S R Kahn

Summary

Affiliation: McGill University
Country: Canada

Publications

  1. ncbi Frequency and determinants of the postthrombotic syndrome after venous thromboembolism
    Susan R Kahn
    Centre for Clinical Epidemiology and Community Studies, SMBD Jewish General Hospital, and Department of Medicine, McGill University, Montreal, Quebec, Canada
    Curr Opin Pulm Med 12:299-303. 2006
  2. ncbi Prospective evaluation of health-related quality of life in patients with deep venous thrombosis
    Susan R Kahn
    Centre for Clinical Epidemiology and Community Studies, Sir Mortimer B Davis Jewish General Hospital, Montreal, Quebec, Canada
    Arch Intern Med 165:1173-8. 2005
  3. ncbi The post-thrombotic syndrome after upper extremity deep venous thrombosis in adults: a systematic review
    Elyssa E Elman
    Faculty of Medicine, McGill University, Montreal, Canada
    Thromb Res 117:609-14. 2006
  4. ncbi The post-thrombotic syndrome: progress and pitfalls
    Susan R Kahn
    Department of Medicine, McGill University, and Center for Clinical Epidemiology and Community Studies, Sir Mortimer B Davis Jewish General Hospital, Montreal, QC, Canada
    Br J Haematol 134:357-65. 2006
  5. pmc Identifying unprovoked thromboembolism patients at low risk for recurrence who can discontinue anticoagulant therapy
    Marc A Rodger
    Thrombosis Program, Division of Hematology, Department of Medicine, University of Ottawa, Ottawa, Ont
    CMAJ 179:417-26. 2008
  6. ncbi The predictive value of markers of fibrinolysis and endothelial dysfunction in the post thrombotic syndrome. A systematic review
    Anat Rabinovich
    Susan R Kahn, MD MSc FRCPC, Division of Internal Medicine and Center for Clinical Epidemiology, Jewish General Hospital, 3755 Cote Ste Catherine Room H420 1, Montreal QC, H3T 1E2, Canada, Tel 1 514 340 8222 X 4667, E mail
    Thromb Haemost 111:1031-40. 2014
  7. pmc Association between Thrombophilia and the Post-Thrombotic Syndrome
    Anat Rabinovich
    Center for Clinical Epidemiology, Jewish General Hospital, 3755 Côte Saint Catherine Room H420 1, Montreal, QC, Canada H3T 1E2
    Int J Vasc Med 2013:643036. 2013
  8. ncbi Compression stockings to prevent post-thrombotic syndrome: a randomised placebo-controlled trial
    Susan R Kahn
    Centre for Clinical Epidemiology, Jewish General Hospital, Montreal, QC, Canada Electronic address
    Lancet 383:880-8. 2014
  9. doi Interventions for implementation of thromboprophylaxis in hospitalized medical and surgical patients at risk for venous thromboembolism
    Susan R Kahn
    Division of Internal Medicine and Department of Medicine, McGill University, Montreal, Canada
    Cochrane Database Syst Rev 7:CD008201. 2013
  10. ncbi Management and adherence to VTE treatment guidelines in a national prospective cohort study in the Canadian outpatient setting. The Recovery Study
    Susan R Kahn
    Centre for Clinical Epidemiology, Jewish General Hospital, Montreal, Quebec, Canada
    Thromb Haemost 108:493-8. 2012

Detail Information

Publications102 found, 100 shown here

  1. ncbi Frequency and determinants of the postthrombotic syndrome after venous thromboembolism
    Susan R Kahn
    Centre for Clinical Epidemiology and Community Studies, SMBD Jewish General Hospital, and Department of Medicine, McGill University, Montreal, Quebec, Canada
    Curr Opin Pulm Med 12:299-303. 2006
    ..This review discusses the knowledge gained from key studies over the last decade on the incidence and determinants of PTS, with special emphasis on published studies from the last 2 years...
  2. ncbi Prospective evaluation of health-related quality of life in patients with deep venous thrombosis
    Susan R Kahn
    Centre for Clinical Epidemiology and Community Studies, Sir Mortimer B Davis Jewish General Hospital, Montreal, Quebec, Canada
    Arch Intern Med 165:1173-8. 2005
    ..To our knowledge, the burden of deep venous thrombosis from the patient's perspective has not been quantified. We evaluated health-related quality of life (QOL) after deep vein thrombosis and compared results with general population norms...
  3. ncbi The post-thrombotic syndrome after upper extremity deep venous thrombosis in adults: a systematic review
    Elyssa E Elman
    Faculty of Medicine, McGill University, Montreal, Canada
    Thromb Res 117:609-14. 2006
    ..Post-thrombotic syndrome is a chronic, potentially debilitating complication of deep vein thrombosis (DVT) of the lower extremity. Comparatively little is known about post-thrombotic syndrome after upper extremity DVT (UEDVT)...
  4. ncbi The post-thrombotic syndrome: progress and pitfalls
    Susan R Kahn
    Department of Medicine, McGill University, and Center for Clinical Epidemiology and Community Studies, Sir Mortimer B Davis Jewish General Hospital, Montreal, QC, Canada
    Br J Haematol 134:357-65. 2006
    ..In addition, new therapies to treat PTS should be sought and evaluated...
  5. pmc Identifying unprovoked thromboembolism patients at low risk for recurrence who can discontinue anticoagulant therapy
    Marc A Rodger
    Thrombosis Program, Division of Hematology, Department of Medicine, University of Ottawa, Ottawa, Ont
    CMAJ 179:417-26. 2008
    ..We sought to determine clinical predictors to identify patients who are at low risk of recurrent venous thromboembolism who could safely discontinue oral anticoagulants...
