Research Topics
| Pierre ErnstSummaryAffiliation: McGill University Country: Canada Publications
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Publications
Pramipexole use and the risk of pneumoniaPierre Ernst
Center for Clinical Epidemiology, Lady Davis Research Institute Jewish General Hospital, 3755 Cote Ste Catherine, Montreal, QC, H3T 1E2, Canada
BMC Neurol 12:113. 2012..It is uncertain whether pramipexole or other dopamine agonists increase the risk of pneumonia...
Systemic effects of inhaled corticosteroidsPierre Ernst
Centre for Clinical Epidemiology, Lady Davis Research Institute, Jewish General Hospital, 3755 Cote Ste Catherine, Montreal, Quebec, Canada
Curr Opin Pulm Med 18:85-9. 2012..We review the articles appearing in the last year which have addressed the safety of ICSs when used in the treatment of asthma and chronic obstructive pulmonary disease (COPD)...- Risk of herpes zoster in patients prescribed inhaled corticosteroids: a cohort studyPierre Ernst
Center for Clinical Epidemiology, Lady Davis Research Institute, Jewish General Hospital, Montreal, Canada
BMC Pulm Med 11:59. 2011..We hypothesised that inhaled corticosteroids (ICS) are a risk factor for herpes zoster especially among users of inhibitors of cytochrome P450 enzymes involved in their metabolism... 
Inhaled corticosteroid use in chronic obstructive pulmonary disease and the risk of hospitalization for pneumoniaPierre Ernst
Pharmacoepidemiology Research Unit, Department of Medicine, McGill University Health Centre, and Division of Clinical Epidemiology, Ross 4 29, Royal Victoria Hospital, 687 Pine Avenue West, Montreal, PQ, Quebec, H3A 1A1 Canada
Am J Respir Crit Care Med 176:162-6. 2007..Inhaled corticosteroids are commonly prescribed to patients with chronic obstructive pulmonary disease (COPD)...- Predictors of a more favourable response to combined therapy with salmeterol and fluticasone as initial maintenance therapy in asthmaPierre Ernst
Division of Clinical Epidemiology, McGill University Health Center, Royal Victoria Hospital R4 29, 687 Pine Avenue West, Montreal, Quebec, Canada
Respir Med 102:77-81. 2008..We wished to identify clinical characteristics of patients which would enable one to identify a sub-group of patients who would benefit most from initiating sustained controller therapy with combination therapy... - Effectiveness of combination therapies in asthma: an observational studySamy Suissa
McGill Pharmacoepidemiology Research Unit, McGill University Health Centre, Montreal, Canada
Pulm Pharmacol Ther 22:194-8. 2009..We compared the effectiveness in a real world setting of two such combinations available in a single inhaler... - Underreporting exacerbation of chronic obstructive pulmonary disease in a longitudinal cohortLisa Langsetmo
Respiratory Epidemiology and Clinical Research Unit, Montreal Chest Institute, 3650 St Urbain, Montreal, PQ, Canada
Am J Respir Crit Care Med 177:396-401. 2008..Unreported exacerbations and failure to seek medical attention may have consequences on the health of patients with chronic obstructive pulmonary disease... - Inhaled corticosteroids and the risks of diabetes onset and progressionSamy Suissa
Lady Davis Research Institute, Jewish General Hospital, Montreal, Quebec, Canada
Am J Med 123:1001-6. 2010..We assessed whether the use and dose of inhaled corticosteroids increase the risk of diabetes onset and progression... - Risk of glaucoma in elderly patients treated with inhaled corticosteroids for chronic airflow obstructionAnne V Gonzalez
Respiratory Epidemiology and Clinical Research Unit, Montreal Chest Institute, McGill University Health Centre, Canada
Pulm Pharmacol Ther 23:65-70. 2010..We sought to determine the risk of new onset ocular hypertension or glaucoma requiring treatment, associated with the use of ICS in elderly patients treated for airways disease... - Inhaled corticosteroids and risk of tuberculosis in patients with respiratory diseasesPaul Brassard
Center for Clinical Epidemiology, Lady Davis Research Institute, Department of Medicine, Jewish General Hospital, Montreal, Quebec, Canada
