J R Jass

Summary

Affiliation: McGill University
Country: Canada

Publications

  1. ncbi Hyperplastic polyps and DNA microsatellite unstable cancers of the colorectum
    J R Jass
    Department of Pathology, The University of Queensland, and Conjoint Gastroenterology Laboratory, Royal Brisbane Hospital, Queensland, Australia
    Histopathology 37:295-301. 2000
  2. ncbi The grading of rectal cancer: historical perspectives and a multivariate analysis of 447 cases. J. R. Jass, W. S. Atkin, J.Cuzick, H. J. R. Bussey, B. C. Morson, J. M. A. Northover, I.P. Todd. Histopathology 1986; 10; 437-459
    J R Jass
    Department of Pathology, McGill University, Montreal, Quebec, Canada
    Histopathology 41:56-7, discussion 57-8. 2002
  3. ncbi Differential significance of tumour infiltrating lymphocytes in sporadic mismatch repair deficient versus proficient colorectal cancers: a potential role for dysregulation of the transforming growth factor-beta pathway
    Kristi Baker
    Department of Pathology, McGill University, Lyman Duff Medical Building, 3755 University Street, Room B22, Montreal, Que, Canada H3A 2B4, and Institute of Pathology, University Hospital of Basel, Switzerland
    Eur J Cancer 43:624-31. 2007
  4. doi Molecular, pathologic, and clinical features of early-onset endometrial cancer: identifying presumptive Lynch syndrome patients
    Michael D Walsh
    Familial Cancer Laboratory and Molecular Cancer Epidemiology Laboratory, Queensland Institute of Medical Research, Herston, Australia
    Clin Cancer Res 14:1692-700. 2008
  5. pmc SnoN expression is differently regulated in microsatellite unstable compared with microsatellite stable colorectal cancers
    June A Chia
    The Conjoint Gastroenterology Laboratory, Royal Brisbane and Women s Hospital Foundation Clinical Research Centre and the Queensland Institute of Medical Research, Brisbane, 4029, Australia
    BMC Cancer 6:252. 2006
  6. pmc Advanced colorectal polyps with the molecular and morphological features of serrated polyps and adenomas: concept of a 'fusion' pathway to colorectal cancer
    J R Jass
    Department of Pathology, McGill University, Montreal, Canada
    Histopathology 49:121-31. 2006
  7. pmc APC mutation and tumour budding in colorectal cancer
    J R Jass
    Department of Molecular and Cellular Pathology, University of Queensland, Queensland 4006, Australia
    J Clin Pathol 56:69-73. 2003
  8. ncbi Pathogenesis of colorectal cancer
    Jeremy R Jass
    Department of Pathology, McGill University, Montreal, Quebec, Canada, H3A2B4
    Surg Clin North Am 82:891-904. 2002
  9. ncbi Colorectal cancer: a multipathway disease
    Jeremy R Jass
    Department of Pathology, McGill University, Duff Medical Building, 3775 University Street, Montreal, Quebec H3A 2B4, Canada
    Crit Rev Oncog 12:273-87. 2006
  10. ncbi Recommendations for the reporting of surgically resected specimens of colorectal carcinoma
    Jeremy R Jass
    Department of Pathology, McGill University, Duff Medical Building, 3775 University Street, Montreal, Quebec, H3A 2B4, Canada
    Virchows Arch 450:1-13. 2007

Detail Information

Publications93

  1. ncbi Hyperplastic polyps and DNA microsatellite unstable cancers of the colorectum
    J R Jass
    Department of Pathology, The University of Queensland, and Conjoint Gastroenterology Laboratory, Royal Brisbane Hospital, Queensland, Australia
    Histopathology 37:295-301. 2000
    ..These mechanisms fit with clinical observations relating to sporadic MSI-H colorectal cancer, specifically proximal location, multiplicity, higher frequency among females and rapid evolution of early cancer...
  2. ncbi The grading of rectal cancer: historical perspectives and a multivariate analysis of 447 cases. J. R. Jass, W. S. Atkin, J.Cuzick, H. J. R. Bussey, B. C. Morson, J. M. A. Northover, I.P. Todd. Histopathology 1986; 10; 437-459
    J R Jass
    Department of Pathology, McGill University, Montreal, Quebec, Canada
    Histopathology 41:56-7, discussion 57-8. 2002
  3. ncbi Differential significance of tumour infiltrating lymphocytes in sporadic mismatch repair deficient versus proficient colorectal cancers: a potential role for dysregulation of the transforming growth factor-beta pathway
    Kristi Baker
    Department of Pathology, McGill University, Lyman Duff Medical Building, 3755 University Street, Room B22, Montreal, Que, Canada H3A 2B4, and Institute of Pathology, University Hospital of Basel, Switzerland
    Eur J Cancer 43:624-31. 2007
    ....
