Alan C Evans

Summary

Affiliation: McGill University
Country: Canada

Publications

  1. doi request reprint Networks of anatomical covariance
    Alan C Evans
    McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Canada
    Neuroimage 80:489-504. 2013
  2. doi request reprint Brain templates and atlases
    Alan C Evans
    McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada
    Neuroimage 62:911-22. 2012
  3. ncbi request reprint The NIH MRI study of normal brain development
    Alan C Evans
    Montreal Neurological Institute, McGill University, Department of Neurology and Neurosurgery, 3801 University St, Montreal, H3A 2B4 Canada
    Neuroimage 30:184-202. 2006
  4. pmc Unbiased average age-appropriate atlases for pediatric studies
    Vladimir Fonov
    McConnell Brain Imaging Centre, Montreal Neurological Institute, Montreal, QC, Canada
    Neuroimage 54:313-27. 2011
  5. doi request reprint Somatosensory-motor bodily representation cortical thinning in Tourette: effects of tic severity, age and gender
    Cherine Fahim
    Department of Neurology and Neurosurgery, McGill University, 3081 University Street, Montreal, Quebec, Canada
    Cortex 46:750-60. 2010
  6. ncbi request reprint Mapping anatomical correlations across cerebral cortex (MACACC) using cortical thickness from MRI
    Jason P Lerch
    McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, 3801 University Street, Montreal, QC, Canada H3A 2B4
    Neuroimage 31:993-1003. 2006
  7. pmc Negative associations between corpus callosum midsagittal area and IQ in a representative sample of healthy children and adolescents
    Hooman Ganjavi
    Department of Psychiatry, McGill University, Montreal, Quebec, Canada
    PLoS ONE 6:e19698. 2011
  8. pmc Testosterone-related cortical maturation across childhood and adolescence
    Tuong Vi Nguyen
    McConnell Brain Imaging Center, Montreal Neurological Institute, Montreal, Quebec, Canada H3A 2B4
    Cereb Cortex 23:1424-32. 2013
  9. ncbi request reprint Graph-theoretical analysis reveals disrupted small-world organization of cortical thickness correlation networks in temporal lobe epilepsy
    Boris C Bernhardt
    Department of Neurology and Neurosurgery and McConnell Brain Imaging Center, Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada H3A 2B4
    Cereb Cortex 21:2147-57. 2011
  10. pmc Musical training shapes structural brain development
    Krista L Hyde
    McConnell Brain Imaging Center, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada H3A 2B4
    J Neurosci 29:3019-25. 2009

Detail Information

Publications89

  1. doi request reprint Networks of anatomical covariance
    Alan C Evans
    McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Canada
    Neuroimage 80:489-504. 2013
    ..This review describes the basic methodological strategies, the biological basis of the observed covariance as well as applications in normal brain and brain disease before a final review of future prospects for the technique. ..
  2. doi request reprint Brain templates and atlases
    Alan C Evans
    McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada
    Neuroimage 62:911-22. 2012
    ..This review article summarizes the evolution of stereotaxic space in term of the basic principles and associated conceptual challenges, the creation of population atlases and the future trends that can be expected in atlas evolution...
  3. ncbi request reprint The NIH MRI study of normal brain development
    Alan C Evans
    Montreal Neurological Institute, McGill University, Department of Neurology and Neurosurgery, 3801 University St, Montreal, H3A 2B4 Canada
    Neuroimage 30:184-202. 2006
    ..All data described here will be available to the scientific community from July, 2006...
  4. pmc Unbiased average age-appropriate atlases for pediatric studies
    Vladimir Fonov
    McConnell Brain Imaging Centre, Montreal Neurological Institute, Montreal, QC, Canada
    Neuroimage 54:313-27. 2011
    ..The public availability of these atlases/templates will facilitate analysis of pediatric MRI data and enable comparison of results between studies in a common standardized space specific to pediatric research...
  5. doi request reprint Somatosensory-motor bodily representation cortical thinning in Tourette: effects of tic severity, age and gender
    Cherine Fahim
    Department of Neurology and Neurosurgery, McGill University, 3081 University Street, Montreal, Quebec, Canada
    Cortex 46:750-60. 2010
    ..Cortical thickness may represent a more reliable measure than volume due to the low variability in the cytoarchitectural structure of the grey matter...
  6. ncbi request reprint Mapping anatomical correlations across cerebral cortex (MACACC) using cortical thickness from MRI
    Jason P Lerch
    McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, 3801 University Street, Montreal, QC, Canada H3A 2B4
    Neuroimage 31:993-1003. 2006
    ..Lastly, IQ-dependent MACACC differences were investigated, revealing steeper correlations between BA 44 and multiple frontal and parietal regions for the higher IQ group, most significantly (t = 4.0) in the anterior cingulate...
