Christina Gianoulakis

Summary

Affiliation: McGill University
Country: Canada

Publications

  1. ncbi request reprint Effect of chronic alcohol consumption on the activity of the hypothalamic-pituitary-adrenal axis and pituitary beta-endorphin as a function of alcohol intake, age, and gender
    Christina Gianoulakis
    Douglas Hospital Research Centre, 6875 LaSalle Blvd, Verdun, Quebec, Canada
    Alcohol Clin Exp Res 27:410-23. 2003
  2. pmc Influence of the endogenous opioid system on high alcohol consumption and genetic predisposition to alcoholism
    C Gianoulakis
    Douglas Hospital Research Centre, Department of Psychiatry, McGill University, Montreal, Que
    J Psychiatry Neurosci 26:304-18. 2001
  3. ncbi request reprint Levels and circadian rhythmicity of plasma ACTH, cortisol, and beta-endorphin as a function of family history of alcoholism
    Christina Gianoulakis
    Douglas Hospital Research Centre, Montreal, Quebec, Canada
    Psychopharmacology (Berl) 181:437-44. 2005
  4. ncbi request reprint Endogenous opioids and addiction to alcohol and other drugs of abuse
    Christina Gianoulakis
    Douglas Mental Health University Institute, 6875 LaSalle Blvd, Montreal, Quebec, H4H 1R3, Canada
    Curr Top Med Chem 9:999-1015. 2009
  5. ncbi request reprint Endogenous opioids and addiction to alcohol and other drugs of abuse
    Christina Gianoulakis
    Douglas Hospital Research Centre and Department of Psychiatry McGill University Montreal Quebec, Canada
    Curr Top Med Chem 4:39-50. 2004
  6. doi request reprint From the brain to bad behaviour and back again: neurocognitive and psychobiological mechanisms of driving while impaired by alcohol
    Thomas G Brown
    Douglas Hospital Research Centre, Montreal, Quebec, Canada
    Drug Alcohol Rev 28:406-18. 2009
  7. ncbi request reprint Response of the HPA-axis to alcohol and stress as a function of alcohol dependence and family history of alcoholism
    Xing Dai
    Douglas Hospital Research Centre and Department of Psychiatry, McGill University, Montreal, Que, Canada
    Psychoneuroendocrinology 32:293-305. 2007
  8. doi request reprint Effects of acute ethanol on opioid peptide release in the central amygdala: an in vivo microdialysis study
    Minh P Lam
    Department of Physiology, McGill University, Montreal, Canada
    Psychopharmacology (Berl) 201:261-71. 2008
  9. doi request reprint Effect of acute ethanol administration on the release of opioid peptides from the midbrain including the ventral tegmental area
    Samuel Jarjour
    Department of Psychiatry, McGill University, Montreal, Quebec, Canada
    Alcohol Clin Exp Res 33:1033-43. 2009
  10. doi request reprint Hypothalamic-pituitary-adrenal axis response to stress in male DUI recidivists
    Sophie Couture
    Addiction Research Program, Douglas Hospital Research Centre, Verdun, Quebec, Canada
    Accid Anal Prev 40:246-53. 2008