  4. doi Molecular, pathologic, and clinical features of early-onset endometrial cancer: identifying presumptive Lynch syndrome patients
    Michael D Walsh
    Familial Cancer Laboratory and Molecular Cancer Epidemiology Laboratory, Queensland Institute of Medical Research, Herston, Australia
    Clin Cancer Res 14:1692-700. 2008
    ..The aim of this study was to determine the incidence of Lynch syndrome in a series of young-onset EC, and to identify molecular, clinical, and pathologic features that may alert clinicians to the presence of this disorder...
  5. pmc SnoN expression is differently regulated in microsatellite unstable compared with microsatellite stable colorectal cancers
    June A Chia
    The Conjoint Gastroenterology Laboratory, Royal Brisbane and Women s Hospital Foundation Clinical Research Centre and the Queensland Institute of Medical Research, Brisbane, 4029, Australia
    BMC Cancer 6:252. 2006
    ..SnoN is an important regulator of the transforming growth factor beta (TGFbeta) signalling pathway and has been shown to exhibit both tumour promotion and suppression activity...
  6. pmc Advanced colorectal polyps with the molecular and morphological features of serrated polyps and adenomas: concept of a 'fusion' pathway to colorectal cancer
    J R Jass
    Department of Pathology, McGill University, Montreal, Canada
    Histopathology 49:121-31. 2006
    ..To establish and explain the pattern of molecular signatures across colorectal polyps...
  7. pmc APC mutation and tumour budding in colorectal cancer
    J R Jass
    Department of Molecular and Cellular Pathology, University of Queensland, Queensland 4006, Australia
    J Clin Pathol 56:69-73. 2003
    ..A subset was immunostained for beta catenin and p16...
  8. ncbi Pathogenesis of colorectal cancer
    Jeremy R Jass
    Department of Pathology, McGill University, Montreal, Quebec, Canada, H3A2B4
    Surg Clin North Am 82:891-904. 2002
    ..Specifically, modern genomics will allow polyps and cancers to be grouped within pathogenic pathways on the basis of shared gene expression profiles. The era of molecular medicine has dawned for colorectal cancer...
  9. ncbi Colorectal cancer: a multipathway disease
    Jeremy R Jass
    Department of Pathology, McGill University, Duff Medical Building, 3775 University Street, Montreal, Quebec H3A 2B4, Canada
    Crit Rev Oncog 12:273-87. 2006
    ..CRC comprises subgroups with particular clinical, pathological, and molecular features...
  10. ncbi Recommendations for the reporting of surgically resected specimens of colorectal carcinoma
    Jeremy R Jass
    Department of Pathology, McGill University, Duff Medical Building, 3775 University Street, Montreal, Quebec, H3A 2B4, Canada
    Virchows Arch 450:1-13. 2007
  11. ncbi Hyperplastic polyps and colorectal cancer: is there a link?
    Jeremy R Jass
    Department of Pathology, McGill University, Montreal, Quebec, Canada
    Clin Gastroenterol Hepatol 2:1-8. 2004
    ..Screening can then be targeted more selectively toward patients who are at significantly increased risk of malignant transformation of hyperplastic polyps...
  12. ncbi Recommendations for the reporting of surgically resected specimens of colorectal carcinoma
    Jeremy R Jass
    Department of Pathology, McGill University, Montreal, Quebec, Canada
    Hum Pathol 38:537-545. 2007
    ....
  13. ncbi HNPCC and sporadic MSI-H colorectal cancer: a review of the morphological similarities and differences
    Jeremy R Jass
    Department of Pathology, McGill University, Montreal, Quebec, Canada
    Fam Cancer 3:93-100. 2004
    ..Morphological features can assist is distinguishing such families from bona fide HNPCC families which they closely mimic...
  14. ncbi Classification of colorectal cancer based on correlation of clinical, morphological and molecular features
    J R Jass
    Department of Pathology, McGill University, Montreal, Canada
    Histopathology 50:113-30. 2007
    ..This approach to the classification of CRC should accelerate understanding of causation and will impact on clinical management in the areas of both prevention and treatment...
  15. ncbi Role of the pathologist in the diagnosis of hereditary non-polyposis colorectal cancer
    Jeremy R Jass
    McGill University, Montreal, Quebec, Canada
    Dis Markers 20:215-24. 2004
    ..Immunohistochemistry to demonstrate loss of expression of DNA mismatch repair genes serves as a highly reliable test of mismatch repair deficiency if antibodies to hMLH1, hMSH2, hMSH6 and hPMS2 are employed...
  16. ncbi Hereditary Non-Polyposis Colorectal Cancer: the rise and fall of a confusing term
    Jeremy R Jass
    Department of Pathology, McGill University, Montreal, Quebec H3A 2B4, Canada
    World J Gastroenterol 12:4943-50. 2006
    ..The first step in characterizing these cancer families is to distinguish them from Lynch syndrome. The term HNPCC no longer serves any useful purpose and should be phased out...
  17. ncbi The intestinal lesion of autistic spectrum disorder
    Jeremy R Jass
    Department of Pathology, McGill University, Montreal, Quebec, Canada
    Eur J Gastroenterol Hepatol 17:821-2. 2005
    ..These possibilities deserve further investigation and should not be lost in the fog of the controversy regarding the role of measles/mumps/rubella vaccination in the aetiology of autistic spectrum disorder...