  7. pmc Negative associations between corpus callosum midsagittal area and IQ in a representative sample of healthy children and adolescents
    Hooman Ganjavi
    Department of Psychiatry, McGill University, Montreal, Quebec, Canada
    PLoS ONE 6:e19698. 2011
    ..These findings suggest that the correlation between CC midsagittal area and IQ may be related to age and gender...
  8. pmc Testosterone-related cortical maturation across childhood and adolescence
    Tuong Vi Nguyen
    McConnell Brain Imaging Center, Montreal Neurological Institute, Montreal, Quebec, Canada H3A 2B4
    Cereb Cortex 23:1424-32. 2013
    ..These findings show the association between testosterone and CTh to be complex, highly dynamic, and to vary, depending on sex and age; they also suggest sex-related hemispheric lateralization effects of testosterone in humans...
  9. ncbi request reprint Graph-theoretical analysis reveals disrupted small-world organization of cortical thickness correlation networks in temporal lobe epilepsy
    Boris C Bernhardt
    Department of Neurology and Neurosurgery and McConnell Brain Imaging Center, Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada H3A 2B4
    Cereb Cortex 21:2147-57. 2011
    ..Increased network disruption was associated with unfavorable postoperative seizure outcome, implying adverse effects of epileptogenesis on large-scale network organization...
  10. pmc Musical training shapes structural brain development
    Krista L Hyde
    McConnell Brain Imaging Center, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada H3A 2B4
    J Neurosci 29:3019-25. 2009
    ..These findings shed light on brain plasticity and suggest that structural brain differences in adult experts (whether musicians or experts in other areas) are likely due to training-induced brain plasticity...
  11. doi request reprint Positional and surface area asymmetry of the human cerebral cortex
    Oliver C Lyttelton
    Department of Biomedical Engineering, McGill University, Montreal, Canada
    Neuroimage 46:895-903. 2009
    ..By clearly separating out the effects of structural translocation and surface area change from those of thickness and curvature, this study resolves the confound of these variables inherent in VBM studies...
  12. ncbi request reprint Twenty new digital brain phantoms for creation of validation image data bases
    Berengere Aubert-Broche
    Montreal Neurological Institute Brain Imaging Center, McGill University, Montreal, QC H3A 2B4, Canada
    IEEE Trans Med Imaging 25:1410-6. 2006
    ..The second comparison enables the study of the regional variations with no a priori class. The experiments demonstrate that these variations are small when real data are corrected for intensity nonuniformity...
  13. doi request reprint Mapping limbic network organization in temporal lobe epilepsy using morphometric correlations: insights on the relation between mesiotemporal connectivity and cortical atrophy
    Boris C Bernhardt
    Department of Neurology and Neurosurgery, McGill University, Montreal Neurological Institute and Hospital, Montreal, Quebec, Canada
    Neuroimage 42:515-24. 2008
    ..This divergence underlines the complexity of the pathophysiological mechanisms leading to neocortical atrophy in TLE...
  14. doi request reprint Callosal fiber length and interhemispheric connectivity in adults with autism: brain overgrowth and underconnectivity
    John D Lewis
    Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada
    Hum Brain Mapp 34:1685-95. 2013
    ..The results provide support for the hypothesized impact of fiber length during development...
  15. pmc Interactive effects of dehydroepiandrosterone and testosterone on cortical thickness during early brain development
    Tuong Vi Nguyen
    McConnell Brain Imaging Center, Montreal Neurological Institute, McGill University, Montreal, Quebec H3A 2B4, Canada
    J Neurosci 33:10840-8. 2013
    ....
  16. ncbi request reprint Automated cortical thickness measurements from MRI can accurately separate Alzheimer's patients from normal elderly controls
    Jason P Lerch
    McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, 3801 University Street, Montreal, Quebec, Canada
    Neurobiol Aging 29:23-30. 2008
    ..We therefore propose automated measurements of cortical thickness as a tool to improve the clinical diagnosis of probable AD, as well as a research method to gain unique insight into the etiology of cortical pathology in the disease...
  17. ncbi request reprint Focal cortical atrophy in multiple sclerosis: relation to lesion load and disability
    Arnaud Charil
    McConnell Brain Imaging Centre, Montreal Neurological Institute, 3801 University St, Montreal Quebec, Canada H3A 2B4
    Neuroimage 34:509-17. 2007
    ..The predilection of the atrophic process for areas that are heavily inter-connected with other brain regions suggests that interruption of WM tracts by MS plaques contributes, at least in part, to the development of cortical atrophy...
