Nada Jabado

Summary

Affiliation: McGill University
Country: Canada

Publications

  1. pmc Iron refractory iron deficiency anemia: presentation with hyperferritinemia and response to oral iron therapy
    Dong Anh Khuong-Quang
    Department of Pediatrics, McGill University McGill University Health Center, 4060 Ste Catherine West, PT 239, Montreal, QC H3Z 2Z3 Canada
    Pediatrics 131:e620-5. 2013
  2. pmc Pediatric hemophagocytic syndromes: a diagnostic and therapeutic challenge
    Nada Jabado
    Division of Haematology and Oncology, Department of Paediatrics, Montreal Children s Hospital, McGill University Health Centre, Montreal, Quebec
    Allergy Asthma Clin Immunol 1:142-60. 2005
  3. pmc Duplication of 7q34 is specific to juvenile pilocytic astrocytomas and a hallmark of cerebellar and optic pathway tumours
    K Jacob
    Department of Pediatrics and Human Genetics, Montreal Children s Hospital, McGill University Health Center, Montreal H3Z 2Z3, Canada
    Br J Cancer 101:722-33. 2009
  4. pmc Mutations in SETD2 and genes affecting histone H3K36 methylation target hemispheric high-grade gliomas
    Adam M Fontebasso
    Division of Experimental Medicine, McGill University and McGill University Health Centre, Montreal, QC, Canada
    Acta Neuropathol 125:659-69. 2013
  5. doi request reprint Frequent ATRX mutations and loss of expression in adult diffuse astrocytic tumors carrying IDH1/IDH2 and TP53 mutations
    Xiao Yang Liu
    Department of Human Genetics, McGill University, Montreal, QC, Canada
    Acta Neuropathol 124:615-25. 2012
  6. ncbi request reprint Gene expression profiling from formalin-fixed paraffin-embedded tumors of pediatric glioblastoma
    Takrima Haque
    Division of Hematooncology, Department of Pediatrics, Montreal Children s Hospital, Montreal, Canada
    Clin Cancer Res 13:6284-92. 2007
  7. doi request reprint Preponderance of sonic hedgehog pathway activation characterizes adult medulloblastoma
    Hani Al-Halabi
    Department of Radiation Oncology, Montreal General Hospital, McGill University Health Centre, Canada
    Acta Neuropathol 121:229-39. 2011
  8. pmc Genome-wide profiling using single-nucleotide polymorphism arrays identifies novel chromosomal imbalances in pediatric glioblastomas
    Hui Qi Qu
    Montreal Children s Hospital, 2300 Tupper, Montreal, Que, Canada, H3H 1P3
    Neuro Oncol 12:153-63. 2010
  9. doi request reprint PAX3 is expressed in the stromal compartment of the developing kidney and in Wilms tumors with myogenic phenotype
    Pierre Alain Hueber
    Department of Experimental Medicine, McGill University, Montreal Children s Hospital Research Institute, 4060 Ste Catherine West, Montreal, QC, Canada
    Pediatr Dev Pathol 12:347-54. 2009
  10. pmc K27M mutation in histone H3.3 defines clinically and biologically distinct subgroups of pediatric diffuse intrinsic pontine gliomas
    Dong Anh Khuong-Quang
    Department of Human Genetics, McGill University, Montreal, QC, Canada
    Acta Neuropathol 124:439-47. 2012

