Nicoletta Eliopoulos

Summary

Affiliation: McGill University
Country: Canada

Publications

  1. pmc Erythropoietin gene-enhanced marrow mesenchymal stromal cells decrease cisplatin-induced kidney injury and improve survival of allogeneic mice
    Nicoletta Eliopoulos
    Department of Surgery, Division of Surgical Research, McGill University, Jewish General Hospital, Montreal, Quebec, Canada
    Mol Ther 19:2072-83. 2011
  2. doi request reprint Human marrow-derived mesenchymal stromal cells decrease cisplatin renotoxicity in vitro and in vivo and enhance survival of mice post-intraperitoneal injection
    Nicoletta Eliopoulos
    Lady Davis Institute for Medical Research and Dept of Surgery, McGill Univ, 3755 Cote Ste Catherine Rd, Montreal, Quebec, Canada H3T 1E2
    Am J Physiol Renal Physiol 299:F1288-98. 2010
  3. doi request reprint Coupling erythropoietin secretion to mesenchymal stromal cells enhances their regenerative properties
    Ian B Copland
    Sir Mortimer B Davis Jewish General Hospital, McGill University, 3755 Cote Ste Catherine Road, Montreal, Quebec, Canada H3T 1E2
    Cardiovasc Res 79:405-15. 2008
  4. doi request reprint Targeted gene addition to human mesenchymal stromal cells as a cell-based plasma-soluble protein delivery platform
    Basma F Benabdallah
    Centre Hospitalier Universitaire Ste Justine, Department of Pharmacology, Universite de Montreal, Montreal, Canada
    Cytotherapy 12:394-9. 2010
  5. doi request reprint Neo-organoid of marrow mesenchymal stromal cells secreting interleukin-12 for breast cancer therapy
    Nicoletta Eliopoulos
    Lady Davis Institute for Medical Research and Division of Hematology Oncology, Jewish General Hospital, McGill University, Montreal, Quebec, Canada
    Cancer Res 68:4810-8. 2008
  6. ncbi request reprint CD34 expression on murine marrow-derived mesenchymal stromal cells: impact on neovascularization
    Ian Copland
    Lady Davis Institute for Research, Jewish General Hospital, Montreal, Canada
    Exp Hematol 36:93-103. 2008
  7. ncbi request reprint Interferon-gamma-stimulated marrow stromal cells: a new type of nonhematopoietic antigen-presenting cell
    John Stagg
    Lady Davis Institute for Medical Research, 3755 Cote Ste Catherine Rd, Montreal, QC, Canada H3T 1E2
    Blood 107:2570-7. 2006
  8. doi request reprint Bone marrow mesenchymal stromal cell therapy for external urethral sphincter restoration in a rat model of stress urinary incontinence
    Jacques Corcos
    Division of Urology, Jewish General Hospital, McGill University, Montreal, Quebec, Canada
    Neurourol Urodyn 30:447-55. 2011
  9. ncbi request reprint Vascular progenitors derived from murine bone marrow stromal cells are regulated by fibroblast growth factor and are avidly recruited by vascularizing tumors
    Borhane Annabi
    Laboratoire d Oncologie Moleculaire, Department of Biochemistry, Universite du Quebec a Montreal, C P 8888, Succ Centre Ville, Montreal, Quebec, Canada H3C 3P8
    J Cell Biochem 91:1146-58. 2004
  10. ncbi request reprint Erythropoietin delivery by genetically engineered bone marrow stromal cells for correction of anemia in mice with chronic renal failure
    Nicoletta Eliopoulos
    Lady Davis Institute for Medical Research, McGill University Health Center, and Division of Hematology Oncology, Jewish General Hospital, 3755 Cote Sainte Catherine Road, Montreal, Quebec, Canada H3T 1E2
    J Am Soc Nephrol 17:1576-84. 2006

