A C Gingras

Summary

Affiliation: McGill University
Country: Canada

Publications

  1. ncbi request reprint eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translation
    A C Gingras
    Department of Biochemistry McGill University, Montreal, Quebec, Canada
    Annu Rev Biochem 68:913-63. 1999
  2. pmc Hierarchical phosphorylation of the translation inhibitor 4E-BP1
    A C Gingras
    Department of Biochemistry and McGill Cancer Centre, McGill University, Montreal, Quebec H3G 1Y6, Canada
    Genes Dev 15:2852-64. 2001
  3. pmc Activation of the translational suppressor 4E-BP1 following infection with encephalomyocarditis virus and poliovirus
    A C Gingras
    Department of Biochemistry and McGill Cancer Centre, McGill University, Montreal, Canada
    Proc Natl Acad Sci U S A 93:5578-83. 1996
  4. ncbi request reprint Regulation of translation initiation by FRAP/mTOR
    A C Gingras
    Department of Biochemistry, McGill University, Montreal, Quebec H3G 1Y6, Canada
    Genes Dev 15:807-26. 2001
  5. ncbi request reprint Adipose tissue reduction in mice lacking the translational inhibitor 4E-BP1
    K Tsukiyama-Kohara
    Department of Biochemistry and McGill Cancer Center, McGill University, Montreal, Quebec, Canada
    Nat Med 7:1128-32. 2001
  6. pmc Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism
    A C Gingras
    Department of Biochemistry and McGill Cancer Center, McGill University, Montreal, Quebec, H3G 1Y6, Canada
    Genes Dev 13:1422-37. 1999
  7. ncbi request reprint Tissue distribution, genomic structure, and chromosome mapping of mouse and human eukaryotic initiation factor 4E-binding proteins 1 and 2
    K Tsukiyama-Kohara
    Department of Biochemistry, McGill University, Montreal, Quebec, H3G 1Y6, Canada
    Genomics 38:353-63. 1996
  8. ncbi request reprint 4E-BP3, a new member of the eukaryotic initiation factor 4E-binding protein family
    F Poulin
    Department of Biochemistry and McGill Cancer Center, McGill University, Montreal, Quebec H3G 1Y6, Canada
    J Biol Chem 273:14002-7. 1998
  9. pmc Translational homeostasis: eukaryotic translation initiation factor 4E control of 4E-binding protein 1 and p70 S6 kinase activities
    K Khaleghpour
    Department of Biochemistry and McGill Cancer Center, McGill University, Montreal, Quebec, Canada H3G 1Y6
    Mol Cell Biol 19:4302-10. 1999
  10. ncbi request reprint Adenovirus infection inactivates the translational inhibitors 4E-BP1 and 4E-BP2
    A C Gingras
    Department of Biochemistry and McGill Cancer Center, McGill University, Montreal, Quebec, H3G 1Y6, Canada
    Virology 237:182-6. 1997

