L J Hoffer

Summary

Affiliation: McGill University
Country: Canada

Publications

  1. doi request reprint Phase I clinical trial of i.v. ascorbic acid in advanced malignancy
    L J Hoffer
    Montreal Centre for Experimental Therapeutics in Cancer, Lady Davis Institute for Medical Research, McGill University and the Jewish General Hospital, Montreal, Quebec, Canada
    Ann Oncol 19:1969-74. 2008
  2. doi request reprint Why critically ill patients are protein deprived
    L John Hoffer
    Lady Davis Institute for Medical Research, Jewish General Hospital, McGill University, Montreal, Quebec, Canada
    JPEN J Parenter Enteral Nutr 37:300-9. 2013
  3. pmc Clinical nutrition: 1. Protein-energy malnutrition in the inpatient
    L J Hoffer
    Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, Montreal, Que
    CMAJ 165:1345-9. 2001
  4. doi request reprint Appropriate protein provision in critical illness: a systematic and narrative review
    L John Hoffer
    Lady Davis Institute for Medical Research, Jewish General Hospital, McGill University, Montreal, Canada
    Am J Clin Nutr 96:591-600. 2012
  5. ncbi request reprint N-acetyl-L-tyrosine as a tyrosine source in adult parenteral nutrition
    L John Hoffer
    Nutrition Support Service, Sir Mortimer B Davis Jewish General Hospital, Montreal, Quebec, Canada
    JPEN J Parenter Enteral Nutr 27:419-22. 2003
  6. ncbi request reprint Parenteral vitamin B12 therapy of hyperhomocysteinemia in end-stage renal disease
    L John Hoffer
    Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, Montreal, Que
    Clin Invest Med 27:10-3. 2004
  7. ncbi request reprint Cobalamin dose regimen for maximum homocysteine reduction in end-stage renal disease
    L John Hoffer
    Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, Montreal, Quebec, Canada
    Metabolism 54:835-40. 2005
  8. ncbi request reprint Human sulfate kinetics
    L John Hoffer
    Lady Davis Institute for Medical Research, Jewish General Hospital, 3755 Cote Ste Catherine Road, Montreal, Quebec, Canada H3T 1E2
    Am J Physiol Regul Integr Comp Physiol 289:R1372-80. 2005
  9. ncbi request reprint Comparative effects of hydroxocobalamin and cyanocobalamin on plasma homocysteine concentrations in end-stage renal disease
    L John Hoffer
    Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, Montreal, Quebec, Canada H3T 1E2
    Metabolism 54:1362-7. 2005
  10. ncbi request reprint Testing the homocysteine hypothesis in end-stage renal disease: Problems and a possible solution
    L J Hoffer
    Lady Davis Institute for Medical Research, McGill University, Montreal, Quebec, Canada
    Kidney Int 69:1507-10. 2006

Collaborators

  • O A Mamer
  • I Bank
  • A Schiffrin
  • W H Miller
  • Mark N Levine
  • M J Hamadeh
  • Line Robitaille
  • Michelle Zhang
  • Sebastian J Padayatty
  • Mazen J Hamadeh
  • Chunsheng Hou
  • Kelly M Elian
  • L N Kaplan
  • Shaun Eintracht
  • Caroline Rousseau
  • Sarit Assouline
  • David Melnychuk
  • Hugh D Riordan
  • Stephen M Hewitt
  • Arie Katz
  • Linda J Wykes

