Marina B Klein

Summary

Affiliation: McGill University
Country: Canada

Publications

  1. doi request reprint Who needs direct-acting antivirals for HCV? Challenges faced in advancing HCV therapy for HIV-HCV-coinfected individuals
    Marina B Klein
    Department of Medicine, Division of Infectious Diseases Chronic Viral Illness Service, McGill University Health Centre, Montreal, Canada
    Antivir Ther 18:717-21. 2013
  2. pmc Factors affecting antiretroviral pharmacokinetics in HIV-infected women with virologic suppression on combination antiretroviral therapy: a cross-sectional study
    Mona Rafik Loutfy
    Women s College Research Institute, Women s College Hospital, 790 Bay Street, Room 736, Toronto, Ontario M5G 2N8, Canada
    BMC Infect Dis 13:256. 2013
  3. doi request reprint HIV and hepatitis C virus coinfection in Canada: challenges and opportunities for reducing preventable morbidity and mortality
    M B Klein
    Department of Medicine, Divisions of Infectious Diseases Immunodeficiency, Royal Victoria Hospital, McGill University Health Centre, Montreal, QC, Canada
    HIV Med 14:10-20. 2013
  4. doi request reprint Incidence of acute hepatitis C virus infection among men who have sex with men with and without HIV infection: a systematic review
    Sean Yaphe
    Department of Medicine, Division of Infectious Diseases, McGill University Health Centre, Chronic Viral Illness Service, Montreal Chest Institute, 3650 Saint Urbain, Montreal, Quebec H2X 2P4, Canada
    Sex Transm Infect 88:558-64. 2012
  5. pmc Regional differences in rates of HIV-1 viral load monitoring in Canada: Insights and implications for antiretroviral care in high income countries
    Janet M Raboud
    Dalla Lana School of Public Health, University of Toronto, Toronto, Canada
    BMC Infect Dis 10:40. 2010
  6. pmc CD4 count at presentation for HIV care in the United States and Canada: are those over 50 years more likely to have a delayed presentation?
    Keri N Althoff
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe St, Baltimore, MD, 21205, USA
    AIDS Res Ther 7:45. 2010
  7. doi request reprint Viral pathogens including human metapneumovirus are the primary cause of febrile respiratory illness in HIV-infected adults receiving antiretroviral therapy
    Marina B Klein
    Department of Medicine, Divisions of Infectious Diseases Immunodeficiency, Royal Victoria Hospital, McGill University Health Centre, Montreal, Canada
    J Infect Dis 201:297-301. 2010
  8. doi request reprint Impact of HIV-1 viral subtype on CD4+ T-cell decline and clinical outcomes in antiretroviral naive patients receiving universal healthcare
    Marina Keller
    Department of Medicine, Division of Infectious Diseases, Immunodeficiency Service, Montreal Chest Institute, McGill University Health Centre, Montreal, Quebec, Canada
    AIDS 23:731-7. 2009
  9. doi request reprint Antiretroviral treatment interruption leads to progression of liver fibrosis in HIV-hepatitis C virus co-infection
    Julia Thorpe
    Department of Medicine, Divisions of Infectious Diseases Immunodeficiency, Royal Victoria Hospital, Canada
    AIDS 25:967-75. 2011
  10. ncbi request reprint Insulin resistance is associated with progression to hepatic fibrosis in a cohort of HIV/hepatitis C virus-coinfected patients
    Mark W Hull
    British Columbia Centre for Excellence in HIV AIDS, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada
    AIDS 26:1789-94. 2012

Detail Information

Publications32

  1. doi request reprint Who needs direct-acting antivirals for HCV? Challenges faced in advancing HCV therapy for HIV-HCV-coinfected individuals
    Marina B Klein
    Department of Medicine, Division of Infectious Diseases Chronic Viral Illness Service, McGill University Health Centre, Montreal, Canada
    Antivir Ther 18:717-21. 2013
    ..We describe the characteristics of coinfected patients who could be eligible for DAAs to determine potential challenges facing clinicians and patients hoping to take advantage of these new therapies...
