Ridha Joober

Summary

Affiliation: McGill University
Country: Canada

Publications

  1. ncbi request reprint Increased prevalence of schizophrenia spectrum disorders in relatives of neuroleptic-nonresponsive schizophrenic patients
    Ridha Joober
    Douglas Hospital Research Center, Douglas Hospital, Verdun, Quebec, Canada
    Schizophr Res 77:35-41. 2005
  2. ncbi request reprint No association between the DRD3 Ser9Gly polymorphism and schizophrenia
    Ferid Fathalli
    Douglas Hospital Research Centre, Montreal University, Quebec, Canada
    Schizophr Res 98:98-104. 2008
  3. doi request reprint Association of trait-defined, eating-disorder sub-phenotypes with (biallelic and triallelic) 5HTTLPR variations
    Howard Steiger
    Eating Disorders Program, Douglas University Institute in Mental Health, Quebec, Canada
    J Psychiatr Res 43:1086-94. 2009
  4. doi request reprint Symptom attribution in first episode psychosis: a cortical thickness study
    Lisa Buchy
    Brain Imaging Group, Douglas Mental Health University Institute, Verdun, Canada
    Psychiatry Res 203:6-13. 2012
  5. doi request reprint Epistatic interactions implicating dopaminergic genes in bulimia nervosa (BN): relationships to eating- and personality-related psychopathology
    Lea Thaler
    Eating Disorders Program, Douglas University Institute, Montreal, Quebec, Canada
    Prog Neuropsychopharmacol Biol Psychiatry 39:120-8. 2012
  6. pmc Comprehensive phenotype/genotype analyses of the norepinephrine transporter gene (SLC6A2) in ADHD: relation to maternal smoking during pregnancy
    Geeta A Thakur
    Integrated Program in Neuroscience, McGill University, Montreal, Quebec, Canada
    PLoS ONE 7:e49616. 2012
  7. pmc The 5HTTLPR polymorphism, prior maltreatment and dramatic-erratic personality manifestations in women with bulimic syndromes
    Howard Steiger
    Eating Disorders Program, Douglas Hospital, 6875 LaSalle Blvd, Montreal QC H4H 1R3, Canada
    J Psychiatry Neurosci 32:354-62. 2007
  8. ncbi request reprint Relevance of the 5-HTTLPR polymorphism and childhood abuse to increased psychiatric comorbidity in women with bulimia-spectrum disorders
    Jodie Richardson
    Eating Disorders Program, Douglas Mental Health University Institute, Montreal, Quebec, Canada
    J Clin Psychiatry 69:981-90. 2008
  9. doi request reprint Association between obesity-related gene FTO and ADHD
    Zia Choudhry
    Clinical Research Division, Douglas Mental Health University Institute, McGill University, Quebec, Canada Department of Human Genetics, McGill University, Quebec, Canada
    Obesity (Silver Spring) 21:E738-44. 2013
  10. doi request reprint Genetic evidence for the association of the hypothalamic-pituitary-adrenal (HPA) axis with ADHD and methylphenidate treatment response
    Marie Eve Fortier
    Douglas Mental Health University Institute, 6875 LaSalle Blvd, Verdun, QC, H4H 1R3, Canada
    Neuromolecular Med 15:122-32. 2013

Detail Information

Publications115 found, 100 shown here

  1. ncbi request reprint Increased prevalence of schizophrenia spectrum disorders in relatives of neuroleptic-nonresponsive schizophrenic patients
    Ridha Joober
    Douglas Hospital Research Center, Douglas Hospital, Verdun, Quebec, Canada
    Schizophr Res 77:35-41. 2005
    ..In order to test this hypothesis, we compared the pattern of familial aggregation of schizophrenia related disorders in schizophrenic patients who are either responders (R) or nonresponders (NR) to typical neuroleptics...
  2. ncbi request reprint No association between the DRD3 Ser9Gly polymorphism and schizophrenia
    Ferid Fathalli
    Douglas Hospital Research Centre, Montreal University, Quebec, Canada
    Schizophr Res 98:98-104. 2008
    ..To investigate the association between a Ser9Gly polymorphism of the dopamine D3 receptor gene (DRD3) and schizophrenia...
  3. doi request reprint Association of trait-defined, eating-disorder sub-phenotypes with (biallelic and triallelic) 5HTTLPR variations
    Howard Steiger
    Eating Disorders Program, Douglas University Institute in Mental Health, Quebec, Canada
    J Psychiatr Res 43:1086-94. 2009
    ..We explored the extent to which an empirical, trait-defined typology of eating-disordered individuals coincided systematically with variations in 5HTTLPR, assayed using biallelic and triallelic models...
  4. doi request reprint Symptom attribution in first episode psychosis: a cortical thickness study
    Lisa Buchy
    Brain Imaging Group, Douglas Mental Health University Institute, Verdun, Canada
    Psychiatry Res 203:6-13. 2012
    ..Evidence for cortical thickness covariation in a variety of regions suggests partial independence in the neural architecture underlying attribution for different symptoms in FEP...
  5. doi request reprint Epistatic interactions implicating dopaminergic genes in bulimia nervosa (BN): relationships to eating- and personality-related psychopathology
    Lea Thaler
    Eating Disorders Program, Douglas University Institute, Montreal, Quebec, Canada
    Prog Neuropsychopharmacol Biol Psychiatry 39:120-8. 2012
    ..We discuss the implications of our observations...
  6. pmc Comprehensive phenotype/genotype analyses of the norepinephrine transporter gene (SLC6A2) in ADHD: relation to maternal smoking during pregnancy
    Geeta A Thakur
    Integrated Program in Neuroscience, McGill University, Montreal, Quebec, Canada
    PLoS ONE 7:e49616. 2012
    ..We tested the association between 30 tag SNPs within the SLC6A2 gene and ADHD, with stratification based on maternal smoking during pregnancy, an environmental factor strongly associated with ADHD...
