Research Topics
| Bruce GottliebSummaryAffiliation: McGill University Country: Canada Publications
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Detail Information
Publications
The Developmental/Health Framework within the McGill Model of Nursing: "laws of nature" guiding whole person careLaurie N Gottlieb
School of Nursing, McGill University, Montreal, Quebec, Canada
ANS Adv Nurs Sci 30:E43-57. 2007..The MMN provides a model of nursing based on a strengths-based approach within a collaborative partnership relationship. The DHFW has been used to modify the MMN to create a universal and comprehensive approach to nursing practice...
Human genome variation and pharmacogeneticsBruce Gottlieb
Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, Montreal, Quebec, Canada
Hum Mutat 29:453-5. 2008..This article discusses the effects of the resultant paradigm shifts and raises a number of important questions that need to be considered in order to truly advance the field in a meaningful and significant way...- Molecular pathology of the androgen receptor in male (in)fertilityBruce Gottlieb
Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, Department of Human Genetics, McGill University, Montreal, Canada
Reprod Biomed Online 10:42-8. 2005..The determination of the significance of longer CAG repeats is likely to require studies that examine CAG repeat lengths in spermatozoa as well as patients' blood... - An examination of how different mutations at arginine 855 of the androgen receptor result in different androgen insensitivity phenotypesYoussef A Elhaji
Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, 3755 Cote Ste Catherine Road, Montreal, Quebec, Canada H3T 1E2
Mol Endocrinol 18:1876-86. 2004..Such novel computational modeling may lead to a better understanding of the structure-function relationships and the molecular mechanics of ligand binding not only of the AR-LBD but also of other nuclear receptors... - An investigation into CAG repeat length variation and N/C terminal interactions in the T877A mutant androgen receptor found in prostate cancerJason Southwell
Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, Montreal, Quebec, Canada
J Steroid Biochem Mol Biol 111:138-46. 2008..These new observations suggest that the AR CAG effect can be overridden by prostate cancer mutations, and also further our understanding of hormone-refractory prostate cancer by helping to explain the promiscuity of the T877A mutation... - Selection and mutation in the "new" genetics: an emerging hypothesisBruce Gottlieb
Lady Davis Institute for Medical Research, Jewish General Hospital, 3755 Cote Ste Catherine Road, Montreal, QC H3T 1E2, Canada
Hum Genet 127:491-501. 2010.... - Somatic mosaicism and cancer: a micro-genetic examination into the role of the androgen receptor gene in prostate cancerCarlos Alvarado
Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, Montreal, Quebec, Canada
Cancer Res 65:8514-8. 2005..It is hypothesized that somatic mosaicism of the AR CAG repeat in prostate cancer tumors may be found to be an important genetic event in precancerous tissue, which may subsequently lead to the development of prostate cancer... - The androgen receptor gene mutations database: 2012 updateBruce Gottlieb
Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Quebec, Canada
Hum Mutat 33:887-94. 2012..The database is available on the internet (http://androgendb.mcgill.ca), and a web-based LSDB with the variants using the Leiden Open Variation Database platform is available at http://www.lovd.nl/AR... - Bridging structural biology and genetics by computational methods: an investigation into how the R774C mutation in the AR gene can result in complete androgen insensitivity syndromeJian Hui Wu
Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, Montreal, Quebec, Canada
Hum Mutat 22:465-75. 2003..g., the mutants' inability to form AR-ligand complexes at 37 degrees C and its characteristic reversible thermolability, clearly indicating the value of such computational methods... - Isolation of human proteasomes and putative proteasome-interacting proteins using a novel affinity chromatography methodThomas C Scanlon
Lady Davis Institute for Medical Research, SMBD Jewish General Hospital, Montreal, Canada
Exp Cell Res 315:176-89. 2009..These results demonstrate the efficacy of using this affinity purification strategy for isolating functional human proteasomes and identifying proteins that may physically interact with human proteasomes... - Nuclear receptors and disease: androgen receptorBruce Gottlieb
Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, Montreal, Quebec, Canada H3T 2E1
Essays Biochem 40:121-36. 2004..Whereas reduced apoptosis sensitivity is a basic characteristic of many tumour cells, accelerated tissue cell death and loss of tissue functions is the underlying cause of many auto-immune and inflammatory diseases... - The androgen receptor gene mutations database (ARDB): 2004 updateBruce Gottlieb
Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, Montreal, Quebec, Canada
Hum Mutat 23:527-33. 2004..The database is available on the Internet (http://www.mcgill.ca/androgendb/)... - The use of androgen receptor amino/carboxyl-terminal interaction assays to investigate androgen receptor gene mutations in subjects with varying degrees of androgen insensitivityShereen A Ghali
Lady Davis Institute for Medical Research, Sir Mortimer B. Davis Jewish General Hospital, and Department of Human Genetics, McGill University, , , Canada
J Clin Endocrinol Metab 88:2185-93. 2003..Thus, measurement of N/C-terminal interactions may assist in the molecular analysis of mutant hARs associated with AIS... - BAK1 gene variation and abdominal aortic aneurysmsBruce Gottlieb
Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, Montreal, Quebec, Canada
Hum Mutat 30:1043-7. 2009.... - Will knowledge of human genome variation result in changing cancer paradigms?Bruce Gottlieb
Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, Montreal, Quebec, Canada
Bioessays 29:678-85. 2007.... - Polymorphisms and HNPCC: PMS2-MLH1 protein interactions diminished by single nucleotide polymorphismsZi Qiang Yuan
Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, Montreal, Quebec, Canada
Hum Mutat 19:108-13. 2002..This study is one of the first to use a functional assay to appraise the role of SNPs and suggests that traditional definitions of polymorphisms and mutations are in need of reconsideration... - PhenCode: connecting ENCODE data with mutations and phenotypeBelinda Giardine
Center for Comparative Genomics and Bioinformatics, Huck Institutes of the Life Sciences, Pennsylvania State University, University Park, Pennsylvania 16802, USA
Hum Mutat 28:554-62. 2007..We present several examples illustrating the power of these connections for exploring phenotypes associated with functional elements, and for identifying genomic data that could help to explain clinical phenotypes... 
A functional analysis of disease-associated mutations in the androgen receptor geneSean D Mooney
Stanford Medical Informatics, Department of Genetics, Stanford University, MSOB X 215, 251 Campus Drive, Stanford, CA 94305 5479, USA
Nucleic Acids Res 31:e42. 2003..Our method provides a means for assessing the significance of single nucleotide polymorphisms (SNPs) and cancer-associated mutations...