Jean Gotman

Summary

Affiliation: McGill University
Country: Canada

Publications

  1. ncbi request reprint The meaning of interictal spikes in temporal lobe epilepsy: should we count them?
    John W Miller
    Neurology 71:392-3. 2008
  2. pmc High frequency oscillations in intracranial EEGs mark epileptogenicity rather than lesion type
    Julia Jacobs
    Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada
    Brain 132:1022-37. 2009
  3. ncbi request reprint Noninvasive methods for evaluating the localization and propagation of epileptic activity
    Jean Gotman
    Montreal Neurological Institute, 3801 University Street, Montreal, Quebec, Canada H3A 2B4
    Epilepsia 44:21-9. 2003
  4. ncbi request reprint Combining EEG and FMRI in epilepsy: methodological challenges and clinical results
    Jean Gotman
    Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada
    J Clin Neurophysiol 21:229-40. 2004
  5. pmc Changes preceding interictal epileptic EEG abnormalities: comparison between EEG/fMRI and intracerebral EEG
    Francesca Pittau
    Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada
    Epilepsia 52:1120-9. 2011
  6. pmc Combining EEG and fMRI in the study of epileptic discharges
    Jean Gotman
    Montreal Neurological Institute, McGill University, Montreal, QC, Canada
    Epilepsia 52:38-42. 2011
  7. ncbi request reprint Combining EEG and fMRI: a multimodal tool for epilepsy research
    Jean Gotman
    Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada
    J Magn Reson Imaging 23:906-20. 2006
  8. pmc Generalized epileptic discharges show thalamocortical activation and suspension of the default state of the brain
    J Gotman
    Montreal Neurological Institute and Department of Neurology and Neurosurgery, McGill University, 3801 University Street, Montreal, QC, Canada H3A 2B4
    Proc Natl Acad Sci U S A 102:15236-40. 2005
  9. pmc Epileptic networks studied with EEG-fMRI
    Jean Gotman
    Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada
    Epilepsia 49:42-51. 2008
  10. ncbi request reprint Pierre Gloor, 1923-2003
    Jean Gotman
    Montreal Neurological Institute, McGill University, 3801 University Street, Montreal, Quebec, Canada H3A 2B4
    Clin Neurophysiol 115:1235-6. 2004

Detail Information

Publications89

  1. ncbi request reprint The meaning of interictal spikes in temporal lobe epilepsy: should we count them?
    John W Miller
    Neurology 71:392-3. 2008
  2. pmc High frequency oscillations in intracranial EEGs mark epileptogenicity rather than lesion type
    Julia Jacobs
    Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada
    Brain 132:1022-37. 2009
    ..The findings suggest that HFOs represent a marker for SOZ areas independent of the underlying pathology and that pathologic tissue changes alone do not lead to high rates of HFOs...
  3. ncbi request reprint Noninvasive methods for evaluating the localization and propagation of epileptic activity
    Jean Gotman
    Montreal Neurological Institute, 3801 University Street, Montreal, Quebec, Canada H3A 2B4
    Epilepsia 44:21-9. 2003
    ....
  4. ncbi request reprint Combining EEG and FMRI in epilepsy: methodological challenges and clinical results
    Jean Gotman
    Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada
    J Clin Neurophysiol 21:229-40. 2004
    ..Finally, the authors give examples of fMRI responses seen with focal spikes and with generalized spike and wave discharges...
  5. pmc Changes preceding interictal epileptic EEG abnormalities: comparison between EEG/fMRI and intracerebral EEG
    Francesca Pittau
    Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada
    Epilepsia 52:1120-9. 2011
    ..To characterize the origin of this prespike BOLD signal change, we looked for electrographic changes in stereo-EEG (SEEG) possibly preceding the scalp spike in patients that showed early BOLD response in EEG/fMRI...
  6. pmc Combining EEG and fMRI in the study of epileptic discharges
    Jean Gotman
    Montreal Neurological Institute, McGill University, Montreal, QC, Canada
    Epilepsia 52:38-42. 2011
    ..In patients with new-onset epilepsy it could be used to evaluate the source and extent of the brain structures involved during discharges and their evolution as the disease progresses...
  7. ncbi request reprint Combining EEG and fMRI: a multimodal tool for epilepsy research
    Jean Gotman
    Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada
    J Magn Reson Imaging 23:906-20. 2006
    ....