  18. doi request reprint Age-related alterations in the modular organization of structural cortical network by using cortical thickness from MRI
    Zhang J Chen
    Montreal Neurological Institute, McGill University, Montreal, Canada
    Neuroimage 56:235-45. 2011
    ..Our results indicate that aging is associated with an altered modular organization in the structural brain networks and provide new evidence for disrupted integrity in the large-scale brain networks that underlie cognition...
  19. pmc Right anterior cingulate cortical thickness and bilateral striatal volume correlate with child behavior checklist aggressive behavior scores in healthy children
    Simon Ducharme
    McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, 3801 University Street, Montreal, Quebec, Canada
    Biol Psychiatry 70:283-90. 2011
    ..The anterior cingulate cortex (ACC), orbitofrontal cortex (OFC), and basal ganglia have been implicated in pathological aggression. This study aimed at identifying neuroanatomical correlates of impulsive aggression in healthy children...
  20. pmc Developmental changes in organization of structural brain networks
    Budhachandra S Khundrakpam
    McConnell Brain Imaging Center, Montreal Neurological Institute, McGill University, Montreal, QC H3A 2B4, Canada
    Cereb Cortex 23:2072-85. 2013
    ..Our finding reveals a time window of plasticity occurring during late childhood which may accommodate crucial changes during puberty and the new developmental tasks that an adolescent faces. ..
  21. pmc Decreased regional cortical thickness and thinning rate are associated with inattention symptoms in healthy children
    Simon Ducharme
    McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Canada
    J Am Acad Child Adolesc Psychiatry 51:18-27.e2. 2012
    ..However, the relationship between cortical maturation and attention capacities in typically developing children is unknown. This study examines cortical thickness correlates of inattention symptoms in a large sample of healthy children...
  22. pmc Revealing modular architecture of human brain structural networks by using cortical thickness from MRI
    Zhang J Chen
    McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, QC, Canada H3A 2B4
    Cereb Cortex 18:2374-81. 2008
    ..This study provides the first report of modular architecture of the structural network in the human brain using cortical thickness measurements...
  23. doi request reprint Longitudinal neuroanatomical changes determined by deformation-based morphometry in a mouse model of Alzheimer's disease
    Jonathan C Lau
    McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, 3801 University Street, Montreal, QC H3A2B4, Canada
    Neuroimage 42:19-27. 2008
    ..These results support the utility of DBM to study longitudinal morphological changes in mouse models of central nervous system diseases in an automated and exploratory fashion...
  24. doi request reprint Multi-level bootstrap analysis of stable clusters in resting-state fMRI
    Pierre Bellec
    McConnell Brain Imaging Center, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada
    Neuroimage 51:1126-39. 2010
    ..g. the specific involvement of subcortical regions in the visual and fronto-parietal networks for some subjects...
  25. pmc Age- and gender-related differences in the cortical anatomical network
    Gaolang Gong
    McConnell Brain Imaging Centre, Montreal Neurological Institute, Montreal, Quebec H3A 2B4, Canada
    J Neurosci 29:15684-93. 2009
    ..There were also distributed regional differences in efficiency between sexes. Our results provide new insights into the substrates that underlie behavioral and cognitive differences in aging and sex...
  26. doi request reprint Sports concussions and aging: a neuroimaging investigation
    Sebastien Tremblay
    Centre de Recherche en Neuropsychologie et Cognition, University of Montreal, Montreal, Canada
    Cereb Cortex 23:1159-66. 2013
    ..Findings from this study highlight patterns of decline often associated with abnormal aging...
  27. ncbi request reprint Automated analysis of multi site MRI phantom data for the NIHPD project
    Luke Fu
    McConnell Brain Imaging Center, Montreal Neurological Institute, Quebec, Canada
    Med Image Comput Comput Assist Interv 9:144-51. 2006
    ..4 mm per year was observed for the diameter while a drift of 0.5 mm per year was observed for the height. Trends observed over time often depended not only on site, but also on modality and scanner manufacturer...
  28. ncbi request reprint Cortical specialization for processing first- and second-order motion
    Serge O Dumoulin
    McGill Vision Research Unit, Department of Ophthalmology, 687 Pine Avenue West, H4 14, Montreal, Quebec, Canada H3A 1A1
    Cereb Cortex 13:1375-85. 2003
    ....
  29. doi request reprint Neuroanatomical differences in brain areas implicated in perceptual and other core features of autism revealed by cortical thickness analysis and voxel-based morphometry
    Krista L Hyde
    McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, Quebec, H3A 2B4, Canada
    Hum Brain Mapp 31:556-66. 2010
    ..We interpret these results as the first structural brain correlates of atypical auditory and visual perception in autism, in support of the enhanced perceptual functioning model [Mottron et al. (2006): J Autism Dev Disord 36:27-43]...