  18. ncbi Serrated adenoma of the colorectum and the DNA-methylator phenotype
    Jeremy R Jass
    Department of Pathology, McGill University, Duff Medical Building, 3775 University Street, Montreal, Quebec H3A 2B4, Canada
    Nat Clin Pract Oncol 2:398-405. 2005
    ..The current lack of guidelines for managing serrated polyps may explain the static incidence of proximal CRC, despite the falling incidence rates for left-sided CRC during the same time period...
  19. ncbi Emerging concepts in colorectal neoplasia
    Jeremy R Jass
    Department of Molecular and Cellular Pathology, University of Queensland Medical School, Australia
    Gastroenterology 123:862-76. 2002
    ..If colorectal cancer is a heterogeneous disease comprising discrete subsets that evolve through different pathways, it is evident that these subsets will need to be studied individually in the future...
  20. pmc Serrated adenoma of the colorectum: a lesion with teeth
    Jeremy R Jass
    Department of Pathology, McGill University, Montreal, Quebec, Canada
    Am J Pathol 162:705-8. 2003
  21. ncbi What's new in hereditary colorectal cancer?
    Jeremy R Jass
    Department of Pathology, McGill University, Montreal, Quebec, Canada
    Arch Pathol Lab Med 129:1380-4. 2005
    ..The remainder of the editorial discusses the role of the revised Bethesda guidelines in the diagnosis of hereditary nonpolyposis colorectal cancer and concludes with the recently identified serrated pathway syndrome...
  22. ncbi Role of APAF-1, E-cadherin and peritumoral lymphocytic infiltration in tumour budding in colorectal cancer
    I Zlobec
    Department of Pathology, McGill University, Montreal, Canada
    J Pathol 212:260-8. 2007
    ..Loss of E-cadherin and APAF-1 within the main body of CRCs are independent predictors of tumour budding. The prognostic benefit of lymphocytic infiltration may be explained by the immune destruction of budding cells...
  23. pmc Extensive DNA methylation in normal colorectal mucosa in hyperplastic polyposis
    P Minoo
    Department of Pathology, McGill University, Duff Medical Building, 3775 University Street, Montreal, Quebec H3A 2B4, Canada
    Gut 55:1467-74. 2006
    ..Sessile serrated adenomas also occur sporadically and appear to be indistinguishable from their counterparts in hyperplastic polyposis...
  24. ncbi Prognostic significance of the wnt signalling pathway molecules APC, beta-catenin and E-cadherin in colorectal cancer: a tissue microarray-based analysis
    A Lugli
    Department of Pathology, McGill University, Montreal, Canada
    Histopathology 50:453-64. 2007
    ....
  25. pmc Prognostic significance of mucins in colorectal cancer with different DNA mismatch-repair status
    A Lugli
    Department of Pathology, McGill University, Duff Medical Building, Montreal, Quebec, Canada
    J Clin Pathol 60:534-9. 2007
    ..Objective: To determine the prognostic significance of MUC1 and MUC2 in CRC with different MMR statuses...
  26. ncbi Use of molecular tumor characteristics to prioritize mismatch repair gene testing in early-onset colorectal cancer
    Melissa C Southey
    Genetic Epidemiology Laboratory, Department of Pathology, Australia
    J Clin Oncol 23:6524-32. 2005
    ..The relationships between mismatch repair (MMR) protein expression, microsatellite instability (MSI), family history, and germline MMR gene mutation status have not been studied on a population basis...
  27. ncbi Role of BRAF-V600E in the serrated pathway of colorectal tumourigenesis
    P Minoo
    Department of Pathology, McGill University, Montreal, Canada
    J Pathol 212:124-33. 2007
    ..Our findings also suggest that BRAF mutation potentiates promoter hypermethylation of the MLH1 gene promoter. Together, these results highlight BRAF as a potential target for therapeutic intervention in sporadic MSI-H colorectal cancers...
  28. ncbi Angiogenic factor VEGF is decreased in human colorectal neoplasms showing DNA microsatellite instability
    C V Wynter
    Department of Surgery, Greenslopes Private Hospital, University of Queensland, Brisbane, Australia
    J Pathol 189:319-25. 1999
    ..The low frequency of VEGF expression amongst MSI-H cancers may partially explain why these cancers are less aggressive, with a better overall prognosis...
  29. pmc Neoplastic progression occurs through mutator pathways in hyperplastic polyposis of the colorectum
    J R Jass
    Department of Pathology, University of Queensland, Mayne Medical School, Herston, Australia
    Gut 47:43-9. 2000
    ....
  30. pmc Characterisation of a subtype of colorectal cancer combining features of the suppressor and mild mutator pathways
    J R Jass
    Department of Pathology, University of Queensland Medical School, Herston, Australia
    J Clin Pathol 52:455-60. 1999
    ....
  31. ncbi Transforming growth factor-beta pathway disruption and infiltration of colorectal cancers by intraepithelial lymphocytes
    K Baker
    Department of Pathology, SMBD Jewish General Hospital, Department of Oncology and Human Genetics, McGill University, Montreal, QC, Canada
    Histopathology 49:371-80. 2006
    ..The present study aimed to explore whether such refractoriness to TGF-beta is an independently contributing factor to IEL retention...