  8. pmc Generalized epileptic discharges show thalamocortical activation and suspension of the default state of the brain
    J Gotman
    Montreal Neurological Institute and Department of Neurology and Neurosurgery, McGill University, 3801 University Street, Montreal, QC, Canada H3A 2B4
    Proc Natl Acad Sci U S A 102:15236-40. 2005
    ..This brief lapse of responsiveness may therefore not result only from the epileptic discharge but also from its effect on normal brain function...
  9. pmc Epileptic networks studied with EEG-fMRI
    Jean Gotman
    Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada
    Epilepsia 49:42-51. 2008
    ..The noninvasive nature of this method opens new horizons in the investigation of brain regions involved and affected by epileptic discharges...
  10. ncbi request reprint Pierre Gloor, 1923-2003
    Jean Gotman
    Montreal Neurological Institute, McGill University, 3801 University Street, Montreal, Quebec, Canada H3A 2B4
    Clin Neurophysiol 115:1235-6. 2004
  11. ncbi request reprint EEG-fMRI of epileptic spikes: concordance with EEG source localization and intracranial EEG
    Christian G Bénar
    Montreal Neurological Institute, 3801 University Street, Montreal, Quebec, Canada H3A 2B4
    Neuroimage 30:1161-70. 2006
    ..This could reflect an increase of metabolism linked to the presence of slow waves, which suggests that fMRI is a new source of information on the mechanisms of spike generation...
  12. pmc Value of electrical stimulation and high frequency oscillations (80-500 Hz) in identifying epileptogenic areas during intracranial EEG recordings
    Julia Jacobs
    Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada
    Epilepsia 51:573-82. 2010
    ..High frequency oscillations (HFOs--ripples, 80-250 Hz; fast ripples, 250-500 Hz) are linked to seizure onset. This study investigates whether interictal HFOs are more frequent in areas with a low threshold to provoke ADs or seizures...
  13. pmc Structures involved at the time of temporal lobe spikes revealed by interindividual group analysis of EEG/fMRI data
    Eliane Kobayashi
    Montreal Neurological Institute and Hospital, McGill University, Montreal, PQ, Canada
    Epilepsia 50:2549-56. 2009
    ....
  14. pmc Independent component analysis reveals dynamic ictal BOLD responses in EEG-fMRI data from focal epilepsy patients
    Pierre Levan
    Montreal Neurological Institute, McGill University, 3801 University Street, Montreal, QC, Canada
    Neuroimage 49:366-78. 2010
    ..In particular, the investigation of HRFs with clear peaks, but varying latency, may be used to differentiate the ictal focus from propagated activity...
  15. ncbi request reprint EEG-fMRI of focal epileptic spikes: analysis with multiple haemodynamic functions and comparison with gadolinium-enhanced MR angiograms
    Andrew P Bagshaw
    Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada
    Hum Brain Mapp 22:179-92. 2004
    ..Signal loss in the temporal lobes seemed to be an important factor in 7 of 12 patients who did not show fMRI activations with any of the HRFs...
  16. ncbi request reprint Temporal and extratemporal BOLD responses to temporal lobe interictal spikes
    Eliane Kobayashi
    Montreal Neurological Institute and Hospital, McGill University, 3801 University Street, Montreal, Quebec, Canada H3A 2B4
    Epilepsia 47:343-54. 2006
    ..Our objective was to investigate blood oxygenation level-dependent (BOLD) responses to temporal lobe (TL) spikes by using EEG-fMRI recording...
  17. ncbi request reprint Analysis of the EEG-fMRI response to prolonged bursts of interictal epileptiform activity
    Andrew P Bagshaw
    Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Room 786, 3801 University Street, Montreal, Quebec, Canada H3A 2B4
    Neuroimage 24:1099-112. 2005
    ..There were no consistent differences between the measured and modelled latencies...
  18. pmc High frequency oscillations (80-500 Hz) in the preictal period in patients with focal seizures
    Julia Jacobs
    Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada
    Epilepsia 50:1780-92. 2009
    ..These HFOs are more frequent in the seizure-onset zone (SOZ) and reported to be linked to seizure genesis. We evaluated whether HFO activity changes in a systematic way during the preictal period...
  19. pmc Functional connectivity in patients with idiopathic generalized epilepsy
    Friederike Moeller
    Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada
    Epilepsia 52:515-22. 2011
    ..The aim of this study was to investigate whether thalamocortical interactions are altered even during GSWD-free EEG periods in patients with IGE...
  20. doi request reprint EEG spectral changes underlying BOLD responses contralateral to spikes in patients with focal epilepsy
    Juming M Yu
    Montreal Neurological Institute and Department of Neurology and Neurosurgery, McGill University, Montreal, Canada
    Epilepsia 50:1804-9. 2009
    ..We aimed to investigate whether minimal EEG changes could underlie these contralateral BOLD responses by using EEG spectral analysis...