  6. ncbi The predictive value of markers of fibrinolysis and endothelial dysfunction in the post thrombotic syndrome. A systematic review
    Anat Rabinovich
    Susan R Kahn, MD MSc FRCPC, Division of Internal Medicine and Center for Clinical Epidemiology, Jewish General Hospital, 3755 Cote Ste Catherine Room H420 1, Montreal QC, H3T 1E2, Canada, Tel 1 514 340 8222 X 4667, E mail
    Thromb Haemost 111:1031-40. 2014
    ..Descriptively, a significant association with PTS was found for D-dimer in four studies and factor XIII in one study. Further prospective research is needed to elucidate whether these markers might be useful to predict PTS development. ..
  7. pmc Association between Thrombophilia and the Post-Thrombotic Syndrome
    Anat Rabinovich
    Center for Clinical Epidemiology, Jewish General Hospital, 3755 Côte Saint Catherine Room H420 1, Montreal, QC, Canada H3T 1E2
    Int J Vasc Med 2013:643036. 2013
    ..Studies vary with regards to the definition of PTS, study design, follow-up period, and present conflicting results. Based on these results, the question of whether thrombophilia predisposes to the development of PTS remains unanswered...
  8. ncbi Compression stockings to prevent post-thrombotic syndrome: a randomised placebo-controlled trial
    Susan R Kahn
    Centre for Clinical Epidemiology, Jewish General Hospital, Montreal, QC, Canada Electronic address
    Lancet 383:880-8. 2014
    ..We aimed to assess the efficacy of ECS, compared with placebo stockings, for the prevention of PTS...
  9. doi Interventions for implementation of thromboprophylaxis in hospitalized medical and surgical patients at risk for venous thromboembolism
    Susan R Kahn
    Division of Internal Medicine and Department of Medicine, McGill University, Montreal, Canada
    Cochrane Database Syst Rev 7:CD008201. 2013
    ..Despite this, prophylactic therapies for VTE are underutilized. System-wide interventions may be more effective to improve the use of VTE prophylaxis than relying on individual providers' prescribing behaviors...
  10. ncbi Management and adherence to VTE treatment guidelines in a national prospective cohort study in the Canadian outpatient setting. The Recovery Study
    Susan R Kahn
    Centre for Clinical Epidemiology, Jewish General Hospital, Montreal, Quebec, Canada
    Thromb Haemost 108:493-8. 2012
    ..Our results suggest there may be important gaps in use of thromboprophylaxis to prevent VTE and use of LMWH monotherapy to treat cancer-related VTE...
  11. doi Villalta scale: goals and limitations
    R H W Strijkers
    Department of Surgery, Maastricht University Medical Centre, Cardiovascular Research Institute Maastricht, Maastricht, Limburg, The Netherlands
    Phlebology 27:130-5. 2012
    ..The Villalta scale should undergo further validation on intra-rater reliability. Ongoing randomized controlled trials will further validate the Villalta scale for use in PTS...
  12. doi Pharmacologic and compression therapies for postthrombotic syndrome: a systematic review of randomized controlled trials
    Jacqueline M Cohen
    Department of Epidemiology, Biostatistics and Occupational Health, Jewish General Hospital, Montreal, QC, Canada
    Chest 141:308-20. 2012
    ..The objective of this study was to systematically review the literature to assess whether pharmacologic and compression therapies are effective and safe for the treatment of PTS...
  13. pmc Scoring and psychometric validation of the Perception of Anticoagulant Treatment Questionnaire (PACT-Q)
    M H Prins
    The Department of Epidemiology, Care and Public Health Research Institutes, University of Maastricht, Maastricht, The Netherlands
    Health Qual Life Outcomes 7:30. 2009
    ..This questionnaire needs to be finalised and psychometrically validated...
  14. pmc Effectiveness of compression stockings to prevent the post-thrombotic syndrome (the SOX Trial and Bio-SOX biomarker substudy): a randomized controlled trial
    Susan R Kahn
    Centre for Clinical Epidemiology and Community Studies, Jewish General Hospital, Montreal, Quebec, Canada
    BMC Cardiovasc Disord 7:21. 2007
    ..Elastic compression stockings (ECS) could be helpful in preventing PTS; however, data on their effectiveness are scarce and conflicting...
  15. ncbi Predictors of the post-thrombotic syndrome during long-term treatment of proximal deep vein thrombosis
    S R Kahn
    McGill University, Montreal, Quebec, Canada
    J Thromb Haemost 3:718-23. 2005
    ..The post-thrombotic syndrome is a chronic, poorly understood complication of deep venous thrombosis (DVT)...
  16. ncbi Post-thrombotic syndrome, functional disability and quality of life after upper extremity deep venous thrombosis in adults
    Susan R Kahn
    McGill University, Department of Medicine, Center for Clinical Epidemiology and Community Studies, Sir Mortimer B Davis Jewish General Hospital, Montreal, Quebec, Canada
    Thromb Haemost 93:499-502. 2005
    ..Patients with dominant arm PTS appear to fare worse than those with non-dominant arm PTS. Larger, prospective studies to identify prognostic factors that lead to PTS after UEDVT are warranted...
  17. doi Measurement properties of the Villalta scale to define and classify the severity of the post-thrombotic syndrome
    S R Kahn
    Division of Internal Medicine and Centre for Clinical Epidemiology and Community Studies, Jewish General Hospital, McGill University, Montreal, Canada
    J Thromb Haemost 7:884-8. 2009
    ..Research aimed at improving the measurement of PTS will also help to improve the overall validity of findings generated by clinical studies of PTS...
  18. doi Definition of post-thrombotic syndrome of the leg for use in clinical investigations: a recommendation for standardization
    S R Kahn
    Division of Internal Medicine, Center for Clinical Epidemiology and Community Studies, Jewish General Hospital, McGill University, Montreal, QC, Canada
    J Thromb Haemost 7:879-83. 2009
    ....
