S J Lupien

Summary

Affiliation: McGill University
Country: Canada

Publications

  1. ncbi The modulatory effects of corticosteroids on cognition: studies in young human populations
    Sonia J Lupien
    Laboratory of Human Psychoneuroendocrine Research, Douglas Hospital Research Center, Department of Psychiatry, McGill University, 6875 Bld LaSalle, Verdun, Quebec, Canada H4H 1R3
    Psychoneuroendocrinology 27:401-16. 2002
  2. ncbi The effects of stress and stress hormones on human cognition: Implications for the field of brain and cognition
    S J Lupien
    Center for Studies on Human Stress, Douglas Hospital Research Center, McGill University, Montreal, QC, Canada
    Brain Cogn 65:209-37. 2007
  3. ncbi [Hippocampal atrophy in humans: consequence or origin of mental health disorders?]
    Sonia J Lupien
    Centre d Etudes sur le Stress Humain, Hôpital Douglas Université McGill, 6875, boulevard LaSalle, Verdun Quebec, Canada
    Med Sci (Paris) 23:694-5. 2007
  4. ncbi Hippocampal volume is as variable in young as in older adults: implications for the notion of hippocampal atrophy in humans
    S J Lupien
    Center for Studies on Human Stress, Douglas Hospital Research Center, McGill University, 6875 Blvd LaSalle, Montreal, Quebec, Canada H4H 1R3
    Neuroimage 34:479-85. 2007
  5. ncbi The differential effects of stress on memory consolidation and retrieval: a potential involvement of reconsolidation? Theoretical comment on Beckner et al. (2006)
    Sonia J Lupien
    Centre for Studies on Human Stress, Douglas Hospital McGill University, Montreal, Quebec, Canada
    Behav Neurosci 120:735-8. 2006
  6. pmc The Douglas Hospital Longitudinal Study of Normal and Pathological Aging: summary of findings
    Sonia J Lupien
    Laboratory of Human Stress Research, Douglas Hospital Research Centre, Borough of Verdun, and Department of Psychiatry, McGill University, Montreal, Quebec, Canada
    J Psychiatry Neurosci 30:328-34. 2005
  7. ncbi Stress hormones and human memory function across the lifespan
    Sonia J Lupien
    Laboratory of Human Stress Research, Department of Psychiatry, Douglas Hospital Research Center, McGill University, 6875 Boudevard, LaSalle, Verdun, Que, Canada H4H 1R3
    Psychoneuroendocrinology 30:225-42. 2005
  8. pmc Successful ageing: from cell to self
    S J Lupien
    Laboratory of Human Stress Research, Douglas Hospital Research Center, Department of Psychiatry, McGill University, 6875 Boulevard LaSalle, Montreal, Quebec H4H 1R3, Canada
    Philos Trans R Soc Lond B Biol Sci 359:1413-26. 2004
  9. ncbi Stress-induced declarative memory impairment in healthy elderly subjects: relationship to cortisol reactivity
    S J Lupien
    Douglas Hospital Research Center, Department of Psychiatry, McGill University, Montreal, Canada
    J Clin Endocrinol Metab 82:2070-5. 1997
  10. ncbi [Memory in the grip of emotions and stress: a necessarily harmful impact?]
    Francoise S Maheu
    Centre de recherche de l Hôpital Douglas, Pavillon Frank B Common, 6875, boulevard LaSalle, Verdun, Quebec, H4H 1R3, Canada
    Med Sci (Paris) 19:118-24. 2003

Detail Information

Publications51

  1. ncbi The modulatory effects of corticosteroids on cognition: studies in young human populations
    Sonia J Lupien
    Laboratory of Human Psychoneuroendocrine Research, Douglas Hospital Research Center, Department of Psychiatry, McGill University, 6875 Bld LaSalle, Verdun, Quebec, Canada H4H 1R3
    Psychoneuroendocrinology 27:401-16. 2002
    ..The results of these two studies provide evidence that GC are necessary for learning and memory in human populations...
