Kelly E Fathers
Affiliation: McGill University
- Crk adaptor proteins act as key signaling integrators for breast tumorigenesisKelly E Fathers
Department of Biochemistry, McGill University, Rosalind and Morris Goodman Cancer Research Centre, 3655 Promenade Sir William Osler, Montreal, QC H3G 1Y6, Canada
Breast Cancer Res 14:R74. 2012..Numerous in vitro studies identified a role for Crk proteins in cell motility, but little is known about how Crk proteins contribute to breast cancer progression in vivo...
- CrkI and CrkII function as key signaling integrators for migration and invasion of cancer cellsSonia P Rodrigues
Department of Biochemistry, McGill University, Molecular Oncology Group, McGill University Health Centre, Montreal, Quebec, Canada
Mol Cancer Res 3:183-94. 2005..Together, these studies identify Crk adaptor proteins as critical integrators of upstream signals for cell invasion and migration in human cancer cell lines and support a role for Crk in metastatic spread...
- CrkII transgene induces atypical mammary gland development and tumorigenesisKelly E Fathers
Departments of Biochemistry, Rosalind and Morris Goodman Cancer Centre, McGill University, Montreal, QC H3A 1A3, Canada
Am J Pathol 176:446-60. 2010..Furthermore, this study provides evidence for a potential role of CrkII in integrating signals for breast cancer progression in vivo, which has important implications for elevated CrkII observed in human cancer...