  7. pmc The 5HTTLPR polymorphism, prior maltreatment and dramatic-erratic personality manifestations in women with bulimic syndromes
    Howard Steiger
    Eating Disorders Program, Douglas Hospital, 6875 LaSalle Blvd, Montreal QC H4H 1R3, Canada
    J Psychiatry Neurosci 32:354-62. 2007
    ..In women with bulimic syndromes, we explored associations with personality pathology of 5HTTLPR and prior sexual or physical maltreatment...
  8. ncbi request reprint Relevance of the 5-HTTLPR polymorphism and childhood abuse to increased psychiatric comorbidity in women with bulimia-spectrum disorders
    Jodie Richardson
    Eating Disorders Program, Douglas Mental Health University Institute, Montreal, Quebec, Canada
    J Clin Psychiatry 69:981-90. 2008
    ....
  9. doi request reprint Association between obesity-related gene FTO and ADHD
    Zia Choudhry
    Clinical Research Division, Douglas Mental Health University Institute, McGill University, Quebec, Canada Department of Human Genetics, McGill University, Quebec, Canada
    Obesity (Silver Spring) 21:E738-44. 2013
    ..The objective of this study is to explore the association between ADHD and FTO, a gene strongly associated with obesity in genome-wide studies...
  10. doi request reprint Genetic evidence for the association of the hypothalamic-pituitary-adrenal (HPA) axis with ADHD and methylphenidate treatment response
    Marie Eve Fortier
    Douglas Mental Health University Institute, 6875 LaSalle Blvd, Verdun, QC, H4H 1R3, Canada
    Neuromolecular Med 15:122-32. 2013
    ..To the best of our knowledge, this is the first report showing an association between functional polymorphisms in NR3C1 and ADHD, providing genetic evidence for involvement of the HPA axis in the disorder and treatment response...
  11. doi request reprint Catechol-o-methyltransferase gene and executive function in children with ADHD
    Zia Choudhry
    1McGill University, Montreal, Quebec, Canada
    J Atten Disord 18:202-11. 2014
    ..To examine the association between functional haplotypes in the catechol-o-methyltransferase (COMT) gene and ADHD diagnosis, and executive function (EF) in children with ADHD...
  12. doi request reprint Dopamine-system genes, childhood abuse, and clinical manifestations in women with Bulimia-Spectrum Disorders
    Patricia Groleau
    Eating Disorders Program, Douglas University Institute, Montreal, Quebec, Canada
    J Psychiatr Res 46:1139-45. 2012
    ....
  13. doi request reprint Methylation of the dopamine D2 receptor (DRD2) gene promoter in women with a bulimia-spectrum disorder: associations with borderline personality disorder and exposure to childhood abuse
    Patricia Groleau
    Eating Disorders Program, Douglas University Institute, Montreal, Quebec, Canada Psychology Department, McGill University, Montreal, Quebec, Canada Research Centre, Douglas University Institute, Montreal, Quebec, Canada Electronic address
    J Psychiatr Res 48:121-7. 2014
    ..In this study, we examined the extent to which DRD2 methylation was associated with the presence or absence of a bulimic eating disorder, to childhood abuse exposure, or to comorbid BPD...
  14. doi request reprint Coping style moderates the effect of intranasal oxytocin on the mood response to interpersonal stress
    Christopher Cardoso
    Centre for Research in Human Development, Concordia University, Montreal, Quebec, Canada
    Exp Clin Psychopharmacol 20:84-91. 2012
    ..Intranasal oxytocin appears to be particularly beneficial to women who endorse high levels of emotion-oriented coping, who may be vulnerable to the negative impact of stress...
  15. doi request reprint Interaction of the BcII glucocorticoid receptor polymorphism and childhood abuse in Bulimia Nervosa (BN): relationship to BN and to associated trait manifestations
    Howard Steiger
    Eating Disorders Program, Douglas University Institute, Montreal, Quebec, Canada
    J Psychiatr Res 46:152-8. 2012
    ..We discuss theoretical and clinical implications of these observations...
  16. pmc A five-year randomized parallel and blinded clinical trial of an extended specialized early intervention vs. regular care in the early phase of psychotic disorders: study protocol
    Danyael Lutgens
    Department of Psychiatry, McGill University Prevention and Early Intervention Program for the Psychoses, Douglas Mental Health University Institute, Montreal, Quebec, Canada
    BMC Psychiatry 15:22. 2015
    ....
  17. pmc Identifying persistent negative symptoms in first episode psychosis
    Cindy L Hovington
    Prevention and Early Intervention Program for Psychoses, PEPP Montreal, Douglas Mental Health University Institute, Montreal, Quebec, Canada
    BMC Psychiatry 12:224. 2012
    ..We also contrasted those definitions to the Proxy for the Deficit Syndrome (PDS) to identify deficit syndrome (DS) in the same FEP cohort...
  18. doi request reprint Family-based association study of ADHD and genes increasing the risk for smoking behaviours
    Geeta A Thakur
    Douglas Mental Health University Institute, 6875 LaSalle Blvd, Montreal, Quebec, Canada
    Arch Dis Child 97:1027-33. 2012
    ....
  19. doi request reprint LPHN3 and attention-deficit/hyperactivity disorder: interaction with maternal stress during pregnancy
    Zia Choudhry
    Douglas Mental Health University Institute, McGill University, Verdun, QC, Canada
    J Child Psychol Psychiatry 53:892-902. 2012
    ..Recently, a significant association was reported between ADHD and LPHN3 (which codes for latrophilin 3), and replicated in independent samples...