  19. doi Inherited thrombophilia and preeclampsia within a multicenter cohort: the Montreal Preeclampsia Study
    Susan R Kahn
    Department of Medicine, McGill University Faculty of Medicine, Montreal, QC, Canada
    Am J Obstet Gynecol 200:151.e1-9; discussion e1-5. 2009
    ..We sought to evaluate the association between inherited thrombophilia and preeclampsia...
  20. ncbi Physical activity in patients with deep venous thrombosis: a systematic review
    Susan R Kahn
    Sir Mortimer B Davis Jewish General Hospital, McGill University, Montreal, Quebec, Canada
    Thromb Res 122:763-73. 2008
    ..We performed a systematic review to assess the benefits or risks of physical activity in patients with an acute or previous DVT of the leg...
  21. ncbi Determinants and time course of the postthrombotic syndrome after acute deep venous thrombosis
    Susan R Kahn
    Centre for Clinical Epidemiology and Community Studies, Sir Mortimer B Davis Jewish General Hospital, Montreal, Quebec, Canada
    Ann Intern Med 149:698-707. 2008
    ..The reason some patients with deep venous thrombosis (DVT) develop the postthrombotic syndrome is not well understood...
  22. ncbi VEINES-QOL/Sym questionnaire was a reliable and valid disease-specific quality of life measure for deep venous thrombosis
    Susan R Kahn
    Centre for Clinical Epidemiology and Community Studies, Jewish General Hospital, Montreal, Quebec, Canada
    J Clin Epidemiol 59:1049-56. 2006
    ..To assess the validity of VEINES-QOL/Sym, a patient-reported questionnaire to evaluate quality of life and symptoms in patients with deep venous thrombosis (DVT)...
  23. doi Determinants of health-related quality of life during the 2 years following deep vein thrombosis
    S R Kahn
    Centre for Clinical Epidemiology and Community Studies, Jewish General Hospital, Montreal, QC, Canada
    J Thromb Haemost 6:1105-12. 2008
    ..We prospectively measured change in quality of life (QOL) during the 2 years after a diagnosis of deep vein thrombosis (DVT) and evaluated determinants of QOL, including development of the post-thrombotic syndrome (PTS)...
  24. ncbi The post-thrombotic syndrome: the forgotten morbidity of deep venous thrombosis
    Susan R Kahn
    Department of Medicine, McGill University, and Center for Clinical Epidemiology and Community Studies, Sir Mortimer B Davis Jewish General Hospital, 3755 Cote Sainte Catherine, Room A 127, Montreal, Quebec, Canada H3T 1E2
    J Thromb Thrombolysis 21:41-8. 2006
    ..In addition, new therapies to treat PTS should be sought and evaluated...
  25. ncbi Multicenter evaluation of the use of venous thromboembolism prophylaxis in acutely ill medical patients in Canada
    Susan R Kahn
    Department of Medicine, McGill University, SMBD Jewish General Hospital, Canada
    Thromb Res 119:145-55. 2007
    ..Venous thromboembolism (VTE) prophylaxis in acutely ill medical patients has been shown to be safe and effective. Underutilization of this patient safety practice may result in avoidable mortality and morbidity...
  26. ncbi Relationship between clinical classification of chronic venous disease and patient-reported quality of life: results from an international cohort study
    Susan R Kahn
    Center for Clinical Epidemiology and Community Studies, Sir Mortimer B Davis Jewish General Hospital, Department of Epidemiology and Biostatistics, McGill University, Montreal, Que, Canada
    J Vasc Surg 39:823-8. 2004
    ....
  27. ncbi The influence of venous thromboembolism on quality of life and severity of chronic venous disease
    S R Kahn
    Center for Clinical Epidemiology and Community Studies, Jewish General Hospital, Montreal, Canada
    J Thromb Haemost 2:2146-51. 2004
    ..It is not known whether burden-of-illness differs in chronic venous disease patients with prior venous thromboembolism compared with patients with other forms of chronic venous disease...
  28. ncbi Use of elastic compression stockings after deep venous thrombosis: a comparison of practices and perceptions of thrombosis physicians and patients
    S R Kahn
    Center for Clinical Epidemiology and Community Studies, SMBD Jewish General Hospital, McGill University, Montreal, Quebec, Canada
    J Thromb Haemost 1:500-6. 2003
    ..Patients with DVT are willing to comply with ECS therapy and most find them to be helpful. Our findings suggest that long-term study of the optimal use of ECS after DVT is both necessary and feasible...
  29. pmc Smoking in preeclamptic women is associated with higher birthweight for gestational age and lower soluble fms-like tyrosine kinase-1 levels: a nested case control study
    Susan R Kahn
    Department of Medicine, McGill University, Montreal, Quebec, Canada
    BMC Pregnancy Childbirth 11:91. 2011
    ....
  30. doi The post thrombotic syndrome
    Susan R Kahn
    Division of Internal Medicine and Centre for Clinical Epidemiology and Community Studies, Jewish General Hospital, Montreal, Quebec, Canada
    Thromb Res 127:S89-92. 2011
    ..Further studies to elucidate the pathophysiology of PTS, to identify clinical and biological risk factors and to test new preventive and therapeutic approaches to PTS are needed...
  31. doi The post-thrombotic syndrome
    Susan R Kahn
    Division of Internal Medicine and Centre for Clinical Epidemiology and Community Studies, Jewish General Hospital, and Department of Medicine, McGill University, Montreal, Quebec, Canada
    Hematology Am Soc Hematol Educ Program 2010:216-20. 2010
    ..Further studies to elucidate the pathophysiology of PTS, to identify clinical and biological risk factors, and to test new preventive and therapeutic approaches to PTS are needed...
