Edith Hamel

Summary

Affiliation: McGill University
Country: Canada

Publications

  1. pmc Transgenic mice overexpressing APP and transforming growth factor-beta1 feature cognitive and vascular hallmarks of Alzheimer's disease
    Brice Ongali
    Laboratory of Cerebrovascular Research, Montreal Neurological Institute, McGill University, Montreal, QC, Canada H3A 2B4
    Am J Pathol 177:3071-80. 2010
  2. pmc Cognitive and cerebrovascular improvements following kinin B1 receptor blockade in Alzheimer's disease mice
    Baptiste Lacoste
    Laboratory of Cerebrovascular Research, Montreal Neurological Institute, McGill University, 3801 University Street, Montréal, QC, H3A 2B4, Canada
    J Neuroinflammation 10:57. 2013
  3. ncbi request reprint Cholinergic modulation of the cortical microvascular bed
    Edith Hamel
    Laboratory of Cerebrovascular Research, Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, 3801 University Street, Montreal, QC H3A 2B4, Canada
    Prog Brain Res 145:171-8. 2004
  4. ncbi request reprint Oxidative stress and cerebrovascular dysfunction in mouse models of Alzheimer's disease
    E Hamel
    Laboratory of Cerebrovascular Research, Montreal Neurological Institute, 3801 University Street, Montreal, QC, Canada, H3A 2B4
    Exp Physiol 93:116-20. 2008
  5. ncbi request reprint Perivascular nerves and the regulation of cerebrovascular tone
    Edith Hamel
    Laboratory of Cerebrovascular Research, Montreal Neurological Institute, 3801 University St, Montreal, QC, Canada, H3A 2B4
    J Appl Physiol 100:1059-64. 2006
  6. pmc Intact memory in TGF-β1 transgenic mice featuring chronic cerebrovascular deficit: recovery with pioglitazone
    Nektaria Nicolakakis
    Laboratory of Cerebrovascular Research, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada
    J Cereb Blood Flow Metab 31:200-11. 2011
  7. doi request reprint Complete rescue of cerebrovascular function in aged Alzheimer's disease transgenic mice by antioxidants and pioglitazone, a peroxisome proliferator-activated receptor gamma agonist
    Nektaria Nicolakakis
    Laboratory of Cerebrovascular Research, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada
    J Neurosci 28:9287-96. 2008
  8. doi request reprint Simvastatin improves cerebrovascular function and counters soluble amyloid-beta, inflammation and oxidative stress in aged APP mice
    Xin Kang Tong
    Laboratory of Cerebrovascular Research, Montreal Neurological Institute, 3801 University Street, Montreal, Quebec H3A 2B4, Canada
    Neurobiol Dis 35:406-14. 2009
  9. doi request reprint Selective in vivo antagonism of endothelin receptors in transforming growth factor-beta1 transgenic mice that mimic the vascular pathology of Alzheimer's disease
    Panayiota Papadopoulos
    Laboratory of Cerebrovascular Research, Montreal Neurological Institute, McGill University, Montreal, QC H3A 2B4, Canada
    Can J Physiol Pharmacol 88:652-60. 2010
  10. doi request reprint Age-dependent rescue by simvastatin of Alzheimer's disease cerebrovascular and memory deficits
    Xin Kang Tong
    Laboratory of Cerebrovascular Research, Montreal Neurological Institute, McGill University, Montreal, Quebec H3A 2B4, Canada
    J Neurosci 32:4705-15. 2012