  20. doi request reprint Functional magnetic resonance imaging correlates of memory encoding in relation to achieving remission in first-episode schizophrenia
    Michael Bodnar
    Douglas Mental Health University Institute, Frank B Common Pavilion, 6875 LaSalle Blvd, Verdun, Quebec H4H 1R3, Canada
    Br J Psychiatry 200:300-7. 2012
    ..Previous studies in schizophrenia have shown a strong relationship between memory deficits and a poor clinical outcome. However, no previous study has identified the functional neural correlates of memory encoding in relation to remission...
  21. doi request reprint Prevalence of psychotic and non-psychotic disorders in relatives of patients with a first episode psychosis
    Kia Faridi
    Prevention and Early Intervention Program for Psychosis, Montreal, Quebec, Canada
    Schizophr Res 114:57-63. 2009
    ..However, few studies have examined familial psychopathology in probands with a first episode of psychosis (FEP). We systematically evaluated family history in patients experiencing an affective or non-affective FEP...
  22. pmc Direct measure of the de novo mutation rate in autism and schizophrenia cohorts
    Philip Awadalla
    Department of Pediatrics, Universite de Montreal, Quebec, Canada
    Am J Hum Genet 87:316-24. 2010
    ..Our results emphasize the importance of DNMs as genetic mechanisms in ASD and SCZ and the limitations of using DNA from archived cell lines to identify functional variants...
  23. ncbi request reprint Dissocial behavior, the 5HTTLPR polymorphism, and maltreatment in women with bulimic syndromes
    Howard Steiger
    Eating Disorders Program, Douglas Institute, Montreal, Quebec, Canada
    Am J Med Genet B Neuropsychiatr Genet 147:128-30. 2008
    ..c) 2007 Wiley-Liss, Inc...
  24. doi request reprint Cortical thickness is associated with poor insight in first-episode psychosis
    Lisa Buchy
    Brain Imaging Group, Douglas Mental Health University Institute, 6875 LaSalle Blvd, Verdun, Quebec, Canada H4H 1R3
    J Psychiatr Res 45:781-7. 2011
    ....
  25. doi request reprint Methylation of BDNF in women with bulimic eating syndromes: associations with childhood abuse and borderline personality disorder
    Lea Thaler
    Eating Disorders Program, Douglas University Institute, Montreal, Quebec, Canada Psychiatry Department, McGill University, Montreal, Quebec, Canada Research Centre, Douglas University Institute, Montreal, Quebec, Canada
    Prog Neuropsychopharmacol Biol Psychiatry 54:43-9. 2014
    ..These findings imply that hypermethylation of the BDNF gene may be related to eating disorder status, developmental stress exposure, and comorbid psychopathology. ..
  26. doi request reprint Blunted cortisol awakening response in men with first episode psychosis: relationship to parental bonding
    Marita Pruessner
    Prevention and Early Intervention Program for Psychosis, Douglas Mental Health University Institute, Department of Psychiatry, McGill University, Montreal, Quebec, Canada
    Psychoneuroendocrinology 38:229-40. 2013
    ..Dysregulation of the HPA axis in male patients might be a consequence of non-optimal parenting and contribute to the less favorable course of psychosis in men compared to women...
  27. doi request reprint Impairment in verbal memory observed in first episode psychosis patients with persistent negative symptoms
    Cindy L Hovington
    Prevention and Early Intervention Program for Psychoses, Douglas Mental Health University Institute, Montreal, Quebec, Canada
    Schizophr Res 147:223-9. 2013
    ..All three-memory domains remained stable over time. Hence, in comparison to non-PNS patients, FEP patients with PNS appear to have greater (selective) verbal memory impairments throughout the first year of treatment...
  28. pmc Investigation of rare variants in LRP1, KPNA1, ALS2CL and ZNF480 genes in schizophrenia patients reflects genetic heterogeneity of the disease
    Loubna Jouan
    Center of Excellence in Neuroscience of Université de Montréal and the Department of Medicine, Montreal, Quebec, Canada
    Behav Brain Funct 9:9. 2013
    ..Recent reports based on exome sequencing analyses have highlighted a significant increase of potentially deleterious de novo mutations in different genes in individuals with schizophrenia...
  29. doi request reprint Cognitive markers of short-term clinical outcome in first-episode psychosis
    Michael Bodnar
    Douglas Mental Health University Institute, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada
    Br J Psychiatry 193:297-304. 2008
    ..Symptomatic ratings at 1 or more years following initiation of treatment have been related to cognition in first-episode psychosis. However, the relationship between cognition and early outcome remains unclear...
  30. doi request reprint Contributions of the glucocorticoid receptor polymorphism (Bcl1) and childhood abuse to risk of bulimia nervosa
    Howard Steiger
    Eating Disorders Program, Douglas University Institute, Montreal, Quebec, Canada
    Psychiatry Res 187:193-7. 2011
    ..We interpret our findings as indicating that traumatic stress, when impacting individuals disposed to lower GR modulation, can be etiological for BN...
  31. doi request reprint The parahippocampal gyrus as a neural marker of early remission in first-episode psychosis: a voxel-based morphometry study
    Michael Bodnar
    Brain Imaging Group, Douglas Mental Health University Institute, Frank B Common Pavilion, Montreal, Quebec, Canada
    Clin Schizophr Relat Psychoses 4:217-28. 2011
    ..No previous study has examined neuroimaging markers in relation to early remission...
  32. ncbi request reprint Intrafamilial correspondences on platelet [3H-]paroxetine-binding indices in bulimic probands and their unaffected first-degree relatives
    Howard Steiger
    Eating Disorders Program, Douglas Hospital, Montreal, QC, Canada
    Neuropsychopharmacology 31:1785-92. 2006
    ..We propose that, under conducive circumstances, such a trait may increase risk of binge-eating behavior, or associated symptoms of affective or behavioral dysregulation...
