Research Topics
| T J HudsonSummaryAffiliation: McGill University Country: Canada Publications
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Detail Information
Publications
Large-scale identification, mapping, and genotyping of single-nucleotide polymorphisms in the human genomeD G Wang
Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA
Science 280:1077-82. 1998..The results provide a characterization of human diversity at the nucleotide level and demonstrate the feasibility of large-scale identification of human SNPs...
A radiation hybrid map of mouse genesT J Hudson
Center for Genome Research, Whitehead Institute Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
Nat Genet 29:201-5. 2001..It includes 3,658 genes homologous to the human genome sequence and provides a framework for overlaying the human genome sequence to the mouse and for sequencing the mouse genome...
Patients with systemic autoimmune diseases could not distinguish comorbidities from their index diseaseMarie Hudson
McGill University, Montreal, Quebec, Canada
J Clin Epidemiol 61:654-62. 2008..To assess the construct validity of the Self-Administered Comorbidity Questionnaire (SCQ) in patients with systemic sclerosis (SSc) and systemic lupus erythematosus (SLE)...
A map of 75 human ribosomal protein genesN Kenmochi
Howard Hughes Medical Institute, Whitehead Institute and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA
Genome Res 8:509-23. 1998..This map provides a foundation for the study of the possible roles of ribosomal protein deficiencies in chromosomal and Mendelian disorders...
A YAC-based physical map of the mouse genomeC Nusbaum
Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA
Nat Genet 22:388-93. 1999..More generally, use of this map in addition to a newly constructed radiation hybrid (RH) map provides a comprehensive framework for mouse genomic studies...
Large-scale discovery and genotyping of single-nucleotide polymorphisms in the mouseK Lindblad-Toh
Whitehead Institute MIT Center for Genome Research, Whitehead Institute for Biomedical Research, Cambridge, MA, USA
Nat Genet 24:381-6. 2000..We have also developed a multiplex genotyping procedure by which a genome scan can be performed with only six genotyping reactions per animal...
Genetic variation in the 5q31 cytokine gene cluster confers susceptibility to Crohn diseaseJ D Rioux
Whitehead Institute/Massachusetts Institute of Technology, Center for Genome Research, Cambridge, Massachusetts, USA
Nat Genet 29:223-8. 2001..These results have important implications for Crohn disease in particular and LD mapping in general...
Genomewide linkage analysis of stature in multiple populations reveals several regions with evidence of linkage to adult heightJ N Hirschhorn
Whitehead MIT Center for Genome Research, One Kendall Square, Cambridge, MA 02139, USA
Am J Hum Genet 69:106-16. 2001..These studies suggest that highly heritable complex traits such as stature may be genetically tractable and provide insight into the genetic architecture of complex traits...
Genomewide search in Canadian families with inflammatory bowel disease reveals two novel susceptibility lociJ D Rioux
Whitehead Institute Massachusetts Institute of Technology, Center for Genome Research, Cambridge, MA 02139, USA
Am J Hum Genet 66:1863-70. 2000..Both of these genomic regions contain numerous genes that are important to the immune and inflammatory systems and that provide good targets for future candidate-gene studies...
Association of LY9 in UK and Canadian SLE familiesD S Cunninghame Graham
Section of Molecular Genetics and Rheumatology, Imperial College Faculty of Medicine, Hammersmith Hospital, London, UK
Genes Immun 9:93-102. 2008....
Common genetic variation in ABCA1 is associated with altered lipoprotein levels and a modified risk for coronary artery diseaseS M Clee
Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, Canada
Circulation 103:1198-205. 2001..However, the extent to which common variation within this gene influences plasma lipid levels and CAD in the general population is unknown...