Collaborators

  • Borhane Annabi
  • Jing Zhao
  • John Stagg
  • Jean Francois Tanguay
  • Anna Taranta
  • Ian B Copland
  • Paola Romagnani
  • Anique Ducharme
  • Diana M Iglesias
  • Paul Goodyer
  • LeeLee Chu
  • Zhao Zhang
  • Jacques Corcos
  • Basma F Benabdallah
  • Jacques Galipeau
  • Rouwayda El-Ayoubi
  • Jaan Toelen
  • Francesco Emma
  • Francesco Bellomo
  • Martine Besouw
  • Elena Levtchenko
  • Reyhan El-Kares
  • Yoon Kow Young
  • Lambertus Van Den Heuvel
  • Manaf Bouchentouf
  • Lysanne Campeau
  • Bertil Blok
  • Diana Iglesias
  • Reyhan El Kares
  • Oleg Loutochin
  • Jeffrey L Spees
  • Julie Fradette
  • Elie Haddad
  • Philip D Gregory
  • Geoffrey Friedman
  • Michael C Holmes
  • Emilie Allard
  • Christian M Beausejour
  • Shuyuan Yao
  • Robert DiRaddo
  • Azizeh Mitra Yousefi

Detail Information

Publications17

  1. pmc Erythropoietin gene-enhanced marrow mesenchymal stromal cells decrease cisplatin-induced kidney injury and improve survival of allogeneic mice
    Nicoletta Eliopoulos
    Department of Surgery, Division of Surgical Research, McGill University, Jewish General Hospital, Montreal, Quebec, Canada
    Mol Ther 19:2072-83. 2011
    ..In conclusion, our study demonstrates that Epo gene-enhanced MSCs exert significant tissue protective effects in allogeneic mice with AKI, and supports the potential use of gene-enhanced cells as universal donors in acute injury...
  2. doi request reprint Human marrow-derived mesenchymal stromal cells decrease cisplatin renotoxicity in vitro and in vivo and enhance survival of mice post-intraperitoneal injection
    Nicoletta Eliopoulos
    Lady Davis Institute for Medical Research and Dept of Surgery, McGill Univ, 3755 Cote Ste Catherine Rd, Montreal, Quebec, Canada H3T 1E2
    Am J Physiol Renal Physiol 299:F1288-98. 2010
    ....
  3. doi request reprint Coupling erythropoietin secretion to mesenchymal stromal cells enhances their regenerative properties
    Ian B Copland
    Sir Mortimer B Davis Jewish General Hospital, McGill University, 3755 Cote Ste Catherine Road, Montreal, Quebec, Canada H3T 1E2
    Cardiovasc Res 79:405-15. 2008
    ..In this work, we tested whether genetically engineering MSCs to secrete erythropoietin (Epo) could represent a better therapeutic platform than MSCs in their native form...
  4. doi request reprint Targeted gene addition to human mesenchymal stromal cells as a cell-based plasma-soluble protein delivery platform
    Basma F Benabdallah
    Centre Hospitalier Universitaire Ste Justine, Department of Pharmacology, Universite de Montreal, Montreal, Canada
    Cytotherapy 12:394-9. 2010
    ..However, to avoid the risk of insertional mutagenesis, targeted integration of a transgene into a 'safe harbor' locus is of great interest...
  5. doi request reprint Neo-organoid of marrow mesenchymal stromal cells secreting interleukin-12 for breast cancer therapy
    Nicoletta Eliopoulos
    Lady Davis Institute for Medical Research and Division of Hematology Oncology, Jewish General Hospital, McGill University, Montreal, Quebec, Canada
    Cancer Res 68:4810-8. 2008
    ..This study therefore establishes the feasibility of using gene-enhanced MSCs in a cell-based neo-organoid approach for cancer treatment...
  6. ncbi request reprint CD34 expression on murine marrow-derived mesenchymal stromal cells: impact on neovascularization
    Ian Copland
    Lady Davis Institute for Research, Jewish General Hospital, Montreal, Canada
    Exp Hematol 36:93-103. 2008
    ..Mesenchymal stromal cells (MSCs) also express CD34, although the functional significance of its expression remains undefined. In this study, we determined whether CD34(pos) MSCs are functionally distinct from CD34(null) MSCs...
  7. ncbi request reprint Interferon-gamma-stimulated marrow stromal cells: a new type of nonhematopoietic antigen-presenting cell
    John Stagg
