J Hiscott

Summary

Affiliation: McGill University
Country: Canada

Publications

  1. pmc Ectopic expression of interferon regulatory factor-1 potentiates granulocytic differentiation
    E M Coccia
    Laboratory of Virology, Istituto Superiore di Sanita, Viale Regina Elena, 299 00161 Rome, Italy
    Biochem J 360:285-94. 2001
  2. ncbi request reprint Triggering the interferon response: the role of IRF-3 transcription factor
    J Hiscott
    Lady Davis Institute for Medical Research, Department of Microbiology and Immunology, McGill University, Montreal, Canada
    J Interferon Cytokine Res 19:1-13. 1999
  3. pmc IkappaB-mediated inhibition of virus-induced beta interferon transcription
    M Algarte
    Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, McGill University, Montreal, Quebec, Canada H3T 1E2
    J Virol 73:2694-702. 1999
  4. pmc Selective DNA binding and association with the CREB binding protein coactivator contribute to differential activation of alpha/beta interferon genes by interferon regulatory factors 3 and 7
    R Lin
    Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, McGill University, Montreal, Quebec, Canada H3T 1E2
    Mol Cell Biol 20:6342-53. 2000
  5. pmc Structural and functional analysis of interferon regulatory factor 3: localization of the transactivation and autoinhibitory domains
    R Lin
    Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, McGill University, Montreal, Canada H3T 1E2
    Mol Cell Biol 19:2465-74. 1999
  6. ncbi request reprint Differential transcriptional activation in vitro by NF-kappa B/Rel proteins
    R Lin
    Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Quebec, Canada
    J Biol Chem 270:3123-31. 1995
  7. pmc Chronic human immunodeficiency virus type 1 infection stimulates distinct NF-kappa B/rel DNA binding activities in myelomonoblastic cells
    A Roulston
    Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, Montreal, Quebec, Canada
    J Virol 67:5235-46. 1993
  8. ncbi request reprint Disruption of NF-kappaB signaling reveals a novel role for NF-kappaB in the regulation of TNF-related apoptosis-inducing ligand expression
    T M Baetu
    Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, McGill University, Montreal, Canada
    J Immunol 167:3164-73. 2001
  9. pmc Induction of monocytic differentiation and NF-kappa B-like activities by human immunodeficiency virus 1 infection of myelomonoblastic cells
    A Roulston
    Lady Davis Institute for Medical Research, Quebec, Canada
    J Exp Med 175:751-63. 1992
  10. pmc Identification by in vivo genomic footprinting of a transcriptional switch containing NF-kappaB and Sp1 that regulates the IkappaBalpha promoter
    M Algarte
    Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, and Departments of Microbiology and Immunology, Medicine, and Oncology, McGill University, Montreal, Canada H3T 1E2
    Mol Cell Biol 19:6140-53. 1999

