T J Hudson
Affiliation: McGill University
- Large-scale identification, mapping, and genotyping of single-nucleotide polymorphisms in the human genomeD G Wang
Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA
Science 280:1077-82. 1998..The results provide a characterization of human diversity at the nucleotide level and demonstrate the feasibility of large-scale identification of human SNPs...
- A radiation hybrid map of mouse genesT J Hudson
Center for Genome Research, Whitehead Institute Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
Nat Genet 29:201-5. 2001..It includes 3,658 genes homologous to the human genome sequence and provides a framework for overlaying the human genome sequence to the mouse and for sequencing the mouse genome...
- Patients with systemic autoimmune diseases could not distinguish comorbidities from their index diseaseMarie Hudson
McGill University, Montreal, Quebec, Canada
J Clin Epidemiol 61:654-62. 2008..To assess the construct validity of the Self-Administered Comorbidity Questionnaire (SCQ) in patients with systemic sclerosis (SSc) and systemic lupus erythematosus (SLE)...
- A map of 75 human ribosomal protein genesN Kenmochi
Howard Hughes Medical Institute, Whitehead Institute and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA
Genome Res 8:509-23. 1998..This map provides a foundation for the study of the possible roles of ribosomal protein deficiencies in chromosomal and Mendelian disorders...
- A YAC-based physical map of the mouse genomeC Nusbaum
Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA
Nat Genet 22:388-93. 1999..More generally, use of this map in addition to a newly constructed radiation hybrid (RH) map provides a comprehensive framework for mouse genomic studies...
- Large-scale discovery and genotyping of single-nucleotide polymorphisms in the mouseK Lindblad-Toh
Whitehead Institute MIT Center for Genome Research, Whitehead Institute for Biomedical Research, Cambridge, MA, USA
Nat Genet 24:381-6. 2000..We have also developed a multiplex genotyping procedure by which a genome scan can be performed with only six genotyping reactions per animal...
- Genetic variation in the 5q31 cytokine gene cluster confers susceptibility to Crohn diseaseJ D Rioux
Whitehead Institute/Massachusetts Institute of Technology, Center for Genome Research, Cambridge, Massachusetts, USA
Nat Genet 29:223-8. 2001..These results have important implications for Crohn disease in particular and LD mapping in general...
- Genomewide linkage analysis of stature in multiple populations reveals several regions with evidence of linkage to adult heightJ N Hirschhorn
Whitehead MIT Center for Genome Research, One Kendall Square, Cambridge, MA 02139, USA
Am J Hum Genet 69:106-16. 2001..These studies suggest that highly heritable complex traits such as stature may be genetically tractable and provide insight into the genetic architecture of complex traits...
- Genomewide search in Canadian families with inflammatory bowel disease reveals two novel susceptibility lociJ D Rioux
Whitehead Institute Massachusetts Institute of Technology, Center for Genome Research, Cambridge, MA 02139, USA
Am J Hum Genet 66:1863-70. 2000..Both of these genomic regions contain numerous genes that are important to the immune and inflammatory systems and that provide good targets for future candidate-gene studies...
- Association of LY9 in UK and Canadian SLE familiesD S Cunninghame Graham
Section of Molecular Genetics and Rheumatology, Imperial College Faculty of Medicine, Hammersmith Hospital, London, UK
Genes Immun 9:93-102. 2008....
- Common genetic variation in ABCA1 is associated with altered lipoprotein levels and a modified risk for coronary artery diseaseS M Clee
Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, Canada
Circulation 103:1198-205. 2001..However, the extent to which common variation within this gene influences plasma lipid levels and CAD in the general population is unknown...