  33. ncbi request reprint Identification of informative strains and provisional QTL mapping of amphetamine (AMPH)-induced locomotion in recombinant congenic strains (RCS) of mice
    Adam Torkamanzehi
    Douglas Hospital Research Centre, and Department of Psychiatry, McGill University, Montreal, Quebec, Canada
    Behav Genet 36:903-13. 2006
    ....
  34. doi request reprint Intranasal oxytocin and salivary cortisol concentrations during social rejection in university students
    Anne Marie Linnen
    Centre for Research in Human Development, Concordia University, Montreal, Quebec, Canada
    Stress 15:393-402. 2012
    ..2002). Intranasal oxytocin, however, appeared to reduce cortisol concentrations during an interpersonal challenge...
  35. doi request reprint Association between schizophrenia and genetic variation in DCC: a case-control study
    Alanna Grant
    Integrated Program in Neuroscience, McGill University, Douglas Mental Health University Institute, 6875 LaSalle Boulevard, Montreal, Quebec, Canada
    Schizophr Res 137:26-31. 2012
    ..These results, together with our previous findings from studies in rodents, point at DCC as a promising novel candidate gene that may contribute to the genetic basis behind individual differences in susceptibility to schizophrenia...
  36. doi request reprint Case manager- and patient-rated alliance as a predictor of medication adherence in first-episode psychosis
    Tina C Montreuil
    Prevention and Early Intervention Program for Psychoses PEPP Montréal, Douglas Mental Health University Institute, Montreal, Quebec, Canada
    J Clin Psychopharmacol 32:465-9. 2012
    ....
  37. doi request reprint Acute and long-term associations between ApoE genetic polymorphism, cortisol levels, and declarative memory performance in older adults
    Alexandra J Fiocco
    Douglas Hospital Research Center, Montreal Verdun, Quebec, Canada H4H 1R3
    Psychoneuroendocrinology 33:625-33. 2008
    ..To date, only one study has reported a relationship between APOE status and cortisol levels, however the relationship was only found to be significant in dementia patients, with a trend observed in healthy controls...
  38. ncbi request reprint Neuropsychological impairments in neuroleptic-responder vs. -nonresponder schizophrenic patients and healthy volunteers
    Ridha Joober
    Douglas Hospital Research Center, McGill University, Que, H3A 1A1, Montreal, Canada
    Schizophr Res 53:229-38. 2002
    ....
  39. doi request reprint Medication adherence mediates the impact of sustained cannabis use on symptom levels in first-episode psychosis
    Kia Faridi
    Prevention and Early Intervention Program for Psychosis, Montreal, Quebec, Canada
    Schizophr Res 141:78-82. 2012
    ....
  40. doi request reprint A 12-month outcome study of insight and symptom change in first-episode psychosis
    Lisa Buchy
    Brain Imaging Group, Douglas Mental Health University Institute, Verdun, Quebec, Canada
    Early Interv Psychiatry 4:79-88. 2010
    ..Secondly, in an exploratory analysis, we aimed to identify quantitatively distinct insight trajectory groups, and to describe the impact of psychopathology over time on the different trajectory groups...
  41. doi request reprint Increased exonic de novo mutation rate in individuals with schizophrenia
    Simon L Girard
    Centre of Excellence in Neuromics of Université de Montréal, Centre Hospitalier de L Universite de Montreal Research Center, Montreal, Quebec, Canada
    Nat Genet 43:860-3. 2011
    ..Our study supports the notion that DNMs may account for some of the heritability reported for schizophrenia while providing a list of genes possibly involved in disease pathogenesis...
  42. ncbi request reprint Association of the promoter polymorphism -1438G/A of the 5-HT2A receptor gene with behavioral impulsiveness and serotonin function in women with bulimia nervosa
    Kenneth R Bruce
    Eating Disorders Program, Research Centre, Douglas Hospital, Department of Psychiatry, McGill University, 6875 LaSalle Boulevard, Montreal, Quebec H4H 1R3, Canada
    Am J Med Genet B Neuropsychiatr Genet 137:40-4. 2005
    ..These findings implicate the GG genotype in the co-aggregation of impulsive behaviors and alterations of post-synaptic 5-HT functioning in women with BN...
  43. doi request reprint Stress and protective factors in individuals at ultra-high risk for psychosis, first episode psychosis and healthy controls
    Marita Pruessner
    Prevention and Early Intervention Program for Psychoses PEPP Montréal, Douglas Mental Health University Institute, McGill University, Montreal, Quebec, Canada
    Schizophr Res 129:29-35. 2011
    ..The results suggest that psychosocial interventions targeted at reducing stress levels and improving resilience in this population may be beneficial in improving outcomes...
  44. ncbi request reprint Medication-adherent first-episode psychosis patients also relapse: why?
    Emmanuelle Levy
    Department of Psychiatry, McGill University, Montreal, Quebec, Canada
    Can J Psychiatry 57:78-84. 2012
    ..However, medication-adherent patients also relapse. We examined what factors influence the risk of relapse after controlling for adherence...
  45. doi request reprint The acute effects of intranasal oxytocin on automatic and effortful attentional shifting to emotional faces
    Mark A Ellenbogen
    Centre for Research in Human Development, Department of Psychology, Concordia University, Montreal, Quebec, Canada
    Psychophysiology 49:128-37. 2012
    ..Oxytocin's influence on social behavior may occur, in part, by eliciting flexible attentional shifting in the early stages of information processing...
  46. doi request reprint Childhood symptoms of inattention-hyperactivity predict cannabis use in first episode psychosis
    Clifford M Cassidy
    Department of Psychiatry, McGill University, Montreal, Quebec, Canada
    Schizophr Res 132:171-6. 2011
    ..In the general population childhood ADHD predicts future cannabis use but the relationship has not been tested in FEP...