Collaborators

Detail Information

Publications28

  1. pmc Iron refractory iron deficiency anemia: presentation with hyperferritinemia and response to oral iron therapy
    Dong Anh Khuong-Quang
    Department of Pediatrics, McGill University McGill University Health Center, 4060 Ste Catherine West, PT 239, Montreal, QC H3Z 2Z3 Canada
    Pediatrics 131:e620-5. 2013
    ....
  2. pmc Pediatric hemophagocytic syndromes: a diagnostic and therapeutic challenge
    Nada Jabado
    Division of Haematology and Oncology, Department of Paediatrics, Montreal Children s Hospital, McGill University Health Centre, Montreal, Quebec
    Allergy Asthma Clin Immunol 1:142-60. 2005
    ....
  3. pmc Duplication of 7q34 is specific to juvenile pilocytic astrocytomas and a hallmark of cerebellar and optic pathway tumours
    K Jacob
    Department of Pediatrics and Human Genetics, Montreal Children s Hospital, McGill University Health Center, Montreal H3Z 2Z3, Canada
    Br J Cancer 101:722-33. 2009
    ..Our aim was to investigate additional chromosomal unbalances in LGA and whether incidence of 7q34 duplication is associated with tumour type or location...
  4. pmc Mutations in SETD2 and genes affecting histone H3K36 methylation target hemispheric high-grade gliomas
    Adam M Fontebasso
    Division of Experimental Medicine, McGill University and McGill University Health Centre, Montreal, QC, Canada
    Acta Neuropathol 125:659-69. 2013
    ..Taken together, our results suggest that mutations disrupting the histone code at H3K36, including H3.3 G34R/V, IDH1 and/or SETD2 mutations, are central to the genesis of hemispheric HGGs in older children and young adults...
  5. doi request reprint Frequent ATRX mutations and loss of expression in adult diffuse astrocytic tumors carrying IDH1/IDH2 and TP53 mutations
    Xiao Yang Liu
    Department of Human Genetics, McGill University, Montreal, QC, Canada
    Acta Neuropathol 124:615-25. 2012
    ..Combined alteration of these genes may contribute to drive the neoplastic growth in a major subset of diffuse astrocytomas in adults...
  6. ncbi request reprint Gene expression profiling from formalin-fixed paraffin-embedded tumors of pediatric glioblastoma
    Takrima Haque
    Division of Hematooncology, Department of Pediatrics, Montreal Children s Hospital, Montreal, Canada
    Clin Cancer Res 13:6284-92. 2007
    ....
  7. doi request reprint Preponderance of sonic hedgehog pathway activation characterizes adult medulloblastoma
    Hani Al-Halabi
    Department of Radiation Oncology, Montreal General Hospital, McGill University Health Centre, Canada
    Acta Neuropathol 121:229-39. 2011
    ..Differences in molecular profiles exist between adult and paediatric SHH-driven MB and further investigations are needed to better characterize age-related molecular profiles in this subgroup...
  8. pmc Genome-wide profiling using single-nucleotide polymorphism arrays identifies novel chromosomal imbalances in pediatric glioblastomas
    Hui Qi Qu
    Montreal Children s Hospital, 2300 Tupper, Montreal, Que, Canada, H3H 1P3
    Neuro Oncol 12:153-63. 2010
    ..It further shows that, despite commonalities in a few CNAs, pGBM and aGBMs are two different diseases...
  9. doi request reprint PAX3 is expressed in the stromal compartment of the developing kidney and in Wilms tumors with myogenic phenotype
    Pierre Alain Hueber
    Department of Experimental Medicine, McGill University, Montreal Children s Hospital Research Institute, 4060 Ste Catherine West, Montreal, QC, Canada
    Pediatr Dev Pathol 12:347-54. 2009
    ..Loss of WT1 permits aberrant PAX3 expression in a subset of WTs with myogenic phenotype...
  10. pmc K27M mutation in histone H3.3 defines clinically and biologically distinct subgroups of pediatric diffuse intrinsic pontine gliomas
    Dong Anh Khuong-Quang
    Department of Human Genetics, McGill University, Montreal, QC, Canada
    Acta Neuropathol 124:439-47. 2012
    ..Based on prognostic and therapeutic implications, our findings argue for H3.3-mutation testing at diagnosis, which should be rapidly integrated into the clinical decision-making algorithm, particularly in atypical DIPG...