  21. pmc High-frequency electroencephalographic oscillations correlate with outcome of epilepsy surgery
    Julia Jacobs
    Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada
    Ann Neurol 67:209-20. 2010
    ..We investigated whether HFOs can delineate epileptogenic areas even outside the SOZ by correlating the resection of HFO-generating areas with surgical outcome...
  22. ncbi request reprint Using voxel-specific hemodynamic response function in EEG-fMRI data analysis
    Yingli Lu
    Montreal Neurological Institute, McGill University, 3801 University Street, Montreal, Quebec, Canada H3A 2B4
    Neuroimage 32:238-47. 2006
    ..The results suggest that the fixed HRF methods may not be the most appropriate for the analysis of epileptic activity with EEG-fMRI, and the deconvolution method may be a better choice...
  23. pmc Reproducibility of interictal EEG-fMRI results in patients with epilepsy
    Taha Gholipour
    Montreal Neurological Institute and Hospital, Montreal, Quebec, Canada
    Epilepsia 52:433-42. 2011
    ..We addressed the intrasubject reproducibility of EEG-fMRI and the possible superiority of higher magnetic field strength in patients who were scanned twice...
  24. pmc High-frequency oscillations, extent of surgical resection, and surgical outcome in drug-resistant focal epilepsy
    Claire Haegelen
    EEG Department, Montreal Neurological Institute, Montreal, Quebec, Canada
    Epilepsia 54:848-57. 2013
    ..We also assessed the relationship between the extent of surgical resection and surgical outcome...
  25. ncbi request reprint Hemodynamic and metabolic responses to activation, deactivation and epileptic discharges
    Bojana Stefanovic
    Montreal Neurological Institute, QC, Canada
    Neuroimage 28:205-15. 2005
    ..17. These findings provide evidence for a preserved coupling between hemodynamic and metabolic changes in response to both functional activation and, for the two case studies available, in response to interictal epileptiform activity...
  26. ncbi request reprint Negative BOLD responses to epileptic spikes
    Eliane Kobayashi
    Montreal Neurological Institute and Hospital, McGill University, Canada
    Hum Brain Mapp 27:488-97. 2006
    ..Involvement of the "default" areas, related to bursts of generalized discharges, provides evidence of a subclinical effect of the discharges, temporarily suspending normal brain function in the resting state...
  27. pmc Improving the identification of High Frequency Oscillations
    Rina Zelmann
    Montreal Neurological Institute and Hospital, EEG Department, McGill University, Que, Canada
    Clin Neurophysiol 120:1457-64. 2009
    ..We implemented a procedure to establish the duration for which a stable measurement of rate of HFOs is achieved...
  28. pmc Continuous high-frequency activity in mesial temporal lobe structures
    Francesco Mari
    Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada
    Epilepsia 53:797-806. 2012
    ..Future studies will need to evaluate systematically the presence of this pattern, as it may have a pathophysiologic significance and it will also have an important influence on the very definition of HFOs...
  29. ncbi request reprint Correspondence between EEG-fMRI and EEG dipole localisation of interictal discharges in focal epilepsy
    Andrew P Bagshaw
    Montreal Neurological Institute, McGill University, Room 786, 3801 University Street, Montreal, QC, Canada H3A 2B4
    Neuroimage 30:417-25. 2006
    ....
  30. ncbi request reprint High-frequency intracerebral EEG activity (100-500 Hz) following interictal spikes
    Elena Urrestarazu
    Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada
    Epilepsia 47:1465-76. 2006
    ....
  31. pmc High frequency oscillations and seizure frequency in patients with focal epilepsy
    Maeike Zijlmans
    Montreal Neurological Institute and Hospital, McGill University, 3801 University Street, Montreal Quebec, Canada H3A 2B4
    Epilepsy Res 85:287-92. 2009
    ..The hypothesis that the more tissue generating HFOs, the higher the seizure frequency, was not confirmed, though there might be a correlation for high FR rates...
  32. pmc Effects of fluctuating physiological rhythms during prolonged EEG-fMRI studies
    Louise Tyvaert
    EEG Department, Montreal Neurological Institute, McGill University, 3801 University Street, Montreal, Que, Canada H3A 2B4
    Clin Neurophysiol 119:2762-74. 2008
    ....
