L C Lands

Summary

Affiliation: McGill University
Country: Canada

Publications

  1. ncbi request reprint Applying physiology to conventional mechanical ventilation
    Larry C Lands
    Respiratory Medicine, Montreal Children s Hospital McGill University Health Centre
    Paediatr Respir Rev 7:S33-6. 2006
  2. ncbi request reprint Nutrition in pediatric lung disease
    Larry C Lands
    McGill University and Pediatric Respiratory Medicine, Montreal Children s Hospital McGill University Health Centre, Montreal, Canada
    Paediatr Respir Rev 8:305-11; quiz 312. 2007
  3. doi request reprint Oral non-steroidal anti-inflammatory drug therapy for lung disease in cystic fibrosis
    Larry C Lands
    Department of Pediatrics, Montreal Children s Hospital, Montreal, Canada
    Cochrane Database Syst Rev 6:CD001505. 2013
  4. ncbi request reprint High-dose ibuprofen in cystic fibrosis: Canadian safety and effectiveness trial
    Larry C Lands
    Department of Pediatrics, Montreal Children s Hospital McGill University Health Center, Montreal, Quebec, Canada
    J Pediatr 151:249-54. 2007
  5. doi request reprint Dietary supplementation with pressurized whey in patients with cystic fibrosis
    L C Lands
    Division of Pediatric Respiratory Medicine, Montreal Children s Hospital McGill University Health Centre, Montreal, Quebec, Canada
    J Med Food 13:77-82. 2010
  6. doi request reprint Asthma and chronic sickle cell lung disease: a dynamic relationship
    N R Shilo
    Division of Pediatric Respiratory Medicine, Montreal Children s Hospital McGill University Health Centre, Montreal, Quebec, Canada
    Paediatr Respir Rev 12:78-82. 2011
  7. ncbi request reprint Effect of supplementation with a cysteine donor on muscular performance
    L C Lands
    Division of Respiratory Medicine, McGill University Health Centre Montreal Children s Hospital, Montreal, Quebec, Canada H3H 1P3
    J Appl Physiol 87:1381-5. 1999
  8. ncbi request reprint Total plasma antioxidant capacity in cystic fibrosis
    L C Lands
    Division of Respiratory Medicine, McGill University Medical Centre Montreal Children s Hospital, Montreal, Quebec, Canada
    Pediatr Pulmonol 29:81-7. 2000
  9. ncbi request reprint Accounting for radioactivity before and after nebulization of tobramycin to insure accuracy of quantification of lung deposition
    A L Coates
    Division of Respiratory Medicine, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    J Aerosol Med 13:169-78. 2000
  10. ncbi request reprint Lymphocyte glutathione levels in children with cystic fibrosis
    L C Lands
    Department of Pediatrics, McGill University Medical Centre Montreal Children s Hospital, Quebec, Canada
    Chest 116:201-5. 1999

