J Genest

Summary

Affiliation: McGill University
Country: Canada

Publications

  1. doi request reprint The Yin and Yang of high-density lipoprotein cholesterol
    Jacques Genest
    J Am Coll Cardiol 51:643-4. 2008
  2. ncbi request reprint Genetic lipoprotein disorders and coronary atherosclerosis
    Mahmoud Alawadhi
    Division of Cardiology Research, MUHC Royal Victoria Hospital, 687 Pine Avenue West, Montreal, QC H3A 1A1, Canada
    Curr Atheroscler Rep 7:196-203. 2005
  3. pmc Smoking in preeclamptic women is associated with higher birthweight for gestational age and lower soluble fms-like tyrosine kinase-1 levels: a nested case control study
    Susan R Kahn
    Department of Medicine, McGill University, Montreal, Quebec, Canada
    BMC Pregnancy Childbirth 11:91. 2011
  4. pmc Sphingomyelin phosphodiesterase-1 (SMPD1) coding variants do not contribute to low levels of high-density lipoprotein cholesterol
    Zari Dastani
    Cardiovascular Research Laboratories, Division of Cardiology, McGill University Health Centre Royal Victoria Hospital, Montreal, Quebec H3A 1A1, Canada
    BMC Med Genet 8:79. 2007
  5. ncbi request reprint Effect of fenofibrate-mediated increase in plasma homocysteine on the progression of coronary artery disease in type 2 diabetes mellitus
    Jacques Genest
    Cardiology Division, McGill University Health Center, Healthy Heart Program, St Paul s Hospital, Vancouver, British Columbia, Canada
    Am J Cardiol 93:848-53. 2004
  6. ncbi request reprint C-reactive protein: risk factor, biomarker and/or therapeutic target?
    Jacques Genest
    Faculty of Medicine, McGill University, Montreal, Quebec, Canada
    Can J Cardiol 26:41A-44A. 2010
  7. pmc 2009 Canadian Cardiovascular Society/Canadian guidelines for the diagnosis and treatment of dyslipidemia and prevention of cardiovascular disease in the adult - 2009 recommendations
    Jacques Genest
    McGill University Health Centre, Montreal, Canada
    Can J Cardiol 25:567-79. 2009
  8. pmc Combination of statin and ezetimibe for the treatment of dyslipidemias and the prevention of coronary artery disease
    Jacques Genest
    Division of Cardiology, McGill University Health Centre, Montreal, Quebec
    Can J Cardiol 22:863-8. 2006
  9. ncbi request reprint Lipoprotein disorders and cardiovascular risk
    J Genest
    Cardiovascular Genetics Laboratory, McGill University Health Center, Royal Victoria Hospital, Montreal, Quebec, Canada
    J Inherit Metab Dis 26:267-87. 2003
  10. ncbi request reprint Prevention of cardiovascular ischemic events: high-risk and secondary prevention
    Jacques Genest
    Division of Cardiology, McGill University Health Center, Montreal, QC, Canada H3A 1A1
    Circulation 107:2059-65. 2003

Collaborators

Detail Information

Publications99

  1. doi request reprint The Yin and Yang of high-density lipoprotein cholesterol
    Jacques Genest
    J Am Coll Cardiol 51:643-4. 2008
  2. ncbi request reprint Genetic lipoprotein disorders and coronary atherosclerosis
    Mahmoud Alawadhi
    Division of Cardiology Research, MUHC Royal Victoria Hospital, 687 Pine Avenue West, Montreal, QC H3A 1A1, Canada
    Curr Atheroscler Rep 7:196-203. 2005
    ..Unraveling the genetic basis of many lipoprotein disorders has allowed fundamental discoveries in molecular cellular physiology and has paved the way for novel therapeutic approaches...
  3. pmc Smoking in preeclamptic women is associated with higher birthweight for gestational age and lower soluble fms-like tyrosine kinase-1 levels: a nested case control study
    Susan R Kahn
    Department of Medicine, McGill University, Montreal, Quebec, Canada
    BMC Pregnancy Childbirth 11:91. 2011
    ....
  4. pmc Sphingomyelin phosphodiesterase-1 (SMPD1) coding variants do not contribute to low levels of high-density lipoprotein cholesterol
    Zari Dastani
    Cardiovascular Research Laboratories, Division of Cardiology, McGill University Health Centre Royal Victoria Hospital, Montreal, Quebec H3A 1A1, Canada
    BMC Med Genet 8:79. 2007
    ..In Niemann-Pick patients, SMPD1 gene defects are reported to be associated with a severe reduction in plasma high-density lipoprotein (HDL) cholesterol...
  5. ncbi request reprint Effect of fenofibrate-mediated increase in plasma homocysteine on the progression of coronary artery disease in type 2 diabetes mellitus
    Jacques Genest
    Cardiology Division, McGill University Health Center, Healthy Heart Program, St Paul s Hospital, Vancouver, British Columbia, Canada
    Am J Cardiol 93:848-53. 2004
    ..This analysis of the the DAIS reveals that the fenofibrate-mediated increase in tHcy levels does not attenuate the beneficial effects of fenofibrate on CAD progression or clinical events...
  6. ncbi request reprint C-reactive protein: risk factor, biomarker and/or therapeutic target?
    Jacques Genest
    Faculty of Medicine, McGill University, Montreal, Quebec, Canada
    Can J Cardiol 26:41A-44A. 2010
    ..The results of this study have now been incorporated in the new Canadian guidelines for the diagnosis and treatment of dyslipidemia and prevention of cardiovascular disease...
  7. pmc 2009 Canadian Cardiovascular Society/Canadian guidelines for the diagnosis and treatment of dyslipidemia and prevention of cardiovascular disease in the adult - 2009 recommendations
    Jacques Genest
    McGill University Health Centre, Montreal, Canada
    Can J Cardiol 25:567-79. 2009
    ..The present article represents the 2009 update of the Canadian Cardiovascular Society guidelines for the diagnosis and treatment of dyslipidemia and prevention of cardiovascular disease in the adult...