  32. ncbi Effect of postthrombotic syndrome on health-related quality of life after deep venous thrombosis
    Susan R Kahn
    Center for Clinical Epidemiology and Community Studies, Sir Mortimer B Davis Jewish General Hospital, 3755 Cote Ste, Catherine Room A 114, Montreal, Quebec, Canada H3T 1E2
    Arch Intern Med 162:1144-8. 2002
    ..We compared generic and venous disease-specific quality of life in patients with and without PTS, and assessed whether quality of life correlated with severity of PTS...
  33. pmc Six-month exercise training program to treat post-thrombotic syndrome: a randomized controlled two-centre trial
    Susan R Kahn
    Department of Medicine, McGill University, Ottawa, Ont, Canada
    CMAJ 183:37-44. 2011
    ....
  34. ncbi The post-thrombotic syndrome: current knowledge, controversies, and directions for future research
    Susan R Kahn
    Department of Medicine, McGill University, Center for Clinical Epidemiology and Community Studies, Sir Mortimer B Davis Jewish General Hospital, Montreal, Que, Canada
    Blood Rev 16:155-65. 2002
    ....
  35. ncbi Acute effects of exercise in patients with previous deep venous thrombosis: impact of the postthrombotic syndrome
    Susan R Kahn
    Center for Clinical Epidemiology and Community Studies, Sir Mortimer B Davis Jewish General Hospital, McGill University, Montreal, Canada
    Chest 123:399-405. 2003
    ..However, the effects of exercise in patients with previous DVT have not been studied...
  36. ncbi Effect of graduated elastic compression stockings on leg symptoms and signs during exercise in patients with deep venous thrombosis: a randomized cross-over trial
    S R Kahn
    Center for Clinical Epidemiology and Community Studies, Sir Mortimer B Davis Jewish General Hospital, McGill University, Montreal, Canada
    J Thromb Haemost 1:494-9. 2003
    ..Whether or not PTS was present, the use of ECS during exercise by patients with prior DVT did not improve symptoms and signs during exercise or increase exercise capacity...
  37. doi Predictors of post-thrombotic syndrome in a population with a first deep vein thrombosis and no primary venous insufficiency
    J P Galanaud
    Centre for Clinical Epidemiology, Jewish General Hospital, Montreal, Quebec, Canada
    J Thromb Haemost 11:474-80. 2013
    ..Its diagnosis is based on clinical characteristics. However, symptoms and signs of PTS are non-specific, and could result from concomitant primary venous insufficiency (PVI) rather than DVT. This could bias evaluation of PTS...
  38. doi Risk of post-thrombotic syndrome after subtherapeutic warfarin anticoagulation for a first unprovoked deep vein thrombosis: results from the REVERSE study
    R S Chitsike
    Centre for Clinical Epidemiology and Community Studies, Jewish General Hospital, Montreal, Canada
    J Thromb Haemost 10:2039-44. 2012
    ..Risk factors for post-thrombotic syndrome (PTS) remain poorly understood...
  39. doi Residual vein obstruction as a predictor for recurrent thromboembolic events after a first unprovoked episode: data from the REVERSE cohort study
    G Le Gal
    Thrombosis Program, Division of Hematology, Department of Medicine, University of Ottawa, Ottawa, ON, Canada
    J Thromb Haemost 9:1126-32. 2011
    ..We sought to determine if RVO as determined by compression ultrasonography (CUS) after completion of 5-7 months of anticoagulation for unprovoked DVT is associated with an increased risk of recurrent venous thromboembolism (VTE)...
  40. doi Comparison of the Villalta post-thrombotic syndrome score in the ipsilateral vs. contralateral leg after a first unprovoked deep vein thrombosis
    J P Galanaud
    Centre for Clinical Epidemiology and Community Studies, Jewish General Hospital, Montreal, Canada
    J Thromb Haemost 10:1036-42. 2012
    ..However, these signs and symptoms are not specific for PTS and their prevalence and relevance in the contralateral leg have not previously been studied...
  41. doi Relation between D-dimer level, venous valvular reflux and the development of post-thrombotic syndrome after deep vein thrombosis
    J Latella
    Department of Medicine, McGill University, Montreal, Canada
    J Thromb Haemost 8:2169-75. 2010
    ..The pathophysiology of post-thrombotic syndrome (PTS) is postulated to involve persistent venous obstruction and venous valvular reflux...
  42. ncbi A pilot study of central venous catheter survival in cancer patients using low-molecular-weight heparin (dalteparin) and warfarin without catheter removal for the treatment of upper extremity deep vein thrombosis (The Catheter Study)
    M J Kovacs
    Department of Medicine, Victoria Hospital, London, ON, Canada
    J Thromb Haemost 5:1650-3. 2007
    ..Central venous catheters in patients with cancer are associated with development of deep vein thrombosis (DVT); however, there is no accepted standard treatment...
  43. doi Serum lipoprotein (a) levels in patients with first unprovoked venous thromboembolism is not associated with subsequent risk of recurrent VTE
    M A Rodger
    Thrombosis Program, Division of Hematology, Department of Medicine, University of Ottawa, Clinical Epidemiology Unit, Ottawa Hospital Research Institute, The Ottawa Hospital, Ottawa, Ottawa, Ontario, Canada
    Thromb Res 126:222-6. 2010
    ..We sought to determine if serum Lp(a) levels in patients with unprovoked VTE who discontinue anticoagulants after 5 to 7 months of therapy predict VTE recurrence in a prospective cohort study...
  44. doi Non-OO blood type influences the risk of recurrent venous thromboembolism. A cohort study
    Esteban Gandara
    Dr Marc Rodger, Division of Hematology, The Ottawa Hospital, General Campus, 501 Smyth Rd, Ottawa, ON K1H 8L6, Canada, Fax 1 613 739 6102, E mail
    Thromb Haemost 110:1172-9. 2013
    ..2-3.8). In conclusion, non-OO blood type is associated with a statistically significant and clinically relevant increased risk of recurrent VTE following discontinuation of anticoagulant therapy for a first episode of unprovoked VTE. ..