  47. doi request reprint A comparison study of multiple measures of adherence to antipsychotic medication in first-episode psychosis
    Clifford M Cassidy
    Department of Psychiatry, McGill University, Montreal, Quebec, Canada
    J Clin Psychopharmacol 30:64-7. 2010
    ..05). Patient or clinician reports provide a reasonable estimate of medication adherence in FEP, but introducing pill counting or a derived measure of adherence may allow more accurate measurement...
  48. ncbi request reprint Physical activity experiences of boys with and without ADHD
    William J Harvey
    Department of Kinesiology and Physical Education, McGill University, Montreal, Quebec, Canada
    Adapt Phys Activ Q 26:131-50. 2009
    ..Task-specific interventions and a wider range of mixed methods research are recommended for future research studies in ADHD...
  49. doi request reprint Disrupted integrity of the fornix in first-episode schizophrenia
    David Luck
    Brain Imaging Group, Douglas Mental Health University Institute, Verdun, Canada
    Schizophr Res 119:61-4. 2010
    ..No significant correlations were found between FA values and clinical and sociodemographic data in FES patients. These findings revealed slight alterations along the fornix in early stage of schizophrenia...
  50. pmc The brain-derived neurotrophic factor Val66Met polymorphism is associated with reduced functional magnetic resonance imaging activity in the hippocampus and increased use of caudate nucleus-dependent strategies in a human virtual navigation task
    Harrison Banner
    Department of Psychiatry, Faculty of Medicine, McGill University, Douglas Mental Health University Institute, FBC Building, 6875 Boul LaSalle, Verdun, QC H4H 1R3, Canada
    Eur J Neurosci 33:968-77. 2011
    ..Our results support the idea that the BDNF gene with the Val66Met polymorphism is a novel candidate gene involved in determining spontaneous strategies during navigation behaviour...
  51. ncbi request reprint Selective abnormal modulation of hippocampal activity during memory formation in first-episode psychosis
    Amelie M Achim
    Brain Imaging Group, Douglas Hospital Research Centre FBC1, 6875 Boul LaSalle, Verdun, QC H4H 1R3, Canada
    Arch Gen Psychiatry 64:999-1014. 2007
    ..Memory is one of the cognitive functions most affected in schizophrenia, with deficits observed from the first episode of psychosis (FEP). Previous studies have indicated that some memory processes may be more affected than others...
  52. ncbi request reprint COMT Val108/158Met gene variant, birth weight, and conduct disorder in children with ADHD
    Sarojini M Sengupta
    Department of Human Genetics, McGill University, and Douglas Hospital Research Centre, Montreal, Quebec, Canada
    J Am Acad Child Adolesc Psychiatry 45:1363-9. 2006
    ..We have attempted to replicate these findings in a group of ADHD children using a similar research design...
  53. doi request reprint A five-year randomized parallel and blinded clinical trial of an extended specialized early intervention vs. regular care in the early phase of psychotic disorders: study protocol
    Danyael Lutgens
    Department of Psychiatry, McGill University Prevention and Early Intervention Program for the Psychoses, Douglas Mental Health University Institute, Montreal, Quebec, Canada
    BMC Psychiatry 15:404. 2015
    ....
  54. pmc Reduced hippocampal volume and hypothalamus-pituitary-adrenal axis function in first episode psychosis: evidence for sex differences
    Marita Pruessner
    Department of Psychiatry, Prevention and Early Intervention Program for Psychosis, Douglas Mental Health University Institute, McGill University, Montreal, Quebec, Canada
    Neuroimage Clin 7:195-202. 2015
    ....
  55. doi request reprint A controlled evaluation of a targeted early case detection intervention for reducing delay in treatment of first episode psychosis
    Ashok Malla
    McGill University, Douglas Mental Health University Institute, Prevention and Early Intervention Program for Psychoses Montreal, 6875 Boul LaSalle, Verdun, QC, H4H 1R2, Canada
    Soc Psychiatry Psychiatr Epidemiol 49:1711-8. 2014
    ..The purpose of this study was to reduce delay in referral to an early intervention service following first contact for help seeking for psychosis in a defined urban catchment area...
  56. doi request reprint Concerns reported by family members of individuals with first-episode psychosis
    Srividya N Iyer
    Department of Psychiatry, McGill University, Douglas Mental Health University Institute, Montreal, Quebec, Canada
    Early Interv Psychiatry 5:163-7. 2011
    ..Our aim was to examine the concerns reported by family members and other caregivers of individuals with first-episode psychosis (FEP)...
  57. doi request reprint Sex differences in the cortisol response to awakening in recent onset psychosis
    Marita Pruessner
    Prevention and Early Intervention Program for Psychosis, Douglas Mental Health University Institute, McGill University, Montreal, Quebec, Canada
    Psychoneuroendocrinology 33:1151-4. 2008
    ..Our findings demonstrate a dysregulation of the HPA axis in male patients with recent onset of psychosis. This sex specificity might be related to and explain in part the unfavorable course of the illness observed in men...
  58. ncbi request reprint CAA insertion polymorphism in the 3'UTR of Nogo gene on 2p14 is not associated with schizophrenia
    Lan Xiong
    Department of Psychiatry, Douglas Hospital Research Centre, 6875 Boulevard LaSalle, FBC Pavillion, Verdun, Quebec, Canada H4H1R3
    Brain Res Mol Brain Res 133:153-6. 2005
    ..0% vs. 15.0%, chi2=0.985, p>0.1). Furthermore, neither CAAins/TATCdel individually, nor the haplotype carrying both CAAins and TATCdel is preferentially transmitted to affected offspring...
  59. ncbi request reprint P300 asymmetry and positive symptom severity: a study in the early stage of a first episode of psychosis
    Louis Renoult
    Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada
    Schizophr Res 93:366-73. 2007
    ..Relative to normal control subjects, no P300 asymmetry was found in patients. Nevertheless, P300 asymmetry was correlated with the severity of positive symptoms and worse global functioning (GAF), a good predictor of poor outcome...