  2. pmc Factors affecting antiretroviral pharmacokinetics in HIV-infected women with virologic suppression on combination antiretroviral therapy: a cross-sectional study
    Mona Rafik Loutfy
    Women s College Research Institute, Women s College Hospital, 790 Bay Street, Room 736, Toronto, Ontario M5G 2N8, Canada
    BMC Infect Dis 13:256. 2013
    ....
  3. doi request reprint HIV and hepatitis C virus coinfection in Canada: challenges and opportunities for reducing preventable morbidity and mortality
    M B Klein
    Department of Medicine, Divisions of Infectious Diseases Immunodeficiency, Royal Victoria Hospital, McGill University Health Centre, Montreal, QC, Canada
    HIV Med 14:10-20. 2013
    ..Hepatitis C virus (HCV) has emerged as an important health problem in the era of effective HIV treatment. However, very few data exist on the health status and disease burden of HIV/HCV-coinfected Canadians...
  4. doi request reprint Incidence of acute hepatitis C virus infection among men who have sex with men with and without HIV infection: a systematic review
    Sean Yaphe
    Department of Medicine, Division of Infectious Diseases, McGill University Health Centre, Chronic Viral Illness Service, Montreal Chest Institute, 3650 Saint Urbain, Montreal, Quebec H2X 2P4, Canada
    Sex Transm Infect 88:558-64. 2012
    ....
  5. pmc Regional differences in rates of HIV-1 viral load monitoring in Canada: Insights and implications for antiretroviral care in high income countries
    Janet M Raboud
    Dalla Lana School of Public Health, University of Toronto, Toronto, Canada
    BMC Infect Dis 10:40. 2010
    ....
  6. pmc CD4 count at presentation for HIV care in the United States and Canada: are those over 50 years more likely to have a delayed presentation?
    Keri N Althoff
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe St, Baltimore, MD, 21205, USA
    AIDS Res Ther 7:45. 2010
    ..10%, respectively). Due to the increasing proportion, consistently lower CD4 counts, and more advanced HIV disease in adults ≥50-year-old at first presentation for HIV care, renewed HIV testing efforts are needed...
  7. doi request reprint Viral pathogens including human metapneumovirus are the primary cause of febrile respiratory illness in HIV-infected adults receiving antiretroviral therapy
    Marina B Klein
    Department of Medicine, Divisions of Infectious Diseases Immunodeficiency, Royal Victoria Hospital, McGill University Health Centre, Montreal, Canada
    J Infect Dis 201:297-301. 2010
    ..Over 80% of patients received antibiotics. Rapid testing to identify specific viral pathogens could aid in patient management and reduce unnecessary antibiotic exposure...
  8. doi request reprint Impact of HIV-1 viral subtype on CD4+ T-cell decline and clinical outcomes in antiretroviral naive patients receiving universal healthcare
    Marina Keller
    Department of Medicine, Division of Infectious Diseases, Immunodeficiency Service, Montreal Chest Institute, McGill University Health Centre, Montreal, Quebec, Canada
    AIDS 23:731-7. 2009
    ..We compared Canadians (clade B), with recent immigrants from Haiti (clade B) and sub-Saharan Africa (clades non-B) to determine whether there were differences in disease progression attributable to viral subtype...
  9. doi request reprint Antiretroviral treatment interruption leads to progression of liver fibrosis in HIV-hepatitis C virus co-infection
    Julia Thorpe
    Department of Medicine, Divisions of Infectious Diseases Immunodeficiency, Royal Victoria Hospital, Canada
    AIDS 25:967-75. 2011
    ..We examined the impact of ART interruption on liver fibrosis progression in co-infected adults, using the aspartate aminotransferase-to-platelet ratio index (APRI) as a surrogate marker of liver fibrosis...
  10. ncbi request reprint Insulin resistance is associated with progression to hepatic fibrosis in a cohort of HIV/hepatitis C virus-coinfected patients
    Mark W Hull
    British Columbia Centre for Excellence in HIV AIDS, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada
    AIDS 26:1789-94. 2012
    ..We evaluated factors associated with insulin resistance in a cohort of HIV/HCV-coinfected patients and determined the effect of insulin resistance on the development of hepatic fibrosis...