Collaborators

Detail Information

Publications37

  1. ncbi request reprint Applying physiology to conventional mechanical ventilation
    Larry C Lands
    Respiratory Medicine, Montreal Children s Hospital McGill University Health Centre
    Paediatr Respir Rev 7:S33-6. 2006
    ..This article reviews the physiological principles that underpin decision making about support for patients with respiratory difficulties, whether they are related to inadequate oxygenation or ventilation...
  2. ncbi request reprint Nutrition in pediatric lung disease
    Larry C Lands
    McGill University and Pediatric Respiratory Medicine, Montreal Children s Hospital McGill University Health Centre, Montreal, Canada
    Paediatr Respir Rev 8:305-11; quiz 312. 2007
    ..The challenge to both clinicians and investigators is to understand how defenses are integrated and coordinated so that enhanced protection can be delivered...
  3. doi request reprint Oral non-steroidal anti-inflammatory drug therapy for lung disease in cystic fibrosis
    Larry C Lands
    Department of Pediatrics, Montreal Children s Hospital, Montreal, Canada
    Cochrane Database Syst Rev 6:CD001505. 2013
    ..Progressive lung damage causes most deaths in cystic fibrosis (CF). Non-steroidal anti-inflammatory drugs (NSAIDs) may prevent progressive pulmonary deterioration and morbidity in CF...
  4. ncbi request reprint High-dose ibuprofen in cystic fibrosis: Canadian safety and effectiveness trial
    Larry C Lands
    Department of Pediatrics, Montreal Children s Hospital McGill University Health Center, Montreal, Quebec, Canada
    J Pediatr 151:249-54. 2007
    ..To assess the effectiveness and safety of high-dose ibuprofen when used as part of routine therapy in patients with cystic fibrosis (CF)...
  5. doi request reprint Dietary supplementation with pressurized whey in patients with cystic fibrosis
    L C Lands
    Division of Pediatric Respiratory Medicine, Montreal Children s Hospital McGill University Health Centre, Montreal, Quebec, Canada
    J Med Food 13:77-82. 2010
    ..Whole blood glutathione levels did not change. Thus, oral supplementation with pressurized whey improves nutritional status and can have additional beneficial effects on inflammation in patients with CF...
  6. doi request reprint Asthma and chronic sickle cell lung disease: a dynamic relationship
    N R Shilo
    Division of Pediatric Respiratory Medicine, Montreal Children s Hospital McGill University Health Centre, Montreal, Quebec, Canada
    Paediatr Respir Rev 12:78-82. 2011
    ..This review will explore what we know about asthma and airway hyper-reactivity in sickle cell disease and whether currently available asthma therapies may be beneficial in delaying or averting the progression of sickle cell lung disease...
  7. ncbi request reprint Effect of supplementation with a cysteine donor on muscular performance
    L C Lands
    Division of Respiratory Medicine, McGill University Health Centre Montreal Children s Hospital, Montreal, Quebec, Canada H3H 1P3
    J Appl Physiol 87:1381-5. 1999
    ..02), with no change in the placebo group (-0.9 +/- 9.6%). This is the first study to demonstrate that prolonged supplementation with a product designed to augment antioxidant defenses resulted in improved volitional performance...
  8. ncbi request reprint Total plasma antioxidant capacity in cystic fibrosis
    L C Lands
    Division of Respiratory Medicine, McGill University Medical Centre Montreal Children s Hospital, Montreal, Quebec, Canada
    Pediatr Pulmonol 29:81-7. 2000
    ..While being responsive to oxidative stress, the mechanism of the response may differ between clinical situations, such that the clinical significance of changes in plasma TEAC remains to be defined...
  9. ncbi request reprint Accounting for radioactivity before and after nebulization of tobramycin to insure accuracy of quantification of lung deposition
    A L Coates
    Division of Respiratory Medicine, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    J Aerosol Med 13:169-78. 2000
    ..This technique could be adapted to accurately quantify the amount of deposition on any inhaled therapeutic agent, but caution must be used when extrapolating performance of a nebulizer on the bench to expected deposition in patients...
  10. ncbi request reprint Lymphocyte glutathione levels in children with cystic fibrosis
    L C Lands
    Department of Pediatrics, McGill University Medical Centre Montreal Children s Hospital, Quebec, Canada
    Chest 116:201-5. 1999
    ..Evidence suggests that lymphocyte GSH reflects lung GSH concentrations, and so could potentially serve as a peripheral marker of lung inflammation...
  11. ncbi request reprint Do sinusoidal models of respiration accurately reflect the respiratory events of patients breathing on nebulizers?
    A L Coates
    Division of Respiratory Medicine, Hospital for Sick Children, University of Toronto, Ontario, Canada
    J Aerosol Med 12:265-73. 1999
    ..These results suggest that there are both systematic and random errors arising from the use of a sinusoidal waveform to mimic respiratory events in patients...
  12. ncbi request reprint Effect of whey protein to modulate immune response in children with atopic asthma
    James B Lothian
    The Department of Respiratory Medicine, McGill University Medical Centre, Montreal Children s Hospital, Montreal, Quebec, Canada