  60. doi request reprint The effects of glucocorticoids on the inhibition of emotional information: A dose-response study
    Véronique A Taylor
    Centre for Research in Experimental Neuropsychology and Cognition, Department of Psychology, Universite de Montreal, Quebec, Canada
    Biol Psychol 86:17-25. 2011
    ....
  61. pmc Efficacy of methylphenidate in children with attention-deficit hyperactivity disorder and learning disabilities: a randomized crossover trial
    Natalie Grizenko
    Department of Psychiatry, McGill University and Division of Child and Adolescent Psychiatry, Douglas Hospital, Montreal, Que
    J Psychiatry Neurosci 31:46-51. 2006
    ..To determine whether children with attention-deficit hyperactivity disorder (ADHD) and learning disabilities respond differently to methylphenidate (MPH) compared with children with ADHD only...
  62. doi request reprint Is there an association between neurocognitive performance and medication adherence in first episode psychosis?
    Martin Lepage
    Douglas Mental Health University Institute and Department of Psychiatry, McGill University, Montreal, Canada
    Early Interv Psychiatry 4:189-95. 2010
    ..We examined early medication adherence following admission to a specialized clinical programme for FEP...
  63. doi request reprint Behavioral response to methylphenidate challenge: influence of early life parental care
    Veronika Engert
    Douglas Mental Health University Institute, Department of Psychiatry, McGill University, Montreal, Quebec, Canada H4H 1R3
    Dev Psychobiol 51:408-16. 2009
    ..Activity measures in response to reward and MPH were uninfluenced by parental care. This is the first human study to reveal that the behavioral MPH response interacts with early life parental care experience...
  64. doi request reprint Is the inattentive subtype of ADHD different from the combined/hyperactive subtype?
    Natalie Grizenko
    McGill University
    J Atten Disord 13:649-57. 2010
    ..To compare the ADHD combined/hyperactive subtype (ADHD/CH) to the ADHD inattentive subtype (ADHD/I) on the level of comorbidity, treatment response, and possible etiological factors...
  65. doi request reprint Neural markers of remission in first-episode schizophrenia: a volumetric neuroimaging study of the hippocampus and amygdala
    Michael Bodnar
    Brain Imaging Group, Douglas Mental Health University Institute, Montreal, Canada
    Schizophr Res 122:72-80. 2010
    ..However, volumetric differences (namely, in the hippocampus) exhibit an ambiguous relationship with long-term outcome. So, we examined the relationship between hippocampus and amygdala volumes and early remission status...
  66. pmc Association study of the trinucleotide repeat polymorphism within SMARCA2 and schizophrenia
    Sarojini Sengupta
    Department of Human Genetics, McGill University, Montreal, Canada
    BMC Genet 7:34. 2006
    ....
  67. ncbi request reprint Sleep and COMT polymorphism in ADHD children: preliminary actigraphic data
    Reut Gruber
    Douglas Hospital Research Centre and McGill University, Montreal
    J Am Acad Child Adolesc Psychiatry 45:982-9. 2006
    ..To examine whether COMT (catechol-O-methyltransferase) polymorphism modulates aspects of sleep in children diagnosed with attention-deficit/hyperactivity disorder (ADHD)...
  68. ncbi request reprint Dopamine transporter 3'-UTR VNTR genotype and ADHD: a pharmaco-behavioural genetic study with methylphenidate
    Ridha Joober
    Department of Psychiatry, McGill University and Douglas Hospital Research Centre, Montreal, QC, Canada
    Neuropsychopharmacology 32:1370-6. 2007
    ..They also suggest the presence of genetic heterogeneity that could be indexed by the quality of behavioral response to MPH...
  69. ncbi request reprint Fundamental movement skills and children with attention-deficit hyperactivity disorder: peer comparisons and stimulant effects
    William J Harvey
    Department of Kinesiology and Physical Education, McGill University, 475 Pine Avenue West, Montreal, QC, Canada
    J Abnorm Child Psychol 35:871-82. 2007
    ..It is concluded that children with ADHD may be at risk for developmental delays in movement skill performance. Potential factors underlying the movement skill difficulties are discussed, with suggestions for future research...
  70. pmc Performance on the continuous performance test in children with ADHD is associated with sleep efficiency
    Reut Gruber
    Douglas Mental Health University Institute and McGill University, Montreal, Canada
    Sleep 30:1003-9. 2007
    ..To examine whether the level of sleep efficiency of children diagnosed with ADHD moderates their performance on the Continuous Performance Test (CPT) while receiving a placebo and while receiving methylphenidate (MPH)...
  71. ncbi request reprint Determinants of help-seeking and system related components of delay in the treatment of first-episode psychosis
    Laura Bechard-Evans
    McGill University, PEPP Montreal, Douglas Hospital Research Centre, 6875 LaSalle Boulevard, Montreal, Quebec, Canada H4H 1R3
    Schizophr Res 96:206-14. 2007
    ..Knowledge about factors that influence different components of duration of untreated psychosis (DUP) is important for designing interventions to reduce DUP...
  72. ncbi request reprint Molecular cloning and characterization of human RAI1, a gene associated with schizophrenia
    André Toulouse
    Centre for Research in Neuroscience, McGill University and the McGill University Health Centre Research Institute, 1650 Cedar Avenue, Montreal, Quebec, Canada H3G 1A4
    Genomics 82:162-71. 2003
    ..This gene, located on chromosome 17p11.2, comprises six exons coding for a 7.6-kb mRNA. The RAI1 gene is highly homologous to its mouse counterpart and it is expressed at high levels mainly in neuronal tissues...
  73. ncbi request reprint First-episode psychosis, early intervention, and outcome: what have we learned?
    Ashok K Malla
    Department of Psychiatry, McGill University, Montreal, Quebec
    Can J Psychiatry 50:881-91. 2005
    ..This study's objective was to examine the concept of early intervention and the evidence that currently exists to support such a shift in the delivery of care...
