Eric Fombonne

..Parent-reported improvement suggests that social skills learned in group sessions generalize to settings outside the treatment group. Larger, controlled studies of social skills training groups would be valuable...

..However, available epidemiological surveys do not provide an adequate test of the hypothesis of a changing incidence of PDDs...

..The rate in this study is comparable to that in previous birth cohorts from the same area and surveyed with the same methods, suggesting a stable incidence...

..In addition, data from many of these surveys indicate correlates of autistic disorder and other PDDs with IQ, gender, and other medical disorders...

..The prevalence of pervasive developmental disorders has increased in recent years. Links with the measles component of the measles-mumps-rubella vaccine and the cumulative exposure to thimerosal through other vaccines have been postulated...

..The SRS is an acceptable screening instrument for epidemiological studies of ASDs in Mexico. Its psychometric properties are excellent and comparable to those derived from North American and other samples...

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..This article reviews available epidemiologic surveys that have shed light on the prevalence of AD...

..If a rate of 30 per 10,000 is taken for all PDDs, only one child out of 175 children with a PDD diagnosis would, on average, meet criteria for CDD...

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..These results further support the role of SHANK3 gene disruption in the etiology of ASD...

..Our findings link NRXN2 disruption to the pathogenesis of ASD for the first time and further strengthen the involvement of NRXN1 in SCZ, supporting the notion of a common genetic mechanism in these disorders...

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..These results indicate that SYNGAP1 disruption is a cause of autosomal dominant nonsyndromic mental retardation...

..Despite the current World Health Organization recommendation that infants be exclusively breastfed for 6 mo, this practice remains unusual in both developed and developing countries...

..Our results emphasize the importance of DNMs as genetic mechanisms in ASD and SCZ and the limitations of using DNA from archived cell lines to identify functional variants...

..The absence of associations based on ITT analyses, in contrast with the significant associations based on observed breast-feeding duration, strongly suggests that the latter are biased by residual confounding...

..All together, our results indicate that mutations in IL1RAPL1 cause a spectrum of neurological impairments ranging from MR to high functioning autism...

..The gene encoding the synaptic motor protein kinesin 17 (KIF17) involved in glutamatergic synapse is a candidate gene for SCZ...

..incorrectly) recognized the emotions. These findings are reviewed within the context of the amygdala theory of autism...

..To estimate the prevalence of suicidal ideation and behaviours in a large, representative sample of French youth and to evaluate age and sex correlates...

..Among school-age children born at term within normal range of birthweight, fetal growth, but not gestational age, was associated with behavioural problem scores...

..025), there were no significant group differences in language level. Bilingually-exposed children with ASDs did not experience additional delays in language development...

..In conclusion, both FOXP1 and FOXP2 are associated with language impairment, but decrease of the former has a more global impact on brain development than that of the latter...

..Our objectives were to determine prevalence rates of PDDs among school-aged children, and to evaluate the impact of discontinuation of thimerosal use in 1996 in routine childhood vaccines on PDD rates...

..The lack of evidence from the majority of the world's population suggests a critical need for further research and capacity building in low- and middle-income countries...

..We conclude that adolescents with ASD perceive and integrate musical soundtracks with visual displays equivalent to typically developing individuals...

..Sensori-motor deficits have an impact on the autonomy of children with ASD and interventions should aim at improving and supporting the development of sensori-motor skills...

..These results suggest that STXBP1 disruption is associated with autosomal dominant mental retardation and nonsyndromic epilepsy...

..Currently displayed Repetitive and Restricted Behaviors and Interests were not found to be useful for differentiating between groups. The similarities found between groups have important implications for intervention...

..Implications for theories of emotion in autism are discussed in light of these findings...

..INTERPRETATION: There is no evidence of measles virus persistence in the peripheral blood mononuclear cells of children with autism spectrum disorder...

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..The objective of this study was to assess the long-term effects of breastfeeding on child behavior and maternal adjustment...

..Serious considerations should be given before initiating treatment and consistent clinical monitoring is essential. More research is needed, especially regarding glucose dysregulation and dyslipidaemia...

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..We investigated whether MMR vaccination is associated with an increased risk of autism or other pervasive developmental disorders...

..The authors investigated whether delayed childhood motor skills predicted persistent anxiety in adolescence among 6,850 subjects from a national 1958 U.K. birth cohort...

..Rates of substance use among adolescents have increased in the 1990s, however little is known about current patterns of substance use among youths entering adulthood...

..Results from this small pilot study point to considerable economic burden for parents and give some indication of the associated costs of autistic spectrum disorder...

..Hypotheses put forward to explain the findings are discussed. We conclude by highlighting areas for future research...

..An understanding of what breaks down in the routine care of these young people would facilitate earlier identification and more effective prevention or early intervention for these vulnerable children and adolescents...

..CONCLUSIONS: It is possible to explain a reasonable amount of variation in adult service costs from factors describing the characteristics of children at the time of receiving care...

..This study is the first to distinguish prospectively between juvenile- and adult-onset cases of MDD in a representative birth cohort followed up from childhood into adulthood...

..The study also contributes towards a methodology of economically evaluating supported employment programs as well as other interventions for people with high-functioning ASD...

..Finally the increasing use of electronic databases in the evaluation of vaccine adverse effects is considered...

..Neurexins team with previously implicated neuroligins for glutamatergic synaptogenesis, highlighting glutamate-related genes as promising candidates for contributing to ASDs...

..Fit indices strongly supported the correlated 8-syndrome structure in each of 30 societies. The results support use of the syndromes in diverse societies...

..Finally, psychotropic drugs may help to reduce some symptoms, but they are neither curative nor a substitute for other forms of support and intervention...

..This study addresses in both genders the relationship between childhood Hyperactivity-inattention symptoms and subsequent adolescent substance use, while controlling for psychiatric comorbidity, temperament and environmental risk factors...