  45. pmc Increased tissue plasminogen activator levels in patients with nonvalvular atrial fibrillation
    S R Kahn
    Division of General Internal Medicine, Sir Mortimer B Davis Jewish General Hospital, Montreal, Que
    CMAJ 157:685-9. 1997
    ....
  46. ncbi Missed opportunities for prevention of venous thromboembolism: an evaluation of the use of thromboprophylaxis guidelines
    D M Arnold
    Department of Medicine, Sir Mortimer B. Davis Jewish General Hospital, Montreal, Canada
    Chest 120:1964-71. 2001
    ..Inadequacy of prophylaxis was most often caused by omission of prophylaxis. Missed opportunities for prevention occurred most commonly in the settings of nonorthopedic surgery, pneumonia, and stroke...
  47. doi Direct and indirect costs of management of long-term warfarin therapy in Canada
    S Schulman
    Department of Medicine, McMaster University, Hamilton, ON, Canada
    J Thromb Haemost 8:2192-200. 2010
    ..The aim of the present study was to assess total costs of warfarin-based anticoagulation in different health care models...
  48. doi Dalteparin for the prevention of recurrence of placental-mediated complications of pregnancy in women without thrombophilia: a pilot randomized controlled trial
    E Rey
    Division of Obstetrics Medicine, Department of Obstetrics and Gynaecology, CHU Sainte Justine, Montreal, QC, Canada
    J Thromb Haemost 7:58-64. 2009
    ..The role of anticoagulants for the prevention of placental-mediated pregnancy complications is uncertain...
  49. pmc Reliability of a device measuring triceps surae muscle fatigability
    M Haber
    SMBD Jewish General Hospital, Montreal, Quebec, Canada
    Br J Sports Med 38:163-7. 2004
    ..To examine the test-retest reliability of a protocol using an apparatus designed to standardise the standing heel rise test for the triceps surae muscle...
  50. pmc Long-term outcomes after deep vein thrombosis: postphlebitic syndrome and quality of life
    S R Kahn
    Center for Clinical Epidemiology and Community Studies, Sir Mortimer B Davis Jewish General Hospital, Montreal, Canada
    J Gen Intern Med 15:425-9. 2000
    ....
  51. doi Validation of a diagnostic approach to exclude recurrent venous thromboembolism
    G Le Gal
    Thrombosis Program, Division of Hematology, Department of Medicine, University of Ottawa, Ottawa, ON, Canada
    J Thromb Haemost 7:752-9. 2009
    ..Our objective was to evaluate the safety of a diagnostic strategy utilizing comparison of diagnostic test results with baseline imaging results to rule out suspected recurrent VTE...
  52. ncbi Long-term dalteparin in pregnancy not associated with a decrease in bone mineral density: substudy of a randomized controlled trial
    M A Rodger
    Ottawa Health Research Institute, University of Ottawa, Ottawa, ON, Canada
    J Thromb Haemost 5:1600-6. 2007
    ..The risk of decreased bone mineral density (BMD) with prophylactic dose long-term low-molecular-weight heparin (LMWH) is unknown...
  53. ncbi The clinical diagnosis of deep venous thrombosis: integrating incidence, risk factors, and symptoms and signs
    S R Kahn
    Center for Clinical Epidemiology and Community Studies and the Division of Internal Medicine, Sir Mortimer B Davis Jewish General Hospital, McGill University, Montreal, Quebec
    Arch Intern Med 158:2315-23. 1998
    ..Further study is needed to determine whether clinical prediction indexes have a role in improving the diagnostic process in patients with suspected DVT...
  54. ncbi The effect of dalteparin on coagulation activation during pregnancy in women with thrombophilia. A randomized trial
    Karim Abou-Nassar
    The Ottawa Hospital, General Campus, 501 Smyth Road, Box 201, Ottawa, ONT K1H 8L6, Canada
    Thromb Haemost 98:163-71. 2007
    ..Prophylaxis with dalteparin at doses used in this study did not reduce coagulation activation in high risk thrombophilic women during pregnancy...
  55. pmc Nonvalvular atrial fibrillation: evidence for a prothrombotic state
    S R Kahn
    Division of General Internal Medicine, Sir Mortimer B Davis Jewish General Hospital, Montreal, Que
    CMAJ 157:673-81. 1997
    ..To determine whether patients with nonvalvular atrial fibrillation (NVAF) have prothrombotic changes compared with patients in sinus rhythm...
  56. ncbi A randomized management study of impedance plethysmography vs. contrast venography in patients with a first episode of clinically suspected deep vein thrombosis
    S R Kahn
    Center for Clinical Epidemiology and Community Studies, Sir Mortimer B Davis Jewish General Hospital, Montreal, Quebec, Canada
    Thromb Res 102:15-24. 2001
    ....
  57. ncbi Severe preeclampsia associated with coinheritance of factor V Leiden mutation and protein S deficiency
    S R Kahn
    Center for Clinical Epidemiology and Community Studies and the Division of General Internal Medicine, Sir Mortimer B Davis Jewish General Hospital, McGill University, Montreal, Quebec, Canada
    Obstet Gynecol 91:812-4. 1998
    ..Inherited thrombophilic disorders are associated with an increased risk of venous thromboembolism during pregnancy. Preliminary research suggests that these disorders might also increase the risk for preeclampsia...
  58. doi Vasculopathic and thrombophilic risk factors for spontaneous preterm birth
    Michael S Kramer
    Department of Pediatrics, McGill University Faculty of Medicine, Montreal, Quebec, Canada
    Int J Epidemiol 38:715-23. 2009
    ..Mothers who give birth to preterm infants are at increased risk of mortality from coronary heart disease and stroke, but the biological pathways underlying these associations have not been explored...