Collaborators

Detail Information

Publications30

  1. pmc Transgenic mice overexpressing APP and transforming growth factor-beta1 feature cognitive and vascular hallmarks of Alzheimer's disease
    Brice Ongali
    Laboratory of Cerebrovascular Research, Montreal Neurological Institute, McGill University, Montreal, QC, Canada H3A 2B4
    Am J Pathol 177:3071-80. 2010
    ....
  2. pmc Cognitive and cerebrovascular improvements following kinin B1 receptor blockade in Alzheimer's disease mice
    Baptiste Lacoste
    Laboratory of Cerebrovascular Research, Montreal Neurological Institute, McGill University, 3801 University Street, Montréal, QC, H3A 2B4, Canada
    J Neuroinflammation 10:57. 2013
    ..The present study aims at identifying the cellular distribution and potentially detrimental role of B1R on cognitive and cerebrovascular functions in a mouse model of Alzheimer's disease (AD)...
  3. ncbi request reprint Cholinergic modulation of the cortical microvascular bed
    Edith Hamel
    Laboratory of Cerebrovascular Research, Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, 3801 University Street, Montreal, QC H3A 2B4, Canada
    Prog Brain Res 145:171-8. 2004
    ..In confirmed cases of Alzheimer's disease, we found a severe ACh denervation of both cortical microvessels and NO neurons, suggesting that two important regulators of cortical perfusion are dysfunctional in this pathology...
  4. ncbi request reprint Oxidative stress and cerebrovascular dysfunction in mouse models of Alzheimer's disease
    E Hamel
    Laboratory of Cerebrovascular Research, Montreal Neurological Institute, 3801 University Street, Montreal, QC, Canada, H3A 2B4
    Exp Physiol 93:116-20. 2008
    ..This review discusses the beneficial role and limitations of antioxidant therapy in AD cerebrovascular pathology...
  5. ncbi request reprint Perivascular nerves and the regulation of cerebrovascular tone
    Edith Hamel
    Laboratory of Cerebrovascular Research, Montreal Neurological Institute, 3801 University St, Montreal, QC, Canada, H3A 2B4
    J Appl Physiol 100:1059-64. 2006
    ..Neurovascular coupling is thus determined by chemical signals released from activated perivascular nerves and astrocytes that alter vascular tone to locally adjust perfusion to the spatial and temporal changes in brain activity...
  6. pmc Intact memory in TGF-β1 transgenic mice featuring chronic cerebrovascular deficit: recovery with pioglitazone
    Nektaria Nicolakakis
    Laboratory of Cerebrovascular Research, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada
    J Cereb Blood Flow Metab 31:200-11. 2011
    ..Our data further highlight the ability of pioglitazone to protect the cerebrovasculature marked by TGF-β1 increase, aging, fibrosis, and antioxidant resistance, thus of high relevance for AD patients...
  7. doi request reprint Complete rescue of cerebrovascular function in aged Alzheimer's disease transgenic mice by antioxidants and pioglitazone, a peroxisome proliferator-activated receptor gamma agonist
    Nektaria Nicolakakis
    Laboratory of Cerebrovascular Research, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada
    J Neurosci 28:9287-96. 2008
    ....
  8. doi request reprint Simvastatin improves cerebrovascular function and counters soluble amyloid-beta, inflammation and oxidative stress in aged APP mice
    Xin Kang Tong
    Laboratory of Cerebrovascular Research, Montreal Neurological Institute, 3801 University Street, Montreal, Quebec H3A 2B4, Canada
    Neurobiol Dis 35:406-14. 2009
    ....
  9. doi request reprint Selective in vivo antagonism of endothelin receptors in transforming growth factor-beta1 transgenic mice that mimic the vascular pathology of Alzheimer's disease
    Panayiota Papadopoulos
    Laboratory of Cerebrovascular Research, Montreal Neurological Institute, McGill University, Montreal, QC H3A 2B4, Canada
    Can J Physiol Pharmacol 88:652-60. 2010
    ..Further, they suggest that ETB receptors play a detrimental role in conditions of increased TGF-beta1 and that vascular dysfunction does not inevitably lead to cognitive deficit...
  10. doi request reprint Age-dependent rescue by simvastatin of Alzheimer's disease cerebrovascular and memory deficits
    Xin Kang Tong
    Laboratory of Cerebrovascular Research, Montreal Neurological Institute, McGill University, Montreal, Quebec H3A 2B4, Canada
    J Neurosci 32:4705-15. 2012
