Bruce Gottlieb

Summary

Affiliation: McGill University
Country: Canada

Publications

  1. ncbi request reprint The Developmental/Health Framework within the McGill Model of Nursing: "laws of nature" guiding whole person care
    Laurie N Gottlieb
    School of Nursing, McGill University, Montreal, Quebec, Canada
    ANS Adv Nurs Sci 30:E43-57. 2007
  2. doi request reprint Human genome variation and pharmacogenetics
    Bruce Gottlieb
    Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, Montreal, Quebec, Canada
    Hum Mutat 29:453-5. 2008
  3. ncbi request reprint Molecular pathology of the androgen receptor in male (in)fertility
    Bruce Gottlieb
    Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, Department of Human Genetics, McGill University, Montreal, Canada
    Reprod Biomed Online 10:42-8. 2005
  4. ncbi request reprint An examination of how different mutations at arginine 855 of the androgen receptor result in different androgen insensitivity phenotypes
    Youssef A Elhaji
    Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, 3755 Cote Ste Catherine Road, Montreal, Quebec, Canada H3T 1E2
    Mol Endocrinol 18:1876-86. 2004
  5. doi request reprint An investigation into CAG repeat length variation and N/C terminal interactions in the T877A mutant androgen receptor found in prostate cancer
    Jason Southwell
    Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, Montreal, Quebec, Canada
    J Steroid Biochem Mol Biol 111:138-46. 2008
  6. doi request reprint Selection and mutation in the "new" genetics: an emerging hypothesis
    Bruce Gottlieb
    Lady Davis Institute for Medical Research, Jewish General Hospital, 3755 Cote Ste Catherine Road, Montreal, QC H3T 1E2, Canada
    Hum Genet 127:491-501. 2010
  7. doi request reprint Making sense of intratumor genetic heterogeneity: altered frequency of androgen receptor CAG repeat length variants in breast cancer tissues
    Bruce Gottlieb
    Lady Davis Institute for Medical Research, Montreal, Quebec, Canada
    Hum Mutat 34:610-8. 2013
  8. doi request reprint The androgen receptor gene mutations database: 2012 update
    Bruce Gottlieb
    Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Quebec, Canada
    Hum Mutat 33:887-94. 2012
  9. ncbi request reprint Somatic mosaicism and cancer: a micro-genetic examination into the role of the androgen receptor gene in prostate cancer
    Carlos Alvarado
    Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, Montreal, Quebec, Canada
    Cancer Res 65:8514-8. 2005
  10. ncbi request reprint Nuclear receptors and disease: androgen receptor
    Bruce Gottlieb
    Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, Montreal, Quebec, Canada H3T 2E1
    Essays Biochem 40:121-36. 2004