  8. pmc Combination of statin and ezetimibe for the treatment of dyslipidemias and the prevention of coronary artery disease
    Jacques Genest
    Division of Cardiology, McGill University Health Centre, Montreal, Quebec
    Can J Cardiol 22:863-8. 2006
    ....
  9. ncbi request reprint Lipoprotein disorders and cardiovascular risk
    J Genest
    Cardiovascular Genetics Laboratory, McGill University Health Center, Royal Victoria Hospital, Montreal, Quebec, Canada
    J Inherit Metab Dis 26:267-87. 2003
    ....
  10. ncbi request reprint Prevention of cardiovascular ischemic events: high-risk and secondary prevention
    Jacques Genest
    Division of Cardiology, McGill University Health Center, Montreal, QC, Canada H3A 1A1
    Circulation 107:2059-65. 2003
  11. ncbi request reprint High-density lipoproteins: multifunctional vanguards of the cardiovascular system
    Michel Marcil
    McGill University Health Center, Royal Victoria Hospital, 687 Pine Avenue West, Montreal, H3A 1A1 QC, Canada
    Expert Rev Cardiovasc Ther 2:417-30. 2004
    ..Novel therapies include injection of purified apolipoprotien AI and short peptides taken orally, mimicking some of the biological effects of apolipoprotein AI...
  12. ncbi request reprint Preventive cardiology: move over low density lipoprotein cholesterol, hello C-reactive protein?
    Jacques Genest
    McGill University Health Center Royal Victoria Hospital, Montreal, Quebec
    Can J Cardiol 20:89B-92B. 2004
    ....
  13. pmc Recommendations for the management of dyslipidemia and the prevention of cardiovascular disease: summary of the 2003 update
    Jacques Genest
    Royal Victoria Hospital, McGill University, Montreal, Que
    CMAJ 169:921-4. 2003
  14. pmc The analysis by Manuel and colleagues creates controversy with headlines, not data
    Jacques Genest
    Division of Cardiology, Royal Victoria Hospital, McGill University, Montreal, Que
    CMAJ 172:1033-4; discussion 1037. 2005
  15. pmc Membrane microdomains modulate oligomeric ABCA1 function: impact on apoAI-mediated lipid removal and phosphatidylcholine biosynthesis
    Iulia Iatan
    Department of Biochemistry, Faculty of Medicine, McGill University Health Center Royal Victoria Hospital, Montreal, Quebec, H3A 1A1, Canada
    J Lipid Res 52:2043-55. 2011
    ..This process may have important implications in preventing and treating atherosclerotic cardiovascular disease...
  16. ncbi request reprint Common genetic variation in ABCA1 is associated with altered lipoprotein levels and a modified risk for coronary artery disease
    S M Clee
    Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, Canada
    Circulation 103:1198-205. 2001
    ..However, the extent to which common variation within this gene influences plasma lipid levels and CAD in the general population is unknown...
  17. pmc Age and residual cholesterol efflux affect HDL cholesterol levels and coronary artery disease in ABCA1 heterozygotes
    S M Clee
    Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, British Columbia, Canada
    J Clin Invest 106:1263-70. 2000
    ..These data provide direct evidence that impairment of cholesterol efflux and consequently reverse cholesterol transport is associated with reduced plasma HDL-C levels and increased risk of CAD...
  18. ncbi request reprint Effect of micronized fenofibrate on plasma lipoprotein levels and hemostatic parameters of hypertriglyceridemic patients with low levels of high-density lipoprotein cholesterol in the fed and fasted state
    J Genest
    Cardiovascular Genetics Laboratory, and the Hyperlipidemia and Atherosclerosis Research Group, Clinical Research Institute of Montreal, Quebec, Canada
    J Cardiovasc Pharmacol 35:164-72. 2000
    ....
  19. ncbi request reprint Cholesterol efflux regulatory protein, Tangier disease and familial high-density lipoprotein deficiency
    M R Hayden
    Centre for Molecular Medicine and Therapeutics, Department of Medical Genetics, University of British Columbia, Vancouver, Canada
    Curr Opin Lipidol 11:117-22. 2000
    ....
  20. ncbi request reprint Cerebral vascular complication and hyperhomocysteinemia in a cystinotic uremic child
    A Merouani
    Department of Pediatric Nephrology, Hospital Sainte Justine, Montreal, Quebec, Canada
    Pediatr Nephrol 13:73-6. 1999
    ....
  21. ncbi request reprint Fenofibrate raises plasma homocysteine levels in the fasted and fed states
    R Bissonnette
    Division of Cardiology, McGill University Health Center/Royal Victoria Hospital, , H3A 1A1, Montreal, Canada
    Atherosclerosis 155:455-62. 2001
    ..Since tHcy is considered an emerging cardiovascular risk factor, the ability of FEN to increase plasma tHcy levels could potentially mitigate the potential of this drug to protect against cardiovascular disease...
  22. ncbi request reprint Cellular cholesterol efflux is modulated by phospholipid-derived signaling molecules in familial HDL deficiency/Tangier disease fibroblasts
    B Haidar
    Cardiovascular Genetics Laboratory, McGill University Health Center, Royal Victoria Hospital, Montreal, Quebec, Canada H3A 1A1
    J Lipid Res 42:249-57. 2001
    ..We conclude that PLC and PLD activities are required for apoA-I-mediated cellular cholesterol efflux, and modulating cellular PA concentration can correct, at least partially, the cholesterol efflux defect in FHD and TD...
  23. ncbi request reprint Rationale for and outline of the recommendations of the Working Group on Hypercholesterolemia and Other Dyslipidemias: interim report. Dyslipidemia Working Group of Health Canada
    J Frohlich
    Healthy Heart Program, St Paul s Hospital, Vancouver, British Columbia
    Can J Cardiol 14:17A-21A. 1998
    ....