  74. ncbi request reprint Serotonin-system polymorphisms (5-HTTLPR and -1438G/A) and responses of patients with bulimic syndromes to multimodal treatments
    Howard Steiger
    Eating Disorders Program, Douglas Mental Health University Institute, 6875 LaSalle Blvd, Montreal, Quebec, Canada H4H 1R3
    J Clin Psychiatry 69:1565-71. 2008
    ....
  75. pmc Dopamine transporter 3'UTR VNTR genotype is a marker of performance on executive function tasks in children with ADHD
    Sherif Karama
    Department of Psychiatry, McGill University, Montreal, Canada
    BMC Psychiatry 8:45. 2008
    ..Executive function deficits are considered among the most important pathogenic pathways leading to ADHD and may index part of the heterogeneity in this disorder...
  76. pmc Relation of maternal stress during pregnancy to symptom severity and response to treatment in children with ADHD
    Natalie Grizenko
    Department of Psychiatry, McGill University, Montreal, Canada
    J Psychiatry Neurosci 33:10-6. 2008
    ..A second objective was to examine whether there is an association between maternal stress and children's response to methylphenidate (MPH)...
  77. pmc Genetics of schizophrenia: from animal models to clinical studies
    Ridha Joober
    Departments of Psychiatry and of Neurology and Neurosurgery, McGill University and Douglas Hospital Research Centre, Montreal, Que
    J Psychiatry Neurosci 27:336-47. 2002
    ....
  78. doi request reprint Cognitive insight and verbal memory in first episode of psychosis
    Martin Lepage
    Douglas Mental Health University Institute and Department of Psychiatry, McGill University, 6875 LaSalle Boulevard, Verdun Quebec, H4H 1R3 Canada
    Eur Psychiatry 23:368-74. 2008
    ..These results suggest that cognitive insight, but not clinical insight, may rely on memory processes whereby current experiences are appraised based on previous ones...
  79. doi request reprint Intranasal oxytocin attenuates the human acoustic startle response independent of emotional modulation
    Mark A Ellenbogen
    Centre for Research in Human Development, Concordia University, Montreal, Quebec, Canada
    Psychophysiology 51:1169-77. 2014
    ..The dampening effect of oxytocin on EMG startle could possibly be used as an inexpensive marker of oxytocin's effect on limbic brain circuits...
  80. ncbi request reprint Maternal exposure to bacterial endotoxin during pregnancy enhances amphetamine-induced locomotion and startle responses in adult rat offspring
    Marie Eve Fortier
    Department of Psychiatry and Neurology, McGill University, Douglas Hospital Research Centre, 6875 LaSalle Boulevard, Verdun, Quebec, Canada H4H 1R3
    J Psychiatr Res 38:335-45. 2004
    ..It is concluded that maternal LPS exposure during pregnancy in the rat may be a useful model to study mechanisms responsible for effects of maternal infection on behaviors relevant to schizophrenia, in offspring...
  81. ncbi request reprint Comparing the clinical presentation of first-episode psychosis across different migrant and ethnic minority groups in Montreal, Quebec
    Elsje van der Ven
    Prevention and Early Intervention Program for Psychoses, Douglas Mental Health University Institute, Montreal, Quebec, Canada
    Can J Psychiatry 57:300-8. 2012
    ..To explore differences in severity and nature of symptoms of first-episode psychosis (FEP) according to ethnic group and migrant status...
  82. ncbi request reprint Relationship between response to methylphenidate treatment in children with ADHD and psychopathology in their families
    Natalie Grizenko
    McGill University and Douglas Hospital, Montreal, Quebec, Canada
    J Am Acad Child Adolesc Psychiatry 45:47-53. 2006
    ..To compare the pattern of familial aggregation of psychopathology in children who are good responders (GR) to methylphenidate (MPH) versus those who are poor responders (PR)...
  83. doi request reprint Effectiveness of a therapeutic summer camp for children with ADHD: Phase I Clinical Intervention Trial
    Julie Hantson
    McGill University, Montreal, Quebec, Canada
    J Atten Disord 16:610-7. 2012
    ..This was an open-label, nonrandomized Phase I Clinical Intervention Trial...
  84. doi request reprint Development and persistence of posttraumatic stress disorder and the 5-HTTLPR polymorphism
    Geeta A Thakur
    Douglas Mental Health University Institute and Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada
    J Trauma Stress 22:240-3. 2009
    ..8 (95% CI = 1.09-21.22). Contrary to previous findings, these data are suggestive of a protective role for the s allele of 5-HTTLPR in chronic PTSD...
  85. ncbi request reprint Provisional mapping of quantitative trait loci modulating the acoustic startle response and prepulse inhibition of acoustic startle
    Ridha Joober
    Department of Psychiatry and of Neurology and Neurosurgery, Montreal, Quebec, Canada
    Neuropsychopharmacology 27:765-81. 2002
    ..If confirmed, these QTLs may suggest candidate genes directing novel mechanisms for regulation of PPI..
  86. ncbi request reprint Effects of clozapine on behavioral and metabolic traits relevant for schizophrenia in two mouse strains
    Jean Mary Zarate
    Department of Neurology and Neurosurgery, McGill University and Douglas Hospital Research Centre, H4H 1R3, Montreal, Quebec, Canada
    Psychopharmacology (Berl) 171:162-72. 2004
    ..In particular, patients with schizophrenia exhibit important variability in their therapeutic and metabolic responses to clozapine, an antipsychotic medication...
  87. doi request reprint Reading impairments in schizophrenia relate to individual differences in phonological processing and oculomotor control: evidence from a gaze-contingent moving window paradigm
    Veronica Whitford
    Centre for Research on Brain, Language and Music, McGill University, Montreal, Quebec, Canada
    J Exp Psychol Gen 142:57-75. 2013
    ..Given that both language and oculomotor dysfunction precede illness onset, reading may provide a sensitive window onto cognitive dysfunction in schizophrenia vulnerability and be an important target for cognitive remediation...
