Research Topics
Species | Lesley K FellowsSummaryAffiliation: McGill University Country: Canada Publications
Research Grants
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Detail Information
Publications
The human ventromedial frontal lobe is critical for learning from negative feedbackElizabeth Z Wheeler
Department of Psychiatry, University of California, San Diego, CA, USA
Brain 131:1323-31. 2008....
Advances in understanding ventromedial prefrontal function: the accountant joins the executiveLesley K Fellows
Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada
Neurology 68:991-5. 2007..quot; This review highlights recent advances in the cognitive neuroscience of decision making and neuroeconomics and discusses how these findings can inform clinical thinking about frontal lobe dysfunction...- The role of orbitofrontal cortex in decision making: a component process accountLesley K Fellows
Montreal Neurological Institute, McGill University, Montreal, QC H3A 2B4, Canada
Ann N Y Acad Sci 1121:421-30. 2007.... - Orbitofrontal contributions to value-based decision making: evidence from humans with frontal lobe damageLesley K Fellows
Department of Neurology and Neurosurgery, McGill University, Montreal, Canada
Ann N Y Acad Sci 1239:51-8. 2011..They also argue for multiple, parallel, value-based processes that influence behavior through dissociable mechanisms... - Deciding how to decide: ventromedial frontal lobe damage affects information acquisition in multi-attribute decision makingLesley K Fellows
Montreal Neurological Institute, Room 276, 3801 rue Université, Montreal, QC H3A 2B4, Canada
Brain 129:944-52. 2006.... - Method matters: an empirical study of impact in cognitive neuroscienceLesley K Fellows
University of Pennsylvania, USA
J Cogn Neurosci 17:850-8. 2005..There were also differences in the degree to which articles using one method cited articles using the other method. Functional neuroimaging articles were less likely to include such cross-method citations... - Dissociable elements of human foresight: a role for the ventromedial frontal lobes in framing the future, but not in discounting future rewardsLesley K Fellows
Center for Cognitive Neuroscience, University of Pennsylvania, 3720 Walnut St, Philadelphia, PA 19104, USA
Neuropsychologia 43:1214-21. 2005..Apathy may deserve more attention in understanding both impaired future thinking and the impaired decision making that may result... - Is anterior cingulate cortex necessary for cognitive control?Lesley K Fellows
Center for Cognitive Neuroscience, University of Pennsylvania, Philadelphia, PA, USA
Brain 128:788-96. 2005..Thus, cognitive control, as assessed by four different measures in two different tasks, appears to be intact in these subjects, arguing against a necessary role for dACC in this process... - Patient registries in cognitive neuroscience research: advantages, challenges, and practical adviceLesley K Fellows
Montreal Neurological Institute, Rm 276, 3801 University Street, Montreal, QC, Canada H3A 2B4
J Cogn Neurosci 20:1107-13. 2008..We report the experience of two such registries: the patient database of the Center for Cognitive Neuroscience at the University of Pennsylvania, and the Cognitive Neuroscience Research Registry at McGill University... - Double dissociation of stimulus-value and action-value learning in humans with orbitofrontal or anterior cingulate cortex damageNathalie Camille
Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec H3A 2B4, Canada
J Neurosci 31:15048-52. 2011..These findings argue that there are distinct, domain-specific mechanisms by which outcome value is applied to guide subsequent decisions, depending on whether the choice is between stimuli or between actions... 
Contrasting roles for lateral and ventromedial prefrontal cortex in transient and dispositional affective experienceSeth J Gillihan
Center for Cognitive Neuroscience, University of Pennsylvania, Philadelphia, PA 19104, USA
Soc Cogn Affect Neurosci 6:128-37. 2011..This study also illustrates the dissociability of different aspects of emotional experience in patients with focal brain injury...- Medial prefrontal cortex plays a critical and selective role in 'feeling of knowing' meta-memory judgmentsMandana Modirrousta
Department of Neurology and Neurosurgery, McGill University, Montreal Neurological Institute, Montreal, Quebec, Canada
Neuropsychologia 46:2958-65. 2008..The role of this region in feeling-of-knowing seems to be, at least in part, independent of its role in memory itself... - Dorsal medial prefrontal cortex plays a necessary role in rapid error prediction in humansMandana Modirrousta
Department of Neurology and Neurosurgery, McGill University, Montreal Neurological Institute, Montreal, Quebec, Canada H3A 2B4
J Neurosci 28:14000-5. 2008..This finding constitutes important converging evidence for a critical role for human dACC in error monitoring, and sheds light on the selectivity and timing of the error-related process affected by dACC damage... - Ventromedial frontal lobe damage disrupts the accuracy, but not the speed, of value-based preference judgmentsAlexandre Henri-Bhargava
Montreal Neurological Institute, Department of Neurology and Neurosurgery, McGill University, 3801 University St, Room 276, Montreal, QC H3A 2B4 Canada
Neuropsychologia 50:1536-42. 2012.... - Beyond reversal: a critical role for human orbitofrontal cortex in flexible learning from probabilistic feedbackAmi Tsuchida
Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada
J Neurosci 30:16868-75. 2010..The findings show that OFC, and not other prefrontal regions, plays a necessary role in flexible stimulus-reinforcement learning in humans... - Ventromedial frontal cortex mediates affective shifting in humans: evidence from a reversal learning paradigmLesley K Fellows
Center for Cognitive Neuroscience, University of Pennsylvania, 3815 Walnut St, Philadelphia, PA 19104 6196, USA
Brain 126:1830-7. 2003..Neither form of frontal damage affected initial stimulus-reinforcement learning; ventromedial frontal damage selectively impaired reversal learning... - The role of ventromedial prefrontal cortex in decision making: judgment under uncertainty or judgment per se?Lesley K Fellows
Department of Neurology and Neurosurgery, McGill University, Montreal Neurological Institute, Montreal, Quebec, Canada
Cereb Cortex 17:2669-74. 2007..These results argue that VMF plays a necessary role in certain as well as uncertain decision making in humans... - Ventromedial frontal lobe plays a critical role in facial emotion recognitionAndrea S Heberlein
University of Pennsylvania, USA
J Cogn Neurosci 20:721-33. 2008..Taken together, our results indicate that the ventromedial frontal lobe plays a crucial role in facial emotion recognition, and suggest that this deficit may be related to the subjective experience of emotion... - Lesion evidence that two distinct regions within prefrontal cortex are critical for n-back performance in humansAmi Tsuchida
Montreal Neurological Institute, Montreal, Canada
J Cogn Neurosci 21:2263-75. 2009..These findings provide converging support for regionally specific models of human prefrontal function... - Different underlying impairments in decision-making following ventromedial and dorsolateral frontal lobe damage in humansLesley K Fellows
Center for Cognitive Neuroscience, University of Pennsylvania, 3720 Walnut St, Philadelphia, PA 19104 6241, USA
Cereb Cortex 15:58-63. 2005..We found that both VMF and DLF damage leads to impaired IGT performance. The impairment of VMF subjects, but not of DLF subjects, seems to be largely explained by an underlying reversal learning deficit... - Ventromedial frontal lobe damage disrupts value maximization in humansNathalie Camille
Department of Neurology and Neurosurgery, McGill University, Montreal Neurological Institute, Montreal, Quebec H3A 2B4, Canada
J Neurosci 31:7527-32. 2011..These results demonstrate that the VMF plays a critical role in value-maximizing choice... - A longitudinal view of apathy and its impact after strokeNancy E Mayo
Division of Clinical Epidemiology, Department of Medicine and School of Physical and Occupational Therapy, McGill University Health Center, Royal Victoria Hospital, Montreal, Quebec, Canada
Stroke 40:3299-307. 2009..The specific objective was to estimate the extent to which apathy changes with time over the first year after stroke and the impact of apathy on recovery... - Clinical significance of complex repetitive discharges: A case-control studyLesley K Fellows
Center for Cognitive Neuroscience, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Muscle Nerve 28:504-7. 2003..However, the absence of CRDs can be of diagnostic value in that it reduces the likelihood of myopathy or motor neuron disease. The likelihood of finding CRDs in acute conditions is the same as that in chronic conditions... - Dissecting the effects of disease and treatment on impulsivity in Parkinson's diseaseAlison C Simioni
Department of Neurology and Neurosurgery, Montreal Neurological Institute, Montreal, Quebec
J Int Neuropsychol Soc 18:942-51. 2012..jins, 2012, 18, 1-10)... - Are you upset? Distinct roles for orbitofrontal and lateral prefrontal cortex in detecting and distinguishing facial expressions of emotionAmi Tsuchida
Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec H3A 2B4, Canada
Cereb Cortex 22:2904-12. 2012.... - Genetic variation in CYP2A6 predicts neural reactivity to smoking cues as measured using fMRIDeborah W Tang
Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, 3801 University St, Room WB 214D, Montreal, QC, Canada H3A 2B4
Neuroimage 60:2136-43. 2012..They also provide insight into how genetics can shape human vulnerability to addiction, and have implications for tailoring smoking cessation programs based on individual genetics... - Acute phenylalanine/tyrosine depletion reduces motivation to smoke cigarettes across stages of addictionViswanath V Venugopalan
Department of Neurology, McGill University, Montreal, QC, Canada
Neuropsychopharmacology 36:2469-76. 2011..In the transition from sporadic to addicted use, the role of DA in the motivation to seek drug may change less than previously proposed... - The cognitive neuroscience of human decision making: a review and conceptual frameworkLesley K Fellows
Montreal Neurological Institute
Behav Cogn Neurosci Rev 3:159-72. 2004..This article reviews the literature on the cognitive neuroscience of human decision making, focusing on the roles of the frontal lobes, and provides a conceptual framework for organizing this disparate body of work...
Research Grants
- Mapping the Anatomy of Decision MakingLesley Fellows; Fiscal Year: 2004..This approach has the potential to provide insights into the basis for a wide range of pathological human behavior. ..
- Orbitofrontal and striatal mechanisms in stress and addictionLesley Fellows; Fiscal Year: 2006..It aims to develop a solid theoretical and experimental foundation for applying neurobiological findings to understand the real-life complexity of addictive behavior in humans. ..