  2. ncbi The effects of stress and stress hormones on human cognition: Implications for the field of brain and cognition
    S J Lupien
    Center for Studies on Human Stress, Douglas Hospital Research Center, McGill University, Montreal, QC, Canada
    Brain Cogn 65:209-37. 2007
    ....
  3. ncbi [Hippocampal atrophy in humans: consequence or origin of mental health disorders?]
    Sonia J Lupien
    Centre d Etudes sur le Stress Humain, Hôpital Douglas Université McGill, 6875, boulevard LaSalle, Verdun Quebec, Canada
    Med Sci (Paris) 23:694-5. 2007
  4. ncbi Hippocampal volume is as variable in young as in older adults: implications for the notion of hippocampal atrophy in humans
    S J Lupien
    Center for Studies on Human Stress, Douglas Hospital Research Center, McGill University, 6875 Blvd LaSalle, Montreal, Quebec, Canada H4H 1R3
    Neuroimage 34:479-85. 2007
    ....
  5. ncbi The differential effects of stress on memory consolidation and retrieval: a potential involvement of reconsolidation? Theoretical comment on Beckner et al. (2006)
    Sonia J Lupien
    Centre for Studies on Human Stress, Douglas Hospital McGill University, Montreal, Quebec, Canada
    Behav Neurosci 120:735-8. 2006
    ..may be explained by the fact that stress can act as a reactivation cue, leading to a 2nd round of consolidation, a process called reconsolidation...
  6. pmc The Douglas Hospital Longitudinal Study of Normal and Pathological Aging: summary of findings
    Sonia J Lupien
    Laboratory of Human Stress Research, Douglas Hospital Research Centre, Borough of Verdun, and Department of Psychiatry, McGill University, Montreal, Quebec, Canada
    J Psychiatry Neurosci 30:328-34. 2005
    ....
  7. ncbi Stress hormones and human memory function across the lifespan
    Sonia J Lupien
    Laboratory of Human Stress Research, Department of Psychiatry, Douglas Hospital Research Center, McGill University, 6875 Boudevard, LaSalle, Verdun, Que, Canada H4H 1R3
    Psychoneuroendocrinology 30:225-42. 2005
    ..Altogether, the results of these studies show that both bottom-up (effects of glucocorticoids on cognitive function), and top-down (effects of cognitive processing on glucocorticoid secretion) effects exist in the human population...
  8. pmc Successful ageing: from cell to self
    S J Lupien
    Laboratory of Human Stress Research, Douglas Hospital Research Center, Department of Psychiatry, McGill University, 6875 Boulevard LaSalle, Montreal, Quebec H4H 1R3, Canada
    Philos Trans R Soc Lond B Biol Sci 359:1413-26. 2004
    ..This ageism view has been observed in each sphere of science, from genetics to social sciences. Perspectives from each domain are described, and new integrative views of successful ageing are summarized...
  9. ncbi Stress-induced declarative memory impairment in healthy elderly subjects: relationship to cortisol reactivity
    S J Lupien
    Douglas Hospital Research Center, Department of Psychiatry, McGill University, Montreal, Canada
    J Clin Endocrinol Metab 82:2070-5. 1997
    ..They also suggest that an altered cortisol responsivity to acute and/or chronic stress, with its detrimental effects on memory, could be an important factor explaining the genesis of memory deficits in aged populations...
  10. ncbi [Memory in the grip of emotions and stress: a necessarily harmful impact?]
    Francoise S Maheu
    Centre de recherche de l Hôpital Douglas, Pavillon Frank B Common, 6875, boulevard LaSalle, Verdun, Quebec, H4H 1R3, Canada
    Med Sci (Paris) 19:118-24. 2003
    ....
  11. ncbi Awakening cortisol response in relation to psychosocial profiles and eating behaviors
    Fanny Therrien
    Laval Hospital Research Center, Quebec, Canada
    Physiol Behav 93:282-8. 2008
    ..020) and strategic (r=-0.28, p=0.049) restraint behaviors. This study highlights a gender-dependent relationship between ACR, hence the activity of the hypothalamic-pituitary-adrenal axis, and eating behaviors and psychological profiles...