  32. ncbi The case for a genetic predisposition to serrated neoplasia in the colorectum: hypothesis and review of the literature
    Joanne Young
    Molecular Cancer Epidemiology Laboratory, Queensland Institute of Medical Research, 300 Herston Road, Herston, Queensland 4006, Australia
    Cancer Epidemiol Biomarkers Prev 15:1778-84. 2006
    ..The tendency for these lesions to be multiple, associated with smoking, and to show frequent BRAF mutation and CIMP points to a defect that may result from interactions between the environment and a weakly penetrant genetic alteration...
  33. ncbi Immunohistochemical staining patterns of MUC1, MUC2, MUC4, and MUC5AC mucins in hyperplastic polyps, serrated adenomas, and traditional adenomas of the colorectum
    A E Biemer-Hüttmann
    Department of Pathology, Mayne Medical School, University of Queensland, Herston, Australia
    J Histochem Cytochem 47:1039-48. 1999
    ....
  34. ncbi Hyperplastic polyps of the colorectum-innocent or guilty?
    J R Jass
    Department of Pathology, University of Queensland School of Medicine, Herston, Australia
    Dis Colon Rectum 44:163-6. 2001
    ..Management of the serrated pathway of colorectal neoplasia may require novel approaches to screening, early detection, and prevention...
  35. ncbi Familial colorectal cancer: pathology and molecular characteristics
    J R Jass
    Department of Pathology, University of Queensland, Mayne Medical School, Herston, Australia
    Lancet Oncol 1:220-6. 2000
    ..Some of these, notably hyperplastic polyposis and mixed polyposis, may closely mimic FAP or HNPCC...
  36. ncbi Tumor buds show reduced expression of laminin-5 gamma 2 chain in DNA mismatch repair deficient colorectal cancer
    Eiji Shinto
    Department of Pathology, McGill University, Montreal, Canada
    Dis Colon Rectum 49:1193-202. 2006
    ..It is hypothesized that tumor budding in this subset may lack biologic aggressiveness because it is not associated with aberrant expression of the independent prognostic factor, laminin-5 gamma 2...
  37. ncbi Adenocarcinoma of colon differentiating as dome epithelium of gut-associated lymphoid tissue
    J R Jass
    Departments of Pathology, University of Queensland, Royal Brisbane Hospital, Queensland, Australia
    Histopathology 36:116-20. 2000
    ..An early adenocarcinoma of the ascending colon was confined to a mass of gut-associated lymphoid tissue (GALT). The first description of an adenocarcinoma of colon differentiating as dome epithelium is presented...
  38. ncbi Distinction between familial and sporadic forms of colorectal cancer showing DNA microsatellite instability
    J R Jass
    Department of Pathology, University of Queensland, Herston, Queensland 4006, Australia
    Eur J Cancer 38:858-66. 2002
    ....
  39. ncbi Senescence and serration: a new twist to an old tale
    P Minoo
    Department of Pathology, McGill University, Montreal, Quebec, Canada
    J Pathol 210:137-40. 2006
    ..Both pathways are associated with mutation of Ras-induced senescence 1 (RIS1), but the biological role of RIS1 requires further elucidation...
  40. ncbi Types of colorectal adenoma
    A Lugli
    Department of Pathology, McGill University, Montreal, Canada
    Verh Dtsch Ges Pathol 90:18-24. 2006
    ....
  41. ncbi Microsatellite unstable colorectal cancer cell lines with truncating TGFbetaRII mutations remain sensitive to endogenous TGFbeta
    K Baker
    Department of Pathology, McGill University, Montreal, Quebec H3A 2B4, Canada
    J Pathol 213:257-65. 2007
    ..In addition to clarifying the true consequences of natural TGFbetaRII loss and the independent function of TGFbetaRI, our results highlight the selective nature of TGFbeta resistance developed by cancers...
  42. ncbi Towards a molecular classification of colorectal cancer
    J R Jass
    Department of Pathology, University of Queensland, Australia
    Int J Colorectal Dis 14:194-200. 1999
    ..It is likely that testing for DNA mismatch repair will be adopted as a routine for colorectal cancer as more is learned of the distinctive pathobiology and behaviour of MSS, MSI-L and MSI-H cancers...
  43. ncbi Altered mucin expression in the gastrointestinal tract: a review
    J R Jass
    Department of Pathology, University of Queensland School of Medicine, Herston Road, Queensland 4006, Australia
    J Cell Mol Med 5:327-51. 2001
    ..As such they may serve as markers to explain pathogenesis and provide novel diagnostic and prognostic information...
  44. ncbi Serrated polyps of the large intestine: a morphologic and molecular review of an evolving concept
    Dale C Snover
    Department of Pathology, Fairview Southdale Hospital, Edina, MN 55435, USA, and McGill University, Montreal, Canada
    Am J Clin Pathol 124:380-91. 2005
    ....
