Research Topics
| Christina GianoulakisSummaryAffiliation: McGill University Country: Canada Publications
| Collaborators
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Detail Information
Publications
Effect of chronic alcohol consumption on the activity of the hypothalamic-pituitary-adrenal axis and pituitary beta-endorphin as a function of alcohol intake, age, and genderChristina Gianoulakis
Douglas Hospital Research Centre, 6875 LaSalle Blvd, Verdun, Quebec, Canada
Alcohol Clin Exp Res 27:410-23. 2003..The objective of the present studies was to investigate the hypothesis that chronic alcohol consumption alters the activity of the HPA axis and pituitary beta-END as a function of severity of alcohol abuse, gender, and age...- Endogenous opioids and addiction to alcohol and other drugs of abuseChristina Gianoulakis
Douglas Hospital Research Centre and Department of Psychiatry McGill University Montreal Quebec, Canada
Curr Top Med Chem 4:39-50. 2004..Furthermore, the use of opioid antagonists in the treatment of drug addiction will be discussed. Special emphasis will be given to ethanol addiction, the drug mainly studied in my laboratory... - Levels and circadian rhythmicity of plasma ACTH, cortisol, and beta-endorphin as a function of family history of alcoholismChristina Gianoulakis
Douglas Hospital Research Centre, Montreal, Quebec, Canada
Psychopharmacology (Berl) 181:437-44. 2005..Individuals with a family history of alcoholism may present a dysfunction in the activity of the hypothalamic-pituitary-adrenal (HPA) axis that predates the development of alcoholism... - Endogenous opioids and addiction to alcohol and other drugs of abuseChristina Gianoulakis
Douglas Mental Health University Institute, 6875 LaSalle Blvd, Montreal, Quebec, H4H 1R3, Canada
Curr Top Med Chem 9:999-1015. 2009..Furthermore, the use of opioid antagonists in the treatment of drug addiction will be discussed. Special emphasis will be given to ethanol addiction, the drug mainly studied in my laboratory... 
Influence of the endogenous opioid system on high alcohol consumption and genetic predisposition to alcoholismC Gianoulakis
Douglas Hospital Research Centre, Department of Psychiatry, McGill University, Montreal, Que
J Psychiatry Neurosci 26:304-18. 2001....- Response of the HPA-axis to alcohol and stress as a function of alcohol dependence and family history of alcoholismXing Dai
Douglas Hospital Research Centre and Department of Psychiatry, McGill University, Montreal, Que, Canada
Psychoneuroendocrinology 32:293-305. 2007.... 
From the brain to bad behaviour and back again: neurocognitive and psychobiological mechanisms of driving while impaired by alcoholThomas G Brown
Douglas Hospital Research Centre, Montreal, Quebec, Canada
Drug Alcohol Rev 28:406-18. 2009..These shortcomings reflect the baffling heterogeneity in the DWI population and the limited focus of much existing DWI recidivism research to psychosocial, psychological and substance use correlates...- Hypothalamic-pituitary-adrenal axis response to stress in male DUI recidivistsSophie Couture
Addiction Research Program, Douglas Hospital Research Centre, Verdun, Quebec, Canada
Accid Anal Prev 40:246-53. 2008.... - Response of the hypothalamic-pituitary-adrenal axis to stress in the absence and presence of ethanol in subjects at high and low risk of alcoholismXing Dai
Douglas Hospital Research Centre and the Department of Psychiatry, McGill University, Montreal, Quebec, Canada
Neuropsychopharmacology 27:442-52. 2002.... - Effects of acute ethanol on opioid peptide release in the central amygdala: an in vivo microdialysis studyMinh P Lam
Department of Physiology, McGill University, Montreal, Canada
Psychopharmacology (Berl) 201:261-71. 2008..However, the precise interactions of ethanol with the endogenous opioid system at the level of the CeA have not been investigated... - Effects of acute ethanol on corticotropin-releasing hormone and β-endorphin systems at the level of the rat central amygdalaMinh P Lam
Department of Physiology, McGill University, Montreal, Canada
Psychopharmacology (Berl) 218:229-39. 2011..The endogenous opioid and corticotropin-releasing hormone (CRH) systems, present in the central amygdala (CeA), are implicated in alcohol consumption... - Effects of acute ethanol on beta-endorphin release in the nucleus accumbens of selectively bred lines of alcohol-preferring AA and alcohol-avoiding ANA ratsMinh P Lam
Department of Physiology, McGill University, Montreal, QC, Canada
Psychopharmacology (Berl) 208:121-30. 2010..Studies have demonstrated differences in distinct components of the endogenous opioid system in various brain regions associated with the process of reinforcement between the AA and ANA lines of rats... - Neurocognitive characteristics of DUI recidivistsMarie Claude Ouimet
Douglas Hospital Research Centre, Montreal, Quebec, Canada
Accid Anal Prev 39:743-50. 2007..Development of a DUI-specific neurocognitive assessment and greater understanding of how neurocognitive status influences DUI risk could lead to remediation strategies better adapted to the individual characteristics of recidivists... - Effects of corticotropin-releasing hormone receptor antagonists on the ethanol-induced increase of dynorphin A1-8 release in the rat central amygdalaMinh P Lam
Department of Physiology, McGill University, Montreal, Canada
