Claire Infante-Rivard

..To investigate the reliability of family history of cancer reported by parents of children with acute lymphoblastic leukemia (ALL) and parents of healthy control children...

....

..51 (95% CI: 1.07, 2.15). Among smokers, the CRL haplotype was protective (odds ratio = 0.48, 95% CI: 0.28, 0.82). Case-parent trio results were compatible with case-control results...

..Most developed countries have medical surveillance programs for some of the workers (typically miners) exposed to silica, but the impact of these programs is not documented...

..The relationship between thrombophilic polymorphisms and intrauterine growth restriction remains unclear. Whereas a subset of these polymorphisms have received some attention, others have not...

..Affected newborns also inherited the prothrombin G20210A variant significantly less often than expected. These results suggest that these three genes exhibit segregation distortion or reduce gestational survival...

..Little is known about the role of xenobiotic-metabolizing gene variants as risk factors for small-for-gestational-age (SGA) births or as modifiers for the effects of exposures such as maternal smoking...

..These are defined and methods to evaluate them are briefly presented...

....

..The studied polymorphisms did not modify the effect of caffeine. Caffeine consumption is unlikely to be a major risk factor for SGA or low birthweight in pregnant women...

....

..However, before reaching any definitive conclusions, methodological issues need to be addressed in future studies, as well as the role of genetic susceptibility. Moreover, subtypes of specific cancers need to be studied separately...

..Suggestions are made for work in the immediate future, which include pooling of data and of analyses, as well as carrying out in-depth reviews of studies with the goal of understanding the reasons for discrepant results...

..The application of all methods is illustrated using a candidate gene study of childhood leukemia that included case-control subjects and their parents...

..4 microg/L) was 13.20 (95% confidence interval, 1.19-146.72). These findings suggest that exposure to trihalomethanes at the highest levels can affect fetal growth but only in genetically susceptible newborns...

..The risk of ALL was not increased in children with a family history of cancers other than hematopoietic cancers. The data suggest a modest familial contribution to childhood ALL...

..Previous data have demonstrated associations between thrombophilia polymorphisms in pregnant women and an increased risk of intrauterine growth restriction in their offspring, but this finding remains uncertain...

..We hypothesized that higher maternal and newborn homocysteine concentrations in plasma would increase the risk of intrauterine growth restriction through placental thrombosis...

..Although substantially different for only one factor, inferences using hospital controls in comparison with population controls resulted in odds ratios closer to the null value...

..Pregnancy is a target period for events that could induce childhood leukemia. There has been little attention to possible effects of maternal occupational exposure to extremely low frequency magnetic fields (ELF-MF) during pregnancy...

..However, ionizing radiation from x rays as well as polymorphisms in DNA repair genes are plausible risk factors for childhood leukemia and should be studied more...

..We found no similar results in the literature, underscoring the need for other studies as well as the potential usefulness of combining exposure and relevant genetic information in such studies...

..In general, our findings suggest that home heating systems are not important determinants of indoor UFP exposures...

..Limited information is available on the association of parental consumption of alcohol prior to and during pregnancy with the risk of childhood leukemia, as well as for the potentially modifying role of genetic polymorphisms...

..To examine the contribution of maternal occupational exposure to extremely low frequency magnetic fields (ELF-MF) shortly before and during pregnancy on the incidence of childhood brain tumors...

..Home exposure was not associated with increased risk. Using an elaborate exposure coding method, this study shows that maternal exposure to solvents in the workplace does not seem to play a major role in childhood leukemia...

..65) and automobile (r=0.77) routes. Further research is required to incorporate variables such as traffic density and vehicle ventilation settings into the models presented...

..This is a cumbersome procedure in perinatal settings, whereby delivery usually takes place at unpredictable times...

....

..Our analysis provides arguments strengthening the conclusions on associations reported in earlier studies...

..In general, our findings suggest that reasonable estimates of classroom UFP counts may be obtained from outdoor UFP data but that the accuracy of such estimates are limited in the presence of indoor UFP sources...

..Our study provides novel insights concerning the pathogenesis of childhood leukemia in white children and has implications for the development of new immunotherapies for this cancer...

..92 (95% CI: 0.87, 0.95). The lymphoma-adapted RECIST is simpler to apply than the IWC and yields near identical response rates. The adapted RECIST should be considered for inclusion into any new draft of the IWC...

..An inverse association between asthma and brain cancer was found in adults, but there is a dearth of studies in children. The goal of this study was to evaluate the association between asthma and brain cancer in children...

..However, SES differences in hospitalization may suggest differential management and/or treatment practices according to socioeconomic status at the emergency departments...

..The ribonuclease protection assay allowed for the quantitation of [gamma/(gamma+beta)]-globin mRNAs, which has a highly significant correlation with the levels of HbF synthesis...

..Hepatitis C virus (HCV) rates have decreased steadily in first-time donors in Canada since testing was implemented but reasons are unclear. A description of factors that may have played a role in this decline is reported...

..CONCLUSION: A modest increase in risk of ALL was found among children of mothers who used medication during pregnancy...

..Methods are illustrated with birth weight and gestational length, two quantitative outcomes for which data were collected in a Montreal, Canada, study of intrauterine growth restriction between May 1998 and June 2000...

..Consequently, in addition to TDT, other complementary strategies will need to be simultaneously applied to dissect genetic predisposition to complex disorders...

..Risk varied by sex, age at diagnosis and tumor type. CONCLUSION: Childhood brain tumor risk may be associated with exposure to infective agents...

....

..We conducted a long-term (8-yr) follow-up of 408 apprentices entering programs involving exposure to high-molecular-weight allergens...

..We hope that the STROBE statement will contribute to improving the quality of reporting of observational studies...

..We hope that the STROBE statement will contribute to improving the quality of reporting of observational studies...