  88. pmc Understanding putative risk factors for schizophrenia: retrospective and prospective studies
    Suzanne King
    Douglas Hospital Research Centre, Borough of Verdun, Montreal, Quebec, Canada
    J Psychiatry Neurosci 30:342-8. 2005
    ..The combination of retrospective and prospective studies is a rich source of triangulated results providing information about developmental psychopathology...
  89. ncbi request reprint The 5HTTLPR polymorphism, psychopathologic symptoms, and platelet [3H-] paroxetine binding in bulimic syndromes
    Howard Steiger
    Eating Disorders Program, Douglas Hospital, Montreal, Quebec, Canada
    Int J Eat Disord 37:57-60. 2005
    ....
  90. pmc Catechol-O-methyltransferase (COMT) Val108/158 Met polymorphism does not modulate executive function in children with ADHD
    Evan Taerk
    Department of Psychiatry, McGill University and Douglas Hospital Research Centre, Montreal, Quebec, H4H 1R3, Canada
    BMC Med Genet 5:30. 2004
    ....
  91. pmc Genetics of developmental psychiatric disorders: pathways to discovery
    Ridha Joober
    Douglas Hospital Research Centre, Borough of Verdun, and Department of Psychiatry, McGill University, Montreal, Quebec, Canada
    J Psychiatry Neurosci 30:349-54. 2005
    ..We also consider the implications of psychiatric genetic research for individual and public health...
  92. doi request reprint De novo truncating mutation in Kinesin 17 associated with schizophrenia
    Julien Tarabeux
    Department of Medicine, Center of Excellence in Neuromics of Université de Montréal, Centre Hospitalier de L Universite de Montreal Research Center, University of Montreal, Montreal, Quebec, Canada
    Biol Psychiatry 68:649-56. 2010
    ..The gene encoding the synaptic motor protein kinesin 17 (KIF17) involved in glutamatergic synapse is a candidate gene for SCZ...
  93. ncbi request reprint Education modulates cortisol reactivity to the Trier Social Stress Test in middle-aged adults
    Alexandra J Fiocco
    Centre for Studies on Human Stress, Douglas Hospital Research Centre, Verdun, Montreal, Quebec, Canada H4H 1R3
    Psychoneuroendocrinology 32:1158-63. 2007
    ....
  94. ncbi request reprint Declarative memory after stress in humans: differential involvement of the beta-adrenergic and corticosteroid systems
    Francoise S Maheu
    Laboratory of Human Stress Research, Douglas Hospital Research Centre, Frank B Common Building, 6875 LaSalle Boulevard, Verdun, Quebec H4H 1R3, Canada
    J Clin Endocrinol Metab 90:1697-704. 2005
    ..These results suggest that, contrary to the beta-adrenergic system, the corticosteroid system is implicated in declarative memory function after stress in humans...
  95. ncbi request reprint Association between 7q31 markers and Tourette syndrome
    Adriana Díaz-Anzaldúa
    Research Institute, McGill University Health Centre, 1650 Cedar Avenue, Montreal, Quebec H3G 1A4, Canada
    Am J Med Genet A 127:17-20. 2004
    ..87, 21 df, P = 0.048). These results may reflect the proximity of markers D7S522, D7S523, and possibly D7S1516 to a gene or regulatory region relevant to TS predisposition...
  96. ncbi request reprint Serotonin transporter, stressful life events, and depression severity
    Ridha Joober
    Am J Psychiatry 164:829-30; author reply 830-1. 2007
  97. pmc Sitting on the edge: when to treat symptoms of inattention without the full DSM-IV criteria of ADHD
    Ridha Joober
    Douglas Mental Health University Institute, Department of Psychiatry, McGill University, Montreal, Que
    J Psychiatry Neurosci 32:447. 2007
  98. ncbi request reprint Mutation screening of FOXP2 in individuals diagnosed with autistic disorder
    Julie Gauthier
    Research Institute of the McGill University Health Center, 1650 Cedar Ave, Montreal, Canada
    Am J Med Genet A 118:172-5. 2003
    ..Using an intra-family association design, we identified no transmission disequilibrium in any of the four identified alleles, suggesting that the FOXP2 gene does not play a significant role in AD...
  99. ncbi request reprint Dopamine beta-hydroxylase (DBH) gene and schizophrenia phenotypic variability: a genetic association study
    Kenji Yamamoto
    Douglas Hospital Research Centre 6875 Boulevard LaSalle, Verdun H4H 1R3, Canada
    Am J Med Genet B Neuropsychiatr Genet 117:33-8. 2003
    ..These results suggest that the DBH gene is not a causative factor in schizophrenia but that it may be a modulator of psychotic symptoms, severity of the disorder and therapeutic response to neuroleptic drugs...
  100. ncbi request reprint Validation of the English and French versions of the Community Assessment of Psychic Experiences (CAPE) with a Montreal community sample
    Karene Brenner
    Department of Psychology, University of Montreal, Canada
    Schizophr Res 95:86-95. 2007
    ..We analyzed the internal consistency of the CAPE to determine whether the 3-factor structure (positive, negative and depressive symptoms) found by the CAPE authors would also be found in our sample...
  101. doi request reprint Are metabolic indices different between drug-naïve first-episode psychosis patients and healthy controls?
    Sarojini Sengupta
    Douglas Mental Health University Institute, Louis H Lafontaine Hospital, Montreal, Canada
    Schizophr Res 102:329-36. 2008
    ..To compare glucose and lipid metabolism parameters between drug-naïve first-episode psychosis (FEP) patients with a diagnosis of schizophrenia spectrum disorder and healthy controls matched for age, ethnicity, and gender...