Rongtuan Lin

Summary

Affiliation: McGill University
Country: Canada

Publications

  1. pmc Dissociation of a MAVS/IPS-1/VISA/Cardif-IKKepsilon molecular complex from the mitochondrial outer membrane by hepatitis C virus NS3-4A proteolytic cleavage
    Rongtuan Lin
    Lady Davis Institute for Medical Research, McGill University, Montreal H3T 1E2, Quebec, Canada
    J Virol 80:6072-83. 2006
  2. pmc Systems analysis of a RIG-I agonist inducing broad spectrum inhibition of virus infectivity
    Marie Line Goulet
    Lady Davis Institute, Jewish General Hospital, McGill University, Montreal, Canada
    PLoS Pathog 9:e1003298. 2013
  3. pmc Functional analysis of a dominant negative mutation of interferon regulatory factor 5
    Long Yang
    Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, Montreal, Quebec, Canada
    PLoS ONE 4:e5500. 2009
  4. pmc Hepatitis C virus NS2 and NS3/4A proteins are potent inhibitors of host cell cytokine/chemokine gene expression
    Pasi Kaukinen
    Department of Viral Diseases and Immunology, National Public Health Institute, Helsinki, Finland
    Virol J 3:66. 2006
  5. ncbi request reprint A CRM1-dependent nuclear export pathway is involved in the regulation of IRF-5 subcellular localization
    Rongtuan Lin
    Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, McGill University, Montreal, Quebec H3T 1E2, Canada
    J Biol Chem 280:3088-95. 2005
  6. ncbi request reprint Negative regulation of the retinoic acid-inducible gene I-induced antiviral state by the ubiquitin-editing protein A20
    Rongtuan Lin
    Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, and Department of Microbiology, McGill University, Montreal, Quebec H3T 1E2, Canada
    J Biol Chem 281:2095-103. 2006
  7. ncbi request reprint Identification of the minimal phosphoacceptor site required for in vivo activation of interferon regulatory factor 3 in response to virus and double-stranded RNA
    Marc J Servant
    Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research and the Departments of Microbiology and Immunology and Medicine, McGill University, Montreal, Quebec H3T 1E2, Canada
    J Biol Chem 278:9441-7. 2003
  8. pmc Activation of TBK1 and IKKvarepsilon kinases by vesicular stomatitis virus infection and the role of viral ribonucleoprotein in the development of interferon antiviral immunity
    Benjamin R tenOever
    Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, McGill University, 3755 Cote Ste Catherine, Montreal, Quebec, Canada H3T 1E2
    J Virol 78:10636-49. 2004
  9. pmc Ubiquitin-regulated recruitment of IkappaB kinase epsilon to the MAVS interferon signaling adapter
    Suzanne Paz
    Lady Davis Institute for Medical Research, Jewish General Hospital, 3755 Cote Ste Catherine, Montreal, Quebec, Canada H3T 1E2
    Mol Cell Biol 29:3401-12. 2009
  10. pmc The E3 ubiquitin ligase Triad3A negatively regulates the RIG-I/MAVS signaling pathway by targeting TRAF3 for degradation
    Peyman Nakhaei
    The Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, Montreal, Quebec, Canada
    PLoS Pathog 5:e1000650. 2009

Detail Information

Publications53

  1. pmc Dissociation of a MAVS/IPS-1/VISA/Cardif-IKKepsilon molecular complex from the mitochondrial outer membrane by hepatitis C virus NS3-4A proteolytic cleavage
    Rongtuan Lin
    Lady Davis Institute for Medical Research, McGill University, Montreal H3T 1E2, Quebec, Canada
    J Virol 80:6072-83. 2006
    ..These observations provide an outline of the mechanism by which hepatitis C virus evades the interferon antiviral response...
  2. pmc Systems analysis of a RIG-I agonist inducing broad spectrum inhibition of virus infectivity
    Marie Line Goulet
    Lady Davis Institute, Jewish General Hospital, McGill University, Montreal, Canada
    PLoS Pathog 9:e1003298. 2013
    ....
  3. pmc Functional analysis of a dominant negative mutation of interferon regulatory factor 5
    Long Yang
    Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, Montreal, Quebec, Canada
    PLoS ONE 4:e5500. 2009
    ..Activation of IRF-5 results in the production of pro-inflammatory cytokines such as TNFalpha, IL6 and IL12p40, as well as type I interferons...