  30. ncbi request reprint Cortical thickness analysis examined through power analysis and a population simulation
    Jason P Lerch
    McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, QC, H3A 2B4, Canada
    Neuroimage 24:163-73. 2005
    ..Smoothing across the 2-D surface manifold also improves precision; in this experiment, the optimal kernel size was 30 mm...
  31. doi request reprint 3-D brain MRI tissue classification on FPGAs
    Jahyun J Koo
    Department of Electrical and ComputerEngineering, McGill University, Montreal, QC H3A2A7, Canada
    IEEE Trans Image Process 18:2735-46. 2009
    ..5 x and 9.4 x , respectively. The overall performance improvement of the FPGA-based PVE algorithm was 5.1 x with four FPGAs...
  32. doi request reprint Robust S1, S2, and thalamic activations in individual subjects with vibrotactile stimulation at 1.5 and 3.0 T
    M Mallar Chakravarty
    McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Canada
    Hum Brain Mapp 30:1328-37. 2009
    ..5 and 3.0 T, and that robust thalamic activations in individual subjects are possible at 3.0 T. These techniques demonstrate that this technique can be used for preoperative planning for surgical candidates...
  33. pmc Bootstrap generation and evaluation of an fMRI simulation database
    Pierre Bellec
    McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, Canada H3A2B4
    Magn Reson Imaging 27:1382-96. 2009
    ..These experiments demonstrated that the bootstrap framework is a powerful new tool that can pinpoint the respective strengths and limitations of simulation models...
  34. doi request reprint Impact of scale space search on age- and gender-related changes in MRI-based cortical morphometry
    Lu Zhao
    McConnell Brain Imaging Center, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada
    Hum Brain Mapp 34:2113-28. 2013
    ....
  35. pmc Cortical thickness correlates of specific cognitive performance accounted for by the general factor of intelligence in healthy children aged 6 to 18
    Sherif Karama
    McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, QC, Canada
    Neuroimage 55:1443-53. 2011
    ..Within a psychometric framework, cortical thickness correlates of cognitive performance on complex tasks are well captured by g in this demographically representative sample...
  36. ncbi request reprint Tuning and comparing spatial normalization methods
    Steven Robbins
    McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, 3801 University Street, Montreal, Que, H3A 2B4, Canada
    Med Image Anal 8:311-23. 2004
    ..We demonstrate the method through a performance analysis of a nonaffine registration algorithm for 3D images and a registration algorithm for 2D cortical surfaces...
  37. doi request reprint Brain connectivity: gender makes a difference
    Gaolang Gong
    McConnell Brain Imaging Center, Montreal Neurological Institute, Montreal, QC, Canada
    Neuroscientist 17:575-91. 2011
    ....
  38. doi request reprint Genetic and environmental influences on structural variability of the brain in pediatric twin: deformation based morphometry
    Uicheul Yoon
    McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, Quebec H3A 2B4, Canada
    Neurosci Lett 493:8-13. 2011
    ..Several brain structures showed significant genetic effects and might therefore serve as biological markers for inherited traits, or as targets for genetic linkage and association studies...
  39. doi request reprint Thinning of the motor-cingulate-insular cortices in siblings concordant for Tourette syndrome
    Cherine Fahim
    Department of Neurology and Neurosurgery, McGill University, Montreal, Canada
    Brain Topogr 22:176-84. 2009
    ..Such delayed maturation may consequently contribute to the development of TS by releasing motor and vocal tics from regulatory control. These findings may have important genetic implications...
  40. ncbi request reprint Realistic simulated MRI and SPECT databases. Application to SPECT/MRI registration evaluation
    Berengere Aubert-Broche
    Montreal Neurological Institute, McGill University, Montreal, Canada
    Med Image Comput Comput Assist Interv 9:330-7. 2006
    ..MR intensity nonuniformity was the main factor decreasing registration accuracy. The proposed simulated database is promising to evaluate many functional neuroimaging methods, involving MRI and SPECT data...
  41. ncbi request reprint Automated 3-D extraction and evaluation of the inner and outer cortical surfaces using a Laplacian map and partial volume effect classification
    June Sic Kim
    McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada H3A 2B4
    Neuroimage 27:210-21. 2005
    ..6 +/- 1.4 mm for conventional ASP and 0.5 +/- 0.4 mm for CLASP. In a repeatability study, CLASP produced a 30% lower RMS error for the GM surface and a 8% lower RMS error for the WM surface compared with ASP...
  42. pmc T(2) relaxometry of normal pediatric brain development
    Ilana R Leppert
    Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada
    J Magn Reson Imaging 29:258-67. 2009
    ..To establish normal age-related changes in the magnetic resonance (MR) T(2) relaxation time constants of brain using data collected as part of the National Institutes of Health (NIH) MRI Study of Normal Brain Development...