Collaborators

Detail Information

Publications35

  1. pmc Ectopic expression of interferon regulatory factor-1 potentiates granulocytic differentiation
    E M Coccia
    Laboratory of Virology, Istituto Superiore di Sanita, Viale Regina Elena, 299 00161 Rome, Italy
    Biochem J 360:285-94. 2001
    ..We conclude that IRF-1 exerts a pivotal role in granulocytic differentiation and that its induction by G-CSF represents a limiting step in the early events of differentiation...
  2. ncbi request reprint Triggering the interferon response: the role of IRF-3 transcription factor
    J Hiscott
    Lady Davis Institute for Medical Research, Department of Microbiology and Immunology, McGill University, Montreal, Canada
    J Interferon Cytokine Res 19:1-13. 1999
    ....
  3. pmc IkappaB-mediated inhibition of virus-induced beta interferon transcription
    M Algarte
    Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, McGill University, Montreal, Quebec, Canada H3T 1E2
    J Virol 73:2694-702. 1999
    ..These experiments demonstrate a major role for IkappaBalpha in the regulation of NF-kappaB-induced IFN-beta gene activation and a minor role for IkappaBbeta in the activation process...
  4. pmc Selective DNA binding and association with the CREB binding protein coactivator contribute to differential activation of alpha/beta interferon genes by interferon regulatory factors 3 and 7
    R Lin
    Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, McGill University, Montreal, Quebec, Canada H3T 1E2
    Mol Cell Biol 20:6342-53. 2000
    ....
  5. pmc Structural and functional analysis of interferon regulatory factor 3: localization of the transactivation and autoinhibitory domains
    R Lin
    Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, McGill University, Montreal, Canada H3T 1E2
    Mol Cell Biol 19:2465-74. 1999
    ....
  6. ncbi request reprint Differential transcriptional activation in vitro by NF-kappa B/Rel proteins
    R Lin
    Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Quebec, Canada
    J Biol Chem 270:3123-31. 1995
    ....
  7. pmc Chronic human immunodeficiency virus type 1 infection stimulates distinct NF-kappa B/rel DNA binding activities in myelomonoblastic cells
    A Roulston
    Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, Montreal, Quebec, Canada
    J Virol 67:5235-46. 1993
    ....
  8. ncbi request reprint Disruption of NF-kappaB signaling reveals a novel role for NF-kappaB in the regulation of TNF-related apoptosis-inducing ligand expression
    T M Baetu
    Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, McGill University, Montreal, Canada
    J Immunol 167:3164-73. 2001
    ..The regulation of TRAIL expression by NF-kappaB may represent a general mechanism that contributes to the control of TRAIL-mediated apoptosis in T lymphocytes...
  9. pmc Induction of monocytic differentiation and NF-kappa B-like activities by human immunodeficiency virus 1 infection of myelomonoblastic cells
    A Roulston
    Lady Davis Institute for Medical Research, Quebec, Canada
    J Exp Med 175:751-63. 1992
    ....
  10. pmc Identification by in vivo genomic footprinting of a transcriptional switch containing NF-kappaB and Sp1 that regulates the IkappaBalpha promoter
    M Algarte
    Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, and Departments of Microbiology and Immunology, Medicine, and Oncology, McGill University, Montreal, Canada H3T 1E2
    Mol Cell Biol 19:6140-53. 1999
    ..These observations provide the first in vivo characterization of a promoter proximal transcriptional switch involving NF-kappaB and Sp1 that is essential for autoregulation of the IkappaBalpha promoter...
  11. ncbi request reprint HHV-8 encoded vIRF-1 represses the interferon antiviral response by blocking IRF-3 recruitment of the CBP/p300 coactivators
    R Lin
    Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, McGill University, Montreal, Quebec H3T IE2, Canada
    Oncogene 20:800-11. 2001
    ..These results illustrate that vIRF-1 is able to block the early stages of the IFN response to virus infection by interfering with the activation of IRF-3 responsive, immediate early IFN genes...
  12. ncbi request reprint Association between HTLV-1 Tax and I kappa B alpha is dependent on the I kappa B alpha phosphorylation state
    L Petropoulos
    Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, Montreal, Quebec, Canada
    Virology 252:189-99. 1998
    ..The association of Tax with hypophosphorylated I kappa B alpha may prevent I kappa B alpha from binding to NF-kappa B and also target I kappa B alpha to the proteasome for degradation via a phosphorylation-independent pathway...
  13. ncbi request reprint Identification of distinct signaling pathways leading to the phosphorylation of interferon regulatory factor 3
