Romain Goutagny

Summary

Affiliation: McGill University
Country: Canada

Publications

  1. doi request reprint Role of the dorsal paragigantocellular reticular nucleus in paradoxical (rapid eye movement) sleep generation: a combined electrophysiological and anatomical study in the rat
    R Goutagny
    CNRS, UMR 5167, Institut Fédératif des Neurosciences de Lyon IFR19, Lyon, F 69372, France
    Neuroscience 152:849-57. 2008
  2. doi request reprint In vitro activation of the medial septum-diagonal band complex generates atropine-sensitive and atropine-resistant hippocampal theta rhythm: an investigation using a complete septohippocampal preparation
    Romain Goutagny
    Department of Psychiatry, Douglas Mental Health University Institute, McGill University, Montreal, Quebec, Canada
    Hippocampus 18:531-5. 2008
  3. doi request reprint The hippocamposeptal pathway generates rhythmic firing of GABAergic neurons in the medial septum and diagonal bands: an investigation using a complete septohippocampal preparation in vitro
    Frédéric Manseau
    Douglas Hospital Research Center, Department of Psychiatry, McGill University, Montreal, Quebec, Canada H4H 1R3
    J Neurosci 28:4096-107. 2008
  4. doi request reprint Dopaminergic neurons expressing Fos during waking and paradoxical sleep in the rat
    Lucienne Leger
    Universite de Lyon, Lyon, Universite Lyon 1, CNRS, UMR5167, Physiologie et physiopathologie du cycle veille sommeil, F 69008, France
    J Chem Neuroanat 39:262-71. 2010
  5. doi request reprint Glutamatergic neurons of the mouse medial septum and diagonal band of Broca synaptically drive hippocampal pyramidal cells: relevance for hippocampal theta rhythm
    Carey Y L Huh
    Douglas Mental Health University Institute, McGill University, Montreal, Quebec H4H 1R3, Canada
    J Neurosci 30:15951-61. 2010
  6. doi request reprint Noradrenergic neurons expressing Fos during waking and paradoxical sleep deprivation in the rat
    Lucienne Leger
    Universite de Lyon, Lyon, France
    J Chem Neuroanat 37:149-57. 2009
  7. doi request reprint Alterations in hippocampal network oscillations and theta-gamma coupling arise before Aβ overproduction in a mouse model of Alzheimer's disease
    Romain Goutagny
    Douglas Mental Health University Institute, McGill University, 6875 LaSalle Blvd, Verdun, Montreal H4H1R3, QC, Canada
    Eur J Neurosci 37:1896-902. 2013
  8. doi request reprint NMDA-dependent phase synchronization between septal and temporal CA3 hippocampal networks
    Ning Gu
    McGill University, Douglas Mental Health University Institute, Montreal, Quebec H4H 1R3, Canada
    J Neurosci 33:8276-87. 2013
  9. pmc Tuberal hypothalamic neurons secreting the satiety molecule Nesfatin-1 are critically involved in paradoxical (REM) sleep homeostasis
    Sonia Jego
    Sleep Waking Neuronal Networks, CNRS UMR5292, Lyon, France
    PLoS ONE 7:e52525. 2012
  10. doi request reprint Fast and slow γ rhythms are intrinsically and independently generated in the subiculum
    Jesse Jackson
    Douglas Mental Health University Institute, McGill University, Department of Psychiatry, Montreal, Quebec, Canada H4H 1R3
    J Neurosci 31:12104-17. 2011