  12. doi Depressive symptoms, cortisol, and cognition during human aging: the role of negative aging perceptions
    S Sindi
    Centre for Studies on Human Stress, Mental Health Research Centre Fernand Seguin, Hospital Louis H Lafontaine, Montreal, Quebec, Canada
    Stress 15:130-7. 2012
    ..These results indicate that the mechanism underlying the association between internalized negative aging stereotypes and cognitive impairments may not be related to dysregulations of cortisol secretion among older adults...
  13. ncbi Diurnal cycle of salivary cortisol in older adult men and women with subjective complaints of memory deficits and/or depressive symptoms: relation to cognitive functioning
    Alexandra J Fiocco
    Centre for Studies on Human Stress, Douglas Hospital McGill University, Montreal, Quebec, Canada, H4H 1R3
    Stress 9:143-52. 2006
    ....
  14. ncbi Stress, memory, and the hippocampus: can't live with it, can't live without it
    S J Lupien
    Research Center, Douglas Hospital Research Center, Department of Psychiatry, McGill University, Verdun, Quebec, Canada H4H 1R3
    Behav Brain Res 127:137-58. 2001
    ....
  15. ncbi Influence of genetic polymorphisms in the apolipoprotein (APOE) and the butyrylcholinesterase (BCHE) gene on stress markers in older adults: a 3-year study
    A J Fiocco
    Douglas Hospital Research Centre, Verdun, Quebec H4H 1R3, Canada
    Neurobiol Aging 30:1001-5. 2009
    ..In addition, the E4-K group reported lower self-esteem and higher levels of depression. These findings may indicate a genotype effect on markers of stress and cognitive integrity years before symptoms of dementia are apparent...
  16. doi Attentional orienting toward social stress stimuli predicts increased cortisol responsivity to psychosocial stress irrespective of the early socioeconomic status
    Kamala Pilgrim
    Douglas Institute Research Centre, McGill University, 6875 LaSalle Boulevard, Montreal, Quebec H4H 1R3, Canada
    Psychoneuroendocrinology 35:588-95. 2010
    ..A natural tendency to rapidly shift attention toward social stress-related information may be the driving force behind cortisol reactivity when handling psychological forms of stress, independent of the early SES environment...
  17. ncbi Impact of a unilateral brain lesion on cortisol secretion and emotional state: anterior/posterior dissociation in humans
    Bwanga M Tchiteya
    Istitut universitaire de gériatrie de Montréal, Centre de Recherche, Montreal, Quebec, Canada
    Psychoneuroendocrinology 28:674-86. 2003
    ..These results, obtained in a human population, go along with recent animal studies reporting an implication of frontal regions in HPA activity...
  18. doi The DeStress for Success Program: effects of a stress education program on cortisol levels and depressive symptomatology in adolescents making the transition to high school
    S J Lupien
    Centre for Studies on Human Stress, Research Center of the Mental Health Institute, Louis H Lafontaine Hospital, Canada
    Neuroscience 249:74-87. 2013
    ....
  19. ncbi Working memory is more sensitive than declarative memory to the acute effects of corticosteroids: a dose-response study in humans
    S J Lupien
    Research Center, Douglas Hospital McGill University and Montreal Geriatric Institute, Quebec, Canada
    Behav Neurosci 113:420-30. 1999
    ....
  20. ncbi Declarative memory after stress in humans: differential involvement of the beta-adrenergic and corticosteroid systems
    Francoise S Maheu
    Laboratory of Human Stress Research, Douglas Hospital Research Centre, Frank B Common Building, 6875 LaSalle Boulevard, Verdun, Quebec H4H 1R3, Canada
    J Clin Endocrinol Metab 90:1697-704. 2005
    ..These results suggest that, contrary to the beta-adrenergic system, the corticosteroid system is implicated in declarative memory function after stress in humans...