Am J Respir Crit Care Med 183:675-8. 2011..Treatment with substantial doses of oral corticosteroids (OCS) for prolonged periods increases the risk of tuberculosis (TB). However, little is known about the effect of inhaled corticosteroids (ICS) in this respect... - Oral corticosteroid use and the risk of acute myocardial infarction in chronic obstructive pulmonary diseaseLaetitia Huiart
Division of Clinical Epidemiology, Royal Victoria Hospital and Department of Epidemiology and Biostatistics, McGill University, , , Canada
Can Respir J 13:134-8. 2006..CONCLUSIONS: An association was found between the current use of oral corticosteroids and the occurrence of an AMI, suggesting that acute exacerbations of COPD are associated with an increased risk of acute coronary syndromes... - T Cells localize with proliferating smooth muscle alpha-actin+ cell compartments in asthmaDavid Ramos-Barbon
Meakins Christie Laboratories, McGill University, Montreal, PQ, Canada
Am J Respir Crit Care Med 182:317-24. 2010..Experimental studies showed that T cells adhere to ASM through vascular cell adhesion molecule-1 (VCAM-1) and drive ASM growth through direct contact between the T cells and smooth muscle alpha-actin (alpha-SMA)(+) cells... - Bronchodilator use and the risk of arrhythmia in COPD: part 2: reassessment in the larger Quebec cohortMachelle Wilchesky
Donald Berman Maimonides Geriatric Centre, McGill University, Montreal, QC, Canada
Chest 142:305-11. 2012..A previous study suggested a potential increased risk of cardiac arrhythmia with new use of long-acting β-agonists and ipratropium bromide in patients with COPD, although conclusions were limited by the small cohort size... - Psychologic distress and maladaptive coping styles in patients with severe vs moderate asthmaKim L Lavoie
Hopital du Sacre Coeur de Montreal, Research Center, Department of Chest Medicine, J 3190, 5400 Gouin West, Montreal, QC, Canada H4J 1C5
Chest 137:1324-31. 2010..This study assessed levels of psychologic distress and a range of disease-relevant emotional and behavioral coping styles in patients with severe vs moderate asthma... - TNF-alpha antagonists and the prevention of hospitalisation for chronic obstructive pulmonary diseaseSamy Suissa
Division of Clinical Epidemiology, McGill University Health Centre, Canada
Pulm Pharmacol Ther 21:234-8. 2008..TNF-alpha may be important in the pathogenesis of COPD. Consequently, the use of TNF-alpha antagonists has been advocated for its treatment... - A population-based evaluation of a regional asthma education centreSimone Cowan
Department of Epidemiology and Biostatistics, and Division of Respiratory Medicine, McGill University Health Centre, Montreal, Quebec
Can Respir J 11:39-44. 2004..53 in the nonintervention community--an increase of 13%. CONCLUSIONS: A conclusive association between the establishment of an asthma education centre and changes in health care use or the quality of prescribing could not be demonstrated... - Inhaled corticosteroid use in asthma and the prevention of myocardial infarctionSamy Suissa
Division of Clinical Epidemiology, Royal Victoria Hospital, and Epidemiology and Biostatistics and Medicine, McGill University, Montreal, Quebec, Canada
Am J Med 115:377-81. 2003..We investigated whether inhaled corticosteroids, which are known to improve asthma control and reduce exacerbations, are associated with a lower rate of myocardial infarction... - Cardiovascular morbidity and mortality in COPDLaetitia Huiart
Division of Clinical Epidemiology, Royal Victoria Hospital and Department of Epidemiology and Biostatistics, McGill University, 687 Pine Ave West, Ross 4.29, Montreal, QC, Canada, H3A 1A1
Chest 128:2640-6. 2005..5 per 1,000 PY). CONCLUSION: CVD is more frequent in COPD patients than in the general population and may represent a burden greater than that of lung disease itself... - Inhaled and nasal corticosteroid use and the risk of fractureSamy Suissa
Division of Clinical Epidemiology, Royal Victoria Hospital, McGill University Health Centre, Montreal, Quebec, Canada