Collaborators

Detail Information

Publications23

  1. ncbi request reprint eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translation
    A C Gingras
    Department of Biochemistry McGill University, Montreal, Quebec, Canada
    Annu Rev Biochem 68:913-63. 1999
    ..The recent determination of the structure of eIF4E at atomic resolution has provided insight about how translation is initiated and regulated. Evidence suggests that eIF4F is also implicated in malignancy and apoptosis...
  2. pmc Hierarchical phosphorylation of the translation inhibitor 4E-BP1
    A C Gingras
    Department of Biochemistry and McGill Cancer Centre, McGill University, Montreal, Quebec H3G 1Y6, Canada
    Genes Dev 15:2852-64. 2001
    ..Finally, we show that phosphorylation of Ser 65 and Thr 70 alone is insufficient to block binding to eIF4E, indicating that a combination of phosphorylation events is necessary to dissociate 4E-BP1 from eIF4E...
  3. pmc Activation of the translational suppressor 4E-BP1 following infection with encephalomyocarditis virus and poliovirus
    A C Gingras
    Department of Biochemistry and McGill Cancer Centre, McGill University, Montreal, Canada
    Proc Natl Acad Sci U S A 93:5578-83. 1996
    ..Dephosphorylation of 4E-BP1 by specifically inhibiting cap-dependent translation may be the major cause of the shutoff phenomenon in EMCV-infected cells...
  4. ncbi request reprint Regulation of translation initiation by FRAP/mTOR
    A C Gingras
    Department of Biochemistry, McGill University, Montreal, Quebec H3G 1Y6, Canada
    Genes Dev 15:807-26. 2001
  5. ncbi request reprint Adipose tissue reduction in mice lacking the translational inhibitor 4E-BP1
    K Tsukiyama-Kohara
    Department of Biochemistry and McGill Cancer Center, McGill University, Montreal, Quebec, Canada
    Nat Med 7:1128-32. 2001
    ..These findings demonstrate that 4E-BP1 is a novel regulator of adipogenesis and metabolism in mammals...
  6. pmc Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism
    A C Gingras
    Department of Biochemistry and McGill Cancer Center, McGill University, Montreal, Quebec, H3G 1Y6, Canada
    Genes Dev 13:1422-37. 1999
    ..Taken together, our results suggest that 4E-BP1 phosphorylation by FRAP/mTOR on Thr-37 and Thr-46 is a priming event for subsequent phosphorylation of the carboxy-terminal serum-sensitive sites...
  7. ncbi request reprint Tissue distribution, genomic structure, and chromosome mapping of mouse and human eukaryotic initiation factor 4E-binding proteins 1 and 2
    K Tsukiyama-Kohara
    Department of Biochemistry, McGill University, Montreal, Quebec, H3G 1Y6, Canada
    Genomics 38:353-63. 1996
    ..Mouse 4E-BP1 and 4E-BP2 map to chromosomes 8 (A4-B1) and 10 (B4-B5), respectively, and human 4E-BP1 and 4E-BP2 localize to chromosomes 8p12 and 10q21-q22, respectively...
  8. ncbi request reprint 4E-BP3, a new member of the eukaryotic initiation factor 4E-binding protein family
    F Poulin
    Department of Biochemistry and McGill Cancer Center, McGill University, Montreal, Quebec H3G 1Y6, Canada
    J Biol Chem 273:14002-7. 1998
    ..The overlapping function and expression of the different 4E-BP family members imply that there is redundancy in this translational control mechanism, underscoring its importance...
  9. pmc Translational homeostasis: eukaryotic translation initiation factor 4E control of 4E-binding protein 1 and p70 S6 kinase activities
    K Khaleghpour
    Department of Biochemistry and McGill Cancer Center, McGill University, Montreal, Quebec, Canada H3G 1Y6
    Mol Cell Biol 19:4302-10. 1999
    ..We conclude that eIF4E engenders a negative feedback loop that targets a component of the PI 3-kinase signalling pathway which lies downstream of PI 3-kinase...
  10. ncbi request reprint Adenovirus infection inactivates the translational inhibitors 4E-BP1 and 4E-BP2
    A C Gingras
    Department of Biochemistry and McGill Cancer Center, McGill University, Montreal, Quebec, H3G 1Y6, Canada
    Virology 237:182-6. 1997
    ..Findings similar to those described here were reported for 4E-BP1 by D. Feigenblum and R. J. Schneider (1996, Mol. Cell. Biol. 16, 5450-5457)...
  11. ncbi request reprint Cloning and characterization of 4EHP, a novel mammalian eIF4E-related cap-binding protein
    E Rom
    Department of Biochemistry, McGill University, Montreal, Quebec, Canada H3G1Y6
    J Biol Chem 273:13104-9. 1998
    ..A putative function for 4EHP is discussed...
  12. pmc Human eukaryotic translation initiation factor 4G (eIF4G) recruits mnk1 to phosphorylate eIF4E
    S Pyronnet
    Department of Biochemistry and McGill Cancer Cancer Center, McGill University, 3655 Drummond Street, Montreal, Quebec, H3G 1Y6 Canada
    EMBO J 18:270-9. 1999
    ..We also show that Mnk1 interacts with the C-terminal region of the translational inhibitor p97, an eIF4G-related protein that does not bind eIF4E, raising the possibility that p97 can block phosphorylation of eIF4E by sequestering Mnk1...