  59. doi Stress pathways to spontaneous preterm birth: the role of stressors, psychological distress, and stress hormones
    Michael S Kramer
    Department of Pediatrics, McGill University Faculty of Medicine, Montreal, Quebec, Canada
    Am J Epidemiol 169:1319-26. 2009
    ..The biologic pathways underlying stress-induced preterm birth remain poorly understood...
  60. doi Investigating socio-economic disparities in preterm birth: evidence for selective study participation and selection bias
    Michael S Kramer
    Department of Pediatrics, McGill University Faculty of Médecine, Montreal, Quebec, Canada
    Paediatr Perinat Epidemiol 23:301-9. 2009
    ..Investigators should consider the potential for biased associations in pregnancy/birth cohort studies, especially associations based on SES or race/ethnicity, and carry out sensitivity analyses to gauge their effects...
  61. doi Antioxidant vitamins, long-chain fatty acids, and spontaneous preterm birth
    Michael S Kramer
    Department of Pediatrics, McGill University Faculty of Medicine, Montreal, Quebec, Canada
    Epidemiology 20:707-13. 2009
    ..However, there has been little attention to carotenoids, tocopherols, and long-chain fatty acids other than n-3 polyunsaturates...
  62. doi Mid-trimester maternal plasma cytokines and CRP as predictors of spontaneous preterm birth
    Michael S Kramer
    Department of Pediatrics, McGill University Faculty of Medicine, Montreal, Que, Canada
    Cytokine 49:10-4. 2010
    ..Our results require confirmation in future studies but suggest that a systemic immune response implicating MMP-9 may have an etiologic role in spontaneous preterm birth...
  63. doi Effect of early physical activity on long-term outcome after venous thrombosis
    Ian Shrier
    Centre for Clinical Epidemiology and Community Studies, Lady Davis Institute for Medical Research, SMBD Jewish General Hospital, Montreal, Quebec, Canada
    Clin J Sport Med 19:487-93. 2009
    ..To determine if the level of self-reported physical activity 1 month after deep vein thrombosis (DVT) is associated with the risk of post-thrombotic syndrome (PTS) in the first 2 years post-DVT...
  64. doi Determining the test characteristics of claims-based diagnostic codes for the diagnosis of venous thromboembolism in a medical service claims database
    Vicky Tagalakis
    Centre for Clinical Epidemiology and Community Studies, Jewish General Hospital, McGill University, Montreal, Quebec, Canada
    Pharmacoepidemiol Drug Saf 20:304-7. 2011
    ..To determine the test characteristics of diagnostic codes within a medical service claims database for deep vein thrombosis (DVT) and pulmonary embolism (PE)...
  65. ncbi Relationship between deep venous thrombosis and the postthrombotic syndrome
    Susan R Kahn
    Department of Medicine, McGill University, Center for Clinical Epidemiology and Community Studies, Sir Mortimer B Davis Jewish General Hospital, Montreal, Quebec, Canada
    Arch Intern Med 164:17-26. 2004
    ..In addition, novel therapies should be sought and evaluated...
  66. doi Non-stress-related factors associated with maternal corticotrophin-releasing hormone (CRH) concentration
    Michael S Kramer
    Departments of Pediatrics, McGill University Faculty of Medicine, and Département de médecine sociale et préventive, Faculte de Medecine de l Universite de Montreal, Montreal, Quebec, Canada
    Paediatr Perinat Epidemiol 24:390-7. 2010
    ..Further studies are indicated both in animal models and human populations to better understand the biochemical and physiological pathways to CRH secretion and their aetiological role, if any, in preterm birth...
  67. pmc Short-term mortality associated with failure to receive home care after hemiarthroplasty
    Elham Rahme
    Department of Medicine, McGill University, Montreal, Que
    CMAJ 182:1421-6. 2010
    ..Such patients may benefit from home care after discharge. We assessed factors associated with the receipt of home care and evaluated the risk of death within three months after discharge...
  68. ncbi Effect of physical activity after recent deep venous thrombosis: a cohort study
    Ian Shrier
    Centre for Clinical Epidemiology and Community Studies, Lady Davis Institute for Medical Research, SMBD Jewish General Hospital, Montreal, Canada
    Med Sci Sports Exerc 37:630-4. 2005
    ..To determine whether increased physical activity 1 month after deep vein thrombosis (DVT) led to worsening of venous symptoms and signs within the subsequent 3 months...
  69. ncbi Use of warfarin and risk of urogenital cancer: a population-based, nested case-control study
    Vicky Tagalakis
    Centre for Clinical Epidemiology and Community Studies, SMBD Jewish General Hospital, Montreal, QC, Canada
    Lancet Oncol 8:395-402. 2007
    ..Indirect evidence suggests that prolonged treatment with warfarin might be associated with a decreased incidence of urogenital cancer. We aimed to assess this association in a large population-based study...
  70. ncbi The effect of anticoagulants on cancer risk and survival: systematic review
    Vicky Tagalakis
    Centre for Clinical Epidemiology and Community Studies, SMBD Jewish General Hospital, McGill University, Montreal, Que, Canada
    Cancer Treat Rev 33:358-68. 2007
    ....
  71. ncbi Association between antiphospholipid antibodies and recurrent fetal loss in women without autoimmune disease: a metaanalysis
    Lucie Opatrny
    Division of Clinical Epidemiology, McGill University Hospital Center, Royal Victoria Hospital, 687 Pine Avenue West, Montreal, Quebec, Canada
    J Rheumatol 33:2214-21. 2006
    ....
  72. ncbi Thrombophilia in short peripheral catheter thrombophlebitis
    Vicky Tagalakis
    Centre for Clinical Epidemiology and Community Studies, SMBD Jewish General Hospital, McGill University, 3755 Cote Ste Catherine, RM A 131, Montreal, Quebec, Canada
    Thromb Res 119:587-92. 2007
  73. ncbi The epidemiology of peripheral vein infusion thrombophlebitis: a critical review
    Vicky Tagalakis
    Center for Clinical Epidemiology and Community Studies, Sir Mortimer B Davis Jewish General Hospital, Montreal, Canada
    Am J Med 113:146-51. 2002
    ..extra nursing time). Although duration of catheterization, catheter-related infection, and catheter material are important risk factors for peripheral vein infusion thrombophlebitis, patient-related risk factors are not well elucidated...
