Barbara Jones

Summary

Affiliation: McGill University
Country: Canada

Publications

  1. ncbi Arousal systems
    Barbara E Jones
    Department of Neurology and Neurosurgery, McGill University, Montreal Neurological Institute, Montreal, Quebec, Canada H3A 2B4
    Front Biosci 8:s438-51. 2003
  2. ncbi Orexin and MCH neurons express c-Fos differently after sleep deprivation vs. recovery and bear different adrenergic receptors
    Mandana Modirrousta
    Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada H3A 2B4
    Eur J Neurosci 21:2807-16. 2005
  3. ncbi Dynamic changes in GABAA receptors on basal forebrain cholinergic neurons following sleep deprivation and recovery
    Mandana Modirrousta
    Department of Neurology and Neurosurgery, McGill University, Montreal Neurological Institute, Montreal, Quebec, Canada
    BMC Neurosci 8:15. 2007
  4. ncbi Glia, adenosine, and sleep
    Barbara E Jones
    Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, QC, H3A 2B4, Canada
    Neuron 61:156-7. 2009
  5. ncbi Paradoxical REM sleep promoting and permitting neuronal networks
    B E Jones
    Department of Neurology and Neurosurgery, McGill University, Montreal Neurological Institute, Montreal, Quebec H3A 2B4, Canada
    Arch Ital Biol 142:379-96. 2004
  6. ncbi From waking to sleeping: neuronal and chemical substrates
    Barbara E Jones
    Department of Neurology and Neurosurgery, McGill University, Montreal Neurological Institute, Montreal, Quebec H3A 2B4, Canada
    Trends Pharmacol Sci 26:578-86. 2005
  7. ncbi Activity, modulation and role of basal forebrain cholinergic neurons innervating the cerebral cortex
    Barbara E Jones
    Department of Neurology and Neurosurgery, McGill University, Montreal Neurological Institute, 3801 University Street, Montreal, QC H3A 2B4, Canada
    Prog Brain Res 145:157-69. 2004
  8. ncbi Modulation of cortical activation and behavioral arousal by cholinergic and orexinergic systems
    Barbara E Jones
    Department of Neurology and Neurosurgery, McGill University, Montreal Neurological Institute, 3801 University Street, Montreal, Quebec H3A2B4, Canada
    Ann N Y Acad Sci 1129:26-34. 2008
  9. ncbi Gabaergic neurons with alpha2-adrenergic receptors in basal forebrain and preoptic area express c-Fos during sleep
    M Modirrousta
    Montreal Neurological Institute, McGill University, 3801 University Street, Room 897, Montreal, Quebec, Canada H3A 2B4
    Neuroscience 129:803-10. 2004
  10. ncbi Suprachiasmatic modulation of noradrenaline release in the ventrolateral preoptic nucleus
    Benoît Saint Mleux
    Département de Neurosciences Fondamentales, Centre Medical Universitaire, 1211 Geneve 4, Switzerland
    J Neurosci 27:6412-6. 2007

Research Grants

  1. Role of Basal Forebrain Neurons in Sleep-Wake States
    Barbara Jones; Fiscal Year: 2007
  2. Role of Basal Forebrain Neurons in Sleep-Wake States
    Barbara Jones; Fiscal Year: 2005
  3. ROLE OF BASAL FOREBRAIN NEURONS IN SLEEP WAKE STATES
    Barbara Jones; Fiscal Year: 2002
  4. Role of Basal Forebrain Neurons in Sleep-Wake States
    Barbara E Jones; Fiscal Year: 2010