  33. pmc Absence seizures: individual patterns revealed by EEG-fMRI
    Friederike Moeller
    Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada
    Epilepsia 51:2000-10. 2010
    ..Furthermore, animal models provide evidence that absences are initiated by a cortical focus with a secondary involvement of the thalamus. The aim of this study was to investigate dynamic changes during absences...
  34. pmc BOLD signal changes preceding negative responses in EEG-fMRI in patients with focal epilepsy
    Rahul Rathakrishnan
    Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada
    Epilepsia 51:1837-45. 2010
    ..Recent studies describe BOLD signal changes before focal EEG spikes. We aimed to systematically study if the undershoot of a preceding positive response might explain the negative BOLD seen in the focus...
  35. ncbi request reprint BOLD changes occur prior to epileptic spikes seen on scalp EEG
    Colin S Hawco
    Montreal Neurological Institute and Hospital, McGill University, 3801 University Street, Montreal, Quebec, Canada H3A 2B4
    Neuroimage 35:1450-8. 2007
    ..This is the first report of a BOLD response occurring several seconds prior to an interictal event seen on the scalp and could have important implications for our understanding of the generation of epileptic discharges...
  36. doi request reprint Continuous High Frequency Activity: a peculiar SEEG pattern related to specific brain regions
    Federico Melani
    Montreal Neurological Institute, McGill University, Montreal, QC, Canada
    Clin Neurophysiol 124:1507-16. 2013
    ..We aim to analyze in all brain regions the occurrence and significance of this particular pattern...
  37. pmc Patterns of altered functional connectivity in mesial temporal lobe epilepsy
    Francesca Pittau
    Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada
    Epilepsia 53:1013-23. 2012
    ..We hypothesize that patients show reduced functional connectivity compared to controls, the interest being to determine which regions show this reduction...
  38. pmc Interictal high frequency oscillations (HFOs) in patients with focal epilepsy and normal MRI
    Luciana Andrade-Valença
    Montreal Neurological Institute, McGill University, Montreal, QC, Canada
    Clin Neurophysiol 123:100-5. 2012
    ..We aim to analysis the relationship between HFOs-generating regions and the seizure onset zone (SOZ) in epileptic patients without a visible lesion on MRI...
  39. pmc Modulation by EEG features of BOLD responses to interictal epileptiform discharges
    Pierre Levan
    Montreal Neurological Institute, McGill University, Montreal, QC, Canada
    Neuroimage 50:15-26. 2010
    ..This study investigates HRF variability with respect to IED amplitude fluctuations using independent component analysis (ICA), with the goal of improving the specificity of EEG-fMRI analyses...
  40. pmc Coexistence of symptomatic focal and absence seizures: video-EEG and EEG-fMRI evidence of overlapping but independent epileptogenic networks
    Serge Chassagnon
    Montreal Neurological Institute and Hospital, McGill University, Montreal, Canada
    Epilepsia 50:1821-6. 2009
    ..Whether the patient had distinct epileptic syndromes or distinct electrographic patterns from the lesional trigger remains debatable...
  41. pmc Contact size does not affect high frequency oscillation detection in intracerebral EEG recordings in a rat epilepsy model
    Claude Edouard Chatillon
    Department of Neurosurgery, Montreal Neurological Hospital, McGill University, Montreal, Canada
    Clin Neurophysiol 122:1701-5. 2011
    ..This study assesses the feasibility of HFO detection in a rat epilepsy model using macrocontacts and clinical amplifiers, and the effect of contact size on HFO detection within the macrocontact range...
  42. pmc Ictal and interictal high frequency oscillations in patients with focal epilepsy
    Maeike Zijlmans
    Montreal Neurological Institute and Hospital, McGill University, Montreal Quebec, Canada
    Clin Neurophysiol 122:664-71. 2011
    ..They occur during seizures and interictally and seem important in seizure genesis. We investigated whether interictal and ictal HFOs occur in the same regions and how they relate to epileptiform spikes...
  43. pmc Interictal high-frequency oscillations (80-500 Hz) are an indicator of seizure onset areas independent of spikes in the human epileptic brain
    Julia Jacobs
    Montreal Neurological Institute and Hospital, Montreal, Canada
    Epilepsia 49:1893-907. 2008
    ..HFOs occur frequently at the time of interictal spikes, but were also found independently. This study analyses the relationship between spikes and HFOs and the occurrence of HFOs in nonspiking channels...