  4. pmc Hepatitis C virus NS2 and NS3/4A proteins are potent inhibitors of host cell cytokine/chemokine gene expression
    Pasi Kaukinen
    Department of Viral Diseases and Immunology, National Public Health Institute, Helsinki, Finland
    Virol J 3:66. 2006
    ..Previously, the serine protease NS3/4A was shown to inhibit IFN-beta gene expression by blocking dsRNA-activated retinoic acid-inducible gene I (RIG-I) and Toll-like receptor 3 (TLR3)-mediated signaling pathways...
  5. ncbi request reprint A CRM1-dependent nuclear export pathway is involved in the regulation of IRF-5 subcellular localization
    Rongtuan Lin
    Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, McGill University, Montreal, Quebec H3T 1E2, Canada
    J Biol Chem 280:3088-95. 2005
    ..Although IRF-5 is phosphorylated by IKKepsilon and TBK1 in co-transfected cells, the phosphorylation of IRF-5 did not lead to IRF-5 nuclear localization or activation...
  6. ncbi request reprint Negative regulation of the retinoic acid-inducible gene I-induced antiviral state by the ubiquitin-editing protein A20
    Rongtuan Lin
    Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, and Department of Microbiology, McGill University, Montreal, Quebec H3T 1E2, Canada
    J Biol Chem 281:2095-103. 2006
    ..These results suggest that the virus-inducible, NF-kappaB-dependent activation of A20 functions as a negative regulator of RIG-I-mediated induction of the antiviral state...
  7. ncbi request reprint Identification of the minimal phosphoacceptor site required for in vivo activation of interferon regulatory factor 3 in response to virus and double-stranded RNA
    Marc J Servant
    Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research and the Departments of Microbiology and Immunology and Medicine, McGill University, Montreal, Quebec H3T 1E2, Canada
    J Biol Chem 278:9441-7. 2003
    ..The inability of the phosphospecific antibody to detect Ser(396) phosphorylation in lipopolysaccharide-treated cells suggests that other major pathways may be involved in IRF-3 activation following Toll-like receptor 4 stimulation...
  8. pmc Activation of TBK1 and IKKvarepsilon kinases by vesicular stomatitis virus infection and the role of viral ribonucleoprotein in the development of interferon antiviral immunity
    Benjamin R tenOever
    Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, McGill University, 3755 Cote Ste Catherine, Montreal, Quebec, Canada H3T 1E2
    J Virol 78:10636-49. 2004
    ..Induction of IKKepsilon potentially functions as a component of the amplification mechanism involved in the establishment of the antiviral state...
  9. pmc Ubiquitin-regulated recruitment of IkappaB kinase epsilon to the MAVS interferon signaling adapter
    Suzanne Paz
    Lady Davis Institute for Medical Research, Jewish General Hospital, 3755 Cote Ste Catherine, Montreal, Quebec, Canada H3T 1E2
    Mol Cell Biol 29:3401-12. 2009
    ..These results provide further support for the differential role of IKKepsilon and TBK-1 in the RIG-I/Mda5 pathway...
  10. pmc The E3 ubiquitin ligase Triad3A negatively regulates the RIG-I/MAVS signaling pathway by targeting TRAF3 for degradation
    Peyman Nakhaei
    The Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, Montreal, Quebec, Canada
    PLoS Pathog 5:e1000650. 2009
    ..Thus, Triad3A represents a versatile E3 ubiquitin ligase that negatively regulates RIG-like receptor signaling by targeting TRAF3 for degradation following RNA virus infection...
  11. pmc A functional C-terminal TRAF3-binding site in MAVS participates in positive and negative regulation of the IFN antiviral response
    Suzanne Paz
    Terry Fox Molecular Oncology Group, Lady Davis Institute, Jewish General Hospital, Montreal, Quebec H3T1E2, Canada
    Cell Res 21:895-910. 2011
    ..This study demonstrates that MAVS harbors a functional C-terminal TRAF3-binding site that participates in positive and negative regulation of the IFN antiviral response...
  12. ncbi request reprint The NEMO adaptor bridges the nuclear factor-kappaB and interferon regulatory factor signaling pathways
    Tiejun Zhao
    Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, McGill University, Montreal H3T 1E2, Canada
    Nat Immunol 8:592-600. 2007
    ..IRF3 phosphorylation and interferon production were restored by ectopic expression of NEMO. Thus, NEMO, like MAVS, acts as an adaptor protein that allows RIG-I to activate both the NF-kappaB and IRF signaling pathways...