Collaborators

Detail Information

Publications26

  1. ncbi Arousal systems
    Barbara E Jones
    Department of Neurology and Neurosurgery, McGill University, Montreal Neurological Institute, Montreal, Quebec, Canada H3A 2B4
    Front Biosci 8:s438-51. 2003
    ....
  2. ncbi Orexin and MCH neurons express c-Fos differently after sleep deprivation vs. recovery and bear different adrenergic receptors
    Mandana Modirrousta
    Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada H3A 2B4
    Eur J Neurosci 21:2807-16. 2005
    ..On the other hand, under certain conditions, Orx neurons may also be submitted to an inhibitory influence by NA through alpha2-ARs...
  3. ncbi Dynamic changes in GABAA receptors on basal forebrain cholinergic neurons following sleep deprivation and recovery
    Mandana Modirrousta
    Department of Neurology and Neurosurgery, McGill University, Montreal Neurological Institute, Montreal, Quebec, Canada
    BMC Neurosci 8:15. 2007
    ..sleep...
  4. ncbi Glia, adenosine, and sleep
    Barbara E Jones
    Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, QC, H3A 2B4, Canada
    Neuron 61:156-7. 2009
    ..In this issue of Neuron, Halassa et al. present evidence that sleep homeostasis depends upon gliotransmission and associated accumulation of AD that dampens neuronal excitability...
  5. ncbi Paradoxical REM sleep promoting and permitting neuronal networks
    B E Jones
    Department of Neurology and Neurosurgery, McGill University, Montreal Neurological Institute, Montreal, Quebec H3A 2B4, Canada
    Arch Ital Biol 142:379-96. 2004
    ..In tandem with the cholinergic neurons, these glutamatergic reticular neurons propagate the paradoxical forebrain activation and peripheral inactivation that characterize PS...
  6. ncbi From waking to sleeping: neuronal and chemical substrates
    Barbara E Jones
    Department of Neurology and Neurosurgery, McGill University, Montreal Neurological Institute, Montreal, Quebec H3A 2B4, Canada
    Trends Pharmacol Sci 26:578-86. 2005
    ..Selective enhancement and attenuation of their discharge, transmitter release and postsynaptic actions comprise the substrates for the major stimulant and hypnotic drugs...
  7. ncbi Activity, modulation and role of basal forebrain cholinergic neurons innervating the cerebral cortex
    Barbara E Jones
    Department of Neurology and Neurosurgery, McGill University, Montreal Neurological Institute, 3801 University Street, Montreal, QC H3A 2B4, Canada
    Prog Brain Res 145:157-69. 2004
    ..Colocalized GABAergic basal forebrain neurons which are inhibited by transmitters of the arousal systems can oppose these actions and promote delta activity and SWS...
  8. ncbi Modulation of cortical activation and behavioral arousal by cholinergic and orexinergic systems
    Barbara E Jones
    Department of Neurology and Neurosurgery, McGill University, Montreal Neurological Institute, 3801 University Street, Montreal, Quebec H3A2B4, Canada
    Ann N Y Acad Sci 1129:26-34. 2008
    ....
  9. ncbi Gabaergic neurons with alpha2-adrenergic receptors in basal forebrain and preoptic area express c-Fos during sleep
    M Modirrousta
    Montreal Neurological Institute, McGill University, 3801 University Street, Room 897, Montreal, Quebec, Canada H3A 2B4
    Neuroscience 129:803-10. 2004
    ....
  10. ncbi Suprachiasmatic modulation of noradrenaline release in the ventrolateral preoptic nucleus
    Benoît Saint Mleux
    Département de Neurosciences Fondamentales, Centre Medical Universitaire, 1211 Geneve 4, Switzerland
    J Neurosci 27:6412-6. 2007
    ..These results show that the SCN can provide an LLI of the sleep-promoting VLPO neurons that could play a role in the circadian organization of the sleep-waking cycle...
  11. ncbi Projections from basal forebrain to prefrontal cortex comprise cholinergic, GABAergic and glutamatergic inputs to pyramidal cells or interneurons
    Pablo Henny
    Department of Neurology and Neurosurgery, McGill University, Montreal Neurological Institute, Montreal, Quebec, Canada H3A 2B4
    Eur J Neurosci 27:654-70. 2008
    ..Through distinct glutamatergic, GABAergic and cholinergic projections, the BF can thus influence cortical activity in a diverse manner...
  12. ncbi Innervation of orexin/hypocretin neurons by GABAergic, glutamatergic or cholinergic basal forebrain terminals evidenced by immunostaining for presynaptic vesicular transporter and postsynaptic scaffolding proteins
    Pablo Henny
    Montreal Neurological Institute, McGill University, Montreal, Quebec H3A 2B4, Canada
    J Comp Neurol 499:645-61. 2006
    ....
  13. ncbi Vesicular glutamate (VGlut), GABA (VGAT), and acetylcholine (VACht) transporters in basal forebrain axon terminals innervating the lateral hypothalamus
    Pablo Henny
    Montreal Neurological Institute, McGill University, Montreal, Quebec H3A 2B4, Canada
    J Comp Neurol 496:453-67. 2006
    ..The important inputs from glutamatergic and GABAergic BF cells could thus regulate LH neurons in an opposing manner to stimulate vs. suppress cortical activation and behavioral arousal reciprocally...
  14. ncbi Muscarinic-2 and orexin-2 receptors on GABAergic and other neurons in the rat mesopontine tegmentum and their potential role in sleep-wake state control
    Frédéric Brischoux
    Department of Neurology and Neurosurgery, McGill University, Montreal Neurological Institute, Montreal, Quebec, Canada