  24. ncbi request reprint Hyperhomocyst(e)inemia--determining factors and treatment
    J Genest
    Clinical Research Institute of Montreal, Montreal, Canada
    Can J Cardiol 15:35B-38B. 1999
    ..Patients with hyperhomocyst(e)inemia should be treated with at least 400 micrograms of folic acid per day. Alternative treatments are vitamin B6 and B12 supplementation, although optimal doses have yet to be identified...
  25. ncbi request reprint Reaching recommended lipid and blood pressure targets with amlodipine/atorvastatin combination in patients with coronary heart disease
    Jean Francois Dorval
    Division of Cardiology, McGill University Health Center, 687 Pine Avenue, Montreal, Quebec H3A 1A1, Canada
    Am J Cardiol 95:249-53. 2005
    ....
  26. ncbi request reprint Cholesterol efflux capacity, carotid atherosclerosis, and cerebrovascular symptomatology
    R J Doonan
    From the Departments of Experimental Medicine R J D, S S D and Biochemistry A H, Faculty of Medicine, McGill University, Montreal, Quebec, Canada Department of Pathology and Laboratory Medicine, University of Ottawa, Ottawa, Ontario, Canada C L, J P V and Faculty of Medicine, Centre for Innovative Medicine, McGill University Health Centre, Montreal, Quebec, Canada J G
    Arterioscler Thromb Vasc Biol 34:921-6. 2014
    ..To investigate the association of cholesterol efflux capacity with carotid atherosclerosis and cerebrovascular disease...
  27. ncbi request reprint Renal function, homocysteine, and other plasma thiol concentrations during the postrenal transplant period
    A Merouani
    From the Department of Pediatrics, Ste Justine Hospital, University of Montreal, Montreal, Quebec, Canada
    Transplant Proc 34:1159-60. 2002
  28. ncbi request reprint Plasma total homocysteine in healthy subjects: sex-specific relation with biological traits
    S Lussier-Cacan
    Hyperlipidemia and Atherosclerosis Research Group, Hotel Dieu Hospital, Montreal, Canada
    Am J Clin Nutr 64:587-93. 1996
    ..This study emphasizes the significance of sex-associated differences in the biology of homocysteine and underlines the importance of considering these in the determination of threshold values...
  29. ncbi request reprint Homocysteine and cardiovascular disease in diabetes mellitus
    M C Audelin
    , H2W 1R7, Montreal, Canada
    Atherosclerosis 159:497-511. 2001
    ....
  30. pmc Analysis of lipid transfer activity between model nascent HDL particles and plasma lipoproteins: implications for current concepts of nascent HDL maturation and genesis
    Dana Bailey
    Cardiovascular Genetics Laboratory, Cardiology Division, McGill University Health Centre Royal Victoria Hospital, Quebec, Canada
    J Lipid Res 51:785-97. 2010
    ..The finding that nascent particles were depleted of their lipids and remodeled in the presence of plasma lipoproteins raises questions about their stability and subsequent interaction with LCAT...
  31. doi request reprint Inherited thrombophilia and preeclampsia within a multicenter cohort: the Montreal Preeclampsia Study
    Susan R Kahn
    Department of Medicine, McGill University Faculty of Medicine, Montreal, QC, Canada
    Am J Obstet Gynecol 200:151.e1-9; discussion e1-5. 2009
    ..We sought to evaluate the association between inherited thrombophilia and preeclampsia...
  32. doi request reprint Vasculopathic and thrombophilic risk factors for spontaneous preterm birth
    Michael S Kramer
    Department of Pediatrics, McGill University Faculty of Medicine, Montreal, Quebec, Canada
    Int J Epidemiol 38:715-23. 2009
    ..Mothers who give birth to preterm infants are at increased risk of mortality from coronary heart disease and stroke, but the biological pathways underlying these associations have not been explored...
  33. doi request reprint Stress pathways to spontaneous preterm birth: the role of stressors, psychological distress, and stress hormones
    Michael S Kramer
    Department of Pediatrics, McGill University Faculty of Medicine, Montreal, Quebec, Canada
    Am J Epidemiol 169:1319-26. 2009
    ..The biologic pathways underlying stress-induced preterm birth remain poorly understood...
  34. doi request reprint Mid-trimester maternal plasma cytokines and CRP as predictors of spontaneous preterm birth
    Michael S Kramer
    Department of Pediatrics, McGill University Faculty of Medicine, Montreal, Que, Canada
    Cytokine 49:10-4. 2010
    ..Our results require confirmation in future studies but suggest that a systemic immune response implicating MMP-9 may have an etiologic role in spontaneous preterm birth...
  35. doi request reprint Non-stress-related factors associated with maternal corticotrophin-releasing hormone (CRH) concentration
    Michael S Kramer
    Departments of Pediatrics, McGill University Faculty of Medicine, and Département de médecine sociale et préventive, Faculte de Medecine de l Universite de Montreal, Montreal, Quebec, Canada
    Paediatr Perinat Epidemiol 24:390-7. 2010
    ..Further studies are indicated both in animal models and human populations to better understand the biochemical and physiological pathways to CRH secretion and their aetiological role, if any, in preterm birth...
  36. doi request reprint Antioxidant vitamins, long-chain fatty acids, and spontaneous preterm birth
    Michael S Kramer
    Department of Pediatrics, McGill University Faculty of Medicine, Montreal, Quebec, Canada
    Epidemiology 20:707-13. 2009
    ..However, there has been little attention to carotenoids, tocopherols, and long-chain fatty acids other than n-3 polyunsaturates...
  37. ncbi request reprint Effects on apoB-100 secretion and bile acid synthesis by redirecting cholesterol efflux from HepG2 cells
    Allan D Sniderman
    Mike Rosenbloom Laboratories for Cardiovascular Research, Cardiovascular Genetics Laboratory, McGill University, Montreal, Canada
    J Lipid Res 44:527-32. 2003
    ..They also point to physiologically important, although still only partially understood, metabolic relationships amongst hepatic apoB-100 secretion, cholesterol efflux, and bile acid synthesis...