  43. pmc β-Amyloid is associated with aberrant metabolic connectivity in subjects with mild cognitive impairment
    Felix Carbonell
    Biospective Inc, 6100 Avenue Royalmount, Montreal, Quebec, Canada
    J Cereb Blood Flow Metab 34:1169-79. 2014
    ..We found that the APOE ɛ4 genotype was closely related to regional glucose hypometabolism, while elevated, fibrillar β-amyloid burden was associated with specific derangements of the metabolic correlation patterns. ..
  44. doi request reprint Individual differences in frontal cortical thickness correlate with the d-amphetamine-induced striatal dopamine response in humans
    Kevin F Casey
    Department of Neurology and Neurosurgery, Department of Psychiatry, and Department of Psychology, McGill University, Montreal, Quebec H3A 0G4, Canada, Department of Psychiatry, University of Alberta, Edmonton, Alberta T6G 2R7, Canada, and Center for Studies in Behavioral Neurobiology, Concordia University, Montreal, Quebec H4B 1R6, Canada
    J Neurosci 33:15285-94. 2013
    ..Although prefrontal regulation of striatal function has been well studied, it was unclear whether the thickness of the prefrontal cortex was an acceptable proxy to the function of that region. These results suggest it is. ..
  45. ncbi request reprint Structural networks in Alzheimer's disease
    Andrew T Reid
    McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada
    Eur Neuropsychopharmacol 23:63-77. 2013
    ..Finally, we discuss how these methodologies have been applied to systems-level analyses of AD, to help characterize the network changes underlying the disease process, and how these patterns relate to specific cognitive outcome measures...
  46. doi request reprint The effects of musical training on structural brain development: a longitudinal study
    Krista L Hyde
    Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada
    Ann N Y Acad Sci 1169:182-6. 2009
    ..These findings shed light on brain plasticity, and suggest that structural brain differences in adult experts (whether musicians or experts in other areas) are likely due to training-induced brain plasticity...
  47. ncbi request reprint Thalamo-cortical network pathology in idiopathic generalized epilepsy: insights from MRI-based morphometric correlation analysis
    Boris C Bernhardt
    Department of Neurology, Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada
    Neuroimage 46:373-81. 2009
    ..Fronto-centro-parietal atrophy in IGE is likely the effect of generalized seizure activity inducing thalamo-cortical network remodeling. On the other hand, limbic abnormalities may take place secondary to thalamic disconnection...
  48. doi request reprint Neuroanatomical correlates of musicianship as revealed by cortical thickness and voxel-based morphometry
    Patrick Bermudez
    Montreal Neurological Institute, McGill University, 3801 University Street, Montreal, Quebec, Canada
    Cereb Cortex 19:1583-96. 2009
    ....
  49. ncbi request reprint A new improved version of the realistic digital brain phantom
    Berengere Aubert-Broche
    McConnell Brain Imaging Center, Montreal Neurological Institute, McGill University, 3801 University Street, Montreal, Quebec, Canada, H3A 2B4
    Neuroimage 32:138-45. 2006
    ..MRI simulations are shown to illustrate the difference between the previous and the new improved digital brain phantom II. Example PET and SPECT simulations are also presented...
  50. pmc Comparing functional connectivity via thresholding correlations and singular value decomposition
    Keith J Worsley
    Department of Mathematics and Statistics, McGill University, Montreal, Canada
    Philos Trans R Soc Lond B Biol Sci 360:913-20. 2005
    ..We apply these results to resting state networks in an fMRI dataset to look for connectivity in cortical thickness...
  51. ncbi request reprint Brain imaging in drug R&D
    Alex P Zijdenbos
    Neuralyse Inc, LaSalle, Canada
    Biomarkers 10:S58-68. 2005
    ..The potential use of these technologies is illustrated by examples of their applications in multiple sclerosis, Alzheimer's disease, and oncology...
  52. doi request reprint Cortical thickness measured from MRI in the YAC128 mouse model of Huntington's disease
    Jason P Lerch
    The Mouse Imaging Centre, The Hospital for Sick Children, Toronto, Ontario, Canada
    Neuroimage 41:243-51. 2008
    ....
  53. ncbi request reprint Automatic "pipeline" analysis of 3-D MRI data for clinical trials: application to multiple sclerosis
    Alex P Zijdenbos
    McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, 3801 University Street, WB 208, Montreal, QC H3A 2B4, Canada
    IEEE Trans Med Imaging 21:1280-91. 2002
    ..While useful for clinical trial analysis in multiple sclerosis, this system holds widespread potential for applications in other neurological disorders, as well as for the study of neurobiology in general...
  54. ncbi request reprint Automatic volumetric segmentation of human visual retinotopic cortex
    Serge O Dumoulin
    Department of Ophthalmology, McGill University, Montreal, Quebec, Canada
    Neuroimage 18:576-87. 2003
    ..A validation of the method is provided by simulations and comparison to cortical surface-based methodology...