Collaborators

Detail Information

Publications27

  1. ncbi request reprint Effect of chronic alcohol consumption on the activity of the hypothalamic-pituitary-adrenal axis and pituitary beta-endorphin as a function of alcohol intake, age, and gender
    Christina Gianoulakis
    Douglas Hospital Research Centre, 6875 LaSalle Blvd, Verdun, Quebec, Canada
    Alcohol Clin Exp Res 27:410-23. 2003
    ..The objective of the present studies was to investigate the hypothesis that chronic alcohol consumption alters the activity of the HPA axis and pituitary beta-END as a function of severity of alcohol abuse, gender, and age...
  2. pmc Influence of the endogenous opioid system on high alcohol consumption and genetic predisposition to alcoholism
    C Gianoulakis
    Douglas Hospital Research Centre, Department of Psychiatry, McGill University, Montreal, Que
    J Psychiatry Neurosci 26:304-18. 2001
    ....
  3. ncbi request reprint Levels and circadian rhythmicity of plasma ACTH, cortisol, and beta-endorphin as a function of family history of alcoholism
    Christina Gianoulakis
    Douglas Hospital Research Centre, Montreal, Quebec, Canada
    Psychopharmacology (Berl) 181:437-44. 2005
    ..Individuals with a family history of alcoholism may present a dysfunction in the activity of the hypothalamic-pituitary-adrenal (HPA) axis that predates the development of alcoholism...
  4. ncbi request reprint Endogenous opioids and addiction to alcohol and other drugs of abuse
    Christina Gianoulakis
    Douglas Mental Health University Institute, 6875 LaSalle Blvd, Montreal, Quebec, H4H 1R3, Canada
    Curr Top Med Chem 9:999-1015. 2009
    ..Furthermore, the use of opioid antagonists in the treatment of drug addiction will be discussed. Special emphasis will be given to ethanol addiction, the drug mainly studied in my laboratory...
  5. ncbi request reprint Endogenous opioids and addiction to alcohol and other drugs of abuse
    Christina Gianoulakis
    Douglas Hospital Research Centre and Department of Psychiatry McGill University Montreal Quebec, Canada
    Curr Top Med Chem 4:39-50. 2004
    ..Furthermore, the use of opioid antagonists in the treatment of drug addiction will be discussed. Special emphasis will be given to ethanol addiction, the drug mainly studied in my laboratory...
  6. doi request reprint From the brain to bad behaviour and back again: neurocognitive and psychobiological mechanisms of driving while impaired by alcohol
    Thomas G Brown
    Douglas Hospital Research Centre, Montreal, Quebec, Canada
    Drug Alcohol Rev 28:406-18. 2009
    ..These shortcomings reflect the baffling heterogeneity in the DWI population and the limited focus of much existing DWI recidivism research to psychosocial, psychological and substance use correlates...
  7. ncbi request reprint Response of the HPA-axis to alcohol and stress as a function of alcohol dependence and family history of alcoholism
    Xing Dai
    Douglas Hospital Research Centre and Department of Psychiatry, McGill University, Montreal, Que, Canada
    Psychoneuroendocrinology 32:293-305. 2007
    ....
  8. doi request reprint Effects of acute ethanol on opioid peptide release in the central amygdala: an in vivo microdialysis study
    Minh P Lam
    Department of Physiology, McGill University, Montreal, Canada
    Psychopharmacology (Berl) 201:261-71. 2008
    ..However, the precise interactions of ethanol with the endogenous opioid system at the level of the CeA have not been investigated...
  9. doi request reprint Effect of acute ethanol administration on the release of opioid peptides from the midbrain including the ventral tegmental area
    Samuel Jarjour
    Department of Psychiatry, McGill University, Montreal, Quebec, Canada
    Alcohol Clin Exp Res 33:1033-43. 2009
    ....
  10. doi request reprint Hypothalamic-pituitary-adrenal axis response to stress in male DUI recidivists
    Sophie Couture
    Addiction Research Program, Douglas Hospital Research Centre, Verdun, Quebec, Canada
    Accid Anal Prev 40:246-53. 2008
    ....
  11. ncbi request reprint Response of the hypothalamic-pituitary-adrenal axis to stress in the absence and presence of ethanol in subjects at high and low risk of alcoholism
    Xing Dai
    Douglas Hospital Research Centre and the Department of Psychiatry, McGill University, Montreal, Quebec, Canada
    Neuropsychopharmacology 27:442-52. 2002
    ....
  12. doi request reprint Effects of acute ethanol on corticotropin-releasing hormone and β-endorphin systems at the level of the rat central amygdala
    Minh P Lam
    Department of Physiology, McGill University, Montreal, Canada
    Psychopharmacology (Berl) 218:229-39. 2011
    ..The endogenous opioid and corticotropin-releasing hormone (CRH) systems, present in the central amygdala (CeA), are implicated in alcohol consumption...
  13. doi request reprint Effects of acute ethanol on beta-endorphin release in the nucleus accumbens of selectively bred lines of alcohol-preferring AA and alcohol-avoiding ANA rats
    Minh P Lam
    Department of Physiology, McGill University, Montreal, QC, Canada
    Psychopharmacology (Berl) 208:121-30. 2010
    ..Studies have demonstrated differences in distinct components of the endogenous opioid system in various brain regions associated with the process of reinforcement between the AA and ANA lines of rats...
  14. ncbi request reprint Neurocognitive characteristics of DUI recidivists
    Marie Claude Ouimet
    Douglas Hospital Research Centre, Montreal, Quebec, Canada
    Accid Anal Prev 39:743-50. 2007
    ..Development of a DUI-specific neurocognitive assessment and greater understanding of how neurocognitive status influences DUI risk could lead to remediation strategies better adapted to the individual characteristics of recidivists...