    M J Servant
    Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, McGill University, Montreal, H3T 1E2 Canada
    J Biol Chem 276:355-63. 2001
    ..The failure of numerous well characterized pharmacological inhibitors to abrogate virus-induced IRF-3 phosphorylation suggests the involvement of a novel kinase activity in IRF-3 regulation by viruses...
  14. pmc Transdominant mutants of I kappa B alpha block Tat-tumor necrosis factor synergistic activation of human immunodeficiency virus type 1 gene expression and virus multiplication
    P Beauparlant
    Lady Davis Institute for Medical Research, Montreal, Quebec, Canada
    J Virol 70:5777-85. 1996
    ..These experiments suggest a strategy that may contribute to inhibition of HIV-1 gene expression by interfering with the NF-kappa B/Rel signaling pathway...
  15. ncbi request reprint Interferon regulatory factors: the next generation
    Y Mamane
    Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Canada
    Gene 237:1-14. 1999
    ..The aim of this review is to provide an update on the novel discoveries in the area of IRF transcription factors and the important roles of the new generation of IRFs--particularly IRF-3, IRF-4 and IRF-7...
  16. ncbi request reprint Multiple regulatory domains control IRF-7 activity in response to virus infection
    R Lin
    Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, Montreal H3T 1E2, Canada
    J Biol Chem 275:34320-7. 2000
    ..These results demonstrate that IRF-3 and IRF-7 transcription factors possess distinct structural characteristics that impart complementary rather than redundant functional roles in cytokine gene activation...
  17. ncbi request reprint Induction of IRF-3 and IRF-7 phosphorylation following activation of the RIG-I pathway
    S Paz
    Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, 3755 Cote Ste Catherine, Montreal, Quebec, Canada H3T 1E2
    Cell Mol Biol (Noisy-le-grand) 52:17-28. 2006
    ..These studies link RIG-I sensing of viral RNA to downstream kinase signaling and phosphorylation of IRF-3 and IRF-7 via the MAVS/IPS/VISA/Cardif adaptor...
  18. ncbi request reprint Posttranslational regulation of IRF-4 activity by the immunophilin FKBP52
    Y Mamane
    Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research and Department of Microbiology, McGill University, Montreal, Canada
    Immunity 12:129-40. 2000
    ..These results demonstrate a novel posttranslational mechanism of transcriptional control, mediated through the interaction of an immunophilin with a transcriptional regulator...
  19. ncbi request reprint Activation of the I kappa B alpha kinase (IKK) complex by double-stranded RNA-binding defective and catalytic inactive mutants of the interferon-inducible protein kinase PKR
    T Ishii
    Department of Microbiology and Immunology, McGill University, Montreal, Quebec, Canada
    Oncogene 20:1900-12. 2001
    ..These data strongly support an indirect role of PKR in I kappa B alpha phosphorylation by modulating IKK activity through pathways that do not utilize the enzymatic and dsRNA-binding properties of PKR...
  20. ncbi request reprint Heterodimerization and transcriptional activation in vitro by NF-kappa B proteins
    L Cohen
    Lady Davis Institute for Medical Research of the Sir Mortimer B Davis Jewish General Hospital, McGill University, Montreal, Quebec
    J Cell Physiol 152:10-8. 1992
    ..These experiments emphasize the role of NF-kappa B dimerization as a distinct level of transcriptional control that may permit functional diversification of a limited number of regulatory proteins...
  21. pmc Virus-dependent phosphorylation of the IRF-3 transcription factor regulates nuclear translocation, transactivation potential, and proteasome-mediated degradation
    R Lin
    Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, McGill University, Montreal, Quebec, Canada
    Mol Cell Biol 18:2986-96. 1998
    ....
  22. ncbi request reprint Biological and biochemical inhibitors of the NF-kappa B/Rel proteins and cytokine synthesis
    P Beauparlant
    Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, Montreal, Quebec, Canada
    Cytokine Growth Factor Rev 7:175-90. 1996
    ....
  23. ncbi request reprint Activation of the wt1 Wilms' tumor suppressor gene by NF-kappaB
    M Dehbi
    Department of Biochemistry, McGill University, Montreal, Quebec, Canada
    Oncogene 16:2033-9. 1998
    ..Taken together, these results indicate that members of the NF-kappaB/Rel family are important for activating expression of wt1 and reside upstream of the regulatory cascade leading to wt1 activation...
  24. ncbi request reprint A role for casein kinase II phosphorylation in the regulation of IRF-1 transcriptional activity