Alcohol 45:621-30. 2011..Therefore, the findings suggest an interaction between the CRH and dynorphin A1-8 systems at the level of CeA in response to acute alcohol exposure... - Effect of acute ethanol administration on the release of opioid peptides from the midbrain including the ventral tegmental areaSamuel Jarjour
Department of Psychiatry, McGill University, Montreal, Quebec, Canada
Alcohol Clin Exp Res 33:1033-43. 2009.... - Differences in the peripheral levels of beta-endorphin in response to alcohol and stress as a function of alcohol dependence and family history of alcoholismXing Dai
Douglas Hospital Research Centre and the Department of Psychiatry, McGill University, Montreal, Quebec, Canada
Alcohol Clin Exp Res 29:1965-75. 2005..Furthermore, alcohol dependence did not alter the alcohol-induced attenuation of beta-endorphin response to stress... - Estradiol valerate and alcohol intake: a comparison between Wistar and Lewis rats and the putative role of endorphinsPeter W Marinelli
Department of Neurology and Neurosurgery, McGill University, Douglas Hospital Research Centre, 6875 LaSalle Boulevard, Que, Verdun, Canada H4H 1R3
Behav Brain Res 139:59-67. 2003..Higher alcohol drinking by Wistar rats might be due to higher behavioral scores or endogenous opioid activity/sensitivity... - Differences in the responses of the pituitary beta-endorphin and cardiovascular system to ethanol and stress as a function of family historyXing Dai
Department of Psychiatry, Douglas Hospital Research Centre, McGill University, Montreal, Quebec, Canada
Alcohol Clin Exp Res 26:1171-80. 2002..This attenuation was stronger in LR subjects. CONCLUSIONS: Thus, there are differences in the response of beta-endorphin to stress and the effect of ethanol on stress responses as a function of a family history of alcoholism... - Salivary cortisol: a predictor of convictions for driving under the influence of alcohol?Thomas G Brown
Thomas G Brown, Douglas Hospital Research Center, 6875 LaSalle Boulevard, Perry 4, Verdun, Quebec, Canada
Alcohol Alcohol 40:474-81. 2005..To examine the relationship between salivary cortisol and frequency of past driving under the influence of alcohol (DUI) convictions... - The effect of naltrexone on alcohol's stimulant properties and self-administration behavior in social drinkers: influence of gender and genotypeElaine Setiawan
Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada
Alcohol Clin Exp Res 35:1134-41. 2011..Few pharmacological treatments for alcohol dependence are available. Moreover, the best supported treatment, naltrexone hydrochloride, appears to work for only some... - Characterization of the mu and delta opioid receptors in the brain of the C57BL/6 and DBA/2 mice, selected for their differences in voluntary ethanol consumptionJ P de Waele
Douglas Hospital Research Centre, McGill University, Verdun, Quebec, Canada
Alcohol Clin Exp Res 21:754-62. 1997.... - Alterations in brain levels of atrial and C-type natriuretic peptides after chronic moderate ethanol consumption in spontaneously hypertensive ratsP Guillaume
Douglas Hospital Research Centre, McGill University, Verdun, Quebec, Canada
Eur J Pharmacol 319:215-24. 1997..Such changes may be partially responsible for the effect of chronic moderate ethanol consumption on blood pressure... - A microdialysis profile of beta-endorphin and catecholamines in the rat nucleus accumbens following alcohol administrationPeter W Marinelli
Department of Neurology and Neurosurgery, Douglas Hospital Research Centre and McGill University, , , Canada
Psychopharmacology (Berl) 169:60-7. 2003..These results suggest that alcohol stimulates dopamine and beta-EP in the NACB, but probably does so via independent mechanisms... - A microdialysis profile of Met-enkephalin release in the rat nucleus accumbens following alcohol administrationPeter W Marinelli
Biobehavioural Pharmacology Section, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
Alcohol Clin Exp Res 29:1821-8. 2005..This may be one of multiple neurological mechanisms that modulate alcohol-drinking behavior... - One injection of estradiol valerate induces dramatic changes in rats' intake of alcoholic beveragesLarry D Reid
Laboratory for Psychopharmacology, Rensselaer Polytechnic Institute, Room 302, Carnegie Hall, Troy, NY 12180, USA
Pharmacol Biochem Behav 72:601-16. 2002..Once enhanced intakes emerged, they were observed with different kinds of alcoholic beverages and endured for months... - A microdialysis profile of dynorphin A(1-8) release in the rat nucleus accumbens following alcohol administrationPeter W Marinelli
Department of Neurology and Neurosurgery, Douglas Hospital Research Centre and McGill University, , , Canada
Alcohol Clin Exp Res 30:982-90. 2006..However, the lack of effect of tail-pinch stress in the present study suggests that dynorphin A(1-8) is not released in response to all forms of stressful/aversive stimuli... - Differential effects of naltrexone on cardiac, subjective and behavioural reactions to acute ethanol intoxicationJordan B Peterson
Department of Psychology, University of Toronto, Toronto, Ont
J Psychiatry Neurosci 31:386-93. 2006..This finding appears to lend moderate support to the notions that, first, naltrexone has differential effects on alcohol reactions and, second, that it specifically blocks the acute psychomotor stimulant properties of alcohol...