  11. doi request reprint Chromatin remodeling defects in pediatric and young adult glioblastoma: a tale of a variant histone 3 tail
    Adam M Fontebasso
    Division of Experimental Medicine, McGill University and McGill University Health Centre, Montreal, QC, Canada
    Brain Pathol 23:210-6. 2013
    ..The distinct changes in chromatin structure and the specific downstream events induced by each mutation need characterizing independently if progress is to be made in tackling this devastating cancer...
  12. doi request reprint Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma
    Jeremy Schwartzentruber
    McGill University and Genome Quebec Innovation Centre, Montreal, Quebec H3A 1A4, Canada
    Nature 482:226-31. 2012
    ..This is, to our knowledge, the first report to highlight recurrent mutations in a regulatory histone in humans, and our data suggest that defects of the chromatin architecture underlie paediatric and young adult GBM pathogenesis...
  13. doi request reprint Genetic aberrations leading to MAPK pathway activation mediate oncogene-induced senescence in sporadic pilocytic astrocytomas
    Karine Jacob
    Department of Human Genetics, McGill University Health Center Research Institute, Montreal, Canada
    Clin Cancer Res 17:4650-60. 2011
    ..Somatic genetic abnormalities affecting this pathway occur in the majority of pilocytic astrocytomas (PA), the most prevalent brain neoplasm in children. We investigated whether OIS is induced in PA...
  14. doi request reprint Extracellular vesicles as prospective carriers of oncogenic protein signatures in adult and paediatric brain tumours
    Delphine Garnier
    Montreal Children s Hospital, RI MUHC, McGill University, Montreal, Quebec, Canada
    Proteomics 13:1595-607. 2013
    ..Still, vesiculation emerges as a unique process that could be harnessed for the benefit of more individualised patient care...
  15. doi request reprint What can exome sequencing do for you?
    Jacek Majewski
    McGill University and Genome Quebec Innovation Centre, Montreal, Canada
    J Med Genet 48:580-9. 2011
    ....
  16. doi request reprint Relative CD4 lymphopenia and a skewed memory phenotype are the main immunologic abnormalities in a child with Omenn syndrome due to homozygous RAG1-C2633T hypomorphic mutation
    Christine McCusker
    Division of Allergy and Immunology, Montreal Children s Hospital, McGill University Health Center, Montreal, Quebec, Canada
    Clin Immunol 131:447-55. 2009
    ..Importantly, this case emphasizes that such hypomorphic mutations may promote an attenuated phenotype, complicating the diagnosis of primary immunodeficiency (PID)...
  17. doi request reprint Unexpected allelic heterogeneity and spectrum of mutations in Fowler syndrome revealed by next-generation exome sequencing
    Emilie Lalonde
    McGill University and Genome Quebec Innovation Centre, Montreal, Canada
    Hum Mutat 31:918-23. 2010
    ..Of importance, we show that we can identify genes underlying rare, monogenic and recessive diseases using a limited number of patients (n=2), in the absence of shared genetic heritage and in the presence of allelic heterogeneity...
  18. ncbi request reprint Molecular profiling identifies prognostic subgroups of pediatric glioblastoma and shows increased YB-1 expression in tumors
    Damien Faury
    Division of Hemato Oncology, Department of Pediatrics, Montreal Children s Hospital Research Institute, Montreal, Quebec, Canada
    J Clin Oncol 25:1196-208. 2007
    ..Pediatric glioblastoma (pGBM) is a rare, but devastating brain tumor. In contrast to GBM in adults (aGBM), little is known about the mechanisms underlying its development. Our aim is to gain insight into the molecular pathways of pGBM...
  19. doi request reprint Intestinal neoplasia induced by low dietary folate is associated with altered tumor expression profiles and decreased apoptosis in mouse normal intestine
    David Garcia-Crespo
    Department of Human Genetics, McGill University Health Center Montreal Children s Hospital, Montreal, Canada H3Z 2Z3