Detail Information

Publications29

  1. doi request reprint Phase I clinical trial of i.v. ascorbic acid in advanced malignancy
    L J Hoffer
    Montreal Centre for Experimental Therapeutics in Cancer, Lady Davis Institute for Medical Research, McGill University and the Jewish General Hospital, Montreal, Quebec, Canada
    Ann Oncol 19:1969-74. 2008
    ..We carried out a dose-finding phase I and pharmacokinetic study of i.v. ascorbic acid in patients with advanced malignancies...
  2. doi request reprint Why critically ill patients are protein deprived
    L John Hoffer
    Lady Davis Institute for Medical Research, Jewish General Hospital, McGill University, Montreal, Quebec, Canada
    JPEN J Parenter Enteral Nutr 37:300-9. 2013
    ..Failing to elucidate these matters, the recommendations for protein provision in the guidelines are incoherent, unconvincing, and easy to ignore...
  3. pmc Clinical nutrition: 1. Protein-energy malnutrition in the inpatient
    L J Hoffer
    Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, Montreal, Que
    CMAJ 165:1345-9. 2001
  4. doi request reprint Appropriate protein provision in critical illness: a systematic and narrative review
    L John Hoffer
    Lady Davis Institute for Medical Research, Jewish General Hospital, McGill University, Montreal, Canada
    Am J Clin Nutr 96:591-600. 2012
    ..Widely varying recommendations have been published with regard to the appropriate amount of protein or amino acids to provide in critical illness...
  5. ncbi request reprint N-acetyl-L-tyrosine as a tyrosine source in adult parenteral nutrition
    L John Hoffer
    Nutrition Support Service, Sir Mortimer B Davis Jewish General Hospital, Montreal, Quebec, Canada
    JPEN J Parenter Enteral Nutr 27:419-22. 2003
    ..NAT retention has not been well studied in parenterally fed adults...
  6. ncbi request reprint Parenteral vitamin B12 therapy of hyperhomocysteinemia in end-stage renal disease
    L John Hoffer
    Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, Montreal, Que
    Clin Invest Med 27:10-3. 2004
    ..End-stage renal disease (ESRD) is associated with moderately severe hyperhomocysteinemia that is incompletely normalized by oral folic acid therapy and vitamin B12...
  7. ncbi request reprint Cobalamin dose regimen for maximum homocysteine reduction in end-stage renal disease
    L John Hoffer
    Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, Montreal, Quebec, Canada
    Metabolism 54:835-40. 2005
    ....
  8. ncbi request reprint Human sulfate kinetics
    L John Hoffer
    Lady Davis Institute for Medical Research, Jewish General Hospital, 3755 Cote Ste Catherine Road, Montreal, Quebec, Canada H3T 1E2
    Am J Physiol Regul Integr Comp Physiol 289:R1372-80. 2005
    ..A substantial fraction of newly synthesized sulfate esters promptly enters the extracellular space for excretion in the urine...
  9. ncbi request reprint Comparative effects of hydroxocobalamin and cyanocobalamin on plasma homocysteine concentrations in end-stage renal disease
    L John Hoffer
    Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, Montreal, Quebec, Canada H3T 1E2
    Metabolism 54:1362-7. 2005
    ..Hydroxocobalamin and CC are equipotent despite producing very different serum cobalamin concentrations...
  10. ncbi request reprint Testing the homocysteine hypothesis in end-stage renal disease: Problems and a possible solution
    L J Hoffer
    Lady Davis Institute for Medical Research, McGill University, Montreal, Quebec, Canada
    Kidney Int 69:1507-10. 2006
    ..Clinical trials using it to test the homocysteine hypothesis will avoid the problems inherent in the HOST...
  11. pmc Tube feeding in advanced dementia: the metabolic perspective
    L John Hoffer
    Faculty of Medicine, McGill University, Montreal, QC, Canada
    BMJ 333:1214-5. 2006
  12. doi request reprint Vitamin C provision improves mood in acutely hospitalized patients
    Michelle Zhang
    Lady Davis Institute for Medical Research, McGill University, and Jewish General Hospital, 3755 Cote Sainte Catherine, Montreal, QC H3T 1E2, Canada
    Nutrition 27:530-3. 2011
    ..Because deficiencies of vitamin C and D have been linked to psychologic abnormalities, vitamin C or D provision could improve the mood state of acutely hospitalized patients...
  13. ncbi request reprint Protein and energy provision in critical illness
    L John Hoffer
    Lady Davis Institute for Medical Research, Jewish General Hospital and Faculty of Medicine, McGill University, Montreal, Canada
    Am J Clin Nutr 78:906-11. 2003
    ..5 g.kg(-1).d(-1). In addition, there are good reasons to suspect that the safe protein requirement of severely underweight, critically ill patients is >1.5 g.kg(-1).d(-1), even when adequate energy is provided...
  14. pmc Complementary or alternative medicine: the need for plausibility
    L John Hoffer
    Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, and the Department of Medicine, McGill University, Montreal, QC
    CMAJ 168:180-2. 2003
  15. ncbi request reprint Methods for measuring sulfur amino acid metabolism
    L John Hoffer
    Lady Davis Institute for Medical Research, Jewish General Hospital, and Department of Medicine, McGill University, Montreal, Quebec, Canada
    Curr Opin Clin Nutr Metab Care 5:511-7. 2002
    ..Both glutathione and homocysteine are affected by abnormalities in sulfur amino acid metabolism that occur in the clinical setting...