    ..They further indicate that simvastatin and, possibly, other brain penetrant statins bear high therapeutic promise in early AD and in patients with vascular diseases who are at risk of developing AD...
  11. pmc Pyramidal cells and cytochrome P450 epoxygenase products in the neurovascular coupling response to basal forebrain cholinergic input
    Clotilde Lecrux
    Laboratory of Cerebrovascular Research, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada
    J Cereb Blood Flow Metab 32:896-906. 2012
    ..Together, the data demonstrate that the hyperemic response to BF stimulation is largely mediated by glutamate released from activated pyramidal cells and by vasoactive EETs, likely originating from activated astrocytes...
  12. pmc Catechin treatment improves cerebrovascular flow-mediated dilation and learning abilities in atherosclerotic mice
    Annick Drouin
    Department of Surgery, Montreal Heart Institute Research Center, Universite de Montreal, Montreal, Quebec, Canada
    Am J Physiol Heart Circ Physiol 300:H1032-43. 2011
    ..05). In conclusion, catechin treatment of ATX mice prevents cerebrovascular dysfunctions and the associated decline in learning capacities...
  13. doi request reprint Pyramidal neurons are "neurogenic hubs" in the neurovascular coupling response to whisker stimulation
    Clotilde Lecrux
    Laboratory of Cerebrovascular Research, McGill University, Montreal, Quebec H3A 2B4, Canada
    J Neurosci 31:9836-47. 2011
    ....
  14. ncbi request reprint Specific subtypes of cortical GABA interneurons contribute to the neurovascular coupling response to basal forebrain stimulation
    Ara Kocharyan
    Laboratory of Cerebrovascular Research, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada
    J Cereb Blood Flow Metab 28:221-31. 2008
    ....
  15. ncbi request reprint Vascular remodeling versus amyloid beta-induced oxidative stress in the cerebrovascular dysfunctions associated with Alzheimer's disease
    Xin Kang Tong
    Laboratory of Cerebrovascular Research, Montreal Neurological Institute, McGill University, Montreal, Quebec, H3A 2B4, Canada
    J Neurosci 25:11165-74. 2005
    ..We conclude that brain vessel remodeling and associated alterations in levels of vasoactive signaling molecules are key contributors to AD cerebrovascular dysfunctions...
  16. doi request reprint DCC expression by neurons regulates synaptic plasticity in the adult brain
    Katherine E Horn
    Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, QC, H3A 2B4, Canada
    Cell Rep 3:173-85. 2013
    ..We demonstrate that enhancing NMDAR function or activating Src rescues LTP in the absence of DCC. We conclude that DCC activation of Src is required for NMDAR-dependent LTP and certain forms of learning and memory...
  17. doi request reprint Locus coeruleus stimulation recruits a broad cortical neuronal network and increases cortical perfusion
    Xavier Toussay
    Laboratory of Cerebrovascular Research, Montreal Neurological Institute, McGill University, Montreal, Quebec H3A 2B4, Canada
    J Neurosci 33:3390-401. 2013
    ....
  18. ncbi request reprint Transforming growth factor-beta 1 impairs endothelin-1-mediated contraction of brain vessels by inducing mitogen-activated protein (MAP) kinase phosphatase-1 and inhibiting p38 MAP kinase
    Xin Kang Tong
    Laboratory of Cerebrovascular Research, Montreal Neurological Institute, McGill University, 3801 University St, Montreal, QC, Canada, H3A 2B4
    Mol Pharmacol 72:1476-83. 2007
    ....
  19. pmc Mice doubly-deficient in lysosomal hexosaminidase A and neuraminidase 4 show epileptic crises and rapid neuronal loss
    Volkan Seyrantepe
    Division of Medical Genetics, Centre Hospitalière Universitaire Sainte Justine, University of Montreal, Montreal, Quebec, Canada
    PLoS Genet 6:e1001118. 2010
    ..However, while disease severity in the double mutant is increased, it is not profound suggesting that Neu4 is not the only sialidase contributing to the metabolic bypass in Hexa(-/-) mice...
  20. ncbi request reprint Schizophrenia-like features in transgenic mice overexpressing human HO-1 in the astrocytic compartment
    Wei Song
    Lady Davis Institute, Jewish General Hospital, Montreal, Quebec H3T 1E2, Canada
    J Neurosci 32:10841-53. 2012
    ..Containment of the glial HO-1 response to noxious stimuli at strategic points of the life cycle may afford novel opportunities for the effective management of human neurodevelopmental and neurodegenerative conditions...