  38. ncbi request reprint Interaction of lecithin:cholesterol acyltransferase (LCAT).alpha 2-macroglobulin complex with low density lipoprotein receptor-related protein (LRP). Evidence for an alpha 2-macroglobulin/LRP receptor-mediated system participating in LCAT clearance
    L Krimbou
    Cardiovascular Genetics Laboratory, McGill University Health Center Royal Victoria Hospital, Montreal, Quebec H3A 1A1, Canada
    J Biol Chem 276:33241-8. 2001
    ..Furthermore, the finding supports the possibility that the LRP receptor can act in vivo to mediate clearance of the LCAT-alpha(2)M complex and may significantly influence the bioavailability of LCAT...
  39. pmc A new method for measurement of total plasma PCSK9: clinical applications
    Geneviève Dubuc
    Hyperlipidemia and Atherosclerosis Research Group, Clinical Research Institute of Montreal, Montreal, Quebec, Canada
    J Lipid Res 51:140-9. 2010
    ..316, P < 0.02 in FH and r = 0.275, P < 0.009 in non-FH). The detection of circulating PCSK9 in both FH and non-FH subjects means that this assay could be used to monitor response to therapy in a wide range of patients...
  40. ncbi request reprint A novel nonsense apolipoprotein A-I mutation (apoA-I(E136X)) causes low HDL cholesterol in French Canadians
    Zari Dastani
    Division of Cardiology, McGill University Health Center, Royal Victoria Hospital, 687 Pine Avenue West, Montreal, Que, Canada H3A 1A1
    Atherosclerosis 185:127-36. 2006
    ..We conclude that apoA-I (E136X) is a cause of HDL-C deficiency in the French Canadian population and is associated with premature CAD...
  41. ncbi request reprint Structural and functional properties of human plasma high density-sized lipoprotein containing only apoE particles
    Larbi Krimbou
    Cardiovascular Genetics Laboratory, McGill University Health Center Royal Victoria Hospital, Montreal, Quebec H3A 1A1, Canada
    J Lipid Res 44:884-92. 2003
    ....
  42. doi request reprint The metabolic syndrome and cardiovascular risk a systematic review and meta-analysis
    Salvatore Mottillo
    Jewish General Hospital McGill University, Montreal, Quebec, Canada
    J Am Coll Cardiol 56:1113-32. 2010
    ....
  43. ncbi request reprint The nested case-control study in cardiology
    Vidal Essebag
    Division of Cardiology, McGill University Health Center, Montreal, Quebec, Canada
    Am Heart J 146:581-90. 2003
    ..The large number of recent prospective studies and randomized trials conducted in cardiology provide cohorts within which the nested case-control approach is increasingly used...
  44. ncbi request reprint Molecular and cellular physiology of apolipoprotein A-I lipidation by the ATP-binding cassette transporter A1 (ABCA1)
    Maxime Denis
    Cardiovascular Genetics Laboratory, Cardiology Division, McGill University Health Center, Royal Victoria Hospital, Montreal, Quebec H3A 1A1, Canada
    J Biol Chem 279:7384-94. 2004
    ..This process plays in vivo a key role in HDL biogenesis...
  45. doi request reprint Effect of fibrates on lipid profiles and cardiovascular outcomes: a systematic review
    Samuel Abourbih
    Division of Cardiology, Jewish General Hospital, Faculty of Medicine, McGill University, Montreal, Quebec, Canada
    Am J Med 122:962.e1-8. 2009
    ..New data from fibrate trials can be synthesized with the existing literature to better estimate their effects...
  46. ncbi request reprint Influence of methylenetetrahydrofolate reductase genotype, age, vitamin B-12, and folate status on plasma homocysteine in children
    E E Delvin
    Departments of Clinical Biochemistry and Pediatrics, Research Centre, Ste Justine Hospital, Universite de Montreal, Montreal, Canada
    Am J Clin Nutr 72:1469-73. 2000
    ..Several studies have examined the association of the methylenetetrahydrofolate reductase (MTHFR) genotype with plasma homocysteine in adults, but few studies have been performed in children...
  47. ncbi request reprint Progress in hypertension research: 1900-2000
    J Genest
    , , Quebec, Canada
    Hypertension 38:E13-8. 2001
    ....
  48. ncbi request reprint Socio-economic disparities in preterm birth: causal pathways and mechanisms
    M S Kramer
    Department of Pediatrics, McGill University, 1020 Pine Avenue West, Montreal, Quebec, Canada H3A 1A2
    Paediatr Perinat Epidemiol 15:104-23. 2001
    ..This improved understanding should help not only in developing strategies to reduce the disparities but also in suggesting preventive interventions applicable across the entire socio-economic spectrum...
  49. ncbi request reprint High-density lipoproteins and endothelial function
    J Genest
    Cardiovascular Genetics Laboratory, McGill University Health Center, Royal Victoria Hospital, Montreal, Quebec, Canada
    Circulation 104:1978-83. 2001
    ..These lead to regulation of genes or the modification of proteins involved in vasomotor function, platelet activation, thrombosis and thrombolysis, cell adhesion, apoptosis and cell proliferation, and cellular cholesterol homeostasis...
  50. doi request reprint Vascular calcifications in homozygote familial hypercholesterolemia
    Z Awan
    McGill University Health Center Royal Victoria Hospital, 687 Pine Avenue West, Montreal, QC H3A 1A1, Canada
    Arterioscler Thromb Vasc Biol 28:777-85. 2008
    ..Early onset coronary heart disease (CHD) and calcific aortic valve stenosis are the major complications of this disorder. We now report extensive premature calcification of the aorta in patients with hmzFH...