    R Lin
    Lady Davis Institute for Medical Research, and Department of Medicine, McGill University, Montreal, Quebec, Canada
    Mol Cell Biochem 191:169-80. 1999
    ..The present experiments, together with previously published studies with IkappaBalpha, c-Jun and other proteins, indicate a broad role for casein kinase II phosphorylation in the regulation of transcription factor activity...
  25. pmc I kappaB alpha physically interacts with a cytoskeleton-associated protein through its signal response domain
    P Crepieux
    Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, Department of Medicine, McGill University, Montreal, Que, Canada
    Mol Cell Biol 17:7375-85. 1997
    ....
  26. ncbi request reprint Disruption of NF-kappa B signaling and chemokine gene activation by retroviral mediated expression of IKK gamma/NEMO mutants
    C Le Page
    Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, McGill University, Montreal H3T 1E2, Canada
    Virology 286:422-33. 2001
    ..This study demonstrates the efficacy of Delta C-IKK gamma as a repressor of IKK signaling and NF-kappa B activation and suggests a potential gene therapy approach to limit chronic inflammation due to chemokine hyperactivation...
  27. ncbi request reprint Manipulation of the nuclear factor-kappaB pathway and the innate immune response by viruses
    J Hiscott
    Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, McGill University, Montreal, Canada
    Oncogene 25:6844-67. 2006
    ....
  28. pmc trans activation of type 1 interferon promoters by simian virus 40 T antigen
    J Hiscott
    Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, Montreal, Quebec, Canada
    Mol Cell Biol 8:3397-405. 1988
    ..Coexpression of T antigen and E1a proteins did not have a cooperative effect on type 1 IFN expression...
  29. pmc Regulation of human immunodeficiency virus type 1 and cytokine gene expression in myeloid cells by NF-kappa B/Rel transcription factors
    A Roulston
    Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, Montreal, Quebec, Canada
    Microbiol Rev 59:481-505. 1995
    ..Elevated levels of several inflammatory cytokines have been detected in the sera of HIV-1-infected individuals. Secretion of myeloid cell-derived cytokines may both increase virus production and contribute to AIDS-associated disorders...
  30. ncbi request reprint Organization of the human tarbp2 gene reveals two promoters that are repressed in an astrocytic cell line
    S Bannwarth
    Molecular Oncology Group, McGill AIDS Centre, Lady Davis Institute for Medical Research, McGill University, Montreal, Quebec H3T 1E2, Canada
    J Biol Chem 276:48803-13. 2001
    ..This minimal TRBP promoter activity may account for minimal HIV-1 replication in astrocytes...
  31. doi request reprint The eukaryotic translation initiation factor eIF4E is a direct transcriptional target of NF-κB and is aberrantly regulated in acute myeloid leukemia
    F Hariri
    Department of Pathology and Cell Biology, Institute for Research in Immunology and Cancer IRIC, Universite de Montreal, Montreal, Quebec, Canada
    Leukemia 27:2047-55. 2013
    ..These findings provide novel insights into the transcriptional control of eIF4E and a novel molecular basis for its dysregulation in at least a subset of M4/M5 AML specimens. ..
  32. doi request reprint Enhancing VSV oncolytic activity with an improved cytosine deaminase suicide gene strategy
    S Leveille
    Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Quebec, Canada
    Cancer Gene Ther 18:435-43. 2011
    ..Altogether, this study emphasizes the potency of the VSV-CD::UPRT and 5FC combination, and demonstrates the necessity of optimizing each step of a multicomponent therapy to design efficient treatment...
  33. ncbi request reprint IFN-beta induces serine phosphorylation of Stat-1 in Ewing's sarcoma cells and mediates apoptosis via induction of IRF-1 and activation of caspase-7
    J Sanceau
    INSERM U 365, Institut Curie, Paris, France
    Oncogene 19:3372-83. 2000
    ....
  34. ncbi request reprint Role of the interferon regulatory factors (IRFs) in virus-mediated signaling and regulation of cell growth
    P M Pitha
    Oncology Center and Department of Molecular Biology and Genetics, The Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Biochimie 80:651-8. 1998
    ..The present review is focused on the recently identified new members of cellular IRF family and their role in virus mediated response, responses and cell growth. In addition the HHV-8 encoded vIRFs are described...
  35. ncbi request reprint IRF regulation of HIV-1 long terminal repeat activity
    A Battistini
    Laboratory of Virology, Istituto Superiore di Sanita, Rome, Rome, Italy
    J Interferon Cytokine Res 22:27-37. 2002
    ....