Lesley K Fellows

Summary

Affiliation: McGill University
Country: Canada

Publications

  1. doi request reprint The human ventromedial frontal lobe is critical for learning from negative feedback
    Elizabeth Z Wheeler
    Department of Psychiatry, University of California, San Diego, CA, USA
    Brain 131:1323-31. 2008
  2. ncbi request reprint Advances in understanding ventromedial prefrontal function: the accountant joins the executive
    Lesley K Fellows
    Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada
    Neurology 68:991-5. 2007
  3. ncbi request reprint The role of orbitofrontal cortex in decision making: a component process account
    Lesley K Fellows
    Montreal Neurological Institute, McGill University, Montreal, QC H3A 2B4, Canada
    Ann N Y Acad Sci 1121:421-30. 2007
  4. doi request reprint Orbitofrontal contributions to value-based decision making: evidence from humans with frontal lobe damage
    Lesley K Fellows
    Department of Neurology and Neurosurgery, McGill University, Montreal, Canada
    Ann N Y Acad Sci 1239:51-8. 2011
  5. doi request reprint Patient registries in cognitive neuroscience research: advantages, challenges, and practical advice
    Lesley K Fellows
    Montreal Neurological Institute, Rm 276, 3801 University Street, Montreal, QC, Canada H3A 2B4
    J Cogn Neurosci 20:1107-13. 2008
  6. ncbi request reprint Is anterior cingulate cortex necessary for cognitive control?
    Lesley K Fellows
    Center for Cognitive Neuroscience, University of Pennsylvania, Philadelphia, PA, USA
    Brain 128:788-96. 2005
  7. ncbi request reprint Dissociable elements of human foresight: a role for the ventromedial frontal lobes in framing the future, but not in discounting future rewards
    Lesley K Fellows
    Center for Cognitive Neuroscience, University of Pennsylvania, 3720 Walnut St, Philadelphia, PA 19104, USA
    Neuropsychologia 43:1214-21. 2005
  8. ncbi request reprint Method matters: an empirical study of impact in cognitive neuroscience
    Lesley K Fellows
    University of Pennsylvania, USA
    J Cogn Neurosci 17:850-8. 2005
  9. ncbi request reprint Deciding how to decide: ventromedial frontal lobe damage affects information acquisition in multi-attribute decision making
    Lesley K Fellows
    Montreal Neurological Institute, Room 276, 3801 rue Université, Montreal, QC H3A 2B4, Canada
    Brain 129:944-52. 2006
  10. doi request reprint Double dissociation of stimulus-value and action-value learning in humans with orbitofrontal or anterior cingulate cortex damage
    Nathalie Camille
    Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec H3A 2B4, Canada
    J Neurosci 31:15048-52. 2011

Research Grants

  1. Mapping the Anatomy of Decision Making
    Lesley Fellows; Fiscal Year: 2004
  2. Orbitofrontal and striatal mechanisms in stress and addiction
    Lesley Fellows; Fiscal Year: 2006