  51. pmc A cluster randomized controlled Trial to Evaluate an Ambulatory primary care Management program for patients with dyslipidemia: the TEAM study
    Julie Villeneuve
    Faculties of Pharmacy, Universite de Montreal, Montreal, Que
    CMAJ 182:447-55. 2010
    ..Few studies have reported the efficacy of collaborative care involving family physicians and community pharmacists for patients with dyslipidemia...
  52. doi request reprint Comparison of treatment of severe high-density lipoprotein cholesterol deficiency in men with daily atorvastatin (20 mg) versus fenofibrate (200 mg) versus extended-release niacin (2 g)
    Khalid Alrasadi
    Cardiovascular Research Laboratories, McGill University Health Center Royal Victoria Hospital, Montreal, Quebec, Canada
    Am J Cardiol 102:1341-7. 2008
    ..Fenofibrate did not change HDL cholesterol levels and caused an increase in LDL cholesterol. Aggressive LDL cholesterol lowering may be the strategy of choice in such patients...
  53. ncbi request reprint Genetics of high-density lipoproteins
    Zari Dastani
    Cardiovascular Genetics Laboratory, Division of Cardiology, McGill University Health Centre Royal Victoria Hospital, Montreal, Quebec, Canada
    Curr Opin Cardiol 21:329-35. 2006
    ..The present review focuses on genetic aspects of high-density lipoprotein metabolism, with genomic approaches used to identify genes that regulate high-density lipoproteins in humans...
  54. ncbi request reprint Increased sphingomyelin content impairs HDL biogenesis and maturation in human Niemann-Pick disease type B
    Ching Yin Lee
    Cardiovascular Genetics Laboratory, Department of Medicine, Division of Cardiology, McGill University Health Centre Royal Victoria Hospital, Montreal, Quebec, Canada
    J Lipid Res 47:622-32. 2006
    ..Thus, S-SMase and LCAT may act in concert and play a crucial role in the biogenesis and maturation of nascent HDL particles...
  55. ncbi request reprint Cellular physiology of cholesterol efflux in vascular endothelial cells
    Brian J O'Connell
    Cardiovascular Genetics Laboratory, McGill University Health Centre, Royal Victoria Hospital, Montreal, Quebec, Canada
    Circulation 110:2881-8. 2004
    ..Of the cells that compose the atherosclerotic plaque, vascular endothelial cells are the most resistant to cholesterol accumulation. Cholesterol efflux pathways may play an important role in endothelial cholesterol homeostasis...
  56. ncbi request reprint Structural modification of plasma HDL by phospholipids promotes efficient ABCA1-mediated cholesterol release
    Houssein Hajj Hassan
    Cardiovascular Genetics Laboratory, Cardiology Division, McGill University Health Center Royal Victoria Hospital, Montreal, Quebec H3A 1A1, Canada
    J Lipid Res 46:1457-65. 2005
    ..Increasing the plasma prebeta(1)-LpA-I level by either pharmacological agents or direct infusions might prevent foam cell formation and reduce atherosclerotic vascular disease...
  57. ncbi request reprint ESI-MS quantitation of increased sphingomyelin in Niemann-Pick disease type B HDL
    Ching Yin Lee
    Cardiovascular Genetics Laboratory, McGill University, Montreal, Canada
    J Lipid Res 46:1213-28. 2005
    ..These data provide insight into the structure of HDLs and identify potential new roles for SMase in lipoprotein metabolism...
  58. doi request reprint High-density lipoproteins and cardiovascular disease: 2010 update
    Khalid Alwaili
    Cardiovascular Research Laboratories, McGill University Health Centre Royal Victoria Hospital, 687 Pine Avenue West, Montreal, Quebec, Canada
    Expert Rev Cardiovasc Ther 8:413-23. 2010
    ..The treatment of low HDL-C remains controversial, in part because the only currently available effective medication, niacin, is relatively poorly tolerated and outcomes studies on cardiovascular disease prevention are still pending...
  59. pmc Genetic variation at the proprotein convertase subtilisin/kexin type 5 gene modulates high-density lipoprotein cholesterol levels
    Iulia Iatan
    Department of Biochemistry, Cardiovascular Research Laboratories, Cardiology Division, McGill University Health Centre Royal Victoria Hospital, Montreal, Quebec, Canada
    Circ Cardiovasc Genet 2:467-75. 2009
    ..We therefore investigated the effect of human PCSK5 genetic variants on plasma HDL-C levels...
  60. ncbi request reprint Mutations in the ABC1 gene in familial HDL deficiency with defective cholesterol efflux
    M Marcil
    Xenon Bioresearch Inc, NRC Innovation Centre, Vancouver, British Columbia, Canada
    Lancet 354:1341-6. 1999
    ..This gene codes for the cholesterol-efflux regulatory protein (CERP). We investigated the presence of mutations in this gene in patients with familial HDL deficiency...
  61. doi request reprint Quantitative analysis of ABCA1-dependent compartmentalization and trafficking of apolipoprotein A-I: implications for determining cellular kinetics of nascent high density lipoprotein biogenesis
    Houssein Hajj Hassan
    Cardiovascular Genetics Laboratory, Division of Cardiology, McGill University Health Centre Royal Victoria Hospital, Montreal, Quebec H3A 1A1, Canada
    J Biol Chem 283:11164-75. 2008
    ....
  62. ncbi request reprint Effect of ABCA1 mutations on risk for myocardial infarction
    Iulia Iatan
    Faculty of Medicine, Division of Cardiology, McGill University Health Center Royal Victoria Hospital, 687 Pine Avenue West, Montreal, QC Canada H3A 1A1
    Curr Atheroscler Rep 10:413-26. 2008
    ..Nevertheless, genomic screening for complex diseases, such as coronary heart disease, and HDL deficiency in particular, may not add additional information to that gained from conventional global cardiovascular risk stratification...