    Int J Food Sci Nutr 57:204-11. 2006
    ..We hypothesized that such supplementation in children with atopic asthma, a Th2 cytokine disease, would improve lung function and decrease atopy...
  13. ncbi request reprint Effect of size and disease on estimated deposition of drugs administered using jet nebulization in children with cystic fibrosis
    A L Coates
    Division of Respiratory Medicine, Hospital for Sick Children, University of Toronto, Toronto, Canada
    Chest 119:1123-30. 2001
    ....
  14. ncbi request reprint An open-label dose-response study of lymphocyte glutathione levels in healthy men and women receiving pressurized whey protein isolate supplements
    Gerald S Zavorsky
    Department of Anesthesia, McGill University Health Center, Montreal, Quebec, Canada
    Int J Food Sci Nutr 58:429-36. 2007
    ....
  15. doi request reprint Efficacy of high dose phylloquinone in correcting vitamin K deficiency in cystic fibrosis
    Donna Drury
    Montreal Children s Hospital, McGill University Health Center, 2300 Tupper Avenue, Montreal, Canada H3H 1P3
    J Cyst Fibros 7:457-9. 2008
    ..The aim of this study is determine if a supplemental dose of 1 mg/day or 5 mg/day vitamin K1 per day would normalize vitamin K status in a population of children with cystic fibrosis...
  16. ncbi request reprint Evaluation of a school-based tuberculosis-screening program and associate investigation targeting recently immigrated children in a low-burden country
    Paul Brassard
    Department of Medicine, McGill University, Montreal, Quebec, Canada
    Pediatrics 117:e148-56. 2006
    ....
  17. ncbi request reprint Comparison of fingertip to arterial blood samples at rest and during exercise
    Gerald S Zavorsky
    Department of Anesthesia, McGill University Health Center, Montreal, Quebec, Canada
    Clin J Sport Med 15:263-70. 2005
    ..The purpose was to determine whether arterialized fingertip blood-gas samples are comparable to arterial samples at rest and at exercise...
  18. ncbi request reprint The relationship between single-breath diffusion capacity of the lung for nitric oxide and carbon monoxide during various exercise intensities
    Gerald S Zavorsky
    Department of Exercise Science, Concordia University, Montreal, QC, Canada
    Chest 125:1019-27. 2004
    ....
  19. ncbi request reprint Lung diffusion capacity for nitric oxide and carbon monoxide is impaired similarly following short-term graded exercise
    Gerald S Zavorsky
    Department of Anesthesia, McGill University Health Center, 1650 Cedar Avenue, Room D10 144, Montreal, Que, Canada H3G 1A4
    Nitric Oxide 12:31-8. 2005
    ....
  20. ncbi request reprint Sex differences in habitual physical activity and lung function decline in children with cystic fibrosis
    J Schneiderman-Walker
    Division of Respiratory Medicine, Hospital for Sick Children, Research Institute, Toronto, Ontario, Canada
    J Pediatr 147:321-6. 2005
    ..To evaluate the feasibility of measuring habitual physical activity (HPA) in children with cystic fibrosis (CF) and to assess the relation between HPA and the rate of decline in FEV1 over a period of 2 years...
  21. ncbi request reprint Cardiorespiratory status after treatment for acute lymphoblastic leukemia
    S O Turner-Gomes
    Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada
    Med Pediatr Oncol 26:160-5. 1996
    ..Longitudinal studies will identify if further abnormalities or overt morbidity develop. In later years, continuing obesity and a sedentary state may contribute to clinically relevant heart disease...
  22. ncbi request reprint Laboratory 20-km cycle time trial reproducibility
    G S Zavorsky
    Department of Anesthesia, McGill University, Montreal, Canada
    Int J Sports Med 28:743-8. 2007
    ..This study demonstrated that (1) a familiarization session improves the reliability of the measurements (i.e., average PO, time to completion and speed), and (2) the CV was much smaller for the best performers...
  23. doi request reprint Oxidative stress and cystic fibrosis-related diabetes: a pilot study in children
    Thierry Ntimbane
    Department of Nutrition, University of Montreal, Montreal, Canada
    J Cyst Fibros 7:373-84. 2008
    ..Cystic fibrosis (CF) is characterized by chronic inflammation with increased oxidative stress. We evaluated the relationship between glucose tolerance and oxidative stress in CF children...
  24. doi request reprint Combined effect of dietary supplementation with pressurized whey and exercise training in chronic obstructive pulmonary disease: a randomized, controlled, double-blind pilot study
    Louis Laviolette
    Centre de Recherche, Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Universite Laval, Quebec, Canada
    J Med Food 13:589-98. 2010
    ..Thus dietary supplementation with pressurized whey may potentiate the effects of exercise training on exercise tolerance and quality of life in patients with COPD...
  25. doi request reprint Ibuprofen modulates NF-kB activity but not IL-8 production in cystic fibrosis respiratory epithelial cells
    Nurlan Dauletbaev
    Research Institute, McGill University Health Centre, Montreal Children s Hospital, Montreal, Que, Canada
    Respiration 79:234-42. 2010
