Research Topics
Genomes and Genes
| Rongtuan LinSummaryAffiliation: McGill University Country: Canada Publications
| Collaborators
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Detail Information
Publications
Dissociation of a MAVS/IPS-1/VISA/Cardif-IKKepsilon molecular complex from the mitochondrial outer membrane by hepatitis C virus NS3-4A proteolytic cleavageRongtuan Lin
Lady Davis Institute for Medical Research, McGill University, Montreal H3T 1E2, Quebec, Canada
J Virol 80:6072-83. 2006..These observations provide an outline of the mechanism by which hepatitis C virus evades the interferon antiviral response...
Hepatitis C virus NS2 and NS3/4A proteins are potent inhibitors of host cell cytokine/chemokine gene expressionPasi Kaukinen
Department of Viral Diseases and Immunology, National Public Health Institute, Helsinki, Finland
Virol J 3:66. 2006..Previously, the serine protease NS3/4A was shown to inhibit IFN-beta gene expression by blocking dsRNA-activated retinoic acid-inducible gene I (RIG-I) and Toll-like receptor 3 (TLR3)-mediated signaling pathways...
A CRM1-dependent nuclear export pathway is involved in the regulation of IRF-5 subcellular localizationRongtuan Lin
Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, McGill University, Montreal, Quebec H3T 1E2, Canada
J Biol Chem 280:3088-95. 2005..Although IRF-5 is phosphorylated by IKKepsilon and TBK1 in co-transfected cells, the phosphorylation of IRF-5 did not lead to IRF-5 nuclear localization or activation...- Negative regulation of the retinoic acid-inducible gene I-induced antiviral state by the ubiquitin-editing protein A20Rongtuan Lin
Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, and Department of Microbiology, McGill University, Montreal, Quebec H3T 1E2, Canada
J Biol Chem 281:2095-103. 2006..These results suggest that the virus-inducible, NF-kappaB-dependent activation of A20 functions as a negative regulator of RIG-I-mediated induction of the antiviral state... - Identification of the minimal phosphoacceptor site required for in vivo activation of interferon regulatory factor 3 in response to virus and double-stranded RNAMarc J Servant
Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research and the Departments of Microbiology and Immunology and Medicine, McGill University, Montreal, Quebec H3T 1E2, Canada
J Biol Chem 278:9441-7. 2003..The inability of the phosphospecific antibody to detect Ser(396) phosphorylation in lipopolysaccharide-treated cells suggests that other major pathways may be involved in IRF-3 activation following Toll-like receptor 4 stimulation... - Ubiquitin-regulated recruitment of IkappaB kinase epsilon to the MAVS interferon signaling adapterSuzanne Paz
Lady Davis Institute for Medical Research, Jewish General Hospital, 3755 Cote Ste Catherine, Montreal, Quebec, Canada H3T 1E2
Mol Cell Biol 29:3401-12. 2009..These results provide further support for the differential role of IKKepsilon and TBK-1 in the RIG-I/Mda5 pathway... - Activation of TBK1 and IKKvarepsilon kinases by vesicular stomatitis virus infection and the role of viral ribonucleoprotein in the development of interferon antiviral immunityBenjamin R tenOever
Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, McGill University, 3755 Cote Ste Catherine, Montreal, Quebec, Canada H3T 1E2
J Virol 78:10636-49. 2004..Induction of IKKepsilon potentially functions as a component of the amplification mechanism involved in the establishment of the antiviral state... - The E3 ubiquitin ligase Triad3A negatively regulates the RIG-I/MAVS signaling pathway by targeting TRAF3 for degradationPeyman Nakhaei
The Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, Montreal, Quebec, Canada
PLoS Pathog 5:e1000650. 2009..Thus, Triad3A represents a versatile E3 ubiquitin ligase that negatively regulates RIG-like receptor signaling by targeting TRAF3 for degradation following RNA virus infection... - A functional C-terminal TRAF3-binding site in MAVS participates in positive and negative regulation of the IFN antiviral responseSuzanne Paz
Terry Fox Molecular Oncology Group, Lady Davis Institute, Jewish General Hospital, Montreal, Quebec H3T1E2, Canada
Cell Res 21:895-910. 2011..This study demonstrates that MAVS harbors a functional C-terminal TRAF3-binding site that participates in positive and negative regulation of the IFN antiviral response... - Functional analysis of a dominant negative mutation of interferon regulatory factor 5Long Yang
Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, Montreal, Quebec, Canada
PLoS ONE 4:e5500. 2009..Activation of IRF-5 results in the production of pro-inflammatory cytokines such as TNFalpha, IL6 and IL12p40, as well as type I interferons... - IκB kinase ε-dependent phosphorylation and degradation of X-linked inhibitor of apoptosis sensitizes cells to virus-induced apoptosisPeyman Nakhaei
Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, Jewish General Hospital, McGill University, Montreal, Canada
J Virol 86:726-37. 2012..Our findings reveal a novel function of IKKε as a regulator of the virus-induced triggering of apoptosis via the phosphorylation-dependent turnover of XIAP... - The NEMO adaptor bridges the nuclear factor-kappaB and interferon regulatory factor signaling pathwaysTiejun Zhao
Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, McGill University, Montreal H3T 1E2, Canada
Nat Immunol 8:592-600. 2007..IRF3 phosphorylation and interferon production were restored by ectopic expression of NEMO. Thus, NEMO, like MAVS, acts as an adaptor protein that allows RIG-I to activate both the NF-kappaB and IRF signaling pathways... - Nuclear accumulation of cRel following C-terminal phosphorylation by TBK1/IKK epsilonJennifer Harris
Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, 3755 chemin de la Cote Sainte Catherine, Montreal, Quebec, Canada
J Immunol 177:2527-35. 2006..These results illustrate a previously unrecognized aspect of cRel regulation, controlled by direct IKKepsilon/TBK1 phosphorylation... - Convergence of the NF-kappaB and interferon signaling pathways in the regulation of antiviral defense and apoptosisJohn Hiscott
Lady Davis Institute for Medical Research, Jewish General Hospital, Departments of Microbiology and Immunology and Medicine, McGill University, Montreal, Canada H3T 1E2
Ann N Y Acad Sci 1010:237-48. 2003..We report that the IKK-related kinases-IKKepsilon/TBK-1-are components of VAK that mediate IRF-3 and IRF-7 phosphorylation and thus functionally link the NF-kappaB and IRF pathways in the development of the antiviral response... - Transcriptional re-programming of primary macrophages reveals distinct apoptotic and anti-tumoral functions of IRF-3 and IRF-7Delphine Goubau
Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, McGill University, Montreal, Que, Canada
Eur J Immunol 39:527-40. 2009..Altogether, these data further highlight the respective functions of IRF-3 and IRF-7 to program apoptotic, immune and anti-tumor responses... - Leukotriene A4 hydrolase expression in PEL cells is regulated at the transcriptional level and leads to increased leukotriene B4 productionMeztli Arguello
Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, Montreal, Quebec, Canada
J Immunol 176:7051-61. 2006.... - Regulation of arginase II by interferon regulatory factor 3 and the involvement of polyamines in the antiviral responseNathalie Grandvaux
Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, Montreal, Canada
FEBS J 272:3120-31. 2005..These results show for the first time that the ArgII gene is an early IRF-3-regulated gene, which participates in the IFN-independent antiviral response through polyamine production and induction of apoptosis... - Regulation of human immunodeficiency virus type 1 gene expression by clade-specific Tat proteinsYan Desfosses
McGill AIDS Center, Lady Davis Institute for Medical Research, Jewish General Hospital, McGill University, 3755 Cote Ste Catherine, Montreal, Quebec, Canada H3T1E2
J Virol 79:9180-91. 2005..Swapping the activation domains of Tat B, C, and E identified the cyclin T1 association domain as a critical determinant of the transactivation efficiency and of Tat-defective HIV-1 provirus rescue... - Disruption of the B-cell specific transcriptional program in HHV-8 associated primary effusion lymphoma cell linesMeztli Arguello
Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, Montreal, Quebec, Canada
Oncogene 22:964-73. 2003..These observations indicate that disruption of the B-cell-specific transcriptional program is likely to contribute to the incomplete B-cell phenotype characteristic of PEL cells... - Triggering the interferon antiviral response through an IKK-related pathwaySonia Sharma
Lady Davis Institute for Medical Research Jewish General Hospital, Departments of Microbiology and Immunology and Medicine, McGill University, Montreal, Quebec H3T 1E2, Canada
Science 300:1148-51. 2003..These studies illustrate an essential role for an IKK-related kinase pathway in triggering the host antiviral response to viral infection... - Bax-dependent mitochondrial membrane permeabilization enhances IRF3-mediated innate immune response during VSV infectionEhssan Sharif Askari
Molecular Oncology Group, Lady Davis Institute, Jewish General Hospital, McGill University, Montreal, Quebec, Canada
Virology 365:20-33. 2007..Therefore, virus-induced apoptosis through a Bax-dependent mitochondrial pathway appears to enhance the full development of the IRF-3 mediated IFN antiviral response... - Recruitment of an interferon molecular signaling complex to the mitochondrial membrane: disruption by hepatitis C virus NS3-4A proteaseJohn Hiscott