    J Comp Neurol 510:607-30. 2008
    ..A few GABAergic cells bear both receptors and could as PS inhibitor neurons serve under these different influences to control PS effector neurons and accordingly gate PS and muscle atonia appropriately across sleep-wake states...
  15. ncbi Discharge of identified orexin/hypocretin neurons across the sleep-waking cycle
    Maan Gee Lee
    Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec, H3A 2B4, Canada
    J Neurosci 25:6716-20. 2005
    ..They increase firing before the end of PS and thereby herald by several seconds the return of waking and muscle tone. The orexin neurons would thus stimulate arousal, while antagonizing sleep and muscle atonia...
  16. ncbi Cholinergic basal forebrain neurons burst with theta during waking and paradoxical sleep
    Maan Gee Lee
    Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada H3A 2B4
    J Neurosci 25:4365-9. 2005
    ..Through their maximal firing and rhythmic theta discharge during active waking and paradoxical sleep, the cholinergic neurons can thus modulate the cortex to promote activation along with plasticity during these two states...
  17. ncbi Selective action of orexin (hypocretin) on nonspecific thalamocortical projection neurons
    Laurence Bayer
    , , 1211 Geneva 4, Switzerland
    J Neurosci 22:7835-9. 2002
    ....
  18. ncbi Rhythmically discharging basal forebrain units comprise cholinergic, GABAergic, and putative glutamatergic cells
    Ian D Manns
    Department of Neurology and Neurosurgery, McGill University, Montreal Neurological Institute, Montreal, Quebec H3A 2B4, Canada
    J Neurophysiol 89:1057-66. 2003
    ....
  19. ncbi Parvalbumin, calbindin, or calretinin in cortically projecting and GABAergic, cholinergic, or glutamatergic basal forebrain neurons of the rat
    Ivana Gritti
    Dipartimento di Scienze Cliniche L Sacco, Universita degli Studi di Milano, 20157 Milan, Italy
    J Comp Neurol 458:11-31. 2003
    ....
  20. ncbi The wake-promoting hypocretin-orexin neurons are in an intrinsic state of membrane depolarization
    Emmanuel Eggermann
    , , 1211 Geneva 4, Switzerland
    J Neurosci 23:1557-62. 2003
    ..We propose that wakefulness and associated energy expenditure thus depend on that property, which allows the hypocretin-orexin neurons to maintain a tonic excitatory influence on the central arousal and peripheral sympathetic systems...
  21. ncbi Alpha 2 adrenergic receptors on GABAergic, putative sleep-promoting basal forebrain neurons
    Ian D Manns
    Department of Neurology and Neurosurgery, McGill University, Montreal Neurological Institute Montreal, Quebec, Canada H3A 2B4
    Eur J Neurosci 18:723-7. 2003
    ..We thus propose that alpha2AR-bearing GABAergic basal forebrain neurons constitute sleep-active and sleep-promoting neurons...
  22. ncbi Nicotinic enhancement of the noradrenergic inhibition of sleep-promoting neurons in the ventrolateral preoptic area
    Benoît Saint-Mleux
    Departement de Physiologie, Centre Medical Universitaire, 1211 Geneva 4, Switzerland
    J Neurosci 24:63-7. 2004
    ..Such dual complementary actions allow ACh and nicotine to enhance wakefulness by inhibiting sleep-promoting systems while facilitating other wake-promoting systems...
  23. ncbi Sleep-wake related discharge properties of basal forebrain neurons recorded with micropipettes in head-fixed rats
    Maan Gee Lee
    Montreal Neurological Institute, Montreal, Quebec H3A 2B4, Canada
    J Neurophysiol 92:1182-98. 2004
    ....
  24. ncbi Exclusive postsynaptic action of hypocretin-orexin on sublayer 6b cortical neurons
    Laurence Bayer
    Departement de Physiologie, Centre Medical Universitaire, 1211 Geneve 4, Switzerland
    J Neurosci 24:6760-4. 2004
    ....
  25. ncbi c-Fos expression in dopaminergic and GABAergic neurons of the ventral mesencephalic tegmentum after paradoxical sleep deprivation and recovery
    Karen J Maloney
    Department of Neurology and Neurosurgery, McGill University, Montreal Neurological Institute, 3801 University Street, Montreal, Quebec H3A 2B4, Canada
    Eur J Neurosci 15:774-8. 2002
    ....
  26. ncbi Addiction and arousal: alternative roles of hypothalamic peptides
    Luis de Lecea
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California 94305, USA
    J Neurosci 26:10372-5. 2006
    ..This review summarizes a Mini-Symposium presented at the 2006 Annual Meeting of the Society for Neuroscience...

Research Grants10

  1. Role of Basal Forebrain Neurons in Sleep-Wake States
    Barbara Jones; Fiscal Year: 2007
    ..They will provide insight into how imbalances in these systems could lead to deficits in attention and arousal as well as disruption of sleep-wake states. ..
  2. Role of Basal Forebrain Neurons in Sleep-Wake States
    Barbara Jones; Fiscal Year: 2005
    ..the first time the specific neurons that are critically involved in state determination and reveal the discharge, chemical neurotransmitters and efferent projections by which they modulate cerebral activity across the sleep-wake cycle ..
  3. ROLE OF BASAL FOREBRAIN NEURONS IN SLEEP WAKE STATES
    Barbara Jones; Fiscal Year: 2002
    ..abstract_text> ..
  4. Role of Basal Forebrain Neurons in Sleep-Wake States
    Barbara E Jones; Fiscal Year: 2010
    ..They will provide insight into how imbalances in these systems could lead to deficits in attention and arousal as well as disruption of sleep-wake states. ..