  44. ncbi request reprint Using patient-specific hemodynamic response functions in combined EEG-fMRI studies in epilepsy
    Joong Koo Kang
    Montreal Neurological Institute, 3801 University Street, McGill University, Montreal, Quebec, Canada H3A 2B4
    Neuroimage 20:1162-70. 2003
    ..Using patient-specific HRFs brings increased sensitivity to the analysis of epileptic spikes by EEG-fMRI...
  45. ncbi request reprint The BOLD response to interictal epileptiform discharges
    Christian G Bénar
    Montreal Neurological Institute, McGill University, Montreal, Quebec, H3A 2B4, Canada
    Neuroimage 17:1182-92. 2002
    ..The possibility of a longer HRF could be used to improve statistical detection of activation in simultaneous EEG-fMRI. The variability in average HRFs across patients could reflect in part different pathophysiological mechanisms...
  46. ncbi request reprint Seizure anticipation: do mathematical measures correlate with video-EEG evaluation?
    Vincent Navarro
    Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada
    Epilepsia 46:385-96. 2005
    ..We therefore performed a systematic comparison of a nonlinear method (the similarity measure) with classic visual inspection of the EEG and the patient's clinical state...
  47. doi request reprint High-frequency (80-500 Hz) oscillations and epileptogenesis in temporal lobe epilepsy
    Maxime Levesque
    Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, 3801 University Street, Montreal, QC, Canada
    Neurobiol Dis 42:231-41. 2011
    ..These distinct categories of interictal spikes point at dynamic processes that should bring neuronal networks close to seizure generation...
  48. pmc Independent component analysis (ICA) of generalized spike wave discharges in fMRI: comparison with general linear model-based EEG-fMRI
    Friederike Moeller
    Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada
    Hum Brain Mapp 32:209-17. 2011
    ..This study demonstrated that the BOLD response largely resembles the standard HRF and that GLM analysis is adequate. However, ICA is more dependent on a sufficient number of events than GLM analysis...
  49. ncbi request reprint Grey matter heterotopia: what EEG-fMRI can tell us about epileptogenicity of neuronal migration disorders
    Eliane Kobayashi
    Montreal Neurological Institute and Hospital, McGill University, Montreal, Canada
    Brain 129:366-74. 2006
    ..EEG-fMRI may become a useful tool to understand the epileptogenicity of such malformations...
  50. ncbi request reprint Metabolic correlates of epileptic spikes in cerebral cavernous angiomas
    Eliane Kobayashi
    Montreal Neurological Institute and Hospital, McGill University, 3801 University Street, Montreal PQ, Canada H3A 2B4
    Epilepsy Res 73:98-103. 2007
    ..Epileptogenicity is usually attributed to hemosiderin deposits. Combined recording of electroencephalogram (EEG) and functional magnetic resonance imaging (fMRI) is a new method to investigate epileptic discharges...
  51. ncbi request reprint Dipole localization using simulated intracerebral EEG
    Nathalie Chang
    Montreal Neurological Institute, McGill University, QC, Canada
    Clin Neurophysiol 116:2707-16. 2005
    ..Our objective was to improve foci detection in intracerebral recordings by applying source localization methods...
  52. ncbi request reprint Using voxel-specific hemodynamic response function in EEG-fMRI data analysis: An estimation and detection model
    Yingli Lu
    Montreal Neurological Institute, McGill University, 3801 University Street, Montreal, Quebec, Canada H3A 2B4
    Neuroimage 34:195-203. 2007
    ..The results suggest that the new model can do better than the fixed HRF GLM for the analysis of epileptic activity with EEG-fMRI...
  53. ncbi request reprint Statistical maps for EEG dipolar source localization
    Christian G Bénar
    Montreal Neurological Institute, McGill University, Montreal, QC H3A 2B4, Canada
    IEEE Trans Biomed Eng 52:401-13. 2005
    ..The maps were compared with LORETA and MUSIC results. For the real data consisting of an average of epileptic spikes, we observed good agreement between the EEG statistical maps, intracranial EEG recordings, and fMRI activations...
  54. ncbi request reprint Removing eye-movement artifacts from the EEG during the intracarotid amobarbital procedure
    Weidong Zhou
    Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada
    Epilepsia 46:409-14. 2005
    ..In scalp recordings, the EEG is always heavily contaminated with eye movement artifacts as the patient actively performs visual tasks...
  55. pmc Noninvasive dynamic imaging of seizures in epileptic patients
    Louise Tyvaert
    Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada H3A 2B4
    Hum Brain Mapp 30:3993-4011. 2009
    ..This new noninvasive approach should open the study of seizure generation and propagation mechanisms in the whole brain to groups of patients with focal epilepsies...