  13. pmc IκB kinase ε-dependent phosphorylation and degradation of X-linked inhibitor of apoptosis sensitizes cells to virus-induced apoptosis
    Peyman Nakhaei
    Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, Jewish General Hospital, McGill University, Montreal, Canada
    J Virol 86:726-37. 2012
    ..Our findings reveal a novel function of IKKε as a regulator of the virus-induced triggering of apoptosis via the phosphorylation-dependent turnover of XIAP...
  14. ncbi request reprint Leukotriene A4 hydrolase expression in PEL cells is regulated at the transcriptional level and leads to increased leukotriene B4 production
    Meztli Arguello
    Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, Montreal, Quebec, Canada
    J Immunol 176:7051-61. 2006
    ....
  15. ncbi request reprint Convergence of the NF-kappaB and interferon signaling pathways in the regulation of antiviral defense and apoptosis
    John Hiscott
    Lady Davis Institute for Medical Research, Jewish General Hospital, Departments of Microbiology and Immunology and Medicine, McGill University, Montreal, Canada H3T 1E2
    Ann N Y Acad Sci 1010:237-48. 2003
    ..We report that the IKK-related kinases-IKKepsilon/TBK-1-are components of VAK that mediate IRF-3 and IRF-7 phosphorylation and thus functionally link the NF-kappaB and IRF pathways in the development of the antiviral response...
  16. ncbi request reprint Nuclear accumulation of cRel following C-terminal phosphorylation by TBK1/IKK epsilon
    Jennifer Harris
    Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, 3755 chemin de la Cote Sainte Catherine, Montreal, Quebec, Canada
    J Immunol 177:2527-35. 2006
    ..These results illustrate a previously unrecognized aspect of cRel regulation, controlled by direct IKKepsilon/TBK1 phosphorylation...
  17. pmc Transcriptional re-programming of primary macrophages reveals distinct apoptotic and anti-tumoral functions of IRF-3 and IRF-7
    Delphine Goubau
    Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, McGill University, Montreal, Que, Canada
    Eur J Immunol 39:527-40. 2009
    ..Altogether, these data further highlight the respective functions of IRF-3 and IRF-7 to program apoptotic, immune and anti-tumor responses...
  18. ncbi request reprint Triggering the interferon antiviral response through an IKK-related pathway
    Sonia Sharma
    Lady Davis Institute for Medical Research Jewish General Hospital, Departments of Microbiology and Immunology and Medicine, McGill University, Montreal, Quebec H3T 1E2, Canada
    Science 300:1148-51. 2003
    ..These studies illustrate an essential role for an IKK-related kinase pathway in triggering the host antiviral response to viral infection...
  19. doi request reprint Linear ubiquitination of NEMO negatively regulates the interferon antiviral response through disruption of the MAVS-TRAF3 complex
    S Mehdi Belgnaoui
    Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Canada
    Cell Host Microbe 12:211-22. 2012
    ..Linear ubiquitination thus switches NEMO from a positive to a negative regulator of RIG-I signaling, resulting in an attenuated IFN response...
  20. ncbi request reprint Disruption of the B-cell specific transcriptional program in HHV-8 associated primary effusion lymphoma cell lines
    Meztli Arguello
    Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, Montreal, Quebec, Canada
    Oncogene 22:964-73. 2003
    ..These observations indicate that disruption of the B-cell-specific transcriptional program is likely to contribute to the incomplete B-cell phenotype characteristic of PEL cells...
  21. ncbi request reprint Regulation of arginase II by interferon regulatory factor 3 and the involvement of polyamines in the antiviral response
    Nathalie Grandvaux
    Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, Montreal, Canada
    FEBS J 272:3120-31. 2005
    ..These results show for the first time that the ArgII gene is an early IRF-3-regulated gene, which participates in the IFN-independent antiviral response through polyamine production and induction of apoptosis...
  22. pmc Regulation of human immunodeficiency virus type 1 gene expression by clade-specific Tat proteins
    Yan Desfosses
    McGill AIDS Center, Lady Davis Institute for Medical Research, Jewish General Hospital, McGill University, 3755 Cote Ste Catherine, Montreal, Quebec, Canada H3T1E2
    J Virol 79:9180-91. 2005
    ..Swapping the activation domains of Tat B, C, and E identified the cyclin T1 association domain as a critical determinant of the transactivation efficiency and of Tat-defective HIV-1 provirus rescue...