  21. ncbi Effects of manipulating the amount of social-evaluative threat on the cortisol stress response in young healthy men
    Julie Andrews
    Centre for Studies on Human Stress, Douglas Mental Health Institute, McGill University, Montreal, PQ, Canada
    Behav Neurosci 121:871-6. 2007
    ..Future studies should include women and try to define the possible threshold to activate the HPA axis...
  22. ncbi Hippocampal volumes are larger in postmenopausal women using estrogen therapy compared to past users, never users and men: a possible window of opportunity effect
    Catherine Lord
    Center for Studies on Human Stress, Douglas Hospital Research Center, McGill University, 6875 Boul LaSalle, Verdun, Que H4H 1R3, Canada
    Neurobiol Aging 29:95-101. 2008
    ..The observed effects were region-specific since no significant differences could be observed for the AG. In summary, these findings support a treatment duration dependent neuroprotective role of estrogen on HC volume in aging...
  23. doi Stress regulation in the central nervous system: evidence from structural and functional neuroimaging studies in human populations - 2008 Curt Richter Award Winner
    Jens C Pruessner
    Douglas Mental Health Institute, Department of Psychiatry, McGill University, Montreal, Quebec, Canada
    Psychoneuroendocrinology 35:179-91. 2010
    ..Taken together, the use of neuroimaging techniques in Psychoneuroendocrinology opens exciting new possibilities for the investigation of stress effects in the central nervous system...
  24. ncbi The perfect time to be stressed: a differential modulation of human memory by stress applied in the morning or in the afternoon
    Francoise S Maheu
    Laboratory of Human Stress Research, Douglas Hospital Research Centre, Frank B Common Pavilion, 6875 LaSalle Blvd, Verdun, Quebec, Canada, H4H 1R3
    Prog Neuropsychopharmacol Biol Psychiatry 29:1281-8. 2005
    ..neutral), modulates the effects of stress on human declarative memory...
  25. ncbi Self-reported depressive symptoms and stress levels in healthy young men: associations with the cortisol response to awakening
    Marita Pruessner
    Douglas Hospital Research Center, McGill University, and McConnell Brain Imaging Centre, Montreal Neurological Hospital, McGill University, Montreal, Canada
    Psychosom Med 65:92-9. 2003
    ..The goal of the present study was to investigate the association of self-reported depressive symptomatology with early morning free cortisol levels and their relationship to measures of stress...
  26. doi Allostatic load biomarkers of chronic stress and impact on health and cognition
    Robert Paul Juster
    Laboratory of Psychoneuroendocrinology of the Centre for Studies on Human Stress, Fernand Seguin Research Centre, University of Montreal, Canada
    Neurosci Biobehav Rev 35:2-16. 2010
    ..Specific risk and protective factors associated with increased allostatic load are elucidated and policies for promoting successful aging are proposed...
  27. doi Effect of sex and estrogen therapy on the aging brain: a voxel-based morphometry study
    Catherine Lord
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada
    Menopause 17:846-51. 2010
    ..In the current study, the effect of sex and estrogen therapy (ET) exposure on GM density using voxel-based morphometry was assessed...
  28. ncbi The associations among hippocampal volume, cortisol reactivity, and memory performance in healthy young men
    Marita Pruessner
    Prevention and Early Intervention Program for Psychoses, Douglas Hospital Research Center, 6875 Boulevard LaSalle, Verdun, Montreal, Quebec, Canada H4H 1R3
    Psychiatry Res 155:1-10. 2007
    ....
  29. ncbi Diurnal salivary cortisol levels in postpartum mothers as a function of infant feeding choice and parity
    Mai Thanh Tu
    Department of Neurology and Neurosurgery, Douglas Hospital Research Center, McGill University, 6875 LaSalle Boulevard, Verdun Montreal, Que, Canada H4H 1R3
    Psychoneuroendocrinology 31:812-24. 2006
    ....
  30. ncbi Education modulates cortisol reactivity to the Trier Social Stress Test in middle-aged adults
    Alexandra J Fiocco
    Centre for Studies on Human Stress, Douglas Hospital Research Centre, Verdun, Montreal, Quebec, Canada H4H 1R3
    Psychoneuroendocrinology 32:1158-63. 2007
    ....
