Research Topics
Species | R JooberSummaryAffiliation: McGill University Country: Canada Publications
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Detail Information
Publications
DRD3 and DAT1 genes in schizophrenia: an association studyR Joober
Douglas Hospital Research Centre, 6875 Boulevard LaSalle, H4H 1R3, Verdun, Canada
J Psychiatr Res 34:285-91. 2000..To investigate the role of the dopamine receptor 3 (DRD3) and transporter 1 (DAT1) genes in schizophrenia or in modulating its phenotype...- Lack of association between the hSKCa3 channel gene CAG polymorphism and schizophreniaR Joober
Montreal General Hospital Research Institute, Department of Psychiatry, McGill University, Quebec, Canada
Am J Med Genet 88:154-7. 1999..In addition, hSKCa3 was mapped to chromosome 1. Our results do not support the involvement of this particular CAG repeat-containing gene in schizophrenia... 
T102C polymorphism in the 5HT2A gene and schizophrenia: relation to phenotype and drug response variabilityR Joober
Montreal General Hospital Research Institute, Douglas Hospital Research Centre, Verdun QC
J Psychiatry Neurosci 24:141-6. 1999..These result suggest that the 5HT2A-receptor gene may play a role in a subset of schizophrenia characterized by poor long-term outcome and poor response to neuroleptics...- Association between the methylenetetrahydrofolate reductase 677C-->T missense mutation and schizophreniaR Joober
Centre for Research in Neuroscience, Montreal General Hospital Research Institute, 1650 Cedar Avenue, Montreal H3G 1A4, Canada
Mol Psychiatry 5:323-6. 2000.... - Polyglutamine coding genes in bipolar disorder: lack of association with selected candidate lociG Turecki
Centre for Research in Neuroscience, The Montreal General Hospital, McGill University, 1650 Cedar Ave, Montreal, Canada
J Affect Disord 58:63-8. 2000..Results obtained with the repeat expansion detection technique (RED) have indicated that bipolar patients have an excess of expanded CAG repeats. However, it is not clear which loci account for this difference... - MAOA: association and linkage studies with lithium responsive bipolar disorderG Turecki
Centre for Research in Neuroscience, Montreal General Hospital, McGill University, Canada
Psychiatr Genet 9:13-6. 1999..The investigation used 138 patients and 108 normal controls. In addition, 25 families were also studied. Our results were not supportive of a major role of MAOA in the predisposition to bipolar disorder... - Prediction of level of serotonin 2A receptor binding by serotonin receptor 2A genetic variation in postmortem brain samples from subjects who did or did not commit suicideG Turecki
Centre for Research in Neuroscience, Montreal General Hospital, McGill University, Canada
Am J Psychiatry 156:1456-8. 1999..However, there remains some controversy regarding the biological specificity of these findings. The authors hypothesized that the variance observed in brain 5-HTR2A binding is genetically mediated, at least in part... - Lithium responsive bipolar disorder, unilineality, and chromosome 18: A linkage studyG Turecki
Centre for Research in Neuroscience, The Montreal General Hospital, McGill University, Montreal, Canada
Am J Med Genet 88:411-5. 1999..In conclusion, our results are congruent with previous reports that suggest an advantage of unilineal pedigrees in linkage analysis of bipolar disorder and cannot rule out a parent-of-origin effect in this genomic region... - Toward a model of cognitive insight in first-episode psychosis: verbal memory and hippocampal structureL Buchy
Brain Imaging Group, Douglas Mental Health University Institute, Quebec, Canada
Schizophr Bull 36:1040-9. 2010..The HC may be a viable location among others for the brain system that underlies aspects of cognitive insight in individuals with an FEP... 
Early intervention in psychosis: specialized intervention and early case identificationA Malla
Douglas Mental Health University Institute, McGill University, Montreal, Quebec, Canada
Encephale 36:S38-45. 2010....- Lack of association between bipolar disorder and tyrosine hydroxylase: a meta-analysisG Turecki
Department of Neurology and Neuroscience, Centre for Research in Neuroscience, McGill University, Montreal, Canada
Am J Med Genet 74:348-52. 1997..02 (0.68-1.54). Test of the null hypothesis that the mean log odds ratio equals zero (chi2 = 0.11; 5 df; P > 0.05) indicated that there was no overall association between bipolar disorder and tyrosine hydroxylase... - Tourette syndrome and dopaminergic genes: a family-based association study in the French Canadian founder populationA Díaz-Anzaldúa
McGill University Health Centre, Montreal, Quebec, Canada
Mol Psychiatry 9:272-7. 2004..No associations were found for DRD2, DRD3 or SLC6A3. These data support the notion that DRD4 and MOA-A genes may confer an increased risk for developing TS in the French Canadian population... - Association and linkage studies of CRH and PENK genes in bipolar disorder: a collaborative IGSLI studyM Alda
Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada
Am J Med Genet 96:178-81. 2000..In conclusion, our study does not support the hypothesis that genes coding for CRH or PENK contribute to the genetic susceptibility to bipolar disorder. Am. J. Med. Genet. (Neuropsychiatr. Genet.) 96:178-181, 2000... - TPH and suicidal behavior: a study in suicide completersG Turecki
Douglas Hospital Research Institute, Department of Psychiatry, McGill University, Verdun, Quebec, Canada
Mol Psychiatry 6:98-102. 2001..These and other results continue to point to the substantial role that the gene that codes for TPH may play in the neurobiology of suicidal behavior... - Cortisol response to a psychosocial stressor in schizophrenia: blunted, delayed, or normal?K Brenner
University of Montreal, Department of Psychology, 2900 Edouard Montpetit Blvd, Montreal, Quebec, Canada
Psychoneuroendocrinology 34:859-68. 2009..Our objective was to determine the extent to which cortisol reaction can discriminate between controls and schizophrenia patients while controlling for symptom severity, personality, body mass index (BMI) and smoking... - Investigating cognitive deficits and symptomatology across pre-morbid adjustment patterns in first-episode psychosisL Bechard-Evans
Department of Psychiatry, McGill University, Montreal, Quebec, Canada
Psychol Med 40:749-59. 2010..In addition, consistent heterogeneity within these impairments remains unexplained. One potential source of variability may be the level of pre-morbid adjustment prior to the onset of first-episode psychosis (FEP)... - Drug induced weight gain, an impediment to successful pharmacotherapy: focus on antipsychoticsT Baptista
Department of Physiology, P O Box 93, Los Andes University Medical School, Merida, 5101 A, Venezuela
Curr Drug Targets 5:279-99. 2004..Notwithstanding this, novel strategies are necessary to treat this side effect in a clinical population particularly prone to poor compliance and under a high risk of negative drug interaction... - Autism spectrum disorders associated with X chromosome markers in French-Canadian malesJ Gauthier
Centre Hospitalier de l Universite de Montreal, Research Centre, Notre Dame Hospital, Montreal, QC, Canada
Mol Psychiatry 11:206-13. 2006..00001). These results provide support for the existence of a locus on the X chromosome that predisposes the FC to autism spectrum disorders... - LRRTM1 on chromosome 2p12 is a maternally suppressed gene that is associated paternally with handedness and schizophreniaC Francks
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
Mol Psychiatry 12:1129-39, 1057. 2007..LRRTM1 is a candidate gene for involvement in several common neurodevelopmental disorders, and may have played a role in human cognitive and behavioral evolution...