  23. ncbi request reprint Bax-dependent mitochondrial membrane permeabilization enhances IRF3-mediated innate immune response during VSV infection
    Ehssan Sharif-Askari
    Molecular Oncology Group, Lady Davis Institute, Jewish General Hospital, McGill University, Montreal, Quebec, Canada
    Virology 365:20-33. 2007
    ..Therefore, virus-induced apoptosis through a Bax-dependent mitochondrial pathway appears to enhance the full development of the IRF-3 mediated IFN antiviral response...
  24. pmc Transcriptional profiling of interferon regulatory factor 3 target genes: direct involvement in the regulation of interferon-stimulated genes
    Nathalie Grandvaux
    Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, McGill University, Montreal, Quebec H3T 1E2, Canada
    J Virol 76:5532-9. 2002
    ....
  25. ncbi request reprint Recruitment of an interferon molecular signaling complex to the mitochondrial membrane: disruption by hepatitis C virus NS3-4A protease
    John Hiscott
    Lady Davis Institute for Medical Research Jewish General Hospital, Department of Microbiology and Immunology, McGill University, Montreal, Canada H3T 1E2
    Biochem Pharmacol 72:1477-84. 2006
    ..These observations provide an outline of the mechanism by which HCV evades the IFN antiviral response...
  26. ncbi request reprint A requirement for NF-kappaB induction in the production of replication-competent HHV-8 virions
    Marco Sgarbanti
    Terry Fox Molecular Oncology Group, Lady Davis Institute Jewish General Hospital, Montreal, Quebec, Canada
    Oncogene 23:5770-80. 2004
    ....
  27. pmc Triptolide-mediated inhibition of interferon signaling enhances vesicular stomatitis virus-based oncolysis
    Fethia Ben Yebdri
    Department of Medicine, Lady Davis Institute Jewish General Hospital, McGill University, Montreal, Quebec, Canada
    Mol Ther 21:2043-53. 2013
    ..Together, these results demonstrate that triptolide inhibition of IFN production sensitizes prostate cancer cells to VSV replication and virus-mediated apoptosis...
  28. doi request reprint SAMHD1 host restriction factor: a link with innate immune sensing of retrovirus infection
    Alexandre Sze
    Lady Davis Institute, Jewish General Hospital, McGill University, Montreal, QC, Canada H3T 1E2
    J Mol Biol 425:4981-94. 2013
    ..This review highlights current knowledge regarding SAMHD1 regulation and its impact on innate immune signaling and retroviral restriction. ..
  29. pmc The herpes simplex virus ICP0 RING finger domain inhibits IRF3- and IRF7-mediated activation of interferon-stimulated genes
    Rongtuan Lin
    Lady Davis Research Institute, Montreal H3T 1E2, Canada
    J Virol 78:1675-84. 2004
    ..Furthermore, we demonstrate that HSV-1 modifies the IRF3 pathway in a manner different from that of the small RNA viruses most commonly studied...
  30. ncbi request reprint Repression of IRF-4 target genes in human T cell leukemia virus-1 infection
    Yael Mamane
    Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, and Department of Microbiology and Immunology, McGill University, Montreal, Canada H3T 1E2
    Oncogene 21:6751-65. 2002
    ..Several of the identified genes are dysregulated in ATL and may provide important mechanistic information concerning pathways critical to the emergence of ATL...
  31. ncbi request reprint MasterCARD: a priceless link to innate immunity
    John Hiscott
    Lady Davis Institute for Medical Research Jewish General Hospital, Department of Microbiology and Immunology, McGill University, Montreal, QC, H3T 1E2, Canada
    Trends Mol Med 12:53-6. 2006
    ..These studies highlight a novel role for the mitochondria and for caspase activation and recruitment domain (CARD)-containing proteins in coordinating immune and apoptotic responses...
  32. pmc Histone deacetylase inhibitors potentiate vesicular stomatitis virus oncolysis in prostate cancer cells by modulating NF-κB-dependent autophagy
    Laura Shulak
    Lady Davis Institute Jewish General Hospital, McGill University, Montreal, Canada
    J Virol 88:2927-40. 2014
    ....