  74. ncbi Identifying orthopedic patients at high risk for venous thromboembolism despite thromboprophylaxis
    Renee L Schiff
    Department of Medicine, McGill University, Montreal, QC, Canada
    Chest 128:3364-71. 2005
    ..To evaluate risk factors for venous thromboembolism (VTE) despite thromboprophylaxis in major orthopedic surgery patients at a tertiary care hospital...
  75. pmc Postdischarge thromboprophylaxis and mortality risk after hip-or knee-replacement surgery
    Elham Rahme
    Department of Medicine, McGill University, Montreal, Que
    CMAJ 178:1545-54. 2008
    ..We sought to identify hospital and patient characteristics associated with receiving thromboprophylaxis after discharge and to compare the risk of short-term mortality among those who did or did not receive thromboprophylaxis...
  76. ncbi Intra- and interobserver agreement and statistical clustering of placental histopathologic features relevant to preterm birth
    Michael S Kramer
    Department of Pediatrics, McGill University Faculty of Medicine, Montreal, Quebec, Canada
    Am J Obstet Gynecol 195:1674-9. 2006
    ..Many previous studies of agreement in identifying placental histopathologic lesions have been based on small sample sizes, and none has examined whether individual histologic features cluster robustly together within and between observers...
  77. ncbi Frequency of renal impairment, advanced age, obesity and cancer in venous thromboembolism patients in clinical practice
    L M Cook
    Thrombosis Clinic and Centre for Clinical Epidemiology and Community Studies, Sir Mortimer B Davis Jewish General Hospital, Montreal, QC, Canada
    J Thromb Haemost 5:937-41. 2007
    ..In 'special populations' such as those with renal impairment or the elderly, weight-based dosing may be excessive, and capping the dose in obese patients may lead to inadequate dosing...
  78. ncbi Short-term natural history of isolated gastrocnemius and soleal vein thrombosis
    P S Macdonald
    Department of Surgery, McGill University, Montreal, Quebec, Canada
    J Vasc Surg 37:523-7. 2003
    ..The purpose of this study was to establish the incidence rate of propagation of isolated gastrocnemius and soleal vein thrombosis (IGSVT) into the deep veins of the calf and thigh...
  79. ncbi Influence of warfarin on symptoms of fatigue: findings of a randomized trial
    Michael J Kovacs
    Department of Medicine, University of Western Ontario, London, Ontario, Canada
    Ann Pharmacother 39:840-2. 2005
    ..Some patients develop fatigue while taking warfarin, but causality is uncertain...
  80. ncbi Risk of prostate cancer death in long-term users of warfarin: a population-based case-control study
    V Tagalakis
    Centre for Clinical Epidemiology, Lady Davis Institute for Medical Research, Jewish General Hospital, McGill University, 3755 Cote Ste Catherine, Suite H 410 1, Montreal, QC, H3T 1E2, Canada
    Cancer Causes Control 24:1079-85. 2013
    ..Recent evidence suggests that warfarin use may be associated with a reduced risk of prostate cancer. We aimed to determine whether exposure to warfarin is also associated with a reduced risk of prostate cancer death...
  81. doi Risk of recurrent venous thromboembolism after a first oestrogen-associated episode. Data from the REVERSE cohort study
    Gregoire Le Gal
    Thrombosis Program, Division of Hematology, Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada
    Thromb Haemost 104:498-503. 2010
    ..The risk of recurrent VTE is low in women after a first otherwise unprovoked oestrogen-associated VTE. However, this risk is not significantly lower than in women whose VTE was not related to oestrogen use...
  82. ncbi Thrombophilic disorders and fetal loss: a meta-analysis
    Evelyne Rey
    Department of Obstetrics and Gynecology, Sainte Justine Hospital, Quebec, Montreal, Canada
    Lancet 361:901-8. 2003
    ..Our aim was to assess the strength of the controversial association between thrombophilia and fetal loss, and to examine whether it varies according to the timing or definition of fetal loss...
  83. ncbi The relationship between inflammation and venous thrombosis. A systematic review of clinical studies
    Eric A Fox
    Faculty of Medicine, McGill University, Montreal, Canada
    Thromb Haemost 94:362-5. 2005
    ..The identification and elucidation of inflammatory markers relevant to venous thrombosis could provide targets for future therapy...
  84. ncbi Levels of inflammatory markers and the development of the post-thrombotic syndrome
    Hadia Shbaklo
    Center for Clinical Epidemiology and Community Studies, Sir Mortimer B Davis Jewish General Hospital, 3755 Cote Ste Catherine Rm A 127, Montreal, Quebec H3T 1E2, Canada
    Thromb Haemost 101:505-12. 2009
    ..If confirmed, this could lead to identification of new therapeutic targets for preventing PTS after DVT...
  85. doi Association between thrombophilia and the post-thrombotic syndrome: a systematic review and meta-analysis
    A Rabinovich
    Center for Clinical Epidemiology, Jewish General Hospital, McGill University, Montreal, QC, Canada
    J Thromb Haemost 12:14-23. 2014
    ..Identifying risk factors for PTS may be useful to provide patients with prognostic information and target prevention strategies...
  86. doi Postthrombotic syndrome in relation to vena cava filter placement: a systematic review
    Mitchell A Fox
    Faculty of Medicine, McGill University, Sir Mortimer B Davis Jewish General Hospital, 3755 Cote Sainte Catherine, Montreal, Quebec, Canada
    J Vasc Interv Radiol 19:981-985. 2008
    ..However, as a result of the important limitations of the articles reviewed, further research is required to directly address this issue...