    ..High-dose ibuprofen is clinically effective in cystic fibrosis (CF); however, its molecular mechanisms are poorly understood...
  26. ncbi request reprint Sweat collection for testing in Canadian Cystic Fibrosis Centers, is it optimal?
    M Beauchamp
    Montreal Children s Hospital McGill University Medical Centre, 2300 Tupper St, Room D 380, Montreal, QC, Canada, H3H 1P3
    Clin Biochem 38:934-7. 2005
    ..The goal of this study was to examine the ability of the current Canadian CF center network to conduct sweat testing, with a particular focus on testing in infants less than 3 months old...
  27. ncbi request reprint Isokinetic muscle function in COPD
    Charles Haccoun
    Montreal Children s Hospital McGill University Health Centre, Montreal, PQ, Canada
    Chest 121:1079-84. 2002
    ....
  28. doi request reprint Voriconazole inhibition of vitamin A metabolism: are adverse events increased in cystic fibrosis patients?
    Matthew Pellan Cheng
    Department of Pediatrics, The Montreal Children s Hospital, McGill University, Montreal, Canada
    Pediatr Pulmonol 45:661-6. 2010
    ..As Voriconazole is being used more frequently in cystic fibrosis (CF) patients, we aimed to describe the adverse events associated with voriconazole treatment in this population...
  29. ncbi request reprint High hydrostatic pressure enhances whey protein digestibility to generate whey peptides that improve glutathione status in CFTR-deficient lung epithelial cells
    Regina Maria Vilela
    School of Dietetics and Human Nutrition, Macdonald Campus of McGill University, Ste Anne de Bellevue, Quebec, Canada
    Mol Nutr Food Res 50:1013-29. 2006
    ..Hydrostatic pressure processing of whey proteins appears to enhance their impact on cellular GSH status in cells with the mutant CFTR condition...
  30. doi request reprint Reliability and validity of the habitual activity estimation scale (HAES) in patients with cystic fibrosis
    Greg D Wells
    Division of Respiratory Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada
    Pediatr Pulmonol 43:345-53. 2008
    ..The Habitual Activity Estimation Scale (HAES) questionnaire has been shown to be a feasible tool to measure physical activity however the reliability and validity have yet to be determined in the CF population...
  31. ncbi request reprint Sweat-testing: a review of current technical requirements
    M Beauchamp
    Montreal Children s Hospital, McGill University Medical Centre, Montreal, Quebec, Canada
    Pediatr Pulmonol 39:507-11. 2005
    ..However, it is technically challenging, especially in young children. This review covers technical aspects related to the devices and protocols associated with conducting successful tests...
  32. ncbi request reprint Induced sputum in cystic fibrosis: within-week reproducibility of inflammatory markers
    Argyrios A Smountas
    Department of Respiratory Medicine, McGill University Medical Centre, Montreal Children s Hospital, Montreal, 2300 Tupper Street, Montreal, Quebec, Canada H3H 1P3
    Clin Biochem 37:1031-6. 2004
    ..We describe the development of a methodology to assess CF sputum, and the within-week reproducibility (to limit the possibility of any change in clinical status) of cellular and inflammatory markers...
  33. ncbi request reprint Improved glutathione status in young adult patients with cystic fibrosis supplemented with whey protein
    Vijaylaxmi Grey
    The Department of Pathology and Molecular Medicine, McMaster Division, Hamilton Health Sciences, Hamilton, Ontario, Canada
    J Cyst Fibros 2:195-8. 2003
    ..We sought to increase glutathione levels in stable patients with cystic fibrosis by supplementation with a whey-based protein...
  34. ncbi request reprint Role of heme oxygenases in sepsis-induced diaphragmatic contractile dysfunction and oxidative stress
    Esther Barreiro
    Department of Respiratory Medicine, Hospital del Mar Municipal Institute of Medical Research, Pompeu Fabra University, 08003 Barcelona, Spain
    Am J Physiol Lung Cell Mol Physiol 283:L476-84. 2002
    ..We conclude that both HO-1 and HO-2 proteins play an important role in the regulation of muscle contractility and in the defense against sepsis-induced oxidative stress...
  35. ncbi request reprint Fenretinide corrects newly found ceramide deficiency in cystic fibrosis
    Claudine Guilbault
    McGill University Health Center, Montreal General Hospital Research Institute, 1650 Cedar Avenue, Room L11 218, Montreal, PQ, H3G 1A4 Canada
    Am J Respir Cell Mol Biol 38:47-56. 2008
    ..Our data provide a strong rationale for clinical intervention that may benefit patients with CF suffering from CF lung disease...
  36. ncbi request reprint Inhibition of IL-8 release from CFTR-deficient lung epithelial cells following pre-treatment with fenretinide
    Regina Maria Vilela
    School of Dietetics and Human Nutrition, Macdonald Campus of McGill University, 21, 111 Lakeshore, Ste Anne de Bellevue, Quebec, Canada H9X 3V9
    Int Immunopharmacol 6:1651-64. 2006
    ..The fenretinide mediated decrease in IL-8 release in CF cells under TNF-alpha stimulated conditions presents the possibility that the lung inflammation in CF could be attenuated via low dose fenretinide treatment...
  37. ncbi request reprint The cystic fibrosis effort in Canada: advancing on many fronts
    André M Cantin
    Pediatr Pulmonol 37:379-81; author reply 381-2; discussion 382. 2004