  55. ncbi request reprint Focal decline of cortical thickness in Alzheimer's disease identified by computational neuroanatomy
    Jason P Lerch
    McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada
    Cereb Cortex 15:995-1001. 2005
    ..Using cortical thickness, moreover, we provide a direct quantitative index of atrophy in the disease...
  56. pmc Lateralized genetic and environmental influences on human brain morphology of 8-year-old twins
    Uicheul Yoon
    McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada H3A 2B4
    Neuroimage 53:1117-25. 2010
    ..Our findings indicate that the genetic and common environmental influences on individual human brain structural differences are lateralized, with the language-dominant left cerebral cortex under stronger genetic control than the right...
  57. doi request reprint Convergence and divergence of thickness correlations with diffusion connections across the human cerebral cortex
    Gaolang Gong
    State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China
    Neuroimage 59:1239-48. 2012
    ..These findings indicate that thickness correlations partly reflect underlying fiber connections but they contains exclusive information, and therefore should not be simply taken as a proxy measure for fiber connections...
  58. ncbi request reprint Small-world anatomical networks in the human brain revealed by cortical thickness from MRI
    Yong He
    McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, 3801 University Street, Montreal, QC, Canada
    Cereb Cortex 17:2407-19. 2007
    ..To our knowledge, this study provides the first report of small-world properties and degree distribution of anatomical networks in the human brain using cortical thickness measurements...
  59. ncbi request reprint A fully automatic and robust brain MRI tissue classification method
    Chris A Cocosco
    McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, 3801 University Street, Montreal, Quebec, H3A 2B4, Canada
    Med Image Anal 7:513-27. 2003
    ..A significant improvement in output quality was observed on subjects who exhibit morphological deviations from the model due to aging and pathology...
  60. doi request reprint Abnormal motor cortex excitability is associated with reduced cortical thickness in X monosomy
    Jean François Lepage
    Departement de Psychologie, Universite de Montreal, Montreal, Quebec, Canada
    Hum Brain Mapp 34:936-44. 2013
    ..These findings demonstrate the presence of converging anatomical and neurophysiological abnormalities of the motor system in X monosomy...
  61. ncbi request reprint Volumetry of temporopolar, perirhinal, entorhinal and parahippocampal cortex from high-resolution MR images: considering the variability of the collateral sulcus
    Jens C Pruessner
    McConnell Brain Imaging Center, Montreal Neurological Institute, Douglas Hospital Research Center, McGill University, Montreal, Quebec, Canada
    Cereb Cortex 12:1342-53. 2002
    ..Intra- and interrater coefficients are presented, together with mean values for the volumes of all PHG structures, correlations with age and sex, and tests for hemispheric differences...
  62. pmc LORIS: a web-based data management system for multi-center studies
    Samir Das
    Montreal Neurological Institute, McGill University Montreal, Canada
    Front Neuroinform 5:37. 2011
    ..LORIS is a complete solution that has been thoroughly tested through a full 10 year life cycle of a multi-center longitudinal project and is now supporting numerous international neurodevelopment and neurodegeneration research projects...
  63. doi request reprint Patterns of cortical thickness and surface area in early Parkinson's disease
    Thomas Jubault
    Unité de Neuroimagerie Fonctionelle, Institut Universitaire de Geriatrie de Montreal, Montreal, QC, Canada
    Neuroimage 55:462-7. 2011
    ..In the future, MRI-generated corticometry, combined with additional behavioral markers, may prove to be a useful diagnosis tool to characterize the evolution of motor and cognitive deficits in PD...
  64. doi request reprint The effect of template choice on morphometric analysis of pediatric brain data
    Uicheul Yoon
    McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada
    Neuroimage 45:769-77. 2009
    ..The results show that it is necessary to be cautious when interpreting results from pediatric imaging studies based on adult reference data...
  65. ncbi request reprint Statistical mapping analysis of lesion location and neurological disability in multiple sclerosis: application to 452 patient data sets
    Arnaud Charil
    McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, Canada
    Neuroimage 19:532-44. 2003
    ..This study demonstrates for the first time a relationship between the site of lesions and the type of disability in large scale MRI data set in MS...
  66. ncbi request reprint Cortical thickness in congenital amusia: when less is better than more
    Krista L Hyde
    Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada H3A 2B4
    J Neurosci 27:13028-32. 2007
    ..These cortical thickness differences suggest the presence of cortical malformations in the amusic brain, such as abnormal neuronal migration, that may have compromised the normal development of a right frontotemporal pathway...