  63. pmc Fine mapping and association studies of a high-density lipoprotein cholesterol linkage region on chromosome 16 in French-Canadian subjects
    Zari Dastani
    Cardiovascular Genetics Laboratory, McGill University Health Centre, Royal Victoria Hospital, Montreal, Quebec, Canada
    Eur J Hum Genet 18:342-7. 2010
    ..Our data constitute additional evidence for a locus on chromosome 16q23-24 that affects HDL-C levels in two independent French-Canadian studies...
  64. ncbi request reprint cAMP induces ABCA1 phosphorylation activity and promotes cholesterol efflux from fibroblasts
    Bassam Haidar
    Cardiovascular Genetics Laboratory, McGill University Health Centre, Royal Victoria Hospital, Montreal, QC H3A 1A1 Faculty of Medicine, Universite de Montreal, Montreal, QC H3C 3J7, Canada
    J Lipid Res 43:2087-94. 2002
    ..Taken together, these findings provide evidence for a link between the cAMP/PKA-dependent pathway, ABCA1 phosphorylation, and apoA-I mediated cellular cholesterol efflux...
  65. ncbi request reprint Limitations of statin monotherapy for the treatment of dyslipidemia: a projection based on the Canadian lipid study--observational
    Martin Senecal
    Health Economics and Outcomes Research, Merck Frosst Canada Ltd, Montreal, Canada
    Curr Med Res Opin 25:47-55. 2009
    ..A cross-sectional study of patients treated with statins for at least 8 weeks (CALIPSO) was used as a basis to project the ability of statin monotherapy in getting high CAD-risk patients to an LDL-C level <2.0 mmol/L...
  66. ncbi request reprint RVX-208: a small molecule that increases apolipoprotein A-I and high-density lipoprotein cholesterol in vitro and in vivo
    Dana Bailey
    Division of Cardiology, McGill University Health Center Royal Victoria Hospital, Montreal, Quebec, Canada
    J Am Coll Cardiol 55:2580-9. 2010
    ..The aim of this study was to determine whether a novel small molecule RVX-208 affects apolipoprotein (apo)A-I and high-density lipoprotein cholesterol (HDL-C) levels in vitro and in vivo...
  67. ncbi request reprint Approach to the diagnosis and management of lipoprotein disorders
    Khalid Alwaili
    Cardiovascular Research Laboratories, McGill University Health Center Research Institute, McGill University, Montreal, Quebec, Canada
    Curr Opin Endocrinol Diabetes Obes 16:132-40. 2009
    ..With the growing epidemic of obesity, dyslipidemias are a component of the metabolic syndrome...
  68. ncbi request reprint Truncation mutations in ABCA1 suppress normal upregulation of full-length ABCA1 by 9-cis-retinoic acid and 22-R-hydroxycholesterol
    Cheryl L Wellington
    Centre for Molecular Medicine and Therapeutics, Childrens and Women s Hospital, University of British Columbia, 980 West 28th Avenue, Vancouver, British Columbia, Canada
    J Lipid Res 43:1939-49. 2002
    ..These data suggest that ABCA1 requires a physical association with itself or other molecules for normal function and has important pharmacogenetic implications for individuals with truncation mutations...
  69. doi request reprint Effect of obesity on high-density lipoprotein metabolism
    Shirya Rashid
    Department of Medicine, Division of Cardiology, McGill University, Royal Victoria Hospital, Room H7 13, 687 Pine Avenue West, Montreal, Quebec, Canada H3A 1A1
    Obesity (Silver Spring) 15:2875-88. 2007
    ..Increased lipid transfer to HDL by lipoprotein lipase and reduced HDL clearance by hepatic triglyceride lipase as a result of endurance training are two important mechanisms for increases in HDL observed from exercise...
  70. pmc Surgical strategies for severe calcification of the aorta (porcelain aorta) in two patients with homozygous familial hypercholesterolemia
    S Marlene Grenon
    Department of Cardial Surgery, McGill University, Royal Victoria Hospital, Montreal, Quebec, Canada
    Can J Cardiol 23:1159-61. 2007
    ..A porcelain aorta appears to be a feature of HzFH. This has an important impact on surgical planning and management and on possible pathophysiological processes related to the cardiovascular complications of HzFH...
  71. ncbi request reprint Elevated homocysteine reduces apolipoprotein A-I expression in hyperhomocysteinemic mice and in males with coronary artery disease
    Leonie G Mikael
    Department of Human Genetics, Montreal Children s Hospital, Montreal, Canada
    Circ Res 98:564-71. 2006
    ..Transfection with a PPARalpha construct upregulated ApoA-I and MTHFR. Our results suggest that hyperhomocysteinemia may increase risk of atherosclerosis by decreasing expression of ApoA-I and increasing expression of CYP7A1...
  72. ncbi request reprint Conversion from cyclosporine microemulsion to tacrolimus-based immunoprophylaxis improves cholesterol profile in heart transplant recipients with treated but persistent dyslipidemia: the Canadian multicentre randomized trial of tacrolimus vs cyclosporine
    Michel White
    Research Center of Montreal Heart Institute, Montreal, Quebec
    J Heart Lung Transplant 24:798-809. 2005
    ..The impact of conversion from cyclosporine microemulsion (Neoral) to tacrolimus (Prograf) in a large randomized study of stable heart transplant recipients with treated but persistent mild dyslipidemia is reported...
  73. pmc Cellular cholesterol homeostasis in vascular endothelial cells
    Hajj Hassan Hassan
    Cardiovascular Genetics Laboratory, Division of Cardiology, McGill University Health Centre Royal Victoria Hospital, Montreal, Quebec
    Can J Cardiol 22:35B-40B. 2006
    ..The role of ABC-type transporters, including ABCG1, requires further examination...
