-episode psychosis patients: a systematic review
    K K Anderson
    Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Quebec, Canada
    Psychol Med 40:1585-97. 2010
    ..Studies were included if they used an observational design to assess the pathways to care of patients with first-episode psychosis (FEP)...
  18. doi Signs and symptoms in the pre-psychotic phase: description and implications for diagnostic trajectories
    S N Iyer
    Douglas Mental Health University Institute, Montreal, Quebec, Canada
    Psychol Med 38:1147-56. 2008
    ..Our objective was to determine whether factors derived from early signs and symptoms are differentially associated with non-affective versus affective psychosis...
  19. ncbi Family history of schizophrenia and the relationship of stress to symptoms: preliminary findings
    R M Norman
    Department of Psychiatry, University of Western Ontario, Ontario, Canada
    Aust N Z J Psychiatry 35:217-23. 2001
    ..In the past this hypothesis has only been tested through manipulations of negative affect in laboratory settings. In this paper we test this hypothesis using longitudinal clinical data...
  20. doi Neural markers of remission in first-episode schizophrenia: a volumetric neuroimaging study of the hippocampus and amygdala
    Michael Bodnar
    Brain Imaging Group, Douglas Mental Health University Institute, Montreal, Canada
    Schizophr Res 122:72-80. 2010
    ..However, volumetric differences (namely, in the hippocampus) exhibit an ambiguous relationship with long-term outcome. So, we examined the relationship between hippocampus and amygdala volumes and early remission status...
  21. ncbi Preliminary findings from a study of first-episode psychosis in Montreal, Canada and Chennai, India: comparison of outcomes
    Srividya N Iyer
    Prevention and Early Intervention Program for Psychoses PEPP Montréal, Douglas Mental Health University Institute, Wilson Pavilion, 6875 Boulevard LaSalle, Montreal, Quebec H4H 1R3, Canada
    Schizophr Res 121:227-33. 2010
    ..Specifically, the aim of this study was to examine whether one year clinical and functional outcomes of first-episode psychosis varied between these two programs...
  22. ncbi Duration of untreated psychosis: a critical examination of the concept and its importance
    R M Norman
    Department of Psychiatry, University of Western Ontario, London, Canada
    Psychol Med 31:381-400. 2001
    ..CONCLUSIONS: It is important that there should be more thorough investigations of DUP, its correlates, and the extent to which it does mediate any advantages of earlier intervention...
  23. ncbi Understanding delay in treatment for first-episode psychosis
    R M G Norman
    Department of Psychiatry, University of Western Ontario, London, Ontario, Canada
    Psychol Med 34:255-66. 2004
    ..In this paper we examine the extent to which this represents a delay in individuals contacting health professionals or a delay in receiving treatment once such contact is made...
  24. ncbi The treatment of negative symptoms: a clinical and methodological study
    Y D Lapierre
    Department of Psychiatry, Royal Ottawa Hospital, Ontario, Canada
    Int Clin Psychopharmacol 14:101-12. 1999
    ..In addition, the design of the study provides a methodology that is appropriate to the study of primary negative symptoms in schizophrenia...
  25. ncbi Examining adherence to medication and substance use as possible confounds of duration of untreated psychosis
    Ross M G Norman
    Department of Psychiatry, London Health Sciences Centre, University of Western Ontario, 392 South Street, London, Ontario N6A 4G5, Canada
    J Nerv Ment Dis 190:331-4. 2002
  26. ncbi Selective abnormal modulation of hippocampal activity during memory formation in first-episode psychosis
    Amelie M Achim
    Brain Imaging Group, Douglas Hospital Research Centre FBC1, 6875 Boul LaSalle, Verdun, QC H4H 1R3, Canada
    Arch Gen Psychiatry 64:999-1014. 2007
    ..Memory is one of the cognitive functions most affected in schizophrenia, with deficits observed from the first episode of psychosis (FEP). Previous studies have indicated that some memory processes may be more affected than others...
  27. ncbi Social cognitive markers of short-term clinical outcome in first-episode psychosis
    Tina Montreuil
    Prevention and Early Intervention Program for Psychoses PEPP Montréal, Douglas Mental Health University Institute, Montreal, Canada
    Clin Schizophr Relat Psychoses 4:105-14. 2010
    ....
  28. ncbi Negative symptoms in first episode non-affective psychosis
    Ashok K Malla
    Department of Psychiatry, University of Western Ontario, Ontario, Canada
    Acta Psychiatr Scand 105:431-9. 2002
    ....
