Affiliation: McGill University
Hermo L, Chung S, Gregory M, Smith C, Wang S, El Alfy M, et al
. Alterations in the testis of hormone sensitive lipase-deficient mice is associated with decreased sperm counts, sperm motility, and fertility. Mol Reprod Dev. 2008;75:565-77 pubmed
..HSL(-/-) mice also show a dramatic reduction in sperm counts and motility and are infertile. ..
Hermo L, Schellenberg M, Liu L, Dayanandan B, Zhang T, Mandato C, et al
. Membrane domain specificity in the spatial distribution of aquaporins 5, 7, 9, and 11 in efferent ducts and epididymis of rats. J Histochem Cytochem. 2008;56:1121-35 pubmed publisher
..These findings indicate unique associations of AQPs with specific membrane domains in a cell type- and region-specific manner within the epididymis of adult animals. ..
Hermo L, Adamali H, Trasler J. Postnatal development and regulation of beta-hexosaminidase in epithelial cells of the rat epididymis. J Androl. 2004;25:69-81 pubmed
Hermo L, Pelletier R, Cyr D, Smith C. Surfing the wave, cycle, life history, and genes/proteins expressed by testicular germ cells. Part 4: intercellular bridges, mitochondria, nuclear envelope, apoptosis, ubiquitination, membrane/voltage-gated channels, methylation/acetylation, and tran. Microsc Res Tech. 2010;73:364-408 pubmed publisher
..All of the above features of germ cells will be discussed along with the specific proteins/genes and abnormalities to fertility related to each topic. ..
Hermo L, Korah N, Gregory M, Liu L, Cyr D, D AZZO A, et al
. Structural alterations of epididymal epithelial cells in cathepsin A-deficient mice affect the blood-epididymal barrier and lead to altered sperm motility. J Androl. 2007;28:784-97 pubmed
Hermo L, Krzeczunowicz D, Ruz R. Cell specificity of aquaporins 0, 3, and 10 expressed in the testis, efferent ducts, and epididymis of adult rats. J Androl. 2004;25:494-505 pubmed
..Together, the data indicate a cell- and tissue-specific expression for AQP-0, AQP-3, and AQP-10 in the testis, efferent ducts, and epididymis, as well as differential regulating factors for the expression of AQP-3 in basal cells. ..
Hermo L, Pelletier R, Cyr D, Smith C. Surfing the wave, cycle, life history, and genes/proteins expressed by testicular germ cells. Part 3: developmental changes in spermatid flagellum and cytoplasmic droplet and interaction of sperm with the zona pellucida and egg plasma membrane. Microsc Res Tech. 2010;73:320-63 pubmed publisher
..Many proteins have been implicated in the process of fertilization as well as a plethora of proteins involved in the development of spermatids and sperm, and these are high lighted in this review...
Hermo L, Pelletier R, Cyr D, Smith C. Surfing the wave, cycle, life history, and genes/proteins expressed by testicular germ cells. Part 2: changes in spermatid organelles associated with development of spermatozoa. Microsc Res Tech. 2010;73:279-319 pubmed publisher
..During spermiogenesis, many genes/proteins have been implicated in the diverse dynamic events occurring at this time of development of germ cells and the absence of some of these have been shown to result in subfertility or infertility...
Hermo L, Pelletier R, Cyr D, Smith C. Surfing the wave, cycle, life history, and genes/proteins expressed by testicular germ cells. Part 1: background to spermatogenesis, spermatogonia, and spermatocytes. Microsc Res Tech. 2010;73:241-78 pubmed publisher
..The meiotic cells form specific structural entities such as the synaptonemal complex and sex body. Many genes involved in spermatogonial renewal and the meiotic process have been identified and shown to be essential for this event...