  56. doi request reprint Electroencephalography/functional magnetic resonance imaging responses help predict surgical outcome in focal epilepsy
    Dongmei An
    Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada Department of Neurology, West China Hospital, Sichuan University, Chengdu, China
    Epilepsia 54:2184-94. 2013
    ..EEG/fMRI is gaining interest as a presurgical evaluation tool. This study aims to determine how hemodynamic responses related to epileptic activity can help predict surgical outcome in patients considered for epilepsy surgery...
  57. doi request reprint A comparison between automated detection methods of high-frequency oscillations (80-500 Hz) during seizures
    Pariya Salami
    Montreal Neurological Institute and Department of Neurology and Neurosurgery, McGill University, Montreal, H3A 2B4 QC, Canada
    J Neurosci Methods 211:265-71. 2012
    ..These findings suggest that method 3 could be used for automated and reliable detection of HFOs on large data sets containing multiple channels during the ictal period...
  58. doi request reprint Conventional and reciprocal approaches to the inverse dipole localization problem for N(20)-P (20) somatosensory evoked potentials
    Stefan Finke
    Institute of Biomedical Engineering, Universite de Montreal, Montreal, QC, Canada
    Brain Topogr 26:24-34. 2013
    ..Reduced computational requirements and similar dipole position accuracy support the use of reciprocal approaches over conventional approaches for N(20)-P(20) SEP source localization...
  59. ncbi request reprint The role of periventricular nodular heterotopia in epileptogenesis
    Yahya Aghakhani
    Department of Neurology and Neurosurgery, Montreal Neurological Hospital and Institute, McGill University, Quebec, Canada
    Brain 128:641-51. 2005
    ..Invasive recording is required in patients with PNH; it improves localization and is the key to better outcome...
  60. ncbi request reprint Interictal high-frequency oscillations (100-500 Hz) in the intracerebral EEG of epileptic patients
    Elena Urrestarazu
    Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada
    Brain 130:2354-66. 2007
    ..Our results also suggest a special capacity of the abnormal hippocampus to generate FRs, although they were also recorded in other structures...
  61. ncbi request reprint fMRI activation in continuous and spike-triggered EEG-fMRI studies of epileptic spikes
    Abdulla Al-Asmi
    Montreal Neurological Institute and Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada
    Epilepsia 44:1328-39. 2003
    ..To evaluate functional magnetic resonance imaging (fMRI) with simultaneous EEG for finding metabolic sources of epileptic spikes. To find the localizing value of activated regions and factors influencing fMRI responses...
  62. pmc Independent component analysis as a model-free approach for the detection of BOLD changes related to epileptic spikes: a simulation study
    Pierre Levan
    Montreal Neurological Institute, McGill University, Montreal, Canada
    Hum Brain Mapp 30:2021-31. 2009
    ..ICA may thus be able to extract BOLD responses from EEG-fMRI data in epileptic patients, in a way that is robust to uncertainty and variability in the shape of the HRF...
  63. ncbi request reprint Quality of EEG in simultaneous EEG-fMRI for epilepsy
    ChristianG Bénar
    Montreal Neurological Institute and Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada
    Clin Neurophysiol 114:569-80. 2003
    ..We present and evaluate techniques to obtain an EEG of good quality when performing simultaneous EEG and fMRI studies...
  64. pmc Resting-state connectivity of the sustained attention network correlates with disease duration in idiopathic generalized epilepsy
    Mona Maneshi
    Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada
    PLoS ONE 7:e50359. 2012
    ....
  65. doi request reprint Widespread epileptic networks in focal epilepsies: EEG-fMRI study
    Firas Fahoum
    Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada
    Epilepsia 53:1618-27. 2012
    ....
  66. ncbi request reprint Two seizure-onset types reveal specific patterns of high-frequency oscillations in a model of temporal lobe epilepsy
    Maxime Levesque
    Montreal Neurological Institute and Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada H3A 2B4
    J Neurosci 32:13264-72. 2012
    ..Our findings demonstrate that ripples and fast ripples show distinct time- and region-specific patterns during LVF and HYP seizures, thus suggesting that they play specific roles in ictogenesis...
  67. pmc Automatic detection of fast oscillations (40-200 Hz) in scalp EEG recordings
    Nicolas von Ellenrieder
    Montreal Neurological Institute, McGill University, Montreal, Canada
    Clin Neurophysiol 123:670-80. 2012
    ..We aim to automatically detect fast oscillations (40-200 Hz) related to epilepsy on scalp EEG recordings...