Am J Respir Crit Care Med 169:83-8. 2004..In conclusion, the long-term use of inhaled and nasal corticosteroids at the usual recommended doses is not associated with a risk of fracture in older patients with respiratory disease... - Long-term natural history of chronic obstructive pulmonary disease: severe exacerbations and mortalitySamy Suissa
Center for Clinical Epidemiology, Lady Davis Institute, Jewish General Hospital, Montreal, Canada
Thorax 67:957-63. 2012..The long-term natural history of chronic obstructive pulmonary disease (COPD) in terms of successive severe exacerbations and mortality is unknown... - Differences in airway cytokine profile in severe asthma compared to moderate asthmaJoanne Shannon
Montreal Chest Institute, Respiratory Division of McGill University Health Centre, Montreal, QC, Canada
Chest 133:420-6. 2008.... - Airway remodeling in subjects with severe asthma with or without chronic persistent airflow obstructionMarta Kaminska
Meakins Christie Laboratories, Montreal, Quebec H2X 2P2, Canada
J Allergy Clin Immunol 124:45-51.e1-4. 2009..The patterns of airway remodeling and the biomarkers that distinguish different subtypes of severe asthma are unknown... - Increased expression of ADAM33 and ADAM8 with disease progression in asthmaSusan C Foley
Meakins Christie Laboratories, McGill University, Montreal Chest Institute, Montreal, Quebec, Canada
J Allergy Clin Immunol 119:863-71. 2007..ADAM8 is strongly induced by allergens and T(H)2 cytokines in the lung in experimental asthma... - Prevalence of obstructive sleep apnea-hypopnea in severe versus moderate asthmaJoanne Y Julien
Meakins Christie Laboratories, McGill University, Montreal, Quebec, Canada
J Allergy Clin Immunol 124:371-6. 2009..Previous studies have suggested a link between obstructive sleep apnea and poor asthma control, which may be mediated through airway inflammation, obesity, and other mechanisms... - Bronchodilator use and the risk of arrhythmia in COPD: part 1: Saskatchewan cohort studyMachelle Wilchesky
Donald Berman Maimonides Geriatric Centre, McGill University, Montreal, Canada
Chest 142:298-304. 2012..Bronchodilators are first-line therapy for COPD. There is some evidence that they may increase the risk of cardiac arrhythmias... - Effect of a web-based chronic disease management system on asthma control and health-related quality of life: study protocol for a randomized controlled trialSara Ahmed
School of Physical and Occupational Therapy, McGill University, 3654 Prom Sir William Osler, Montreal, QC, Canada
Trials 12:260. 2011.... - Leflunomide use and the risk of interstitial lung disease in rheumatoid arthritisSamy Suissa
McGill University Health Centre, Montreal, Quebec, Canada
Arthritis Rheum 54:1435-9. 2006..To assess this risk, we conducted a population-based epidemiologic study... - Implementing practice guidelines: a workshop on guidelines dissemination and implementation with a focus on asthma and COPDLouis Philippe Boulet
Hopital Laval, 2725 Chemin Sainte Foy, Quebec, Canada
Can Respir J 13:5-47. 2006..It is hoped that this event will be followed by other meetings that focus on how to improve the transfer of key recommendations from evidence-based guidelines into current care, and how to stimulate research to accomplish this... - Bias in observational study of the effectiveness of nasal corticosteroids in asthmaSamy Suissa
Division of Clinical Epidemiology, Royal Victoria Hospital, McGill University Health Centre, 687 Pine Avenue West, Montreal, Quebec, Canada H3A 1A1
J Allergy Clin Immunol 115:714-9. 2005..The approach to data analysis may have led to biased results because of misclassification of immortal time... - Adult Asthma Consensus Guidelines update 2003Catherine Lemiere
Universite de Montreal, Montreal, Quebec
Can Respir J 11:9A-18A. 2004..Since the last revision of the 1999 Canadian Asthma Consensus Report, important new studies have highlighted the need to incorporate new information into the asthma guidelines... - Gender differences in survival following hospitalisation for COPDAnne V Gonzalez