  45. ncbi Molecular and cellular biology of pre-malignancy in the gastrointestinal tract
    J R Jass
    Department of Pathology, University of Queensland Mayne Medical School, Herston Road, Herston, Queensland, 4006, Australia
    Best Pract Res Clin Gastroenterol 15:175-89. 2001
    ..This chapter outlines the principles underlying the molecular characterization of pre-malignant lesions, taking colorectal neoplasia as the main model...
  46. ncbi A novel classification of tumour budding in colorectal cancer based on the presence of cytoplasmic pseudo-fragments around budding foci
    E Shinto
    Department of Pathology, McGill University, Montreal, Canada
    Histopathology 47:25-31. 2005
    ..Tumour budding is an adverse prognostic factor in colorectal cancer (CRC). We have investigated the significance of cytoplasmic fragments occurring in the immediate vicinity of tumour budding foci...
  47. ncbi Demographic and pathological characteristics of serrated polyps of colorectum
    T Higuchi
    Department of Pathology, McGill University, Montreal, Quebec, Canada
    Histopathology 47:32-40. 2005
    ..To characterize a series of colorectal polyps, focusing on the clinicopathological features of serrated adenoma (SA), mixed polyp (MP) and the recently recognized sessile serrated adenoma (SSA)...
  48. ncbi Prognostic significance of mammalian sterile20-like kinase 1 in colorectal cancer
    Parham Minoo
    Department of Pathology, McGill University, Montreal, QC, Canada
    Mod Pathol 20:331-8. 2007
    ..These results are suggestive of a tumor suppressor role for Mst1 in human colorectal cancer...
  49. ncbi Colorectal cancer cells express functional cell surface-bound TGFbeta
    Kristi Baker
    Department of Pathology, McGill University, Montreal, Quebec, Canada
    Int J Cancer 122:1695-700. 2008
    ..Signaling competent membrane-bound TGFbeta on cancer cells is thus likely to be a key player in regulating tumor cell interactions with each other as well as with other cells in their microenvironment...
  50. doi MSI-H colorectal cancers preferentially retain and expand intraepithelial lymphocytes rather than peripherally derived CD8+ T cells
    Kristi Baker
    Department of Pathology, McGill University, Montreal, QC, Canada
    Cancer Immunol Immunother 58:135-44. 2009
    ..These results suggest that the abundant iTILs present in MSI-H CRCs result from expansion of the preexisting mucosal IEL population and imply a limited prognostic role for iTILs in MSI-H CRC...
  51. ncbi Role of the mitogen-activated protein kinase and phosphoinositide 3-kinase/AKT pathways downstream molecules, phosphorylated extracellular signal-regulated kinase, and phosphorylated AKT in colorectal cancer-a tissue microarray-based approach
    Alessandro Lugli
    Department of Pathology, McGill University, Montreal, Canada H3A 2B4
    Hum Pathol 37:1022-31. 2006
    ....
  52. pmc Selecting immunohistochemical cut-off scores for novel biomarkers of progression and survival in colorectal cancer
    Inti Zlobec
    Department of Pathology, McGill University, Montreal, Quebec, Canada
    J Clin Pathol 60:1112-6. 2007
    ..Cut-off scores for determining positivity of biomarkers detected by immunohistochemistry are often set arbitrarily and vary between reports...
  53. ncbi Overexpression of the receptor for hyaluronic acid mediated motility is an independent adverse prognostic factor in colorectal cancer
    Alessandro Lugli
    Department of Pathology, McGill University, Duff Medical Building, Montreal, QC, Canada
    Mod Pathol 19:1302-9. 2006
    ..012) and with complete RHAMM expression in presumed HNPCC (P=0.03). Increasing and complete RHAMM expressions are independent adverse prognostic factors in MMR-proficient CRC and presumed Lynch syndrome...
  54. ncbi Scoring of p53, VEGF, Bcl-2 and APAF-1 immunohistochemistry and interobserver reliability in colorectal cancer
    Inti Zlobec
    Department of Pathology, McGill University, Montreal, QC, Canada
    Mod Pathol 19:1236-42. 2006
    ..In conclusion, p53 and VEGF protein expression assessed by immunohistochemistry in colorectal cancer and scored as a percentage of positive tumor cells may be a viable alternative scoring method...
  55. ncbi Loss of APAF-1 expression is associated with tumour progression and adverse prognosis in colorectal cancer
    Inti Zlobec
    Department of Pathology, McGill University, Duff Medical Building, 3775 University Street, Montreal, Canada H3A 2B4
    Eur J Cancer 43:1101-7. 2007
    ..001). No methylation was found in the selected region of APAF-1. APAF-1 is a marker of tumour progression in MMR-proficient CRC and an independent adverse prognostic factor in MLH1-negative CRC...
  56. pmc Proximal versus distal hyperplastic polyps of the colorectum: different lesions or a biological spectrum?
    K Baker
    Department of Pathology, McGill University, Montreal, Quebec Canada
    J Clin Pathol 57:1089-93. 2004
    ....