  11. doi request reprint Impact of hepatitis C viral replication on CD4+ T-lymphocyte progression in HIV-HCV coinfection before and after antiretroviral therapy
    Martin Potter
    Department of Medicine, Division of Infectious Diseases, Royal Victoria Hospital, McGill University Health Centre, Montreal, Quebec, Canada
    AIDS 24:1857-65. 2010
    ..We examined the impact of spontaneous clearance of HCV on CD4(+) T-lymphocyte count progression before and after initiation of antiretroviral therapy (ART) in HIV-HCV coinfected adults...
  12. ncbi request reprint Influenzavirus infection is a primary cause of febrile respiratory illness in HIV-infected adults, despite vaccination
    Marina B Klein
    Department of Medicine, Division of Infectious Diseases, Royal Victoria Hospital, McGill University Health Centre, Montreal, Quebec, Canada
    Clin Infect Dis 45:234-40. 2007
    ..We performed a surveillance study of outpatients who presented with fever and respiratory symptoms to examine the role of viral pathogens in these patients...
  13. ncbi request reprint Gender and long-term metabolic toxicities from antiretroviral therapy in HIV-1 infected persons
    Mohamed Rachid Boulassel
    Immunodeficiency Service, Montreal Chest Institute, McGill University Health Centre, Montreal, Quebec, Canada
    J Med Virol 78:1158-63. 2006
    ..4 (95% CI: 2.1-9.3)). Collectively, these data suggest that metabolic toxicities after HAART do not differ by gender but that lactic acidosis and hypersensitivity reactions are more frequent in women than men...
  14. ncbi request reprint The impact of hepatitis C virus coinfection on HIV progression before and after highly active antiretroviral therapy
    Marina B Klein
    Division of Infectious Diseases Immunodeficiency, Department of Medicine, Royal Victoria Hospital, McGill University Health Centre, Montreal, Quebec, Canada
    J Acquir Immune Defic Syndr 33:365-72. 2003
    ..HCV coinfection and comorbidity associated with injection drug use are preventing the realization of substantial health benefits associated with HAART...
  15. doi request reprint Comparison of abacavir/lamivudine and tenofovir/emtricitabine among treatment-naive HIV-infected patients initiating therapy
    Darrell H S Tan
    Department of Medicine, University of Toronto, Ontario, Canada
    J Acquir Immune Defic Syndr 58:38-46. 2011
    ..Controversy about the relative performance of abacavir (ABC)/lamivudine (3TC) and tenofovir (TDF)/emtricitabine (FTC) in initial combination antiretroviral therapy (cART) exists...
  16. doi request reprint CTN-194 (PICCO): design of a trial of citalopram for the prevention of depression and its consequences in HIV-hepatitis C co-infected individuals initiating pegylated interferon/ribavirin therapy
    Marina B Klein
    Department of Medicine, Divisions of Infectious Diseases Immunodeficiency, Royal Victoria Hospital, McGill University Health Centre, Montreal, Quebec, Canada
    Contemp Clin Trials 29:617-30. 2008
    ..Effective prevention of a broad range of neuropsychiatric symptoms by citalopram has the potential to diminish PEG-IFN-alpha associated morbidity and consequently, allow a greater number of patients to complete full therapy...
  17. pmc Marijuana smoking does not accelerate progression of liver disease in HIV-hepatitis C coinfection: a longitudinal cohort analysis
    Laurence Brunet
    Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Quebec, Canada, H2X 2P4
    Clin Infect Dis 57:663-70. 2013
    ..We aimed to estimate the effect of marijuana smoking on liver disease progression in a Canadian prospective multicenter cohort of human immunodeficiency virus/hepatitis C virus (HIV/HCV) coinfected persons...