  67. pmc FDG-PET imaging for the evaluation of antiglioma agents in a rat model
    Sarah Assadian
    McConnell Brain Imaging Centre, Montreal Neurological Institute, 3801 University St, Montreal, QC, Canada H3A 2B4
    Neuro Oncol 10:292-9. 2008
    ..As such, we successfully demonstrated the ability of FDG-PET to rapidly determine the TE of novel agents for the treatment of glioma in the preclinical phase of evaluation...
  68. ncbi request reprint Positron emission tomography partial volume correction: estimation and algorithms
    John A D Aston
    McConnell Brain Imaging Center, Montreal Neurological Institute, McGill University, Quebec, Canada
    J Cereb Blood Flow Metab 22:1019-34. 2002
    ..The suitability of their application to dynamic and static images is discussed...
  69. ncbi request reprint Focal white matter density changes in schizophrenia: reduced inter-hemispheric connectivity
    Hilleke E Hulshoff Pol
    Neuroscience Division, A01 126, University Medical Center Utrecht, 3584 CX, Utrecht, The Netherlands
    Neuroimage 21:27-35. 2004
    ..These findings suggest aberrant inter-hemispheric connectivity of anterior cortical and sub-cortical brain regions in schizophrenia, reflecting decreased hemispheric specialisation in schizophrenia...
  70. ncbi request reprint Genes, maternal smoking, and the offspring brain and body during adolescence: design of the Saguenay Youth Study
    Zdenka Pausova
    Brain and Body Centre, University of Nottingham, Nottingham, United Kingdom
    Hum Brain Mapp 28:502-18. 2007
    ....
  71. ncbi request reprint Deformation-based surface morphometry applied to gray matter deformation
    Moo K Chung
    Department of Statistics, University of Wisconsin, 1210 West Dayton Street, Madison, WI 53706 1685, USA
    Neuroimage 18:198-213. 2003
    ....
  72. ncbi request reprint Cortical thickness analysis in autism with heat kernel smoothing
    Moo K Chung
    Department of Statistics, University of Wisconsin, 1210 West Dayton Street, Madison, WI 53706, USA
    Neuroimage 25:1256-65. 2005
    ..As an illustration, we apply our methods in detecting the regions of abnormal cortical thickness in 16 high functioning autistic children via random field based multiple comparison correction that utilizes the new smoothing technique...
  73. ncbi request reprint Brain size and cortical structure in the adult human brain
    Kiho Im
    Department of Biomedical Engineering, Hanyang University, Seoul, 133 605 South Korea
    Cereb Cortex 18:2181-91. 2008
    ....
  74. ncbi request reprint Unified statistical approach to cortical thickness analysis
    Moo K Chung
    Department of Statistics, University of Wisconsin Madison, USA
    Inf Process Med Imaging 19:627-38. 2005
    ..As an illustration, we have applied the method in detecting the regions of abnormal cortical thickness in 16 high functioning autistic children...
  75. ncbi request reprint Weighted fourier series representation and its application to quantifying the amount of gray matter
    Moo K Chung
    Department of Statistics, Biostatistics, and Medical Informatics, and the Waisman Laboratory for Brain Imaging and Behavior, University of Wisconsin, Madison, WI 53706, USA
    IEEE Trans Med Imaging 26:566-81. 2007
    ..html. As an illustration, the WFS is applied i n quantifying the amount ofgray matter in a group of high functioning autistic subjects. Within the WFS framework, cortical thickness and gray matter density are computed and compared...
  76. ncbi request reprint Assignment of functional activations to probabilistic cytoarchitectonic areas revisited
    Simon B Eickhoff
    Institut fur Medizin, Forschungszentrum Julich GmbH, D 52425 Julich, Germany
    Neuroimage 36:511-21. 2007
    ..Finally, the advantages and disadvantages of the various methods are discussed, focussing on the question of which approach is most appropriate for a particular situation...
  77. ncbi request reprint Creation and application of a simulated database of dynamic [18f]MPPF PET acquisitions incorporating inter-individual anatomical and biological variability
    Anthonin Reilhac
    CERMEP, F 69667 Bron, France
    IEEE Trans Med Imaging 25:1431-9. 2006
    ..This latter feature is of a great interest in the context of the improvement of the detectability of biological variation in PET...
  78. ncbi request reprint Spatial patterns of cortical thinning in mild cognitive impairment and Alzheimer's disease
    Vivek Singh
    Sunnybrook and Women s College Health Sciences Centre Ontario, Canada
    Brain 129:2885-93. 2006
    ..These novel findings support the notion of increased isocortical involvement with the progression of disease...