  57. ncbi Loss of raf-1 kinase inhibitor protein expression is associated with tumor progression and metastasis in colorectal cancer
    Parham Minoo
    Department of Pathology, McGill University, Montreal, Canada
    Am J Clin Pathol 127:820-7. 2007
    ..Methylation analysis of 28 cases showed that loss of RKIP expression is unlikely to be due to promoter methylation.Loss of RKIP expression is a marker of tumor progression and distant metastasis in MMR-proficient and MMR-deficient CRCs...
  58. ncbi Poorly differentiated tumours of the anal canal: a diagnostic strategy for the surgical pathologist
    B Balachandra
    Department of Pathology, McGill University, Montreal, Quebec, Canada
    Histopathology 50:163-74. 2007
    ..This review discusses the differential diagnosis of these neoplasms with the aid of short illustrative case studies...
  59. ncbi Broadsheet number 52: Molecular genetics of colorectal cancer
    J R Jass
    Department of Pathology, University of Queensland Medical School, Brisbane, Australia
    Pathology 31:354-64. 1999
    ..It is shown how the fundamental principle of genetic instability cuts across applied research, tissue diagnosis and clinical management with respect to both sporadic and inherited forms of colorectal cancer...
  60. ncbi Hyperplastic polyposis and cancer of the colon with gastrinoma of the duodenum
    Rashmi S Goswami
    Anatomic Pathology, McGill University, Montreal, QC, Canada
    Nat Clin Pract Oncol 3:281-4; quiz 285. 2006
    ..She had a 12-year history of peptic ulcers, which had been treated with histamine-2 blockers...
  61. ncbi Pathology of hereditary nonpolyposis colorectal cancer
    J R Jass
    Department of Pathology, University of Queensland Mayne Medical School, Australia
    Ann N Y Acad Sci 910:62-73; discussion 73-4. 2000
    ..Immunohistochemical staining for hMLH1 and hMSH2 identifies the underlying mutation in a proportion of cases. The colorectal adenoma is the usual precursor lesion in HNPCC, though serrated polyps are implicated in a small subset...
  62. ncbi Postchemotherapy characteristics of hepatic colorectal metastases: remnants of uncertain malignant potential
    Tamara L Znajda
    Department of Surgery and Hepatic, Royal Victoria Hospital, McGill University, Montreal, Quebec, Canada
    J Gastrointest Surg 10:483-9. 2006
    ..We propose the acronym RUMP to denote the remnants of uncertain malignant potential remaining. Further investigation is required to determine any correlation between the drug received and the resulting lesion...
  63. doi High frequency of exon deletions and putative founder effects in French Canadian Lynch syndrome families
    George Chong
    Departments of Medical Genetics and Oncology, Cancer Prevention Centre, Jewish General Hospital, Montreal, Quebec H3T 1E2, Canada
    Hum Mutat 30:E797-812. 2009
    ..Fifteen of the 29 (52%) families carried one of these five putative founder mutations. These findings may simplify genetic testing for Lynch syndrome in French Canadians...
  64. ncbi Value of staining intensity in the interpretation of immunohistochemistry for tumor markers in colorectal cancer
    Inti Zlobec
    Institute of Pathology, University Hospital of Basel, Schonbeinstrasse 40, Basel 4031, Switzerland
    Virchows Arch 451:763-9. 2007
    ....
  65. ncbi Emerging pathways in colorectal-cancer development
    Andrew M M Haydon
    Department of Epidemiology and Preventive Medicine, Monash Medical School, Alfred Hospital, Prahran, Victoria, Australia
    Lancet Oncol 3:83-8. 2002
    ..Tumours may have high or low type C (cancer-related) CpG-island methylation. When methylation affects hMLH1 (mismatch repair gene), the resultant cancer has high MSI...
  66. pmc Pathology features in Bethesda guidelines predict colorectal cancer microsatellite instability: a population-based study
    Mark A Jenkins
    Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, University of Melbourne, Parkville, Victoria, Australia
    Gastroenterology 133:48-56. 2007
    ..Our aim was to identify pathology and other features that independently predict high MSI (MSI-H)...
  67. ncbi Re: Ward et al. Routine testing for mismatch repair deficiency in sporadic colorectal cancer is justified. J Pathol 2005;207:377-384
    Jeremy R Jass
    J Pathol 208:590-1. 2006
  68. ncbi Number and size of lymph nodes recovered from dukes B rectal cancers: correlation with prognosis and histologic antitumor immune response
    John Murphy
    Cork Cancer Research Center and Departments of Surgery and Histopathology, Mercy University Hospital, Cork, Ireland
    Dis Colon Rectum 50:1526-34. 2007
    ..However, the possible prognostic importance of node size and inherent patient/tumor characteristics in determining node recovery has not been studied...
  69. ncbi Gastrointestinal polyposes: clinical, pathological and molecular features
    Jeremy R Jass
    Department of Cellular Pathology, St Mark s Hospital and Imperial College, Watford Road, Harrow, Middlesex HA1 3UJ, UK
    Gastroenterol Clin North Am 36:927-46, viii. 2007
    ..One of the most important, but often neglected, of these is hyperplastic polyposis...