  18. pmc Is antiretroviral therapy causing long-term liver damage? A comparative analysis of HIV-mono-infected and HIV/hepatitis C co-infected cohorts
    Erica E M Moodie
    Department of Epidemiology, Biostatistics, and Occupational Health, McGill University, Montreal, Quebec, Canada
    PLoS ONE 4:e4517. 2009
    ..HAART use associated is with increased APRI in patients with HIV/HCV co-infection. Therefore treatment for HCV infection may be required to slow the growing epidemic of end-stage liver disease in this population...
  19. ncbi request reprint Role of genetic diversity amongst HIV-1 non-B subtypes in drug resistance: a systematic review of virologic and biochemical evidence
    Jorge L Martinez-Cajas
    McGill University AIDS Centre, Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Canada
    AIDS Rev 10:212-23. 2008
    ..Tools may need to be optimized to accurately measure drug susceptibility of non-B subtypes, especially for protease inhibitors...
  20. ncbi request reprint The cost-effectiveness of highly active antiretroviral therapy, Canada 1991-2001
    Eduard J Beck
    Departement de sante publique de Montréal centre, Montreal, Quebec, Canada
    AIDS 18:2411-8. 2004
    ..To estimate the cost-effectiveness ratio of highly-active antiretroviral therapy (HAART) in Canada...
  21. ncbi request reprint Prevention of HIV-associated opportunistic infections and diseases in the age of highly active antiretroviral therapy
    Patrick Willemot
    Royal Victoria Hospital, McGill University Health Center, Montreal, Quebec H2X 2P4, Canada
    Expert Rev Anti Infect Ther 2:521-32. 2004
    ..This review will provide an update on HIV-associated opportunistic infections and their prevention in the age of HAART, as well as discuss novel presentations of opportunistic illnesses, such as immune restoration syndromes...
  22. ncbi request reprint The impact of initial highly active antiretroviral therapy on future treatment sequences in HIV infection
    Marina B Klein
    Department of Medicine, Divisions of Infectious Diseases Immunodeficiency, Royal Victoria Hospital, McGill University Health Centre, Montreal, Quebec, Canada
    AIDS 18:1895-904. 2004
    ..To determine whether the initial use of non-nucleoside reverse transcriptase inhibitors (NNRTI) or protease inhibitors (PI) differentially influences subsequent HIV therapy...
  23. ncbi request reprint Peering at peer review revealed high degree of chance associated with funding of grant applications
    Nancy E Mayo
    Division of Clinical Epidemiology R4 29, McGill University Health Center, RVH Site, 687 Pine Avenue West, Montreal, H3A 1A1, Canada
    J Clin Epidemiol 59:842-8. 2006
    ..Eleven reviewers, reviewed 32 applications for a pilot project competition at a major university medical center...
  24. doi request reprint Significant differences in clinical outcomes between HIV-hepatitis C virus coinfected individuals with and without injection drug use history
    Angela Cescon
    aBritish Columbia Centre for Excellence in HIV AIDS, Vancouver, British Columbia bUniversity Health Network, Toronto cUniversity of Toronto dOntario HIV Treatment Network, Toronto, Ontario eMcGill University, Montreal, Quebec fWomen s College Research Institute, Toronto gMaple Leaf Medical Clinic, Toronto, Ontario hClinique Médicale l Actuel, Montreal, Quebec iUniversity of British Columbia, Vancouver jSimon Fraser University, Burnaby, British Columbia kUniversity of Ottawa, The Ottawa Hospital Research Institute, Ottawa, Ontario, Canada The members of the CANOC Collaboration are listed in the Acknowledgements
    AIDS 28:121-7. 2014
    ..This study compares HIV treatment outcomes and survival between HIV-HCV coinfected individuals with and without IDU history...