  33. ncbi request reprint Distinct roles for IFN regulatory factor (IRF)-3 and IRF-7 in the activation of antitumor properties of human macrophages
    Raphaelle Romieu-Mourez
    Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, McGill University, Montreal, Quebec, Canada
    Cancer Res 66:10576-85. 2006
    ..In conclusion, transduction of active forms of IRF-3 or IRF-7 differentially modulate the apoptotic and antitumor properties of primary macrophages, with active IRF-7 leading to the acquisition of novel antitumor effector functions...
  34. doi request reprint The IGF-I receptor can alter the matrix metalloproteinase repertoire of tumor cells through transcriptional regulation of PKC-{alpha}
    Shun Li
    Department of Medicine, McGill University Health Center, Royal Victoria Hospital, Montreal, Quebec, Canada
    Mol Endocrinol 23:2013-25. 2009
    ....
  35. ncbi request reprint Host restriction factor SAMHD1 limits human T cell leukemia virus type 1 infection of monocytes via STING-mediated apoptosis
    Alexandre Sze
    Lady Davis Institute Jewish General Hospital, McGill University, Montreal, QC H3T 1E2, Canada
    Cell Host Microbe 14:422-34. 2013
    ..This study provides a mechanistic explanation for abortive HTLV-1 infection of monocytes and reports a link between SAMHD1 restriction, HTLV-1 RTI sensing by STING, and initiation of IRF3-Bax driven apoptosis. ..
  36. pmc Recognition of the measles virus nucleocapsid as a mechanism of IRF-3 activation
    Benjamin R tenOever
    Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, McGill University, Montreal, Quebec, Canada H3T 1E2
    J Virol 76:3659-69. 2002
    ..Altogether, this study suggests that IRF-3 recognizes nucleocapsid structures during the course of an MeV infection and triggers the induction of interferon production...
  37. pmc Methylation of Tat by PRMT6 regulates human immunodeficiency virus type 1 gene expression
    Marie Chloe Boulanger
    Terry Fox Molecular Oncology Group, Lady Davis Institute, Sir Mortimer B Davis Jewish General Hospital, Montreal, Quebec, Canada
    J Virol 79:124-31. 2005
    ..Our study demonstrates that arginine methylation of Tat negatively regulates its transactivation activity and that PRMT6 acts as a restriction factor for HIV replication...
  38. ncbi request reprint STING-ing the antiviral pathway
    Peyman Nakhaei
    Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, Montreal, QC, Canada
    J Mol Cell Biol 2:110-2. 2010
    ..The cytosolic DNA sensing pathway has remained poorly defined thus far. A recent study by Ishikawa et al. demonstrates that STING is essential for DNA-mediated type I IFN production and host defence against DNA pathogens...
  39. ncbi request reprint In vivo interferon regulatory factor 3 tumor suppressor activity in B16 melanoma tumors
    Delphine Duguay
    Terry Fox Molecular Oncology Group, Lady Davis Institute Jewish General Hospital, 3755 Cote Ste Catherine Road, Montreal, Quebec H3T 1E2, Canada
    Cancer Res 62:5148-52. 2002
    ..These findings suggest a novel role for IRF-3 as a potential molecular target for gene therapy of cancer...
  40. ncbi request reprint Overlapping and distinct mechanisms regulating IRF-3 and IRF-7 function
    Marc J Servant
    Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, and Departments of Medicine, McGill University, Montreal, Canada
    J Interferon Cytokine Res 22:49-58. 2002
    ....
  41. doi request reprint Synthesis and in vitro characterization of ionone-based compounds as dual inhibitors of the androgen receptor and NF-κB
    Weiguo Liu
    Segal Cancer Center, Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, 3755 Cote Ste Catherine, Rd, Montreal, QC, H3T 1E2, Canada
    Invest New Drugs 32:227-34. 2014
    ..Our studies indicate 3b is effective against the CRPC cells. ..
  42. doi request reprint Learning from estrogen receptor antagonism: structure-based identification of novel antiandrogens effective against multiple clinically relevant androgen receptor mutants
    Bing Liu
    Segal Cancer Centre and Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, McGill University, Montreal, Canada
    Chem Biol Drug Des 79:300-12. 2012
    ..We found compound 3 has dual functions, inhibiting androgen receptor and IKK(β) ...
  43. ncbi request reprint Inhibition of the interferon antiviral response by hepatitis C virus
    John Hiscott
    McGill University, Lady Davis Institute for Medical Research Jewish General Hospital, Departments of Microbiology and Immunology and Medicine, McGill University, Montreal, H3T 1E2, Canada
    Expert Rev Clin Immunol 2:49-58. 2006
    ....