Respiratory Epidemiology and Clinical Research Unit, Montreal Chest Institute, McGill University Health Centre, Montreal, Canada
Thorax 66:38-42. 2011..Gender differences in survival and rate of rehospitalisation were investigated in a large cohort of elderly patients with chronic airflow obstruction hospitalised for COPD... - Evaluating asthma control: a comparison of measures using an item response theory approachSara Ahmed
Department of Medicine, McGill University, Montreal, Canada
J Asthma 44:547-54. 2007..The IRT approach identified gaps in current measurement that need to be addressed to provide more precise evaluations of control required to accurately monitor changes in patient status... - Fluoroquinolones and the risk of serious arrhythmia: a population-based studyFrancesco Lapi
Centre for Clinical Epidemiology, Lady Davis Research Institute, Jewish General Hospital, Montreal, Quebec, Canada
Clin Infect Dis 55:1457-65. 2012..We assessed the risk of serious arrhythmia, defined as ventricular arrhythmia or sudden/unattended death identified in hospital discharge diagnoses, related to fluoroquinolones as a class as well as for each individual molecule... - Validation of The 30 Second Asthma Test as a measure of asthma controlSara Ahmed
Faculty of Medicine, McGill University, Montreal, Canada
Can Respir J 14:105-9. 2007..Simple and efficient tools are needed to assess patient-reported symptoms so that they can be used with or without airway function to evaluate asthma control... - Childhood predictors of smoking in adolescence: a follow-up study of Montreal schoolchildrenMargaret R Becklake
Respiratory Epidemiology and Clinical Research Unit, Montreal Chest Institute, Montreal, Que
CMAJ 173:377-9. 2005..The factors that cause children to become smokers in adolescence remain unclear. Although parental smoking and peer pressure may play a role, physiological factors such as lung volume have also been identified... - The impact of over-the-counter simvastatin on the number of statin prescriptions in the United Kingdom: a view from the General Practice Research DatabaseKristian B Filion
McGill University, Division of Clinical Epidemiology, Royal Victoria Hospital, Montreal, Canada
Pharmacoepidemiol Drug Saf 16:1-4. 2007..We assessed the impact of this policy change on statin prescribing... - Teaching time for metered-dose inhalers in the emergency settingYuka Numata
Respiratory Epidemiology Unit, McGill University, Montreal, PQ, Canada
Chest 122:498-504. 2002..CONCLUSIONS: Successful MDI/DED teaching followed by self-medication is feasible in the emergency setting, based on a simple protocol. A single bronchodilator dose administered by wet nebulization may facilitate subsequent MDI teaching... - Airway inflammation assessed by invasive and noninvasive means in severe asthma: eosinophilic and noneosinophilic phenotypesCatherine Lemiere
Hopital du Sacre Coeur de Montreal, University of Montreal, Montreal, Quebec, Canada
J Allergy Clin Immunol 118:1033-9. 2006.... - Rates and patterns of chronic obstructive pulmonary disease exacerbationsMagda Nunes de Melo
Department of Epidemiology and Biostatistics, McGill University, Montreal, Canada
Can Respir J 11:559-64. 2004..04 exacerbations/person-year. CONCLUSIONS: The results indicate that in a population-based cohort of patients with COPD, the average rate of exacerbations was 1.12/person-year. Men and women had similar rates of exacerbations... - The determinants of prevalence of health complaints among young competitive swimmersBenoît Lévesque
Institut National de Sante Publique du Quebec, 945 Ave Wolfe, G1V 5B3, Sainte Foy, Quebec, Canada
Int Arch Occup Environ Health 80:32-9. 2006..The objective of this study was to compare the prevalence of health complaints of young swimmers and young indoor soccer players and to evaluate the relationship between chloramine concentrations and the athletes' health complaints... - The early course of newly diagnosed asthmaPierre Ernst