  13. ncbi request reprint The eIF4E-binding proteins 1 and 2 are negative regulators of cell growth
    D Rousseau
    Department of Biochemistry and McGill Cancer Center, McGill University, Montreal, Quebec, Canada
    Oncogene 13:2415-20. 1996
    ..Thus, we demonstrate that the eIF4E-binding proteins act as negative regulators of cell growth. We propose that 4E-BPs are members of a class of negative regulators of cell growth acting on the translation machinery of the cell...
  14. ncbi request reprint Phosphorylation of eIF-4E on serine 209 by protein kinase C is inhibited by the translational repressors, 4E-binding proteins
    S G Whalen
    Department of Biochemistry and McGill Cancer Centre, McGill University, Montreal, Quebec, Canada
    J Biol Chem 271:11831-7. 1996
    ..This suggests a two-step model for the phosphorylation (and activation) of eIF4E by growth factors and hormones: first, dissociation of eIF4E from 4E-BPs, followed by eIF4E phosphorylation...
  15. ncbi request reprint mTOR signaling to translation
    A C Gingras
    Department of Biochemistry, McGill Cancer Centre, McGill University, 3655 Promenade Sir William Osler, Montreal, Quebec, H3G 1Y6, Canada
    Curr Top Microbiol Immunol 279:169-97. 2004
    ..We then describe how the TOR pathway can modulate translation in yeast and in mammals, through the modulation of the phosphorylation of key translation components, and the regulation of the abundance of ribosomes and translation factors...
  16. ncbi request reprint The mRNA 5' cap-binding protein eIF4E and control of cell growth
    N Sonenberg
    Department of Biochemistry, McGill University, Montreal, Quebec, Canada
    Curr Opin Cell Biol 10:268-75. 1998
    ..A major unresolved question is how the changes in translation modulate cell growth rate, and a working model will be discussed...
  17. ncbi request reprint Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function
    A Pause
    Department of Biochemistry, McGill University, Montreal, Quebec, Canada
    Nature 371:762-7. 1994
    ..The action of this new regulator of protein synthesis is therefore modulated by insulin, which acts to stimulate the overall rate of translation and promote cell growth...
  18. ncbi request reprint Regulation of the rapamycin and FKBP-target 1/mammalian target of rapamycin and cap-dependent initiation of translation by the c-Abl protein-tyrosine kinase
    V Kumar
    Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 275:10779-87. 2000
    ..These findings with the c-Abl tyrosine kinase represent the first demonstration of a negative physiologic regulator of RAFT1-mediated 5' cap-dependent translation...
  19. ncbi request reprint Cap-dependent translation initiation in eukaryotes is regulated by a molecular mimic of eIF4G
    J Marcotrigiano
    Laboratories of Molecular Biophysics, Rockefeller University, New York, New York 10021, USA
    Mol Cell 3:707-16. 1999
    ..The implications of our results for translation initiation are discussed in detail, and a molecular mechanism for relief of translation inhibition following phosphorylation of the 4E-BPs is proposed...
  20. ncbi request reprint Insulin regulation of protein translation repressor 4E-BP1, an eIF4E-binding protein, in renal epithelial cells
    B K Bhandari
    Department of Medicine, University of Texas Health Science Center, San Antonio, Texas 78299-3900, USA
    Kidney Int 59:866-75. 2001
    ..The requirement for Erk-1/-2 MAP kinase activation for 4E-BP1 phosphorylation by insulin suggests a cross-talk between PI 3-kinase and Erk-1/-2-type MAP kinase pathways...
  21. ncbi request reprint Differential regulation of translation and eIF4E phosphorylation during human thymocyte maturation
    L Beretta
    INSERM U 365, Institut Curie, Paris, France
    J Immunol 160:3269-73. 1998
    ..These data provide evidence for differential regulation of the translational machinery during T cell development...
  22. ncbi request reprint Requirement for Akt (protein kinase B) in insulin-induced activation of glycogen synthase and phosphorylation of 4E-BP1 (PHAS-1)
    M Takata
    Second Department of Internal Medicine, Kobe University School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    J Biol Chem 274:20611-8. 1999
    ..These data suggest that Akt, but not PKClambda, is required for insulin activation of glycogen synthase and for insulin-induced phosphorylation of 4E-BP1...
  23. pmc The target of rapamycin (TOR) proteins
    B Raught
    Department of Biochemistry and McGill Cancer Centre, McGill University, 3655 Promenade Sir-William-Osler, , QC H3G 1Y6 Canada
    Proc Natl Acad Sci U S A 98:7037-44. 2001
    ..Intriguingly, recent studies have also suggested that TOR signaling plays a critical role in brain development, learning, and memory formation...