    J Nutr 139:488-94. 2009
    ..Folate depletion in normal intestine may trigger neoplasia through increased DNA damage and defective apoptosis; upregulation of CD44 and gelsolin, and the mitochondrial apoptotic pathway are implicated...
  20. pmc Acquired Omenn-like syndrome, a novel posttransplant autoaggression syndrome reversed by rapamycin
    Donald C Vinh
    Division of Infectious Diseases, Department of Medicine, McGill University Health Centre, Montreal, QC, Canada
    Clin Vaccine Immunol 19:109-12. 2012
    ..We identified a profound FOXP3(+) regulatory T cell defect that coincided with hyperinflammatory T cell responses which were reversible with rapamycin in vitro...
  21. doi request reprint Biomarkers in cancer micrometastasis: where are we at?
    Noha Gerges
    Department of Human Genetics, Montreal Children s Hospital Research Institute, 4060 Ste Catherine West, PT 239, Montreal, QC, H3Z 2Z3, Canada
    Bioanalysis 2:881-99. 2010
    ....
  22. doi request reprint Molecular biomarkers in pediatric glial tumors: a needed wind of change
    Adam M Fontebasso
    aDivision of Experimental Medicine bDepartments of Pediatrics and Human Genetics, McGill University and McGill University Health Centre, Montreal, Quebec, Canada
    Curr Opin Oncol 25:665-73. 2013
    ..Novel molecular markers/pathways identified by integrated genomic/transcriptomic/epigenomic studies of cohorts of pediatric gliomas are revolutionizing this field and are summarized herein...
  23. ncbi request reprint Isolation of a natural inhibitor of human malignant glial cell invasion: inter alpha-trypsin inhibitor heavy chain 2
    Tamra E Werbowetski-Ogilvie
    Brain Tumour Research Centre, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada
    Cancer Res 66:1464-72. 2006
    ....
  24. doi request reprint Fusion of TTYH1 with the C19MC microRNA cluster drives expression of a brain-specific DNMT3B isoform in the embryonal brain tumor ETMR
    Claudia L Kleinman
    1 McGill University and Génome Québec Innovation Centre, Montreal, Quebec, Canada 2 Department of Human Genetics, McGill University, Montreal, Quebec, Canada 3
    Nat Genet 46:39-44. 2014
    ..Our data suggest a potential oncogenic re-engagement of an early developmental program in ETMR via epigenetic alteration mediated by an embryonic, brain-specific DNMT3B isoform. ..
  25. doi request reprint Wilms tumor arising in a child with X-linked nephrogenic diabetes insipidus
    Reyhan El-Kares
    Department of Pediatrics, Montreal Children s Hospital Research Institute, 4060 Ste Catherine West, Montreal, Quebec, Canada
    Pediatr Nephrol 24:1313-9. 2009
    ..The concurrence of WT and NDI has not been previously reported and may be unrelated. Nevertheless, this case nicely illustrates the sequence of events leading to sporadic Wilms tumor...
  26. ncbi request reprint Circulating tumor cells: detection, molecular profiling and future prospects
    Karine Jacob
    Department of Pediatrics, Montreal Children s Hospital, McGill University Health Center, Montreal, Canada
    Expert Rev Proteomics 4:741-56. 2007
    ..Ultimately, understanding CTC biology and host-tumor 'complementarities' will help define metastasis-related biomarkers providing formidable and tailored novel therapeutic targets...
  27. ncbi request reprint Long-term therapy with aerosolized ribavirin for parainfluenza 3 virus respiratory tract infection in an infant with severe combined immunodeficiency
    Jitka Stankova
    Division of Hematology and Oncology, Montreal Children s Hospital, McGill University Health Centre, Montreal, QC, Canada
    Pediatr Transplant 11:209-13. 2007
    ....
  28. doi request reprint New technologies for the detection of circulating tumour cells
    Noha Gerges
    Department of Human Genetics, Montreal Children s Hospital, McGill University Health Centre, Montreal, Canada
    Br Med Bull 94:49-64. 2010
    ..This review will focus on the techniques currently used, the technical advancements made, the limitations of CTC detection and future perspectives in this field...