  29. doi Disrupted integrity of the fornix in first-episode schizophrenia
    David Luck
    Brain Imaging Group, Douglas Mental Health University Institute, Verdun, Canada
    Schizophr Res 119:61-4. 2010
    ..No significant correlations were found between FA values and clinical and sociodemographic data in FES patients. These findings revealed slight alterations along the fornix in early stage of schizophrenia...
  30. doi Structural neural correlates of impairments in social cognition in first episode psychosis
    Marie Claude Bertrand
    Douglas Hospital Research Centre, Montreal, Quebec, Canada
    Soc Neurosci 3:79-88. 2008
    ..We concluded that structural abnormalities within the MSN may account for the social cognitive deficits present in some psychiatric disorders, such as schizophrenia...
  31. ncbi Medial temporal lobe activations during associative memory encoding for arbitrary and semantically related object pairs
    Amelie M Achim
    Brain Imaging Group, Douglas Hospital Research Centre, Montreal, Canada
    Brain Res 1161:46-55. 2007
    ..Most importantly, this study suggests that associative processing can activate the MTL regardless of the pre-existence of an association between the items of a pair...
  32. ncbi Social cognitive impairments in first episode psychosis
    Marie Claude Bertrand
    Department of Psychology, University of Montreal, 90 Vincent d Indy Avenue, Montreal, Quebec, Canada H2V 2S9
    Schizophr Res 95:124-33. 2007
    ..However, most have focused on a single aspect of social cognition, namely "theory of mind" and/or included patients with long standing illness...
  33. ncbi Can patients at risk for persistent negative symptoms be identified during their first episode of psychosis?
    Ashok K Malla
    McGill University, Montreal, Quebec, Canada
    J Nerv Ment Dis 192:455-63. 2004
    ..It may therefore be possible to distinguish a subgroup of FEP patients whose primary negative symptoms are likely to persist on the basis of characteristics shown at initial presentation for treatment...
  34. doi Prevalence of psychotic and non-psychotic disorders in relatives of patients with a first episode psychosis
    Kia Faridi
    Prevention and Early Intervention Program for Psychosis, Montreal, Quebec, Canada
    Schizophr Res 114:57-63. 2009
    ..However, few studies have examined familial psychopathology in probands with a first episode of psychosis (FEP). We systematically evaluated family history in patients experiencing an affective or non-affective FEP...
  35. ncbi Changes in cognitive functioning following comprehensive treatment for first episode patients with schizophrenia spectrum disorders
    Laurel A Townsend
    Department of Psychiatry, University of Western Ontario, 392 South Street, London, Ontario, Canada, N6A 4G5
    Psychiatry Res 113:69-81. 2002
    ..Neither gender nor duration of untreated psychosis were related to the degree of change in cognitive functioning for this sample. The implications of these findings and the impact of early intervention with this population are discussed...
  36. ncbi An evaluation of a stress management program for individuals with schizophrenia
    Ross M G Norman
    Department of Psychiatry, University of Western Ontario, London, Ontario, Canada
    Schizophr Res 58:293-303. 2002
    ..It was concluded that training in stress management may provide patients with skills for coping with acute stressors and reduce the likelihood of subsequent acute exacerbation of symptoms with need for hospitalization...
  37. ncbi An interstitial deletion of the long arm of chromosome 21 in a case of a first episode of psychosis
    J Takhar
    Department of Psychiatry, University of Western Ontario, London Health Sciences Centre, London, Ontario, Canada
    Acta Psychiatr Scand 106:71-4; discussion 74-5. 2002
    ..Case of an interstitial deletion of the long arm of chromosome 21 presenting with first episode of psychosis...
  38. ncbi Status of patients with first-episode psychosis after one year of phase-specific community-oriented treatment
    Ashok K Malla
    University of Western Ontario, Victoria Campus, London, Ontario, Canada
    Psychiatr Serv 53:458-63. 2002
    ..One-year status is reported for a consecutive sample of patients with nonaffective mostly schizophrenic first-episode psychosis who were receiving treatment in this program...
  39. ncbi Persistent psychoses in first episode patients
    Rahul Manchanda
    Prevention and Early Intervention Program for Psychoses PEPP, London Health Sciences Centre, 392 South Street, London, Ontario, Canada N6A 4G5
    Schizophr Res 80:113-6. 2005
    ..Duration of untreated psychoses or untreated illness did not discriminate between the groups...