  68. doi request reprint Convulsive status epilepticus duration as determinant for epileptogenesis and interictal discharge generation in the rat limbic system
    Aleksandra Bortel
    Montreal Neurological Institute, McGill University, Montreal, QC, Canada
    Neurobiol Dis 40:478-89. 2010
    ..These findings indicate that convulsive SE duration influences the development of interictal and ictal activity, and that interictal discharges undergo structure-specific changes after seizure appearance...
  69. ncbi request reprint An automatic warning system for epileptic seizures recorded on intracerebral EEGs
    Sukhi Grewal
    Montreal Neurological Institute, McGill University, Montreal, Que, Canada H3A 2B4
    Clin Neurophysiol 116:2460-72. 2005
    ..A new clinical seizure waning system for intracerebral EEG is proposed. It is aimed at a better performance than existing systems and at user tuneability...
  70. pmc Contribution of EEG/fMRI to the definition of the epileptic focus
    Francesca Pittau
    Montreal Neurological Institute and Hospital, McGill University, Montreal, Canada
    Neurology 78:1479-87. 2012
    ..To evaluate the clinical relevance of EEG/fMRI in patients with focal epilepsy, by assessing the information it adds to the scalp EEG in the definition of the epileptic focus...
  71. doi request reprint Antiepileptic drugs abolish ictal but not interictal epileptiform discharges in vitro
    Margherita D'Antuono
    Montreal Neurological Institute and Department of Neurology, McGill University, Montreal, Quebec, Canada
    Epilepsia 51:423-31. 2010
    ....
  72. ncbi request reprint Conventional and reciprocal approaches to the inverse dipole localization problem of electroencephalography
    Stefan Finke
    Institute of Biomedical Engineering, Universite de Montreal, Succursale Centre Ville, Montreal, QC H3C 3J7, Canada
    IEEE Trans Biomed Eng 50:657-66. 2003
    ..In the presence of Gaussian noise, both conventional and reciprocal approaches were also found to be equally robust to skull conductivity errors...
  73. doi request reprint Using continuous electroencephalography in the management of delayed cerebral ischemia following subarachnoid hemorrhage
    Rahul Rathakrishnan
    Montreal Neurological Institute, McGill University, 3801 University Street, Montreal, QC, H3A 3B4, Canada
    Neurocrit Care 14:152-61. 2011
    ..We sought to determine whether continuous electroencephalography (CEEG) aids the prediction of the clinical course and response to treatment of DCI...
  74. ncbi request reprint Intracranial Electrode Visualization in Invasive Pre-surgical Evaluation for Epilepsy
    Yunhua Wang
    Stellate, 376 Victoria Avenue, Montreal, QC, H3Z1C3 Canada E mail
    Conf Proc IEEE Eng Med Biol Soc 1:952-5. 2005
    ..This platform can efficiently facilitate the epilepsy pre-surgical evaluation and epilepsy surgery planning...
  75. doi request reprint Computed basis functions for finite element analysis based on tomographic data
    Huanhuan Gu
    Department of Electrical and Computer Engineering, McGill University, Montreal, QC H3A 2A7, Canada
    IEEE Trans Biomed Eng 58:2498-505. 2011
    ..The new method gives potentials that are different to those obtained by treating each voxel as an element by 1% of the peak voltage, yet the global finite element matrix has a dimension which is more than 50 times smaller...
  76. ncbi request reprint Computer-aided spatial classification of epileptic spikes
    Danny Flanagan
    Stellate Systems, Montreal, Quebec, Canada
    J Clin Neurophysiol 19:125-35. 2002
    ..Overall, they found that this method performs very well for frequent events, but does not perform well for rare events or for diffuse EEG abnormalities...
  77. ncbi request reprint Heart rate changes and ECG abnormalities during epileptic seizures: prevalence and definition of an objective clinical sign
    Maeike Zijlmans
    Montreal Neurological Institute and Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada
    Epilepsia 43:847-54. 2002
    ..To assess the risk factors for the occurrence of ECG abnormalities...
  78. ncbi request reprint Systematic source estimation of spikes by a combination of independent component analysis and RAP-MUSIC. II: Preliminary clinical application
    Katsuhiro Kobayashi
    Department of Child Neurology, Okayama University Medical School, 5 1 Shikatacho 2 chome, Japan
    Clin Neurophysiol 113:725-34. 2002
    ..We tried to estimate epileptic sources by a combination of independent component analysis (ICA) and recursively applied and projected multiple signal classification (RAP-MUSIC) in real epileptiform EEG discharges...