  70. ncbi Molecular heterogeneity of colorectal cancer: Implications for cancer control
    Jeremy R Jass
    Department of Cellular Pathology, St Mark s Hospital, Watford Road, Harrow, Middx HA1 3UJ, UK
    Surg Oncol 16:S7-9. 2007
    ..In particular, new strategies for detecting and managing sessile serrated polyps will need to be developed and evaluated...
  71. ncbi The "Fas counterattack" is not an active mode of tumor immune evasion in colorectal cancer with high-level microsatellite instability
    Aileen M Houston
    Department of Medicine, National University of Ireland Cork, Clinical Science Building, Cork University Hospital, Wilton, Cork, Ireland
    Hum Pathol 39:243-50. 2008
    ..059). Together, these findings suggest that the abundance of TILs found in MSI-H tumors may be due to the failure of these tumor cells to up-regulate FasL and may explain, in part, the improved prognosis associated with these tumors...
  72. ncbi Multimarker phenotype predicts adverse survival in patients with lymph node-negative colorectal cancer
    Inti Zlobec
    Institute of Pathology, University Hospital of Basel, Basel, Switzerland
    Cancer 112:495-502. 2008
    ..The objective of this study was to define a multimarker prognostic model of 5-year survival in patients with lymph node-negative, mismatch repair (MMR)-proficient colorectal cancer (CRC)...
  73. doi Node-negative colorectal cancer at high risk of distant metastasis identified by combined analysis of lymph node status, vascular invasion, and Raf-1 kinase inhibitor protein expression
    Inti Zlobec
    Institute of Pathology, University Hospital of Basel, Basel, Switzerland
    Clin Cancer Res 14:143-8. 2008
    ....
  74. doi Bone morphogenic protein 3 inactivation is an early and frequent event in colorectal cancer development
    Kim Loh
    Conjoint Gastroenterology Laboratory, Royal Brisbane and Women s Hospital Research Foundation Clinical Research Centre and Queensland Institute of Medical Research, Brisbane 4029, Australia
    Genes Chromosomes Cancer 47:449-60. 2008
    ..This study provides molecular and functional data supporting the importance of BMP3 silencing as an early and frequent event in colorectal tumors progressing via the serrated and traditional pathways...
  75. doi Sporadic and syndromic hyperplastic polyps and serrated adenomas of the colon: classification, molecular genetics, natural history, and clinical management
    James E East
    Wolfson Unit for Endoscopy, St Mark s Hospital, Watford Road, Harrow, Middlesex HA1 3UJ, UK
    Gastroenterol Clin North Am 37:25-46, v. 2008
    ..The currently proposed management plan for serrated polyps is tentative because of incomplete knowledge of the nature and behavior of these polyps. This article highlights key areas warranting further research...
  76. ncbi Morphological and molecular heterogeneity within nonmicrosatellite instability-high colorectal cancer
    Vicki L J Whitehall
    Conjoint Gastroenterology Laboratory, Clinical Research Centre, Royal Brisbane Hospital Research Foundation, Queensland 4029, Australia
    Cancer Res 62:6011-4. 2002
    ..004) and lower frequency of hMLH1 methylation (P < 0.001) in the latter. These data demonstrate that the separation of CRC into two nonoverlapping groups (MSI-H versus MSS/MSI-L) is a misleading oversimplification...
  77. ncbi Mutation searching in colorectal cancer studies: experience with a denaturing high-pressure liquid chromatography system for exon-by-exon scanning of tumour suppressor genes
    Joanne Young
    Conjoint Gastroenterology Laboratory, Royal Brisbane Hospital Foundation Clinical Research Centre, Bancroft Centre, Herston, Queensland, Australia
    Pathology 34:529-33. 2002
    ..Here we report our progress using denaturing gradient high-pressure liquid chromatography (DHPLC) in the screening of the mismatch repair genes MLH1 and MSH2 and in screening the APC and HPP1 tumour suppressor genes for mutations...
  78. ncbi Evidence for BRAF mutation and variable levels of microsatellite instability in a syndrome of familial colorectal cancer
    Joanne Young
    Conjoint Gastroenterology Laboratory, Queensland Institute of Medical Research, Herston, Australia
    Clin Gastroenterol Hepatol 3:254-63. 2005
    ..Here, we discuss their role in the development of other familial colorectal cancers (CRC). We studied non-FAP, non-HNPCC CRC families characterized by tumors that varied in their level of MSI between individual members...
  79. ncbi Isolated loss of PMS2 expression in colorectal cancers: frequency, patient age, and familial aggregation
    Sharlene Gill
    British Columbia Cancer Agency, Vancouver, British Columbia, Canada
    Clin Cancer Res 11:6466-71. 2005
    ..Rarely, there is selective loss of PMS2 expression. We sought to describe the frequency and clinical correlates of selective loss of expression of PMS2 with the MSI-H tumor phenotype...
  80. ncbi DNA methylation patterns in adenomas from FAP, multiple adenoma and sporadic colorectal carcinoma patients
    Coral V A Wynter
    Conjoint Gastroenterology Laboratory, Clinical Research Centre, Queensland Institute of Medical Research, Brisbane, Queensland Australia
    Int J Cancer 118:907-15. 2006
    ..Genetic profiling of adenomas supports the concept that adenomas belonging to familial syndromes pursue a different pathway to tumorigenesis than their sporadic counterpar/ts from their earliest formation...