  74. ncbi request reprint Biogenesis and speciation of nascent apoA-I-containing particles in various cell lines
    Larbi Krimbou
    Cardiovascular Genetics Laboratory, Cardiology Division, McGill University Health Centre Royal Victoria Hospital, Montreal, Quebec H3A 1A1, Canada
    J Lipid Res 46:1668-77. 2005
    ..Thus, our study provides direct evidence for a new link between specific cell lines and the speciation of nascent HDL that occurs by both ABCA1-dependent and -independent pathways...
  75. ncbi request reprint Homocysteine-betaine interactions in a murine model of 5,10-methylenetetrahydrofolate reductase deficiency
    Bernd C Schwahn
    Department of Pediatrics, McGill University Montreal Children s Hospital, Montreal, Canada
    FASEB J 17:512-4. 2003
    ..Hyperhomocysteinemia, in the range of that associated with folate deficiency or with homozygosity for the 677T MTHFR variant, may be associated with disturbed choline metabolism...
  76. ncbi request reprint New insights into the biogenesis of human high-density lipoproteins
    Larbi Krimbou
    Cardiovascular Genetics Laboratory, Division of Cardiology, McGill University Health Center Royal Victoria Hospital, Montreal, Quebec, Canada
    Curr Opin Lipidol 17:258-67. 2006
    ..The present review focuses on recent progress in our understanding of the basic mechanisms underlying HDL biogenesis pathways...
  77. ncbi request reprint Statin therapy in Canadian patients with hypercholesterolemia: the Canadian Lipid Study -- Observational (CALIPSO)
    C Bourgault
    McGill University, Montreal, Canada
    Can J Cardiol 21:1187-93. 2005
    ..Although statins are widely used to reduce low density lipoprotein cholesterol (LDL-C), there is little information about patient profiles, treatment patterns and goal achievement among statin-treated patients in Canada...
  78. ncbi request reprint Cellular phospholipid and cholesterol efflux in high-density lipoprotein deficiency
    Michel Marcil
    Department of Cardiovascular Genetics, McGill University Health Centre, Montreal, Canada
    Circulation 107:1366-71. 2003
    ..Prospective studies have examined the relationship between coronary artery disease and low plasma levels of high-density lipoprotein cholesterol (HDL-C)...
  79. ncbi request reprint Subclinical inflammation and prothrombotic state in heart transplant recipients: impact of cyclosporin microemulsion vs. tacrolimus
    Michel White
    Research Center, Montreal Heart Institute, Montreal, Quebec, Canada
    Transplantation 82:763-70. 2006
    ..tacrolimus immunoprophylaxis on these parameters...
  80. ncbi request reprint Identification of an ABCA1-dependent phospholipid-rich plasma membrane apolipoprotein A-I binding site for nascent HDL formation: implications for current models of HDL biogenesis
    Houssein Hajj Hassan
    Cardiovascular Genetics Laboratory, Cardiology Division, McGill University Health Centre Royal Victoria Hospital, Montreal, Quebec, Canada
    J Lipid Res 48:2428-42. 2007
    ..Our results provide a biochemical basis for the HDL biogenesis pathway that involves both ABCA1 and the HCBS, supporting a two binding site model for ABCA1-mediated nascent HDL genesis...
  81. ncbi request reprint Characterization of oligomeric human ATP binding cassette transporter A1. Potential implications for determining the structure of nascent high density lipoprotein particles
    Maxime Denis
    Cardiovascular Genetics Laboratory, Cardiology Division, McGill University Health Centre Royal Victoria Hospital, Montreal, Quebec H3A 1A1, Canada
    J Biol Chem 279:41529-36. 2004
    ....
  82. ncbi request reprint Expression, regulation, and activity of ABCA1 in human cell lines
    Maxime Denis
    Cardiovascular Genetics Laboratory, McGill University Health Center, Royal Victoria Hospital, 687 Pine Avenue West, Montreal, Quebec, Canada H3A 1A1
    Mol Genet Metab 78:265-74. 2003
    ..Taken together, these results demonstrate that: (1) ABCA1 expression varies among tissues, and (2) cholesterol conversion to hydroxycholesterol is an important mechanism for the maintenance of cholesterol homeostasis in fibroblasts...
  83. ncbi request reprint Is the decreased high-density lipoprotein cholesterol in the metabolic syndrome due to cellular lipid efflux defect?
    Mohammad Y Alenezi
    Cardiovascular Genetics Laboratory, Division of Cardiology, Department of Medicine, McGill University Health Center Royal Victoria Hospital, Montreal, Quebec, Canada
    J Clin Endocrinol Metab 89:761-4. 2004
    ..No patient with the MS and low HDL-C showed a cellular lipid efflux defect. We conclude that primary cellular lipid efflux defects do not contribute to the low HDL-C frequently encountered in the MS...
  84. ncbi request reprint Genetics and prevention: a new look at high-density lipoprotein cholesterol
    Jacques Genest
    Division of Cardiology, McGill University Health Center Royal Victoria Hospital, 687 Pine Avenue West, Montreal, Quebec, Canada
    Cardiol Rev 10:61-71. 2002
    ....
  85. ncbi request reprint Carboxyl-terminal disulfide bond of acid sphingomyelinase is critical for its secretion and enzymatic function
    Ching Yin Lee
    Cardiovascular Genetics Laboratory, Cardiology Division, McGill University Health Center Royal Victoria Hospital, Montreal, Quebec H3A 1A1, Canada
    Biochemistry 46:14969-78. 2007
    ..Altogether, we provide evidence that the carboxyl-terminus of the ASM is crucial for its protein structure, which in turns dictates the enzymatic function and secretion...
  86. ncbi request reprint Functional mutations of the ABCA1 gene in subjects of French-Canadian descent with HDL deficiency
    Khalid Alrasadi
    Division of Cardiology, McGill University Health Center, Royal Victoria Hospital, Montreal, Quebec, Canada
    Atherosclerosis 188:281-91. 2006
    ..Interestingly, in two families studied, mutations in the ABCA1 gene did not segregate with the lipid efflux defect, suggesting that other proteins are involved in the ABCA1-mediated cellular lipid efflux...