Collaborators

Detail Information

Publications30

  1. doi request reprint The human ventromedial frontal lobe is critical for learning from negative feedback
    Elizabeth Z Wheeler
    Department of Psychiatry, University of California, San Diego, CA, USA
    Brain 131:1323-31. 2008
    ....
  2. ncbi request reprint Advances in understanding ventromedial prefrontal function: the accountant joins the executive
    Lesley K Fellows
    Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada
    Neurology 68:991-5. 2007
    ..This review highlights recent advances in the cognitive neuroscience of decision making and neuroeconomics and discusses how these findings can inform clinical thinking about frontal lobe dysfunction...
  3. ncbi request reprint The role of orbitofrontal cortex in decision making: a component process account
    Lesley K Fellows
    Montreal Neurological Institute, McGill University, Montreal, QC H3A 2B4, Canada
    Ann N Y Acad Sci 1121:421-30. 2007
    ....
  4. doi request reprint Orbitofrontal contributions to value-based decision making: evidence from humans with frontal lobe damage
    Lesley K Fellows
    Department of Neurology and Neurosurgery, McGill University, Montreal, Canada
    Ann N Y Acad Sci 1239:51-8. 2011
    ..They also argue for multiple, parallel, value-based processes that influence behavior through dissociable mechanisms...
  5. doi request reprint Patient registries in cognitive neuroscience research: advantages, challenges, and practical advice
    Lesley K Fellows
    Montreal Neurological Institute, Rm 276, 3801 University Street, Montreal, QC, Canada H3A 2B4
    J Cogn Neurosci 20:1107-13. 2008
    ..We report the experience of two such registries: the patient database of the Center for Cognitive Neuroscience at the University of Pennsylvania, and the Cognitive Neuroscience Research Registry at McGill University...
  6. ncbi request reprint Is anterior cingulate cortex necessary for cognitive control?
    Lesley K Fellows
    Center for Cognitive Neuroscience, University of Pennsylvania, Philadelphia, PA, USA
    Brain 128:788-96. 2005
    ..Thus, cognitive control, as assessed by four different measures in two different tasks, appears to be intact in these subjects, arguing against a necessary role for dACC in this process...
  7. ncbi request reprint Dissociable elements of human foresight: a role for the ventromedial frontal lobes in framing the future, but not in discounting future rewards
    Lesley K Fellows
    Center for Cognitive Neuroscience, University of Pennsylvania, 3720 Walnut St, Philadelphia, PA 19104, USA
    Neuropsychologia 43:1214-21. 2005
    ..Apathy may deserve more attention in understanding both impaired future thinking and the impaired decision making that may result...
  8. ncbi request reprint Method matters: an empirical study of impact in cognitive neuroscience
    Lesley K Fellows
    University of Pennsylvania, USA
    J Cogn Neurosci 17:850-8. 2005
    ..There were also differences in the degree to which articles using one method cited articles using the other method. Functional neuroimaging articles were less likely to include such cross-method citations...
  9. ncbi request reprint Deciding how to decide: ventromedial frontal lobe damage affects information acquisition in multi-attribute decision making
    Lesley K Fellows
    Montreal Neurological Institute, Room 276, 3801 rue Université, Montreal, QC H3A 2B4, Canada
    Brain 129:944-52. 2006
    ....
  10. doi request reprint Double dissociation of stimulus-value and action-value learning in humans with orbitofrontal or anterior cingulate cortex damage
    Nathalie Camille
    Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec H3A 2B4, Canada
    J Neurosci 31:15048-52. 2011
    ..These findings argue that there are distinct, domain-specific mechanisms by which outcome value is applied to guide subsequent decisions, depending on whether the choice is between stimuli or between actions...
  11. pmc Contrasting roles for lateral and ventromedial prefrontal cortex in transient and dispositional affective experience
    Seth J Gillihan
    Center for Cognitive Neuroscience, University of Pennsylvania, Philadelphia, PA 19104, USA
    Soc Cogn Affect Neurosci 6:128-37. 2011
    ..This study also illustrates the dissociability of different aspects of emotional experience in patients with focal brain injury...
  12. doi request reprint Medial prefrontal cortex plays a critical and selective role in 'feeling of knowing' meta-memory judgments
    Mandana Modirrousta
    Department of Neurology and Neurosurgery, McGill University, Montreal Neurological Institute, Montreal, Quebec, Canada
    Neuropsychologia 46:2958-65. 2008
    ..The role of this region in feeling-of-knowing seems to be, at least in part, independent of its role in memory itself...
  13. doi request reprint Are core component processes of executive function dissociable within the frontal lobes? Evidence from humans with focal prefrontal damage
    Ami Tsuchida
    Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada
    Cortex 49:1790-800. 2013
    ..These findings are easier to reconcile with modular, material-specific accounts than with more unitary models of executive function...
  14. pmc Dorsal medial prefrontal cortex plays a necessary role in rapid error prediction in humans
    Mandana Modirrousta
    Department of Neurology and Neurosurgery, McGill University, Montreal Neurological Institute, Montreal, Quebec, Canada H3A 2B4
    J Neurosci 28:14000-5. 2008
    ..This finding constitutes important converging evidence for a critical role for human dACC in error monitoring, and sheds light on the selectivity and timing of the error-related process affected by dACC damage...
  15. doi request reprint Ventromedial frontal lobe damage disrupts the accuracy, but not the speed, of value-based preference judgments
    Alexandre Henri-Bhargava
    Montreal Neurological Institute, Department of Neurology and Neurosurgery, McGill University, 3801 University St, Room 276, Montreal, QC H3A 2B4 Canada
    Neuropsychologia 50:1536-42. 2012
    ....
  16. doi request reprint Beyond reversal: a critical role for human orbitofrontal cortex in flexible learning from probabilistic feedback
    Ami Tsuchida
    Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada
    J Neurosci 30:16868-75. 2010
    ..The findings show that OFC, and not other prefrontal regions, plays a necessary role in flexible stimulus-reinforcement learning in humans...