Division of Clinical Epidemiology, Royal Victoria Hospital, and Pharmacoepidemiology Research Unit, McGill University Health Center, Montreal, , Canada
Am J Med 112:44-8. 2002..Patients initially dispensed medications suggesting the presence of severe asthma often see the intensity of treatment wane over time... - Newer disease-modifying antirheumatic drugs and the risk of serious hepatic adverse events in patients with rheumatoid arthritisSamy Suissa
Division of Clinical Epidemiology, McGill University Health Centre, Montreal, Canada
Am J Med 117:87-92. 2004..We assessed the risk of hepatic events associated with the use of leflunomide and other DMARDs... - Evaluation of the use of an integrated drug information system by primary care physicians for vulnerable populationYuko Kawasumi
Department of Epidemiology and Biostatistics, McGill University, and Division of Clinical Epidemiology, Royal Victoria Hospital, Montreal, Quebec H3A1A3, Canada
Int J Med Inform 77:98-106. 2008..To investigate whether an electronic prescribing and integrated drug information system was more likely to be used by primary care physicians for patients of low socioeconomic (SES) patients... - Geographic and gender variability in the prevalence of bronchial responsiveness in CanadaJure Manfreda
Department of Medicine, University of Manitoba, Winnipeg, MB, Canada
Chest 125:1657-64. 2004..We measured bronchial responsiveness using the standardized protocol of the European Community Respiratory Health Survey (ECRHS) in six sites in Canada, and compared prevalences across Canada with international sites... - Mega trials in COPD--clinical data analysis and design issuesSamy Suissa
Centre for Clinical Epidemiology, Lady Davis Institute, Jewish General Hospital, Department of Epidemiology, McGill University, Montreal, Canada
Pneumonol Alergol Pol 79:227-31. 2011..With COPD one of the major causes of morbidity and mortality worldwide, mega trials such as TORCH and UPLIFT are much needed, but must achieve the utmost scientific rigour in their design and analysis... - Altitude-related hypoxia: risk assessment and management for passengers on commerical aircraftAmir Mortazavi
Division of Cardiology, McGill University, Montreal, Quebec, Canada
Aviat Space Environ Med 74:922-7. 2003..There are a number of guidelines for the pre-flight assessment of patients with pulmonary and/or cardiac diseases. However, these data are based on small studies in patients with a limited group of diseases... - Statins and the risk of interstitial lung disease: a cohort studyNathalie Saad
Pulmonary Division, Jewish General Hospital, Montreal, Quebec, Canada
Thorax 68:361-4. 2013..Case reports have suggested that the use of statins may be associated with an increase in the risk of interstitial lung disease (ILD)... - The Asthma Quiz for Kidz: a validated tool to appreciate the level of asthma control in childrenFrancine M Ducharme
Department of Pediatrics Montreal Children s Hospital McGill University Health Centre, 2300 Tupper Street, Montreal, Quebec H3H 1P3, Canada
Can Respir J 11:541-6. 2004..There is an urgent need to bridge the large gap between optimal and observed asthma control among Canadian children... - Airflow obstruction in young adults in CanadaManal Al Hazmi
University of Manitoba, Winnipeg, Manitoba
Can Respir J 14:221-7. 2007..The objective of the present study was to enumerate and characterize airflow obstruction in a random sample of Canadians aged 20 to 44 years... - Should combination therapy with inhaled corticosteroids and long-acting beta2-agonists be prescribed as initial maintenance treatment for asthma?Catherine Lemiere
Service de Pneumologie, Universite de Montreal, Montreal, Que
CMAJ 167:1008-9. 2002 - Safety and efficacy of HFA-134a beclomethasone dipropionate extra-fine aerosol over six monthsLouis Philippe Boulet
Institut Universitaire de Cardiologie et de Pneumologie, l Université Laval, Hopital Laval, Sainte Foy, Quebec