Lady Davis Institute for Medical Research Jewish General Hospital, Department of Microbiology and Immunology, McGill University, Montreal, Canada H3T 1E2
Biochem Pharmacol 72:1477-84. 2006..These observations provide an outline of the mechanism by which HCV evades the IFN antiviral response... - A requirement for NF-kappaB induction in the production of replication-competent HHV-8 virionsMarco Sgarbanti
Terry Fox Molecular Oncology Group, Lady Davis Institute-Jewish General Hospital, Montreal, Quebec, Canada
Oncogene 23:5770-80. 2004.... - Transcriptional profiling of interferon regulatory factor 3 target genes: direct involvement in the regulation of interferon-stimulated genesNathalie Grandvaux
Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, McGill University, Montreal, Quebec H3T 1E2, Canada
J Virol 76:5532-9. 2002.... - The herpes simplex virus ICP0 RING finger domain inhibits IRF3- and IRF7-mediated activation of interferon-stimulated genesRongtuan Lin
Lady Davis Research Institute, Montreal H3T 1E2, Canada
J Virol 78:1675-84. 2004..Furthermore, we demonstrate that HSV-1 modifies the IRF3 pathway in a manner different from that of the small RNA viruses most commonly studied... - Repression of IRF-4 target genes in human T cell leukemia virus-1 infectionYael Mamane
Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, and Department of Microbiology and Immunology, McGill University, Montreal, Canada H3T 1E2
Oncogene 21:6751-65. 2002..Several of the identified genes are dysregulated in ATL and may provide important mechanistic information concerning pathways critical to the emergence of ATL... - MasterCARD: a priceless link to innate immunityJohn Hiscott
Lady Davis Institute for Medical Research Jewish General Hospital, Department of Microbiology and Immunology, McGill University, Montreal, QC, H3T 1E2, Canada
Trends Mol Med 12:53-6. 2006..These studies highlight a novel role for the mitochondria and for caspase activation and recruitment domain (CARD)-containing proteins in coordinating immune and apoptotic responses... 
The IGF-I receptor can alter the matrix metalloproteinase repertoire of tumor cells through transcriptional regulation of PKC-{alpha}Shun Li
Department of Medicine, McGill University Health Center, Royal Victoria Hospital, Montreal, Quebec, Canada
Mol Endocrinol 23:2013-25. 2009....- Recognition of the measles virus nucleocapsid as a mechanism of IRF-3 activationBenjamin R tenOever
Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, McGill University, Montreal, Quebec, Canada H3T 1E2
J Virol 76:3659-69. 2002..Altogether, this study suggests that IRF-3 recognizes nucleocapsid structures during the course of an MeV infection and triggers the induction of interferon production... - Methylation of Tat by PRMT6 regulates human immunodeficiency virus type 1 gene expressionMarie Chloe Boulanger
Terry Fox Molecular Oncology Group, Lady Davis Institute, Sir Mortimer B Davis Jewish General Hospital, Montreal, Quebec, Canada
J Virol 79:124-31. 2005..Our study demonstrates that arginine methylation of Tat negatively regulates its transactivation activity and that PRMT6 acts as a restriction factor for HIV replication... - Distinct roles for IFN regulatory factor (IRF)-3 and IRF-7 in the activation of antitumor properties of human macrophagesRaphaelle Romieu-Mourez
Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, McGill University, Montreal, Quebec, Canada
Cancer Res 66:10576-85. 2006..In conclusion, transduction of active forms of IRF-3 or IRF-7 differentially modulate the apoptotic and antitumor properties of primary macrophages, with active IRF-7 leading to the acquisition of novel antitumor effector functions... - STING-ing the antiviral pathwayPeyman Nakhaei
Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, Montreal, QC, Canada
J Mol Cell Biol 2:110-2. 2010..The cytosolic DNA sensing pathway has remained poorly defined thus far. A recent study by Ishikawa et al. demonstrates that STING is essential for DNA-mediated type I IFN production and host defence against DNA pathogens... - In vivo interferon regulatory factor 3 tumor suppressor activity in B16 melanoma tumorsDelphine Duguay
Terry Fox Molecular Oncology Group, Lady Davis Institute-Jewish General Hospital, 3755 Cote-Ste.-Catherine Road, Montreal, Quebec H3T-1E2, Canada
Cancer Res 62:5148-52. 2002..These findings suggest a novel role for IRF-3 as a potential molecular target for gene therapy of cancer... - Linear ubiquitination of NEMO negatively regulates the interferon antiviral response through disruption of the MAVS-TRAF3 complexS Mehdi Belgnaoui
Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Canada
Cell Host Microbe 12:211-22. 2012..Linear ubiquitination thus switches NEMO from a positive to a negative regulator of RIG-I signaling, resulting in an attenuated IFN response... - Overlapping and distinct mechanisms regulating IRF-3 and IRF-7 functionMarc J Servant
Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, and Departments of Medicine, McGill University, Montreal, Canada
J Interferon Cytokine Res 22:49-58. 2002.... - Learning from estrogen receptor antagonism: structure-based identification of novel antiandrogens effective against multiple clinically relevant androgen receptor mutantsBing Liu
Segal Cancer Centre and Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, McGill University, Montreal, Canada
Chem Biol Drug Des 79:300-12. 2012..We found compound 3 has dual functions, inhibiting androgen receptor and IKK(β) ... - Inhibition of the interferon antiviral response by hepatitis C virusJohn Hiscott
McGill University, Lady Davis Institute for Medical Research Jewish General Hospital, Departments of Microbiology and Immunology and Medicine, McGill University, Montreal, H3T 1E2, Canada
Expert Rev Clin Immunol 2:49-58. 2006.... - Preferential binding sites for interferon regulatory factors 3 and 7 involved in interferon-A gene transcriptionPierre Morin
UPR 2228 CNRS, Laboratoire de Régulation Transcriptionnelle et Maladies Génétiques, UFR Biomédicale des Saints Pères, Universite Paris V, 45 Rue des Saints Peres, 75270 Paris Cedex 06, France
J Mol Biol 316:1009-22. 2002.... - Retinoic acid inducible gene-I and mda-5 are involved in influenza A virus-induced expression of antiviral cytokinesJukka Sirén
Department of Viral Diseases and Immunology, National Public Health Institute, Helsinki, Finland
Microbes Infect 8:2013-20. 2006..In conclusion, our results show that in epithelial cells influenza A virus-induced antiviral cytokine gene expression is triggered by RIG-I and mda-5, whose expression is positively regulated by IFN-alpha... - Tumor necrosis factor alpha enhances influenza A virus-induced expression of antiviral cytokines by activating RIG-I gene expressionSampsa Matikainen
Department of Viral Diseases and Immunology, National Public Health Institute, Helsinki, Finland
J Virol 80:3515-22. 2006.... - Super-activated interferon-regulatory factors can enhance plasmid immunizationJonathan L Bramson
Department of Pathology and Molecular Medicine, Center for Gene Therapeutics, McMaster University, 1200 Main Street West, Hamilton, Ont, Canada L8N 3Z5
Vaccine 21:1363-70. 2003..These results support further investigation of the potential of these agents as adjuvants for genetic immunization... - Promoter organization of the interferon-A genes differentially affects virus-induced expression and responsiveness to TBK1 and IKKepsilonAhmet Civas
UPR 2228 CNRS, Laboratoire de Régulation Transcriptionnelle et Maladies Génétiques, UFR Biomédicale des Saints Pères, Universite Paris V, 45 Rue des Saints Peres, 75270 Paris Cedex 06, France
J Biol Chem 281:4856-66. 2006.... - Regulation of IRF-3-dependent innate immunity by the papain-like protease domain of the severe acute respiratory syndrome coronavirusSanthana G Devaraj
Department of Microbiology and Immunology, Center of Biodefense and Emerging Infectious Diseases, Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, TX 77555 1019, USA
J Biol Chem 282:32208-21. 2007..Our data suggest that regulation of IRF-3-dependent innate antiviral defenses by PLpro may contribute to the establishment of SARS-CoV infection... - Inhibition of RIG-I-dependent signaling to the interferon pathway during hepatitis C virus expression and restoration of signaling by IKKepsilonAdrien Breiman
Unité Hépacivirus, Institut Pasteur, 75724 Paris Cedex 15, France
J Virol 79:3969-78. 2005..The partial restoration of the capacity of the host cell to transcribe IFN-beta indicates that IKKepsilon expression is able to bypass the HCV-mediated inhibition and restore the innate antiviral response... - Multiple NF-kappaB and IFN regulatory factor family transcription factors regulate CCL19 gene expression in human monocyte-derived dendritic cellsTaija E Pietila
Department of Viral Diseases and Immunology, National Public Health Institute, Helsinki, Finland
J Immunol 178:253-61. 2007..Our experiments reveal that expression of the CCL19 gene is regulated by a combined action of several members of the NF-kappaB, IRF, and STAT family transcription factors... - Targeting dendritic cell signaling to regulate the response to immunizationDavid Escors
Infection and Immunity, University College London, London, United Kingdom
Blood 111:3050-61. 2008.... - Interferon regulatory factor 3 is involved in Toll-like receptor 4 (TLR4)- and TLR3-induced IL-12p35 gene activationStanislas Goriely
Institute for Medical Immunology IMI, Universite Libre de Bruxelles, Charleroi, Belgium
Blood 107:1078-84. 2006..We conclude that IRF-3 binds to a critical cis-acting element in the IL-12p35 gene promoter and thereby represents a key factor for the induction of IL-12p70 synthesis in DCs...