  15. ncbi request reprint A microdialysis profile of dynorphin A(1-8) release in the rat nucleus accumbens following alcohol administration
    Peter W Marinelli
    Department of Neurology and Neurosurgery, Douglas Hospital Research Centre and McGill University, Montreal, Quebec, Canada
    Alcohol Clin Exp Res 30:982-90. 2006
    ....
  16. ncbi request reprint A microdialysis profile of beta-endorphin and catecholamines in the rat nucleus accumbens following alcohol administration
    Peter W Marinelli
    Department of Neurology and Neurosurgery, Douglas Hospital Research Centre and McGill University, Montreal, Quebec, Canada
    Psychopharmacology (Berl) 169:60-7. 2003
    ..There is evidence to suggest that the activation of beta-endorphin (beta-EP) in the mesolimbic pathway by alcohol and other drugs of abuse may be associated with the rise in dopamine levels in the NACB...
  17. doi request reprint Effects of corticotropin-releasing hormone receptor antagonists on the ethanol-induced increase of dynorphin A1-8 release in the rat central amygdala
    Minh P Lam
    Department of Physiology, McGill University, Montreal, Canada
    Alcohol 45:621-30. 2011
    ..Therefore, the findings suggest an interaction between the CRH and dynorphin A1-8 systems at the level of CeA in response to acute alcohol exposure...
  18. ncbi request reprint Differences in the peripheral levels of beta-endorphin in response to alcohol and stress as a function of alcohol dependence and family history of alcoholism
    Xing Dai
    Douglas Hospital Research Centre and the Department of Psychiatry, McGill University, Montreal, Quebec, Canada
    Alcohol Clin Exp Res 29:1965-75. 2005
    ..The objective of the present studies was to test the hypothesis that there are differences in the response of the pituitary beta-endorphin system to stress as a function of family history of alcoholism and alcohol dependence...
  19. ncbi request reprint Differences in the responses of the pituitary beta-endorphin and cardiovascular system to ethanol and stress as a function of family history
    Xing Dai
    Department of Psychiatry, Douglas Hospital Research Centre, McGill University, Montreal, Quebec, Canada
    Alcohol Clin Exp Res 26:1171-80. 2002
    ..These studies investigated the response of pituitary beta-endorphin to stress and the effect of alcohol on the stress response in subjects at low (LR) and high (HR) risk of alcoholism, as determined from their family history...
  20. ncbi request reprint Estradiol valerate and alcohol intake: a comparison between Wistar and Lewis rats and the putative role of endorphins
    Peter W Marinelli
    Department of Neurology and Neurosurgery, McGill University, Douglas Hospital Research Centre, 6875 LaSalle Boulevard, Que, Verdun, Canada H4H 1R3
    Behav Brain Res 139:59-67. 2003
    ..Higher alcohol drinking by Wistar rats might be due to higher behavioral scores or endogenous opioid activity/sensitivity...
  21. ncbi request reprint Salivary cortisol: a predictor of convictions for driving under the influence of alcohol?
    Thomas G Brown
    Thomas G Brown, Douglas Hospital Research Center, 6875 LaSalle Boulevard, Perry 4, Verdun, Quebec, Canada
    Alcohol Alcohol 40:474-81. 2005
    ..To examine the relationship between salivary cortisol and frequency of past driving under the influence of alcohol (DUI) convictions...
  22. doi request reprint The effect of naltrexone on alcohol's stimulant properties and self-administration behavior in social drinkers: influence of gender and genotype
    Elaine Setiawan
    Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada
    Alcohol Clin Exp Res 35:1134-41. 2011
    ..Few pharmacological treatments for alcohol dependence are available. Moreover, the best supported treatment, naltrexone hydrochloride, appears to work for only some...
  23. ncbi request reprint Characterization of the mu and delta opioid receptors in the brain of the C57BL/6 and DBA/2 mice, selected for their differences in voluntary ethanol consumption
    J P de Waele
    Douglas Hospital Research Centre, McGill University, Verdun, Quebec, Canada
    Alcohol Clin Exp Res 21:754-62. 1997
    ....
  24. ncbi request reprint Alterations in brain levels of atrial and C-type natriuretic peptides after chronic moderate ethanol consumption in spontaneously hypertensive rats
    P Guillaume
    Douglas Hospital Research Centre, McGill University, Verdun, Quebec, Canada
    Eur J Pharmacol 319:215-24. 1997
    ..Such changes may be partially responsible for the effect of chronic moderate ethanol consumption on blood pressure...
  25. ncbi request reprint A microdialysis profile of Met-enkephalin release in the rat nucleus accumbens following alcohol administration
    Peter W Marinelli
    Biobehavioural Pharmacology Section, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Alcohol Clin Exp Res 29:1821-8. 2005
    ....
  26. ncbi request reprint One injection of estradiol valerate induces dramatic changes in rats' intake of alcoholic beverages
    Larry D Reid
    Laboratory for Psychopharmacology, Rensselaer Polytechnic Institute, Room 302, Carnegie Hall, Troy, NY 12180, USA
    Pharmacol Biochem Behav 72:601-16. 2002
    ..Once enhanced intakes emerged, they were observed with different kinds of alcoholic beverages and endured for months...
  27. pmc Differential effects of naltrexone on cardiac, subjective and behavioural reactions to acute ethanol intoxication
    Jordan B Peterson
    Department of Psychology, University of Toronto, Toronto, Ont
    J Psychiatry Neurosci 31:386-93. 2006
    ....