Collaborators

Detail Information

Publications18

  1. doi request reprint Role of the dorsal paragigantocellular reticular nucleus in paradoxical (rapid eye movement) sleep generation: a combined electrophysiological and anatomical study in the rat
    R Goutagny
    CNRS, UMR 5167, Institut Fédératif des Neurosciences de Lyon IFR19, Lyon, F 69372, France
    Neuroscience 152:849-57. 2008
    ....
  2. doi request reprint In vitro activation of the medial septum-diagonal band complex generates atropine-sensitive and atropine-resistant hippocampal theta rhythm: an investigation using a complete septohippocampal preparation
    Romain Goutagny
    Department of Psychiatry, Douglas Mental Health University Institute, McGill University, Montreal, Quebec, Canada
    Hippocampus 18:531-5. 2008
    ..Moreover, these MS-DB generated theta oscillations are mediated by muscarinic and nonmuscarinic receptors and have a pharmacological profile similar to theta rhythm observed in awake animals...
  3. doi request reprint The hippocamposeptal pathway generates rhythmic firing of GABAergic neurons in the medial septum and diagonal bands: an investigation using a complete septohippocampal preparation in vitro
    Frédéric Manseau
    Douglas Hospital Research Center, Department of Psychiatry, McGill University, Montreal, Quebec, Canada H4H 1R3
    J Neurosci 28:4096-107. 2008
    ..Our data demonstrate that hippocamposeptal inhibition facilitates theta rhythmic discharges in MS/DB GABAergic neurons while favoring the inhibition of most ACh and glutamate neurons...
  4. doi request reprint Dopaminergic neurons expressing Fos during waking and paradoxical sleep in the rat
    Lucienne Leger
    Universite de Lyon, Lyon, Universite Lyon 1, CNRS, UMR5167, Physiologie et physiopathologie du cycle veille sommeil, F 69008, France
    J Chem Neuroanat 39:262-71. 2010
    ..These results suggest that some DA neurons (A11) could participate in waking and/or the inhibition of PS during PS deprivation whereas others (A13) would be involved in the control of PS...
  5. doi request reprint Glutamatergic neurons of the mouse medial septum and diagonal band of Broca synaptically drive hippocampal pyramidal cells: relevance for hippocampal theta rhythm
    Carey Y L Huh
    Douglas Mental Health University Institute, McGill University, Montreal, Quebec H4H 1R3, Canada
    J Neurosci 30:15951-61. 2010
    ..Our findings suggest that the glutamatergic septohippocampal pathway may play an important role in hippocampal theta oscillations and relevant cognitive functions...
  6. doi request reprint Noradrenergic neurons expressing Fos during waking and paradoxical sleep deprivation in the rat
    Lucienne Leger
    Universite de Lyon, Lyon, France
    J Chem Neuroanat 37:149-57. 2009
    ..They further suggest that the inhibitory effect of noradrenaline on PS may be due to the A1/C1, A2 and to a lesser degree to A5 neurons but not from those of the LC as previously hypothesized...
  7. doi request reprint Alterations in hippocampal network oscillations and theta-gamma coupling arise before Aβ overproduction in a mouse model of Alzheimer's disease
    Romain Goutagny
    Douglas Mental Health University Institute, McGill University, 6875 LaSalle Blvd, Verdun, Montreal H4H1R3, QC, Canada
    Eur J Neurosci 37:1896-902. 2013
    ..Thus, initial alterations in hippocampal network activity arise before Aβ accumulation and may represent an early biomarker for AD...
  8. doi request reprint NMDA-dependent phase synchronization between septal and temporal CA3 hippocampal networks
    Ning Gu
    McGill University, Douglas Mental Health University Institute, Montreal, Quebec H4H 1R3, Canada
    J Neurosci 33:8276-87. 2013
    ..These data demonstrate that plastic changes in communication between septal and temporal hippocampal regions can arise from the NMDA-dependent phase locking of neural oscillators...
  9. pmc Tuberal hypothalamic neurons secreting the satiety molecule Nesfatin-1 are critically involved in paradoxical (REM) sleep homeostasis
    Sonia Jego
    Sleep Waking Neuronal Networks, CNRS UMR5292, Lyon, France