  87. ncbi request reprint Baseline characteristics of participants in the JUPITER trial, a randomized placebo-controlled primary prevention trial of statin therapy among individuals with low low-density lipoprotein cholesterol and elevated high-sensitivity C-reactive protein
    Paul M Ridker
    JUPITER Coordinating Center, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Am J Cardiol 100:1659-64. 2007
    ..In conclusion, as 20 mg of rosuvastatin can reduce LDL cholesterol by up to 50%, JUPITER will also provide crucial safety data for several thousand patients who should achieve LDL cholesterol levels<50 mg/dl on a long-term basis...
  88. ncbi request reprint Can combining different risk interventions into a single formulation contribute to improved cardiovascular disease risk reduction? Rationale and design for an international, open-label program to assess the effectiveness of a single pill (amlodipine/atorv
    F D Richard Hobbs
    Primary Care Clinical Sciences Building, University of Birmingham, Edgbaston, UK
    Int J Cardiol 110:242-50. 2006
    ..The JEWEL study program will investigate the use of single-pill amlodipine/atorvastatin as a strategy to improve management of these patients...
  89. ncbi request reprint Modulation of arterial reactivity using amlodipine and atorvastatin measured by ultrasound examination (MARGAUX)
    Francois Charbonneau
    Department of Cardiovascular Sciences and the Libin Cardiovascular Institute, University of Calgary, Calgary, AB, Canada
    Atherosclerosis 197:420-7. 2008
    ..To evaluate the effect of the calcium channel blocker amlodipine on endothelial function in normotensive patients with coronary disease taking concomitant atorvastatin therapy...
  90. ncbi request reprint Secretory vesicular transport from the Golgi is altered during ATP-binding cassette protein A1 (ABCA1)-mediated cholesterol efflux
    Xiaohui Zha
    Lipoprotein and Atherosclerosis Group, University of Ottawa Heart Institute, Ontario K1Y 4W7, Canada
    J Biol Chem 278:10002-5. 2003
    ..ABCA1 may influence cholesterol efflux in part by enhancing vesicular trafficking from the Golgi to the plasma membrane...
  91. ncbi request reprint Homocysteine lowering with folic acid and B vitamins in vascular disease
    Eva Lonn
    Population Health Research Institute, Hamilton General Hospital, McMaster University, and the Department of Medicine, Division of Cardiology, Hamilton Health Sciences, Hamilton, Ont
    N Engl J Med 354:1567-77. 2006
    ..Folic acid and vitamins B6 and B12 lower homocysteine levels. We assessed whether supplementation reduced the risk of major cardiovascular events in patients with vascular disease...
  92. ncbi request reprint Identification of a novel C5L2 variant (S323I) in a French Canadian family with familial combined hyperlipemia
    Michel Marcil
    Centre de recherche Hopital Laval, Universite Laval, Y2186, 2725 Chemin Ste Foy, Ste Foy, Quebec, G1V 4G5
    Arterioscler Thromb Vasc Biol 26:1619-25. 2006
    ..Impaired ASP-mediated triglyceride synthesis has previously been described in a subset of hyperapolipoprotein B/familial combined hyperlipidemia subjects...
  93. ncbi request reprint Evidence for a gene influencing high-density lipoprotein cholesterol on chromosome 4q31.21
    Zari Dastani
    Department of Medicine, McGill University, Montreal, Canada
    Arterioscler Thromb Vasc Biol 26:392-7. 2006
    ..To identify novel genes regulating plasma HDL-C levels, we investigated 13 multigenerational French Canadian families with an average of 12 affected individuals per family for genome-wide signals, which we subsequently fine mapped...
  94. pmc Canadian Cardiovascular Society position statement--recommendations for the diagnosis and treatment of dyslipidemia and prevention of cardiovascular disease
    Ruth McPherson
    University of Ottawa Heart Institute, Ottawa, Canada
    Can J Cardiol 22:913-27. 2006
    ..0) and recommendations regarding additional investigations of potential use in the further evaluation of coronary artery disease risk in subjects in the moderate-risk category...
  95. ncbi request reprint Watching sports or doing sports: children's investment in cardiovascular health
    Jacques Genest
    Can J Cardiol 20:303-4. 2004
  96. ncbi request reprint Compound heterozygosity at the sphingomyelin phosphodiesterase-1 (SMPD1) gene is associated with low HDL cholesterol
    Ching Yin Lee
    Cardiovascular Genetics Laboratory, Royal Victoria Hospital, McGill University Health Centre, Montreal, Quebec, Canada
    Hum Genet 112:552-62. 2003
    ....
  97. ncbi request reprint Plasma homocysteine concentration changes after renal transplantation in children
    Aicha Merouani
    Department of Pediatric Nephrology, Ste Justine Hospital, 3175 Cote Sainte Catherine, Montreal, Quebec, Canada, H3T1C5
    Pediatr Nephrol 17:520-3. 2002
    ..However, normalization was attained when patients were supplemented with folic acid. Further controlled studies are required to evaluate the determinants and treatment of elevated plasma homocysteine in pediatric transplant patients...
  98. ncbi request reprint Apolipoprotein A-I activates cellular cAMP signaling through the ABCA1 transporter
    Bassam Haidar
    Cardiovascular Genetics Laboratory, Division of Cardiology, McGill University Health Centre Royal Victoria Hospital, Montreal, Quebec H3A 1A1, Canada
    J Biol Chem 279:9963-9. 2004
    ..These findings suggest that apoA-I may activate cAMP signaling through G protein-coupled ABCA1 transporter...
  99. pmc WW-domain-containing oxidoreductase is associated with low plasma HDL-C levels
    Jenny C Lee
    Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Am J Hum Genet 83:180-92. 2008
    ..In conclusion, analyses of 9,798 subjects show significant association between HDL-C and a WWOX variant with an allele-specific cis-regulatory function...