  81. pmc Conversion analysis for mutation detection in MLH1 and MSH2 in patients with colorectal cancer
    Graham Casey
    Department of Cancer Biology, Cleveland Clinic Lerner College of Medicine, Cleveland, Ohio 44195, USA
    JAMA 293:799-809. 2005
    ..Current data suggest that mismatch repair mutations are highly heterogeneous and that many mutations are not detected when conventional DNA sequencing alone is used...
  82. ncbi High prevalence of sessile serrated adenomas with BRAF mutations: a prospective study of patients undergoing colonoscopy
    Kevin J Spring
    Conjoint Gastroenterology Laboratory, Queensland Institute of Medical Research, Herston, Brisbane, Australia
    Gastroenterology 131:1400-7. 2006
    ..This prospective study examined the prevalence of sessile serrated adenomas and determined the incidence of BRAF and K-ras mutations in different types of polyps...
  83. ncbi Stability of BAT26 in Lynch syndrome colorectal tumours
    Lesley Jaskowski
    Eur J Hum Genet 15:139-41; author reply 141-2. 2007
  84. ncbi Colorectal cancer with mutation in BRAF, KRAS, and wild-type with respect to both oncogenes showing different patterns of DNA methylation
    Takeshi Nagasaka
    Department of Gastroenterological Surgery and Surgical Oncology, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
    J Clin Oncol 22:4584-94. 2004
    ..The aim of this study was to further investigate the link between genetic alterations in the RAS/RAF/ERK pathway and an underlying epigenetic disorder...
  85. ncbi Sporadic versus hereditary forms of colorectal cancer with the DNA microsatellite instability phenotype: to 'lump' or 'split'?
    Jeremy R Jass
    Fam Cancer 3:83. 2004
  86. ncbi Role of inherited defects of MYH in the development of sporadic colorectal cancer
    Takeshi Kambara
    Conjoint Gastroenterology Laboratory, Royal Brisbane and Women s Hospital Research Foundation and Queensland Institute of Medical Research, Brisbane, Australia
    Genes Chromosomes Cancer 40:1-9. 2004
    ..02). These results suggest that single germ-line variants of MYH may influence genetic pathways in CRC...
  87. ncbi Allelic loss of a common microsatellite marker MYCL1: a useful prognostic factor of poor outcomes in colorectal cancer
    Takeshi Kambara
    Department of Gastroenterological Surgery and Surgical Oncology, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
    Clin Cancer Res 10:1758-63. 2004
    ..Our aim in the present study was to determine whether allelic losses on 1p were likely to be of much value in predicting the prognosis of CRC cases...
  88. ncbi Hypermethylation of O6-methylguanine-DNA methyltransferase promoter may predict nonrecurrence after chemotherapy in colorectal cancer cases
    Takeshi Nagasaka
    Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
    Clin Cancer Res 9:5306-12. 2003
    ....
  89. ncbi Clinical significance of early-onset "sporadic" colorectal cancer with microsatellite instability
    Jeremy R Jass
    Dis Colon Rectum 46:1305-9. 2003
  90. ncbi The MUC13 cell surface mucin is highly expressed by human colorectal carcinomas
    Michael D Walsh
    Molecular Cancer Epidemiology Laboratory, Bancroft Centre, Queensland Institute of Medical Research, Herston, QLD, Australia
    Hum Pathol 38:883-92. 2007
    ..In summary, MUC13 was expressed abundantly by all colorectal cancers, with the highest expression in more poorly differentiated tumors...
  91. ncbi Fas ligand and tumour counter-attack in colorectal cancer stratified according to microsatellite instability status
    Julie M Michael-Robinson
    Inflammatory Bowel Disease Laboratory, Royal Brisbane Hospital Foundation Clinical Research Centre, Brisbane, Australia
    J Pathol 201:46-54. 2003
    ..004; p = 0.046 respectively). This study therefore suggests that MSS colorectal cancers are killing incoming TILs in an effective tumour counter-attack, but apparently not via membrane-bound FasL...
  92. ncbi Immunohistochemistry versus microsatellite instability testing in phenotyping colorectal tumors
    Noralane M Lindor
    Department of Medical Genetics, Mayo Foundation, Rochester, MN 55905, USA
    J Clin Oncol 20:1043-8. 2002
    ..To compare microsatellite instability (MSI) testing with immunohistochemical (IHC) detection of hMLH1 and hMSH2 in colorectal cancer...
  93. ncbi Cancer risks for mismatch repair gene mutation carriers: a population-based early onset case-family study
    Mark A Jenkins
    Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, The University of Melbourne, Victoria, Australia
    Clin Gastroenterol Hepatol 4:489-98. 2006
    ..These may be overestimates, due to analytic problems, and not generalizable. We estimated average cancer risks for mutations identified in population-based early onset colorectal cancer cases (probands) unselected for family history...