  44. pmc Inhibition of RIG-I-dependent signaling to the interferon pathway during hepatitis C virus expression and restoration of signaling by IKKepsilon
    Adrien Breiman
    Unité Hépacivirus, Institut Pasteur, 75724 Paris Cedex 15, France
    J Virol 79:3969-78. 2005
    ..The partial restoration of the capacity of the host cell to transcribe IFN-beta indicates that IKKepsilon expression is able to bypass the HCV-mediated inhibition and restore the innate antiviral response...
  45. ncbi request reprint Preferential binding sites for interferon regulatory factors 3 and 7 involved in interferon-A gene transcription
    Pierre Morin
    UPR 2228 CNRS, Laboratoire de Régulation Transcriptionnelle et Maladies Génétiques, UFR Biomédicale des Saints Pères, Universite Paris V, 45 Rue des Saints Peres, 75270 Paris Cedex 06, France
    J Mol Biol 316:1009-22. 2002
    ....
  46. ncbi request reprint Promoter organization of the interferon-A genes differentially affects virus-induced expression and responsiveness to TBK1 and IKKepsilon
    Ahmet Civas
    UPR 2228 CNRS, Laboratoire de Régulation Transcriptionnelle et Maladies Génétiques, UFR Biomédicale des Saints Pères, Universite Paris V, 45 Rue des Saints Peres, 75270 Paris Cedex 06, France
    J Biol Chem 281:4856-66. 2006
    ....
  47. ncbi request reprint Retinoic acid inducible gene-I and mda-5 are involved in influenza A virus-induced expression of antiviral cytokines
    Jukka Sirén
    Department of Viral Diseases and Immunology, National Public Health Institute, Helsinki, Finland
    Microbes Infect 8:2013-20. 2006
    ..In conclusion, our results show that in epithelial cells influenza A virus-induced antiviral cytokine gene expression is triggered by RIG-I and mda-5, whose expression is positively regulated by IFN-alpha...
  48. ncbi request reprint Super-activated interferon-regulatory factors can enhance plasmid immunization
    Jonathan L Bramson
    Department of Pathology and Molecular Medicine, Center for Gene Therapeutics, McMaster University, 1200 Main Street West, Hamilton, Ont, Canada L8N 3Z5
    Vaccine 21:1363-70. 2003
    ..These results support further investigation of the potential of these agents as adjuvants for genetic immunization...
  49. ncbi request reprint Multiple NF-kappaB and IFN regulatory factor family transcription factors regulate CCL19 gene expression in human monocyte-derived dendritic cells
    Taija E Pietila
    Department of Viral Diseases and Immunology, National Public Health Institute, Helsinki, Finland
    J Immunol 178:253-61. 2007
    ..Our experiments reveal that expression of the CCL19 gene is regulated by a combined action of several members of the NF-kappaB, IRF, and STAT family transcription factors...
  50. pmc Regulation of IRF-3-dependent innate immunity by the papain-like protease domain of the severe acute respiratory syndrome coronavirus
    Santhana G Devaraj
    Department of Microbiology and Immunology, Center of Biodefense and Emerging Infectious Diseases, Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, TX 77555 1019, USA
    J Biol Chem 282:32208-21. 2007
    ..Our data suggest that regulation of IRF-3-dependent innate antiviral defenses by PLpro may contribute to the establishment of SARS-CoV infection...
  51. pmc Tumor necrosis factor alpha enhances influenza A virus-induced expression of antiviral cytokines by activating RIG-I gene expression
    Sampsa Matikainen
    Department of Viral Diseases and Immunology, National Public Health Institute, Helsinki, Finland
    J Virol 80:3515-22. 2006
    ....
  52. ncbi request reprint Interferon regulatory factor 3 is involved in Toll-like receptor 4 (TLR4)- and TLR3-induced IL-12p35 gene activation
    Stanislas Goriely
    Institute for Medical Immunology IMI, Universite Libre de Bruxelles, Charleroi, Belgium
    Blood 107:1078-84. 2006
    ..We conclude that IRF-3 binds to a critical cis-acting element in the IL-12p35 gene promoter and thereby represents a key factor for the induction of IL-12p70 synthesis in DCs...
  53. doi request reprint Targeting dendritic cell signaling to regulate the response to immunization
    David Escors
    Infection and Immunity, University College London, London, United Kingdom
    Blood 111:3050-61. 2008
    ....