  40. ncbi One year outcome in first episode psychosis: influence of DUP and other predictors
    Ashok K Malla
    University of Western Ontario and London Health Sciences Centre, WMCH Building, 375 South Street, London, N6A 4G5, Ontario, Canada
    Schizophr Res 54:231-42. 2002
    ....
  41. ncbi The significance of family history in first-episode schizophrenia spectrum disorder
    Ross M G Norman
    University of Western Ontario, Prevention and Early Intervention Program for Psychosis, London, Ontario, Canada
    J Nerv Ment Dis 195:846-52. 2007
    ..The findings provide evidence that presence of a positive family history in first-episode patients is associated with a more pernicious form of illness...
  42. ncbi Relationship of neuromotor disturbances to psychosis symptoms in first-episode neuroleptic-naive schizophrenia patients
    Leonardo Cortese
    The University of Western Ontario and Windsor Regional Hospital, Windsor Ontario, Canada
    Schizophr Res 75:65-75. 2005
    ....
  43. ncbi Social support and three-year symptom and admission outcomes for first episode psychosis
    Ross M G Norman
    University of Western Ontario and Prevention and Early Intervention Program for Psychoses, London Health Sciences Centre, Room 114A, WMCH Building, 392 South Street, London, Ontario, Canada
    Schizophr Res 80:227-34. 2005
    ..The relationship of social support to follow-up symptoms and hospitalization was independent of other potential predictors such as gender, age, premorbid adjustment and duration of untreated illness...
  44. ncbi Removing barriers to treatment of first-episode psychotic disorders
    Derek J Scholten
    Department of Psychiatry, University of Western Ontario, London, Ontario
    Can J Psychiatry 48:561-5. 2003
    ....
  45. ncbi Delay in treatment for psychosis : its relation to family history
    Ross M G Norman
    Dept of Psychiatry, University of Western Ontario, London ON, Canada
    Soc Psychiatry Psychiatr Epidemiol 42:507-12. 2007
    ..Data were derived from 169 patients who presented for treatment to a first episode psychotic disorders program. Information was collected concerning family history, DUP, DUI and the timing of family recognition of the need for help...
  46. ncbi Early premorbid adjustment as a moderator of the impact of duration of untreated psychosis
    Ross M G Norman
    University of Western Ontario and Prevention and Early Intervention Program for Psychoses, WMCH Building, 392 South Street, London, Ontario, Canada N6A 4G5
    Schizophr Res 95:111-4. 2007
    ..Shorter duration of untreated psychosis (DUP) is often correlated with a poorer response to treatment. In this paper we test the hypothesis that the importance of DUP is moderated by early premorbid adjustment...
  47. ncbi Early signs in schizophrenia spectrum disorders
    Ross M G Norman
    Department of Psychiatry, University of Western Ontario, Room 114A, WMCH Building, 392 South Street, London, Ontario, Canada N6A 4G5
    J Nerv Ment Dis 193:17-23. 2005
    ..The latter findings may indicate that patients with more profound indications of affective disturbance or stress have a better prognosis...
  48. pmc Computed tomography of the brain morphology of patients with first-episode schizophrenic psychosis
    Ashok K Malla
    Department of Psychiatry, University of Western Ontario, London Health Sciences Centre, Victoria Campus, 392 South St, London, ON N6A 4G5
    J Psychiatry Neurosci 27:350-8. 2002
    ....
  49. ncbi Longitudinal grey-matter and glutamatergic losses in first-episode schizophrenia
    Jean Théberge
    St Joseph s Health Care, Nuclear Medicine and MR, Room B5 233, 268 Grosvenor Street, London, Ontario N6A 4V2, Canada
    Br J Psychiatry 191:325-34. 2007
    ..Progressive volumetric changes in the brains of people with schizophrenia have been attributed to a number of factors...
  50. ncbi Duration of untreated psychosis vs. N-acetylaspartate and choline in first episode schizophrenia: a 1H magnetic resonance spectroscopy study at 4.0 Tesla
    Jean Théberge
    Department of Medical Biophysics, University of Western Ontario, London, ON, Canada
    Psychiatry Res 131:107-14. 2004
    ..Increased choline is associated with longer duration of untreated psychosis and could indicate that psychosis-related membrane alterations precede the appearance of NAA reductions observed by studies of chronic schizophrenia...