  31. pmc The Montreal Imaging Stress Task: using functional imaging to investigate the effects of perceiving and processing psychosocial stress in the human brain
    Katarina Dedovic
    Douglas Hospital Research Centre, Borough of Verdun, and Department of Psychiatry, McGill University, Montreal, Quebec, Canada
    J Psychiatry Neurosci 30:319-25. 2005
    ..We developed a protocol for inducing moderate psychologic stress in a functional imaging setting and evaluated the effects of stress on physiology and brain activation...
  32. doi Acute and long-term associations between ApoE genetic polymorphism, cortisol levels, and declarative memory performance in older adults
    Alexandra J Fiocco
    Douglas Hospital Research Center, Montreal Verdun, Quebec, Canada H4H 1R3
    Psychoneuroendocrinology 33:625-33. 2008
    ..To date, only one study has reported a relationship between APOE status and cortisol levels, however the relationship was only found to be significant in dementia patients, with a trend observed in healthy controls...
  33. ncbi The acute effects of corticosteroids on cognition: integration of animal and human model studies
    S J Lupien
    Research Center, Douglas Hospital Research Center, McGill University, Montreal, Quebec, Canada
    Brain Res Brain Res Rev 24:1-27. 1997
    ....
  34. ncbi Acute modulation of aged human memory by pharmacological manipulation of glucocorticoids
    S J Lupien
    Laboratory of Human Psychoneuroendocrine Research, Douglas Hospital Research Center, Department of Psychiatry, McGill University, LaSalle, Verdun, Quebec H4H 1R3, Canada
    J Clin Endocrinol Metab 87:3798-807. 2002
    ..These results suggest that memory function in elderly humans can be intensely modulated by pharmacological manipulation of glucocorticoids, although the direction of these effects depends on the cortisol history of each individual...
  35. ncbi Multiparity reveals the blunting effect of breastfeeding on physiological reactivity to psychological stress
    M T Tu
    Department of Neurology and Neurosurgery, Department of Psychiatry, McGill University, Douglas Hospital Research Centre, Montreal, Canada
    J Neuroendocrinol 18:494-503. 2006
    ..This would serve to 'desensitise' stress circuits and reduce the overall stress-induced cortisol secretion after multiple births...
  36. ncbi A physiological correlate for the intolerance to both internal and external sounds
    Sylvie Hébert
    Université de Montréal and Centre de Recherche, Institut Universitaire de Geriatrie de Montreal, Montreal, QC, Canada
    Hear Res 190:1-9. 2004
    ....
  37. ncbi Physiological stress response to video-game playing: the contribution of built-in music
    Sylvie Hébert
    Ecole d Orthophonie et d Audiologie, Faculte de Medecine, Universite de Montreal, C P 6128, Succ Centre Ville, Montreal, QC, Canada
    Life Sci 76:2371-80. 2005
    ..These findings suggest for the first time that the auditory input contributes significantly to the stress response found during video game playing...
  38. doi Variations in heritability of cortisol reactivity to stress as a function of early familial adversity among 19-month-old twins
    Isabelle Ouellet-Morin
    School of Psychology, Universite Laval, Quebec City, Quebec, Canada
    Arch Gen Psychiatry 65:211-8. 2008
    ..However, little is known about gene-environment interplay in early cortisol reactivity...
  39. ncbi Feeding upon awakening in breastfeeding and bottlefeeding mothers does not affect the awakening cortisol response
    Mai Thanh Tu
    McGill University, Department of Neurology and Neurosurgery, Douglas Hospital Research Center, Montreal, Canada, H4H 1R3
    Stress 8:213-6. 2005
    ....
  40. doi Effects of stress throughout the lifespan on the brain, behaviour and cognition
    Sonia J Lupien
    Universite de Montreal, Mental Health Research Centre, Fernand Seguin Hôpital Louis H Lafontaine, Quebec, Canada
    Nat Rev Neurosci 10:434-45. 2009
    ....