  16. doi request reprint How much protein do parenteral amino acid mixtures provide?
    L John Hoffer
    Lady Davis Institute for Medical Research, McGill University, Jewish General Hospital, Montreal, Canada
    Am J Clin Nutr 94:1396-8. 2011
    ..5 g mixed amino acids/kg normal weight per day, on the assumption that they are equivalent to formed proteins, but they are not equivalent. Clinicians who aim to provide 0.8-1.5 g protein/kg must administer 1.0-1.8 g mixed amino acids/kg...
  17. ncbi request reprint Effect of protein restriction on (15)N transfer from dietary [(15)N]alanine and [(15)N]Spirulina platensis into urea
    M J Hamadeh
    Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Quebec, Canada H3T 1E2
    Am J Physiol Endocrinol Metab 281:E349-56. 2001
    ..Information about adaptive reductions in dietary amino acid catabolism obtained by adding [(15)N]Ala to a test meal appears to be equivalent to that obtained using an intrinsically labeled protein tracer...
  18. ncbi request reprint Use of sulfate production as a measure of short-term sulfur amino acid catabolism in humans
    M J Hamadeh
    Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Quebec H3T 1E2, Canada
    Am J Physiol Endocrinol Metab 280:E857-66. 2001
    ..A significant portion of the sulfur derived from methionine appears to be retained in nonprotein compounds immediately after its ingestion...
  19. ncbi request reprint Plasma reduced homocysteine concentrations are increased in end-stage renal disease
    L J Hoffer
    Lady Davis Institute for Medical Research, School of Dietetics and Human Nutrition, The Mass Spectrometry Unit, McGill University, Montreal, Quebec, Canada
    Kidney Int 59:372-7. 2001
    ....
  20. ncbi request reprint Hydroxocobalamin reduces hyperhomocysteinemia in end-stage renal disease
    Kelly M Elian
    School of Dietetics and Human Nutrition, and the Lady Davis Institute for Medical Research, Jewish General Hospital, Department of Medicine, McGill University, Montreal, Quebec, Canada
    Metabolism 51:881-6. 2002
    ..Persons with considerable persisting hyperhomocysteinemia despite high-dose folic acid therapy are likely to respond to the addition of hydroxocobalamin, irrespective of their serum vitamin B(12) concentrations...
  21. ncbi request reprint Parenteral vitamin B12 reduces hyperhomocysteinemia in end-stage renal disease
    L N Kaplan
    Lady Davis Institute for Medical Research, Sir Mortimer B. Davis-Jewish General Hospital, Montreal, Que
    Clin Invest Med 24:5-11. 2001
    ....
  22. ncbi request reprint Urinary sulfur excretion and the nitrogen/sulfur balance ratio reveal nonprotein sulfur amino acid retention in piglets
    Chunsheng Hou
    School of Dietetics and Human Nutrition, McGill University, Montreal, Quebec, Canada H9X 3V9
    J Nutr 133:766-72. 2003
    ..Urinary S excretion, a simple nontracer measurement, can provide an accurate measure of SAA catabolism, and the N/S balance ratio is a potentially useful indicator of changes in nonprotein SAA stores of growing piglets...
  23. ncbi request reprint Sulfate production depicts fed-state adaptation to protein restriction in humans
    M J Hamadeh
    Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Quebec, Canada H3T 1E2
    Am J Physiol Endocrinol Metab 281:E341-8. 2001
    ..Sulfate production effectively depicts fed-state adaptation to protein restriction...
  24. ncbi request reprint Effect of protein restriction on sulfur amino acid catabolism in insulin-dependent diabetes mellitus
    Mazen J Hamadeh
    Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Quebec, Canada H3T 1E2
    Am J Physiol Endocrinol Metab 284:E382-9. 2003
    ..SAA catabolism, as measured by fed-state sulfate production, may be a convenient and useful method to determine the extent of whole body protein dysregulation in IDDM...
  25. ncbi request reprint Homocysteine remethylation and trans-sulfuration
    L John Hoffer
    Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Quebec H3T1E2, Canada
    Metabolism 53:1480-3. 2004
    ..Failure to appreciate this has led to some confusion in the literature dealing with whole body Hcy metabolism...
  26. pmc Oxalic acid excretion after intravenous ascorbic acid administration
    Line Robitaille
    Lady Davis Institute for Medical Research, Jewish General Hospital, McGill University, Montreal, Quebec, Canada
    Metabolism 58:263-9. 2009
    ..5% of a very large intravenous dose of ascorbic acid is recovered as urinary oxalic acid in people with normal renal function...
  27. ncbi request reprint Editorial: Renal failure, homocysteine and the pharmacology of vitamin B12
    L John Hoffer
    Metabolism 51:399-402. 2002
  28. pmc Intravenously administered vitamin C as cancer therapy: three cases
    Sebastian J Padayatty
    Molecular and Clinical Nutrition Section, Digestive Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD 20892 1372, USA
    CMAJ 174:937-42. 2006
    ..In light of recent clinical pharmacokinetic findings and in vitro evidence of anti-tumour mechanisms, these case reports indicate that the role of high-dose intravenous vitamin C therapy in cancer treatment should be reassessed...
  29. ncbi request reprint Folate supplementation in sickle cell anemia
    L John Hoffer
    N Engl J Med 349:813; author reply 813. 2003