Can Respir J 11:123-30. 2004..To compare the systemic safety and efficacy of hydrofluoroalkane beclomethasone dipropionate (HFA-BDP) extra-fine aerosol 800 microg/day with chlorofluorocarbon (CFC)-BDP 1500 microg/day... - Inhaled corticosteroids and fracture risk in COPDSamy Suissa
Am J Respir Crit Care Med 170:94; author reply 94-5. 2004 - Asthma and allergic rhinitis in Quebec childrenBenoît Lévesque
Direction régionale de santé publique de Quebec, Beauport, Quebec City
Can Respir J 11:343-8. 2004..The Health and Social Survey of Quebec Children and Youth, conducted on representative samples of children nine, 13 and 16 years of age, provided data on the prevalence and determinants of asthma and allergic rhinitis in Quebec... - Adjustable maintenance dosing with budesonide/formoterol reduces asthma exacerbations compared with traditional fixed dosing: a five-month multicentre Canadian studyJ Mark FitzGerald
The University of British Columbia, Vancouver, Canada
Can Respir J 10:427-34. 2003..Adjustable maintenance dosing with budesonide/formoterol in a single inhaler (Symbicort, AstraZeneca, Lund, Sweden) may provide a convenient means of maintaining asthma control with the minimum effective medication level... - Correlates of quality of life in patients with asthmaLaurent Laforest
Centre Hospitalier Universitaire de Lyon, Lyon, France
Ann Allergy Asthma Immunol 94:473-9. 2005..The relationships among HRQOL, therapy, and the determinants of control should be investigated in prospective studies... - Patterns and determinants of compliance with inhaled steroids in adults with asthmaYves Lacasse
Centre de Recherche, Hopital Laval, Institut Universitaire de Cardiologie et de Pneumologie de l Universite Laval, Ste Foy, Qubec, Canada
Can Respir J 12:211-7. 2005..Patient compliance with inhaled corticosteroids (ICS) in asthma is considered to be suboptimal... - Canadian Pediatric Asthma Consensus guidelines, 2003 (updated to December 2004): introductionAllan Becker
Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, Man
CMAJ 173:S12-4. 2005..Since the last revision of the 1999 Canadian asthma consensus report, important new studies, particularly in children, have highlighted the need to incorporate this new information into asthma guidelines... - Safety and effectiveness of long-acting inhaled beta-agonist bronchodilators when taken with inhaled corticosteroidsPierre Ernst
McGill University, , , Canada
Ann Intern Med 145:692-4. 2006.... - Differences in airway remodeling between subjects with severe and moderate asthmaCarmela Pepe
Meakins-Christie Laboratories, Montreal H2X2P2, Quebec. CA
J Allergy Clin Immunol 116:544-9. 2005.... - Women and asthma: lessons from a gender analysis of the asthma in Canada surveyAnna Day
Division of Respiratory Medicine, University of Toronto, Toronto, Canada
J Asthma 43:169-73. 2006..36%, p < 0.05). CONCLUSION: Women report greater need for urgent asthma care despite more frequent use of inhaled corticosteroids and better asthma knowledge scores than men... - Increased glucocorticoid receptor-beta expression, but not decreased histone deacetylase 2, in severe asthmaCeline Bergeron
J Allergy Clin Immunol 117:703-5. 2006 - Total and specific immunoglobulin E and their relationship to respiratory symptoms in Quebéc children and adolescentsBenoît Lévesque
CHUL Centre de recherche du CHUQ, Sainte Foy, Canada
Can Respir J 12:426-32. 2005..Respiratory disease is a major cause of morbidity in young people. It is now recognized that atopy plays an important role in the development of chronic respiratory symptoms in children... - Increased risk of childhood asthma from antibiotic use in early lifeAnita L Kozyrskyj
Faculty of Pharmacy, University of Manitoba, Winnipeg, MB, Canada R3T 2N2
Chest 131:1753-9. 2007.... - Environmental measures and asthmaPierre Ernst
Chest 122:1509-10. 2002 - Symposium on obesity and asthma - November 2, 2006Louis Philippe Boulet
Centre de Pneumologie, Institut Universitaire de Cardiologie et de Pneumologie de l Universite Laval, Hopital Laval, Quebec
Can Respir J 14:201-8. 2007.... - Pesticide exposure and asthmaPierre Ernst
Am J Respir Crit Care Med 165:563-4. 2002