  79. ncbi request reprint Quantitative interictal subdural EEG analyses in children with neocortical epilepsy
    Eishi Asano
    Department of Pediatrics, Children s Hospital of Michigan, Detroit, Michigan 48201, USA
    Epilepsia 44:425-34. 2003
    ....
  80. ncbi request reprint A simulation study of the error in dipole source localization for EEG spikes with a realistic head model
    Katsuhiro Kobayashi
    Department of Child Neurology, Okayama University Graduate School of Medicine and Dentistry, 5 1 Shikatacho 2 chome, 700 8558, Okayama, Japan
    Clin Neurophysiol 114:1069-78. 2003
    ..The computed error range was also compared with the degree of disturbance of dipole modeling caused by adding background activity to the spike...
  81. ncbi request reprint Hemodynamic responses to interictal epileptiform discharges in children with symptomatic epilepsy
    Julia Jacobs
    Neuropediatric Department, Christian Albrechts University Kiel, Schwanenweg 20, Kiel, Germany
    Epilepsia 48:2068-78. 2007
    ..Childhood epilepsies, however, differ from those in adults due to interactions between epileptogenic and developmental processes. The purpose of this study was to investigate EEG-fMRI in children with lesional epilepsies...
  82. ncbi request reprint EEG-fMRI using z-shimming in patients with temporal lobe epilepsy
    Andrew P Bagshaw
    School of Psychology, University of Birmingham, Birmingham, United Kingdom
    J Magn Reson Imaging 24:1025-32. 2006
    ....
  83. ncbi request reprint Systematic source estimation of spikes by a combination of independent component analysis and RAP-MUSIC. I: Principles and simulation study
    Katsuhiro Kobayashi
    Department of Child Neurology, Okayama University Medical School, 5 1 Shikatacho 2 chome, Japan
    Clin Neurophysiol 113:713-24. 2002
    ..The method is minimally dependent on subjective decisions...
  84. ncbi request reprint Dipole modeling of epileptic spikes can be accurate or misleading
    Katsuhiro Kobayashi
    Department of Child Neurology, Okayama University Graduate School of Medicine and Dentistry, and Okayama University Hospital, Okayama, Japan
    Epilepsia 46:397-408. 2005
    ..Spike generators were realistically simulated with cortical areas of different extents...
  85. pmc Quantitative visualization of ictal subdural EEG changes in children with neocortical focal seizures
    Eishi Asano
    Department of Pediatrics, Children s Hospital of Michigan, Wayne State University, Detroit, MI 48201, USA
    Clin Neurophysiol 115:2718-27. 2004
    ..To quantify the ictal subdural electroencephalogram (EEG) changes using spectral analysis, and to delineate the quantitatively defined ictal onset zones on high-resolution 3D MR images in children with intractable neocortical epilepsy...
  86. doi request reprint Evaluation of epileptogenic networks in children with tuberous sclerosis complex using EEG-fMRI
    Julia Jacobs
    Neuropediatric Department, Christian Albrechts University Kiel, Kiel, Germany
    Epilepsia 49:816-25. 2008
    ..Ninety percent of patients with tuberous sclerosis complex (TSC) have epilepsy. Identification of epileptogenic areas can be difficult and studies are needed to characterize the epileptogenic network in more detail...
  87. pmc Variability of the hemodynamic response as a function of age and frequency of epileptic discharge in children with epilepsy
    Julia Jacobs
    Neuropediatric Department, Pediatric Hospital, Christian Albrechts University, Schwanenweg 20, D 24105 Kiel, Germany
    Neuroimage 40:601-14. 2008
    ..This reflects a violation of the assumptions of the General Linear Model and therefore the use of alternative analysis techniques may be more appropriate with high spiking rates, a common situation in children...
  88. ncbi request reprint Recommendations regarding the requirements and applications for long-term recordings in epilepsy
    Demetrios Velis
    Department of Clinical Neurophysiology and Epilepsy Monitoring Unit, Dutch Epilepsy Clinics Foundation, Heemstede, The Netherlands
    Epilepsia 48:379-84. 2007
    ....
  89. ncbi request reprint Detection of rapid-eye movements in sleep studies
    Rajeev Agarwal
    Stellate Systems, 376 Victoria Ave, Suite 200, Montreal, QC H3Z 1C3 Canada
    IEEE Trans Biomed Eng 52:1390-6. 2005
    ..8% and specificity of 81.6%. The performance on the testing data (recording from five subjects different from the training data) showed overall sensitivity of 67.2% and specificity of 77.5%...