  25. pmc Invasive cervical cancer risk among HIV-infected women: a North American multicohort collaboration prospective study
    Alison G Abraham
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY Division of Infectious Diseases, School of Medicine, Vanderbilt University, Nashville, TN Division of Research, Kaiser Permanente Northern California, Oakland, CA Division of Infectious Diseases, University of Alabama, Birmingham, AL Ontario Treatment Network, University of Toronto, Toronto, ON, Canada Division of Infectious Diseases, University of North Carolina at Chapel Hill, Chapel Hill, NC Department of Medicine, Johns Hopkins University, Baltimore, MD Department of Medicine, Division of Infectious Diseases Chronic Viral Illness Service, McGill University, Montreal, Quebec, Canada Department of Medicine, University of Washington, Seattle, WA Department of Health Sciences, British Columbia Centre for Excellence and HIV AIDS, Simon Fraser University, Vancouver, British Columbia, Canada Department of Clinical Pharmacy and Medicine, University of California, San Francisco, CA Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD Department of Medicine, University of Calgary, Calgary
    J Acquir Immune Defic Syndr 62:405-13. 2013
    ..Few reported prospective cohort studies have characterized the incidence of invasive cervical cancer (ICC) in HIV-infected women...
  26. ncbi request reprint Didanosine, interferon-alfa and ribavirin: a highly synergistic combination with potential activity against HIV-1 and hepatitis C virus
    Marina B Klein
    Immunodeficiency Service, Montreal Chest Institute, Department of Medicine, McGill University Health Centre, Montreal, Quebec Canada
    AIDS 17:1001-8. 2003
    ..To evaluate the antiviral triple combination didanosine (ddI), interferon-alfa (IFN-alpha), and ribavirin for potential synergy in inhibition of HIV-1 replication in vitro...
  27. doi request reprint Rapid testing at labor and delivery to prevent mother-to-child HIV transmission in developing settings: issues and challenges
    Nitika Pant Pai
    Immunodeficiency Service, Montreal Chest Institute, McGill University Health Center, Montreal, Canada
    Womens Health (Lond Engl) 5:55-62. 2009
    ....
  28. pmc Impact of round-the-clock, rapid oral fluid HIV testing of women in labor in rural India
    Nitika Pant Pai
    Division of Infectious Diseases and Immunodeficiency Service, Montreal Chest Institute, McGill University Health Center, Montreal, Canada
    PLoS Med 5:e92. 2008
    ..In this context, we investigated the impact of introducing round-the-clock, rapid, point-of-care HIV testing and counseling in a busy labor ward at a tertiary care hospital in rural India...
  29. pmc Receptor-ligand requirements for increased NK cell polyfunctional potential in slow progressors infected with HIV-1 coexpressing KIR3DL1*h/*y and HLA-B*57
    Philomena Kamya
    Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada
    J Virol 85:5949-60. 2011
    ..The protective effect of HLA-B*57 on slow progression to AIDS and low VL may be mediated through its interaction with KIR3DL1 alleles to educate NK cells for potent activity upon stimulation...
  30. pmc Tuberculosis screening and active tuberculosis among HIV-infected persons in a Canadian tertiary care centre
    Paul Brassard
    Department of Medicine, Division of Clinical Epidemiology, Royal Victoria Hospital, McGill University Health Center
    Can J Infect Dis Med Microbiol 20:51-7. 2009
    ..HIV infection increases the risk of reactivation of latent tuberculosis (TB). The present study evaluates how latent TB is detected and treated to determine the effectiveness of screening in HIV-infected patients with diverse risk profiles...
  31. pmc Differences in resistance mutations among HIV-1 non-subtype B infections: a systematic review of evidence (1996-2008)
    Jorge L Martinez-Cajas
    McGill University AIDS Centre, Jewish General Hospital, Montreal, Quebec, Canada
    J Int AIDS Soc 12:11. 2009
    ..Attention to newer drug combinations, as well as baseline genotyping of non-B isolates, in well-designed longitudinal studies with long duration of follow up are needed...
  32. pmc Mycobacterium haemophilum epididymal abscess in a renal transplant patient
    Marina Keller
    Department of Microbiology, McGill University Health Centre, Montreal, Quebec, Canada
    J Clin Microbiol 46:2459-60. 2008
    ..We report the first known case of epididymal abscess, which highlights the need to work up all specimens that are acid-fast bacillus-positive for M. haemophilum from immunocompromised hosts, regardless of body site...