    PLoS ONE 7:e52525. 2012
    ..This could be done through the inhibition of downstream targets comprised primarily of the local hypothalamic wake-active orexin- and histamine-containing neurons...
  10. doi request reprint Fast and slow γ rhythms are intrinsically and independently generated in the subiculum
    Jesse Jackson
    Douglas Mental Health University Institute, McGill University, Department of Psychiatry, Montreal, Quebec, Canada H4H 1R3
    J Neurosci 31:12104-17. 2011
    ....
  11. pmc Localization of the brainstem GABAergic neurons controlling paradoxical (REM) sleep
    Emilie Sapin
    CNRS, UMR5167, Physiopathologie des réseaux neuronaux du cycle veille sommeil, Lyon, France
    PLoS ONE 4:e4272. 2009
    ..From these results, we propose a revised model for PS control in which GABAergic PS-on and PS-off neurons localized in the vlPAG/dDPMe region play leading roles...
  12. pmc Early alterations in hippocampal circuitry and theta rhythm generation in a mouse model of prenatal infection: implications for schizophrenia
    Guillaume Ducharme
    Douglas Mental Health University Institute, McGill University, Department of Psychiatry, Montreal, Quebec, Canada
    PLoS ONE 7:e29754. 2012
    ....
  13. ncbi request reprint Paradoxical sleep in mice lacking M3 and M2/M4 muscarinic receptors
    Romain Goutagny
    CNRS UMR 5167, Physiopathologie des réseaux neuronaux du cycle veille sommeil, Institut Fédératif des Neurosciences de Lyon IFR19, Université C Bernard, 7 rue Guillaume Paradin, FR 69372 Lyon Cedex 08, France
    Neuropsychobiology 52:140-6. 2005
    ....
  14. doi request reprint Self-generated theta oscillations in the hippocampus
    Romain Goutagny
    Douglas Mental Health University Institute, McGill University, Department of Psychiatry, Quebec, Canada
    Nat Neurosci 12:1491-3. 2009
    ..These oscillators were organized along the septotemporal axis and arose independently from CA3. Our results suggest that CA1 theta rhythm can emerge from the coupling of multiple autonomous hippocampal theta oscillators...
  15. ncbi request reprint GABAergic control of hypothalamic melanin-concentrating hormone-containing neurons across the sleep-waking cycle
    Romain Goutagny
    CNRS, UMR 5167, Faculte de Medecine, RTH Laennec, 7 rue G Paradin, 69372 Lyon Cedex 08, France
    Neuroreport 16:1069-73. 2005
    ..These results suggest that neurons containing melanin-concentrating hormone are not active during waking and that the lack of a potent GABAergic influence during waking is consistent with their role in sleep regulation...
  16. ncbi request reprint Paradoxical (REM) sleep genesis: the switch from an aminergic-cholinergic to a GABAergic-glutamatergic hypothesis
    Pierre Hervé Luppi
    UMR5167 CNRS, Faculte de Medecine Laennec, Institut Fédératif des Neurosciences de Lyon IFR 19, Universite Claude Bernard Lyon I, 7, Rue Guillaume Paradin, 69372 Lyon Cedex 08, France
    J Physiol Paris 100:271-83. 2006
    ..We propose that these GABAergic neurons also inhibit the GABAergic neurons of the DPMe at the onset and during PS and are therefore responsible for the onset and maintenance of PS...
  17. pmc A role of melanin-concentrating hormone producing neurons in the central regulation of paradoxical sleep
    Laure Verret
    CNRS UMR5167, Institut Fédératif des Neurosciences de Lyon IFR 19, Universite Claude Bernard Lyon I, 7 rue Guillaume Paradin, 69372 Lyon Cedex 08, France
    BMC Neurosci 4:19. 2003
    ..Next, we compared the effect of MCH and NaCl intracerebroventricular (ICV) administrations on sleep stage quantities to further determine whether MCH neurons play an active role in PS regulation...
  18. doi request reprint Sleep architecture of the melanin-concentrating hormone receptor 1-knockout mice
    Antoine Adamantidis
    Research Center for Cellular and Molecular Neurobiology, Unit of Molecular Neurophysiology, University of Liege, 1 Avenue de l Hopital, Bat B 36, 4000 Liege, Belgium
    Eur J Neurosci 27:1793-800. 2008
    ..This study also suggests that the MCH system may modulate central pathways involved in the wake-promoting effect of modafinil...