  21. pmc Neurovascular function in Alzheimer's disease patients and experimental models
    Nektaria Nicolakakis
    Laboratory of Cerebrovascular Research, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada
    J Cereb Blood Flow Metab 31:1354-70. 2011
    ..These and several others are emerging as compounds with pleiotropic actions that may positively impact dysfunctional cerebrovascular, glial, and neuronal networks in AD...
  22. doi request reprint Ligand-dependent TrkA activity in brain differentially affects spatial learning and long-term memory
    Tahar Aboulkassim
    Lady Davis Institute Jewish General Hospital and McGill University, Montreal, Quebec, Canada
    Mol Pharmacol 80:498-508. 2011
    ..Understanding mechanisms that govern learning and memory is important for better treatment of cognitive disorders...
  23. ncbi request reprint Endothelial nitric oxide synthase activation leads to dilatory H2O2 production in mouse cerebral arteries
    Annick Drouin
    Universite de Montreal, Department of Surgery and Research Center, Institut de Cardiologie de Montreal, Montreal, Quebec, Canada
    Cardiovasc Res 73:73-81. 2007
    ..We hypothesized that H2O2 derived from eNOS activity could play a physiological role in endothelium-dependent dilation of mouse cerebral arteries...
  24. pmc Pioglitazone improves reversal learning and exerts mixed cerebrovascular effects in a mouse model of Alzheimer's disease with combined amyloid-β and cerebrovascular pathology
    Panayiota Papadopoulos
    Laboratory of Cerebrovascular Research, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada
    PLoS ONE 8:e68612. 2013
    ..They further suggest a potential benefit of pioglitazone in managing neuroinflammation, cerebral perfusion and glucose metabolism in AD patients devoid of cerebrovascular pathology. ..
  25. pmc Direct modulation of P2X1 receptor-channels by the lipid phosphatidylinositol 4,5-bisphosphate
    Louis Philippe Bernier
    Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada
    Mol Pharmacol 74:785-92. 2008
    ....
  26. ncbi request reprint A neurotrophic rationale for the therapy of neurodegenerative disorders
    H Uri Saragovi
    Pharmacology and Therapeutics, The Lady Davis Institute, Jewish General Hospital, University of Montreal, Montreal, Quebec, Canada
    Curr Alzheimer Res 6:419-23. 2009
    ..Targeting neurotrophin receptors with ligands that activate survival pathways or inhibit death pathways is an alternative worth pursuing...
  27. ncbi request reprint Glutamatergic Control of Microvascular Tone by Distinct GABA Neurons in the Cerebellum
    Armelle Rancillac
    Laboratoire de Neurobiologie et Diversité Cellulaire, Centre National de la Recherche Scientifique CNRS, Unité Mixte de Recherche UMR 7637, Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris, France
    J Neurosci 26:6997-7006. 2006
    ..These findings demonstrate that cerebellar stellate and Purkinje cells dilate and constrict, respectively, neighboring microvessels and highlight distinct roles for different neurons in neurovascular coupling...
  28. ncbi request reprint Cortical GABA interneurons in neurovascular coupling: relays for subcortical vasoactive pathways
    Bruno Cauli
    Laboratoire de Neurobiologie et Diversité Cellulaire, Centre National de la Recherche Scientifique Unité Mixte de Recherche 7637, Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris, 75005 Paris, France
    J Neurosci 24:8940-9. 2004
    ....
  29. ncbi request reprint Brain hemodynamic changes mediated by dopamine receptors: Role of the cerebral microvasculature in dopamine-mediated neurovascular coupling
    Ji Kyung Choi
    MGH NMR Center and Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Building 149 13th Street Charlestown, MA 02129, USA
    Neuroimage 30:700-12. 2006
    ..These data provide additional support for the role of local post-synaptic events in neurovascular coupling and emphasize that the interpretation of fMRI signals exclusively in terms of neuronal activity may be incomplete...
  30. ncbi request reprint 5-HT3 receptors mediate serotonergic fast synaptic excitation of neocortical vasoactive intestinal peptide/cholecystokinin interneurons
    Isabelle Ferezou
    Laboratoire de Neurobiologie et Diversité Cellulaire, Centre National de la Recherche Scientifique, Unité Mixte de Rechérche 7637, Ecole Superieure de Physique et Chime Industrielles de la ville de Paris, 75005 Paris, France
    J Neurosci 22:7389-97. 2002
    ....