Collaborators

Detail Information

Publications20

  1. ncbi request reprint The Developmental/Health Framework within the McGill Model of Nursing: "laws of nature" guiding whole person care
    Laurie N Gottlieb
    School of Nursing, McGill University, Montreal, Quebec, Canada
    ANS Adv Nurs Sci 30:E43-57. 2007
    ..The MMN provides a model of nursing based on a strengths-based approach within a collaborative partnership relationship. The DHFW has been used to modify the MMN to create a universal and comprehensive approach to nursing practice...
  2. doi request reprint Human genome variation and pharmacogenetics
    Bruce Gottlieb
    Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, Montreal, Quebec, Canada
    Hum Mutat 29:453-5. 2008
    ..This article discusses the effects of the resultant paradigm shifts and raises a number of important questions that need to be considered in order to truly advance the field in a meaningful and significant way...
  3. ncbi request reprint Molecular pathology of the androgen receptor in male (in)fertility
    Bruce Gottlieb
    Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, Department of Human Genetics, McGill University, Montreal, Canada
    Reprod Biomed Online 10:42-8. 2005
    ..The determination of the significance of longer CAG repeats is likely to require studies that examine CAG repeat lengths in spermatozoa as well as patients' blood...
  4. ncbi request reprint An examination of how different mutations at arginine 855 of the androgen receptor result in different androgen insensitivity phenotypes
    Youssef A Elhaji
    Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, 3755 Cote Ste Catherine Road, Montreal, Quebec, Canada H3T 1E2
    Mol Endocrinol 18:1876-86. 2004
    ..Such novel computational modeling may lead to a better understanding of the structure-function relationships and the molecular mechanics of ligand binding not only of the AR-LBD but also of other nuclear receptors...
  5. doi request reprint An investigation into CAG repeat length variation and N/C terminal interactions in the T877A mutant androgen receptor found in prostate cancer
    Jason Southwell
    Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, Montreal, Quebec, Canada
    J Steroid Biochem Mol Biol 111:138-46. 2008
    ..These new observations suggest that the AR CAG effect can be overridden by prostate cancer mutations, and also further our understanding of hormone-refractory prostate cancer by helping to explain the promiscuity of the T877A mutation...
  6. doi request reprint Selection and mutation in the "new" genetics: an emerging hypothesis
    Bruce Gottlieb
    Lady Davis Institute for Medical Research, Jewish General Hospital, 3755 Cote Ste Catherine Road, Montreal, QC H3T 1E2, Canada
    Hum Genet 127:491-501. 2010
    ....
  7. doi request reprint Making sense of intratumor genetic heterogeneity: altered frequency of androgen receptor CAG repeat length variants in breast cancer tissues
    Bruce Gottlieb
    Lady Davis Institute for Medical Research, Montreal, Quebec, Canada
    Hum Mutat 34:610-8. 2013
    ....
  8. doi request reprint The androgen receptor gene mutations database: 2012 update
    Bruce Gottlieb
    Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Quebec, Canada
    Hum Mutat 33:887-94. 2012
    ..The database is available on the internet (http://androgendb.mcgill.ca), and a web-based LSDB with the variants using the Leiden Open Variation Database platform is available at http://www.lovd.nl/AR...
  9. ncbi request reprint Somatic mosaicism and cancer: a micro-genetic examination into the role of the androgen receptor gene in prostate cancer
    Carlos Alvarado
    Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, Montreal, Quebec, Canada
    Cancer Res 65:8514-8. 2005
    ..It is hypothesized that somatic mosaicism of the AR CAG repeat in prostate cancer tumors may be found to be an important genetic event in precancerous tissue, which may subsequently lead to the development of prostate cancer...
  10. ncbi request reprint Nuclear receptors and disease: androgen receptor
    Bruce Gottlieb
    Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, Montreal, Quebec, Canada H3T 2E1
    Essays Biochem 40:121-36. 2004
    ..Whereas reduced apoptosis sensitivity is a basic characteristic of many tumour cells, accelerated tissue cell death and loss of tissue functions is the underlying cause of many auto-immune and inflammatory diseases...
  11. ncbi request reprint Bridging structural biology and genetics by computational methods: an investigation into how the R774C mutation in the AR gene can result in complete androgen insensitivity syndrome
    Jian Hui Wu
    Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, Montreal, Quebec, Canada
    Hum Mutat 22:465-75. 2003
    ..g., the mutants' inability to form AR-ligand complexes at 37 degrees C and its characteristic reversible thermolability, clearly indicating the value of such computational methods...
  12. doi request reprint Isolation of human proteasomes and putative proteasome-interacting proteins using a novel affinity chromatography method
    Thomas C Scanlon
    Lady Davis Institute for Medical Research, SMBD Jewish General Hospital, Montreal, Canada
    Exp Cell Res 315:176-89. 2009
    ..These results demonstrate the efficacy of using this affinity purification strategy for isolating functional human proteasomes and identifying proteins that may physically interact with human proteasomes...
  13. ncbi request reprint The androgen receptor gene mutations database (ARDB): 2004 update
    Bruce Gottlieb
    Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, Montreal, Quebec, Canada
    Hum Mutat 23:527-33. 2004
    ..The database is available on the Internet (http://www.mcgill.ca/androgendb/)...
  14. ncbi request reprint The use of androgen receptor amino/carboxyl-terminal interaction assays to investigate androgen receptor gene mutations in subjects with varying degrees of androgen insensitivity
    Shereen A Ghali
    Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, and Department of Human Genetics, McGill University, Montreal, Quebec, Canada
    J Clin Endocrinol Metab 88:2185-93. 2003
    ..Thus, measurement of N/C-terminal interactions may assist in the molecular analysis of mutant hARs associated with AIS...
  15. ncbi request reprint BAK1 gene variation and abdominal aortic aneurysms
    Bruce Gottlieb
    Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, Montreal, Quebec, Canada
    Hum Mutat 30:1043-7. 2009
    ....
  16. pmc Changing genetic paradigms: creating next-generation genetic databases as tools to understand the emerging complexities of genotype/phenotype relationships
    Bruce Gottlieb
    Lady Davis Institute for Medical Research, 3755 Cote Ste Catherine Road, Montreal, QC H3T 1E2, Canada
    Hum Genomics 8:9. 2014
    ....
  17. ncbi request reprint Will knowledge of human genome variation result in changing cancer paradigms?
    Bruce Gottlieb
    Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, Montreal, Quebec, Canada
    Bioessays 29:678-85. 2007
    ....
  18. ncbi request reprint Polymorphisms and HNPCC: PMS2-MLH1 protein interactions diminished by single nucleotide polymorphisms
    Zi Qiang Yuan
    Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, Montreal, Quebec, Canada
    Hum Mutat 19:108-13. 2002
    ..This study is one of the first to use a functional assay to appraise the role of SNPs and suggests that traditional definitions of polymorphisms and mutations are in need of reconsideration...
  19. ncbi request reprint PhenCode: connecting ENCODE data with mutations and phenotype
    Belinda Giardine
    Center for Comparative Genomics and Bioinformatics, Huck Institutes of the Life Sciences, Pennsylvania State University, University Park, Pennsylvania 16802, USA
    Hum Mutat 28:554-62. 2007
    ..We present several examples illustrating the power of these connections for exploring phenotypes associated with functional elements, and for identifying genomic data that could help to explain clinical phenotypes...
  20. pmc A functional analysis of disease-associated mutations in the androgen receptor gene
    Sean D Mooney
    Stanford Medical Informatics, Department of Genetics, Stanford University, MSOB X 215, 251 Campus Drive, Stanford, CA 94305 5479, USA
    Nucleic Acids Res 31:e42. 2003
    ..Our method provides a means for assessing the significance of single nucleotide polymorphisms (SNPs) and cancer-associated mutations...