  79. ncbi request reprint A novel quantitative cross-validation of different cortical surface reconstruction algorithms using MRI phantom
    Jun Ki Lee
    Department of Biomedical Engineering, Hanyang University, 17 Haengdang dong Sungdong gu P O Box 55, Seoul 133 791, Republic of Korea
    Neuroimage 31:572-84. 2006
    ..In the validation of local density of points, Freesurfer and BrainVISA showed more even distribution of points on the cortical surface compared to CLASP...
  80. pmc Sexual dimorphism of brain developmental trajectories during childhood and adolescence
    Rhoshel K Lenroot
    Child Psychiatry Branch of the National Institute of Mental Health, NIMH CHP 10 Center Drive, Bethesda, MD 20814 9692, USA
    Neuroimage 36:1065-73. 2007
    ..These sexually dimorphic trajectories confirm the importance of longitudinal data in studies of brain development and underline the need to consider sex matching in studies of brain development...
  81. ncbi request reprint A novel quantitative validation of the cortical surface reconstruction algorithm using MRI phantom: issues on local geometric accuracy and cortical thickness
    Junki Lee
    Dept Biomedical Engineering, Hanyang University, 17 Haengdang Dong Sungdong Gu, Seoul, 133 791, Korea
    Med Image Comput Comput Assist Interv 9:183-90. 2006
    ..This study could present a generic metric for the quantitative evaluation of cortical surface reconstruction algorithm...
  82. doi request reprint Cerebral white matter in early puberty is associated with luteinizing hormone concentrations
    Jiska S Peper
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands
    Psychoneuroendocrinology 33:909-15. 2008
    ..In addition, genes involved in LH production may be promising candidate genes in neuropsychiatric illnesses with an onset in early adolescence...
  83. ncbi request reprint Regional frontal cortical volumes decrease differentially in aging: an MRI study to compare volumetric approaches and voxel-based morphometry
    Danielle J Tisserand
    Brain and Behaviour Institute, Maastricht University, 6229 GP Maastricht, The Netherlands
    Neuroimage 17:657-69. 2002
    ..Overall, it was concluded that although semiautomated and voxel-based methods can provide a reasonable estimate of regional brain volume, they cannot serve as a substitute for manual volumetry...
  84. pmc Offering to share: how to put heads together in autism neuroimaging
    Matthew K Belmonte
    Department of Human Development, Cornell University, Martha Van Rensselaer Hall, Ithaca, NY 14853 4401, USA
    J Autism Dev Disord 38:2-13. 2008
    ..A theme in these requirements is the need to preserve creative approaches and risk-taking within individual laboratories at the same time as common standards are provided for these laboratories to build on...
  85. ncbi request reprint Focal gray matter changes in schizophrenia across the course of the illness: a 5-year follow-up study
    Neeltje E M van Haren
    Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    Neuropsychopharmacology 32:2057-66. 2007
    ..Moreover, the progression in left frontal density loss appears to be related to an increased number of psychotic episodes, with atypical antipsychotic medication attenuating these changes...
  86. ncbi request reprint XXY (Klinefelter syndrome): a pediatric quantitative brain magnetic resonance imaging case-control study
    Jay N Giedd
    Child Psychiatry Branch NIMH, National Institutes of Health, Building 10, Room 4C110, 10 Center Dr, MSC 1367, Bethesda, MD 20892, USA
    Pediatrics 119:e232-40. 2007
    ..The objective of this study was to examine possible neuroanatomical substrates of these cognitive and behavioral features during childhood and adolescence...
  87. ncbi request reprint Focal brain matter differences associated with lifetime alcohol intake and visual attention in male but not in female non-alcohol-dependent drinkers
    Eveline A de Bruin
    Department of Psychopharmacology, Utrecht Institute of Pharmaceutical Sciences, Utrecht University, The Netherlands
    Neuroimage 26:536-45. 2005
    ..As the confounding effects of genetic factors were reduced, the present results may selectively relate to the effects of alcohol intake on focal brain matter...
  88. ncbi request reprint A voxel-based morphometric study to determine individual differences in gray matter density associated with age and cognitive change over time
    Danielle J Tisserand
    Rotman Research Institute, Baycrest Centre for Geriatric Care, Toronto, ON M6A 2E1, Canada
    Cereb Cortex 14:966-73. 2004
    ..These findings suggest that prefrontal and temporal cortical regions are of particular relevance both in aging and age-related cognitive decline in healthy elderly individuals...
  89. ncbi request reprint Correlation of cerebrospinal fluid levels of tau protein phosphorylated at threonine 231 with rates of hippocampal atrophy in Alzheimer disease
    Harald Hampel
    Alzheimer Memorial Center and Geriatric Psychiatry Branch, Dementia and Neuroimaging Section, Department of Psychiatry, Ludwig Maximilian University, Munich, Germany
    Arch Neurol 62:770-3. 2005
    ..We hypothesized that these variations partially reflect differences in the degree of neuronal damage and therefore may be used to predict structural disease progression...