  41. ncbi Awakening cortisol response in lean, obese, and reduced obese individuals: effect of gender and fat distribution
    Fanny Therrien
    Department of Anatomy and Physiology, Laval University, Sainte Foy, Quebec, Canada
    Obesity (Silver Spring) 15:377-85. 2007
    ..Our goal was to assess the awakening cortisol response (ACR) in obese and reduced obese men and women...
  42. ncbi Measuring stress responses in postpartum mothers: perspectives from studies in human and animal populations
    Mai Thanh Tu
    Department of Psychiatry, Douglas Hospital Research Center, McGill University, Montreal, Canada
    Stress 8:19-34. 2005
    ..Knowing the reciprocal relationship in the mother-infant dyad, it is clear that investigation of the mechanisms regulating stress responses and mental health in postpartum mothers can only be beneficial to the development of the infant...
  43. ncbi The "steroid dementia syndrome": an unrecognized complication of glucocorticoid treatment
    Owen M Wolkowitz
    University of California, San Francisco, School of Medicine, 401 Parnassus Ave, Box F 0984, San Francisco, CA 94143 0984, USA
    Ann N Y Acad Sci 1032:191-4. 2004
    ..Several clinical cases of this syndrome, with shared phenomenological and neuropsychological features, are presented here...
  44. ncbi Examination stress as an ecological inducer of cortisol and psychological responses to stress in undergraduate students
    Nicole Weekes
    Department of Psychology and Program for Neuroscience, Pomona College, Claremont, CA 91711, USA
    Stress 9:199-206. 2006
    ..Together, these findings suggest the need to better define and consider the implications of both the specific measures of stress being used and individual differences in the subject samples in psychoendocrine studies...
  45. ncbi Memory performance in Holocaust survivors with posttraumatic stress disorder
    Julia A Golier
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA
    Am J Psychiatry 159:1682-8. 2002
    ..The authors evaluated memory performance in Holocaust survivors and its association with posttraumatic stress disorder (PTSD) and age...
  46. ncbi The sound of stress: blunted cortisol reactivity to psychosocial stress in tinnitus sufferers
    Sylvie Hébert
    Ecole d Orthophonie et d Audiologie, Universite de Montreal, Canada Centre de recherche, Institut Universitaire de Geriatrie de Montreal, Canada
    Neurosci Lett 411:138-42. 2007
    ..Their cortisol response is similar to that found in other bodily stress-related diseases and thus suggests that tinnitus is related to stress. However, tinnitus intensity might not be modulated by stress in a concurrent manner...
  47. ncbi Maternal care modulates the relationship between prenatal risk and hippocampal volume in women but not in men
    Claudia Buss
    University of Trier, Department for Theoretical and Clinical Psychobiology, 54290 Trier, Germany
    J Neurosci 27:2592-5. 2007
    ..The results suggest that the postnatal environment modulates the neurodevelopmental consequences of prenatal risk and that this effect is sex-specific...
  48. ncbi The "steroid dementia syndrome": a possible model of human glucocorticoid neurotoxicity
    Owen M Wolkowitz
    Department of Psychiatry, Medical Center, University of California, San Francisco, San Francisco, CA, USA
    Neurocase 13:189-200. 2007
    ..Although this syndrome is uncommon, it is consistent with evolving theories of the neurotoxic or neuroendangering potential of glucocorticoids in some situations...
  49. ncbi Effects of relaxing music on salivary cortisol level after psychological stress
    Stephanie Khalfa
    INSERM EMI U 9926, Universite de la Mediterranee, Faculte de Medecine Timone, 13385 Marseille Cedex 05, France
    Ann N Y Acad Sci 999:374-6. 2003
    ..The data show that in the presence of music, the salivary cortisol level ceased to increase after the stressor, whereas in silence it continued to increase for 30 minutes...
  50. ncbi Memory for trauma-related information in Holocaust survivors with PTSD
    Julia A Golier
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Psychiatry Res 121:133-43. 2003
    ..This trauma-related facilitation of explicit memory, together with generally poorer explicit memory, may help to explain the bi-directional nature of the memory impairments in PTSD...