Adel Giaid

Summary

Affiliation: McGill University
Country: Canada

Publications

  1. pmc A closer look at the role of urotensin II in the metabolic syndrome
    Pierre Olivier Barrette
    Division of Cardiology, Department of Medicine, McGill University Health Center Montreal, QC, Canada
    Front Endocrinol (Lausanne) 3:165. 2012
  2. pmc Potential Clinical Implications of the Urotensin II Receptor Antagonists
    Philip Tsoukas
    Division of Cardiology, Department of Medicine, Montreal General Hospital, McGill University Health Center Montreal, QC, Canada
    Front Pharmacol 2:38. 2011
  3. doi request reprint Genetic and pharmacological manipulation of urotensin II ameliorate the metabolic and atherosclerosis sequalae in mice
    Zhipeng You
    Division of Cardiology, McGill University Health Centre, Montreal, Quebec, Canada
    Arterioscler Thromb Vasc Biol 32:1809-16. 2012
  4. doi request reprint Urotensin II receptor knockout mice on an ApoE knockout background fed a high-fat diet exhibit an enhanced hyperlipidemic and atherosclerotic phenotype
    Nicolas Bousette
    Division of Cardiology and Department of Medicine, Montreal General Hospital, McGill University Health Center, Quebec, Canada
    Circ Res 105:686-95, 19 p following 695. 2009
  5. doi request reprint Urotensin II differentially regulates macrophage and hepatic cholesterol homeostasis
    Robert S Kiss
    Division of Cardiology, McGill University Health Center, Montreal, Quebec, Canada
    Peptides 32:956-63. 2011
  6. pmc Protein expression of urotensin II, urotensin-related peptide and their receptor in the lungs of patients with lymphangioleiomyomatosis
    Arnold S Kristof
    Department of Medicine, McGill University Health Center, Montreal, Quebec, Canada
    Peptides 31:1511-6. 2010
  7. ncbi request reprint Inducible activation of TLR4 confers resistance to hyperoxia-induced pulmonary apoptosis
    Salman T Qureshi
    McGill Centre for the Study of Host Resistance, Montreal, Canada
    J Immunol 176:4950-8. 2006
  8. doi request reprint The LDLR deficient mouse as a model for aortic calcification and quantification by micro-computed tomography
    Zuhier Awan
    Institut de Recherches Cliniques, Montreal, Quebec, Canada
    Atherosclerosis 219:455-62. 2011
  9. doi request reprint Potential role of endothelin-1 in pulmonary fibrosis: from the bench to the clinic
    Bryan Ross
    Cardiology, Montreal General Hospital, 1650 Cedar Avenue, Montreal, PQ, Canada
    Am J Respir Cell Mol Biol 42:16-20. 2010
  10. doi request reprint Role of urotensin II in health and disease
    Bryan Ross
    McGill University Health Center, Montreal, Quebec, Canada
    Am J Physiol Regul Integr Comp Physiol 298:R1156-72. 2010

Detail Information

Publications12

  1. pmc A closer look at the role of urotensin II in the metabolic syndrome
    Pierre Olivier Barrette
    Division of Cardiology, Department of Medicine, McGill University Health Center Montreal, QC, Canada
    Front Endocrinol (Lausanne) 3:165. 2012
    ..Moreover, UII also plays an important role in hypertension and hyperlipidemia thereby contributing to cardiovascular complications associated with the MetS...
  2. pmc Potential Clinical Implications of the Urotensin II Receptor Antagonists
    Philip Tsoukas
    Division of Cardiology, Department of Medicine, Montreal General Hospital, McGill University Health Center Montreal, QC, Canada
    Front Pharmacol 2:38. 2011
    ..Recently, UT antagonists such as SB-611812, palosuran, and most recently a piperazino-isoindolinone based antagonist have been developed in the hope of better understanding the UII system and treating its associated diseases...
  3. doi request reprint Genetic and pharmacological manipulation of urotensin II ameliorate the metabolic and atherosclerosis sequalae in mice
    Zhipeng You
    Division of Cardiology, McGill University Health Centre, Montreal, Quebec, Canada
    Arterioscler Thromb Vasc Biol 32:1809-16. 2012
    ..We tested the hypothesis that UII gene deletion or UT blockade ameliorate experimental atherosclerosis...
  4. doi request reprint Urotensin II receptor knockout mice on an ApoE knockout background fed a high-fat diet exhibit an enhanced hyperlipidemic and atherosclerotic phenotype
    Nicolas Bousette
    Division of Cardiology and Department of Medicine, Montreal General Hospital, McGill University Health Center, Quebec, Canada
    Circ Res 105:686-95, 19 p following 695. 2009
    ..Expression of the vasoactive peptide Urotensin II (UII) is elevated in a number of cardiovascular diseases...
  5. doi request reprint Urotensin II differentially regulates macrophage and hepatic cholesterol homeostasis
    Robert S Kiss
    Division of Cardiology, McGill University Health Center, Montreal, Quebec, Canada
    Peptides 32:956-63. 2011
    ..These results demonstrate a fundamental difference between macrophages and hepatocytes in terms of cholesterol homeostasis, and suggest an important role for UII in modulating cholesterol regulation...
  6. pmc Protein expression of urotensin II, urotensin-related peptide and their receptor in the lungs of patients with lymphangioleiomyomatosis
    Arnold S Kristof
    Department of Medicine, McGill University Health Center, Montreal, Quebec, Canada
    Peptides 31:1511-6. 2010
    ..These findings demonstrate for the first time the presence of UII, URP and their receptor in the lesions of patients with LAM, and suggest a possible role in the pathogenesis of the disease...
  7. ncbi request reprint Inducible activation of TLR4 confers resistance to hyperoxia-induced pulmonary apoptosis
    Salman T Qureshi
    McGill Centre for the Study of Host Resistance, Montreal, Canada
    J Immunol 176:4950-8. 2006
    ..These results define a novel role for lung epithelial TLR4 as a modulator of cellular apoptosis in response to oxidant stress...
  8. doi request reprint The LDLR deficient mouse as a model for aortic calcification and quantification by micro-computed tomography
    Zuhier Awan
    Institut de Recherches Cliniques, Montreal, Quebec, Canada
    Atherosclerosis 219:455-62. 2011
    ..To better understand this process, we examined a murine model...
  9. doi request reprint Potential role of endothelin-1 in pulmonary fibrosis: from the bench to the clinic
    Bryan Ross
    Cardiology, Montreal General Hospital, 1650 Cedar Avenue, Montreal, PQ, Canada
    Am J Respir Cell Mol Biol 42:16-20. 2010
    ..A guided perspective begins from the scope of its various molecular interactions to its many cellular processes, and finally to the implications of these functions in IPF...
  10. doi request reprint Role of urotensin II in health and disease
    Bryan Ross
    McGill University Health Center, Montreal, Quebec, Canada
    Am J Physiol Regul Integr Comp Physiol 298:R1156-72. 2010
    ..As such, the UT receptor is emerging as a promising target for therapeutic intervention. Here, a concise review is given on the vast physiologic and pathologic roles of UII...
  11. doi request reprint Targeted overexpression of the human urotensin receptor transgene in smooth muscle cells: effect of UT antagonism in ApoE knockout mice fed with Western diet
    Panayiota Papadopoulos
    Division of Cardiology, Montreal General Hospital, McGill University Health Center, Montreal, Que, Canada
    Atherosclerosis 204:395-404. 2009
    ..05). The present findings demonstrate an important role for UT in the pathogenesis of atherosclerosis. The use of UT receptor antagonists may provide a beneficial tool in the management of this debilitating disease process...