  87. doi Long-term prognosis after deep venous thrombosis
    Hadia Shbaklo
    Center for Clinical Epidemiology and Community Studies, Sir Mortimer B Davis Jewish General Hospital, Canada
    Curr Opin Hematol 15:494-8. 2008
    ..Knowledge acquired during the last decade is presented, with emphasis on reports published in the past 2 years...
  88. doi Computed tomographic pulmonary angiography vs ventilation-perfusion lung scanning in patients with suspected pulmonary embolism: a randomized controlled trial
    David R Anderson
    Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
    JAMA 298:2743-53. 2007
    ..Ventilation-perfusion scanning has been largely replaced by CTPA in many centers despite limited comparative formal evaluations and concerns about CTPA's low sensitivity (ie, chance of missing clinically important pulmonary embuli)...
  89. doi How I treat postthrombotic syndrome
    Susan R Kahn
    Division of Internal Medicine and Centre for Clinical Epidemiology and Community Studies, Jewish General Hospital, and Department of Medicine, McGill University, Montreal, QC
    Blood 114:4624-31. 2009
    ....
  90. ncbi Measuring the outcomes and pharmacoeconomic consequences of venous thromboembolism prophylaxis in major orthopaedic surgery
    Sean D Sullivan
    Pharmaceutical Outcomes Research and Policy Program, University of Washington, Seattle 98195 7630, USA
    Pharmacoeconomics 21:477-96. 2003
    ..These recommendations are based on extensive examination of recent advances in the management of VTE combined with a greater understanding of its natural history...
  91. ncbi A cost-effectiveness analysis of fondaparinux sodium compared with enoxaparin sodium as prophylaxis against venous thromboembolism: use in patients undergoing major orthopaedic surgery
    Sean D Sullivan
    Department of Pharmacy and Health Services, University of Washington, Seattle, Washington 98195, USA
    Pharmacoeconomics 22:605-20. 2004
    ..To determine the cost effectiveness of fondaparinux sodium compared with enoxaparin sodium for prophylaxis against venous thromboembolism in patients undergoing major orthopaedic surgery...
  92. ncbi Antithrombotic therapy for venous thromboembolic disease: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition)
    Clive Kearon
    Hamilton Health Sciences, Henderson Division, 711 Concession Street, Hamilton, Ontario, Canada
    Chest 133:454S-545S. 2008
    ..For extensive superficial vein thrombosis, we recommend treatment with prophylactic or intermediate doses of LMWH or intermediate doses of UFH for 4 weeks (Grade 1B)...
  93. doi Inter-observer reliability of measures to assess the post-thrombotic syndrome
    Marc A Rodger
    Thromb Haemost 100:164-6. 2008
  94. ncbi Markers of coagulation and angiogenesis in cancer-associated venous thromboembolism
    Neil Goldenberg
    Department of Internal Medicine, University of South Florida, Tampa, FL, USA
    J Clin Oncol 21:4194-9. 2003
    ..We sought to determine whether venous thromboembolism in cancer patients is associated with aberrant plasma levels of hemostatic and angiogenic factors...
  95. ncbi Comparison of low-intensity warfarin therapy with conventional-intensity warfarin therapy for long-term prevention of recurrent venous thromboembolism
    Clive Kearon
    McMaster University, Hamilton, Ont
    N Engl J Med 349:631-9. 2003
    ..After three months of conventional warfarin therapy, a lower dose of anticoagulant medication may result in less bleeding and still prevent recurrent venous thromboembolism...
  96. ncbi Evaluation of outcomes in chronic venous disorders of the leg: development of a scientifically rigorous, patient-reported measure of symptoms and quality of life
    Donna L Lamping
    Health Services Research Unit, Department of Public Health and Policy, London School of Hygiene and Tropical Medicine, London, United Kingdom
    J Vasc Surg 37:410-9. 2003
    ....
  97. ncbi Pharmacoeconomic analysis of fondaparinux versus enoxaparin for the prevention of thromboembolic events in orthopedic surgery patients
    George Dranitsaris
    Augmentium Pharma Consulting, Toronto, Ontario, Canada
    Am J Cardiovasc Drugs 4:325-33. 2004
    ....
  98. ncbi Recurrent venous thromboembolism in men and women
    Susan R Kahn
    N Engl J Med 351:2015-8; author reply 2015-8. 2004
  99. doi Evaluation of a venous-return assist device to treat severe post-thrombotic syndrome (VENOPTS). A randomized controlled trial
    MARTIN J O'DONNELL
    Henderson Research Centre, McMaster University, Hamilton, Ontario, Canada
    Thromb Haemost 99:623-9. 2008
    ..2; SD 6.3) compared to control (15.0; SD 6.1). In conclusion, Venowave appears to be a very promising new therapy for patients with severe PTS, which may be used alone or in combination with graduated compression stockings...
  100. ncbi Risk factors for the first-time development of venous ulcers of the lower limbs: the influence of heredity and physical activity
    Anick Berard
    Albert Einstein College of Medicine, Department of Epidemiology and of Emergency Medicine, Bronx, NY, USA
    Angiology 53:647-57. 2002
    ..Although physical activity is recommended for patients with venous insufficiency, vigorous exercise increases the likelihood of ulcerations...
  101. ncbi The economics of venous thromboembolism prophylaxis: a primer for clinicians
    Bruce L Davidson
    Pulmonary and Critical Care Medicine Division, Swedish Medical Center and University of Washington School of Medicine, 801 Broadway, Suite 915, Seattle, WA 98122, USA
    Chest 124:393S-396S. 2003
    ..It is possible to list the important safety and efficacy outcomes of prophylaxis, estimate their incidences and costs, and "model" comparisons of one modality vs another, in order to help decide whether one is preferable...