  17. doi request reprint Dissecting the effects of disease and treatment on impulsivity in Parkinson's disease
    Alison C Simioni
    Department of Neurology and Neurosurgery, Montreal Neurological Institute, Montreal, Quebec
    J Int Neuropsychol Soc 18:942-51. 2012
    ..These findings suggest a different neural basis for temporal discounting and risk-taking, and demonstrate that risk-taking can be further decomposed into initial and trial-by-trial effects, with dopamine affecting only the latter...
  18. ncbi request reprint The role of ventromedial prefrontal cortex in decision making: judgment under uncertainty or judgment per se?
    Lesley K Fellows
    Department of Neurology and Neurosurgery, McGill University, Montreal Neurological Institute, Montreal, Quebec, Canada
    Cereb Cortex 17:2669-74. 2007
    ..These results argue that VMF plays a necessary role in certain as well as uncertain decision making in humans...
  19. ncbi request reprint Ventromedial frontal cortex mediates affective shifting in humans: evidence from a reversal learning paradigm
    Lesley K Fellows
    Center for Cognitive Neuroscience, University of Pennsylvania, 3815 Walnut St, Philadelphia, PA 19104 6196, USA
    Brain 126:1830-7. 2003
    ..Neither form of frontal damage affected initial stimulus-reinforcement learning; ventromedial frontal damage selectively impaired reversal learning...
  20. ncbi request reprint Ventromedial frontal lobe plays a critical role in facial emotion recognition
    Andrea S Heberlein
    University of Pennsylvania, USA
    J Cogn Neurosci 20:721-33. 2008
    ..Taken together, our results indicate that the ventromedial frontal lobe plays a crucial role in facial emotion recognition, and suggest that this deficit may be related to the subjective experience of emotion...
  21. doi request reprint Are you upset? Distinct roles for orbitofrontal and lateral prefrontal cortex in detecting and distinguishing facial expressions of emotion
    Ami Tsuchida
    Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec H3A 2B4, Canada
    Cereb Cortex 22:2904-12. 2012
    ....
  22. ncbi request reprint Different underlying impairments in decision-making following ventromedial and dorsolateral frontal lobe damage in humans
    Lesley K Fellows
    Center for Cognitive Neuroscience, University of Pennsylvania, 3720 Walnut St, Philadelphia, PA 19104 6241, USA
    Cereb Cortex 15:58-63. 2005
    ..We found that both VMF and DLF damage leads to impaired IGT performance. The impairment of VMF subjects, but not of DLF subjects, seems to be largely explained by an underlying reversal learning deficit...
  23. ncbi request reprint Lesion evidence that two distinct regions within prefrontal cortex are critical for n-back performance in humans
    Ami Tsuchida
    Montreal Neurological Institute, Montreal, Canada
    J Cogn Neurosci 21:2263-75. 2009
    ..These findings provide converging support for regionally specific models of human prefrontal function...
  24. pmc Ventromedial frontal lobe damage disrupts value maximization in humans
    Nathalie Camille
    Department of Neurology and Neurosurgery, McGill University, Montreal Neurological Institute, Montreal, Quebec H3A 2B4, Canada
    J Neurosci 31:7527-32. 2011
    ..These results demonstrate that the VMF plays a critical role in value-maximizing choice...
  25. pmc Neurobehavioural correlates of body mass index and eating behaviours in adults: a systematic review
    Uku Vainik
    Montreal Neurological Institute, Department of Neurology and Neurosurgery, McGill University, 3801 University Street, Montreal, QC H3A 2B4, Canada
    Neurosci Biobehav Rev 37:279-99. 2013
    ..This review can guide selection of the highest yield neurobehavioural measures for future studies...
  26. doi request reprint A longitudinal view of apathy and its impact after stroke
    Nancy E Mayo
    Division of Clinical Epidemiology, Department of Medicine and School of Physical and Occupational Therapy, McGill University Health Center, Royal Victoria Hospital, Montreal, Quebec, Canada
    Stroke 40:3299-307. 2009
    ..The specific objective was to estimate the extent to which apathy changes with time over the first year after stroke and the impact of apathy on recovery...
  27. ncbi request reprint Clinical significance of complex repetitive discharges: A case-control study
    Lesley K Fellows
    Center for Cognitive Neuroscience, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Muscle Nerve 28:504-7. 2003
    ..However, the absence of CRDs can be of diagnostic value in that it reduces the likelihood of myopathy or motor neuron disease. The likelihood of finding CRDs in acute conditions is the same as that in chronic conditions...
  28. pmc Acute phenylalanine/tyrosine depletion reduces motivation to smoke cigarettes across stages of addiction
    Viswanath V Venugopalan
    Department of Neurology, McGill University, Montreal, QC, Canada
    Neuropsychopharmacology 36:2469-76. 2011
    ..In the transition from sporadic to addicted use, the role of DA in the motivation to seek drug may change less than previously proposed...
  29. doi request reprint Genetic variation in CYP2A6 predicts neural reactivity to smoking cues as measured using fMRI
    Deborah W Tang
    Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, 3801 University St, Room WB 214D, Montreal, QC, Canada H3A 2B4
    Neuroimage 60:2136-43. 2012
    ..They also provide insight into how genetics can shape human vulnerability to addiction, and have implications for tailoring smoking cessation programs based on individual genetics...
  30. ncbi request reprint The cognitive neuroscience of human decision making: a review and conceptual framework
    Lesley K Fellows
    Montreal Neurological Institute
    Behav Cogn Neurosci Rev 3:159-72. 2004
    ..This article reviews the literature on the cognitive neuroscience of human decision making, focusing on the roles of the frontal lobes, and provides a conceptual framework for organizing this disparate body of work...

Research Grants3

  1. Mapping the Anatomy of Decision Making
    Lesley Fellows; Fiscal Year: 2004
    ..This approach has the potential to provide insights into the basis for a wide range of pathological human behavior. ..
  2. Orbitofrontal and striatal mechanisms in stress and addiction
    Lesley Fellows; Fiscal Year: 2006
    ..It aims to develop a solid theoretical and experimental foundation for applying neurobiological findings to understand the real-life complexity of addictive behavior in humans. ..