    Lady Davis Institute for Medical Research, 3755 Cote Ste Catherine Rd, Montreal, QC, Canada H3T 1E2
    Blood 107:2570-7. 2006
    ..Taken together, our data strongly suggest that MSCs behave as conditional APCs in syngeneic immune responses...
  8. doi request reprint Bone marrow mesenchymal stromal cell therapy for external urethral sphincter restoration in a rat model of stress urinary incontinence
    Jacques Corcos
    Division of Urology, Jewish General Hospital, McGill University, Montreal, Quebec, Canada
    Neurourol Urodyn 30:447-55. 2011
    ..To assess the effect of intra-sphincteric injections of bone marrow mesenchymal stromal cells (MSCs) on Valsalva leak point pressure (VLPP) changes in an animal model of stress urinary incontinence (SUI)...
  9. ncbi request reprint Vascular progenitors derived from murine bone marrow stromal cells are regulated by fibroblast growth factor and are avidly recruited by vascularizing tumors
    Borhane Annabi
    Laboratoire d Oncologie Moleculaire, Department of Biochemistry, Universite du Quebec a Montreal, C P 8888, Succ Centre Ville, Montreal, Quebec, Canada H3C 3P8
    J Cell Biochem 91:1146-58. 2004
    ..These observations may have crucial implications in the development of novel therapies using BMSC engineered to secrete anti-cancerous agents and to antagonize tumor progression...
  10. ncbi request reprint Erythropoietin delivery by genetically engineered bone marrow stromal cells for correction of anemia in mice with chronic renal failure
    Nicoletta Eliopoulos
    Lady Davis Institute for Medical Research, McGill University Health Center, and Division of Hematology Oncology, Jewish General Hospital, 3755 Cote Sainte Catherine Road, Montreal, Quebec, Canada H3T 1E2
    J Am Soc Nephrol 17:1576-84. 2006
    ..In conclusion, these results demonstrate that subcutaneous implantation of Epo-secreting genetically engineered MSCs can correct anemia that occurs in a murine model of CRF...
  11. ncbi request reprint Allogeneic marrow stromal cells are immune rejected by MHC class I- and class II-mismatched recipient mice
    Nicoletta Eliopoulos
    Lady Davis Institute for Medical Research, McGill University, 3755 Cote St Catherine Rd, Montreal, QC Canada H3T1E2
    Blood 106:4057-65. 2005
    ..These results strongly suggest that MSCs are not intrinsically immunoprivileged and cannot serve as a "universal donor" in immunocompetent MHC-mismatched recipients...
  12. ncbi request reprint Human-compatible collagen matrix for prolonged and reversible systemic delivery of erythropoietin in mice from gene-modified marrow stromal cells
    Nicoletta Eliopoulos
    Lady Davis Institute for Medical Research, Jewish General Hospital, McGill University, Montreal, Quebec H3T 1E2, Canada
    Mol Ther 10:741-8. 2004
    ..In conclusion, this investigation demonstrates that mEpo(+) MSCs embedded in a human-compatible viscous collagen matrix offers a potent, durable, and reversible approach for delivery of plasma-soluble therapeutic proteins...
  13. doi request reprint Design and fabrication of 3D porous scaffolds to facilitate cell-based gene therapy
    Rouwayda El-Ayoubi
    Industrial Materials Institute, National Research Council of Canada, Boucherville, Quebec, Canada
    Tissue Eng Part A 14:1037-48. 2008
    ....
  14. ncbi request reprint Matrix metalloproteinase regulation of sphingosine-1-phosphate-induced angiogenic properties of bone marrow stromal cells
    Borhane Annabi
    Laboratoire de Medecine Moleculaire, Centre de cancérologie Charles Bruneau, Hôpital Sainte Justine and Université du Québec à Montréal, Montreal, Quebec, Canada
    Exp Hematol 31:640-9. 2003
    ..In this study we examined the effect of sphingosine-1-phosphate (S1P), a platelet-derived bioactive lysophospholipid that is believed to specifically stimulate EC migration and tube formation, on the angiogenic properties of MSC...
  15. doi request reprint A variant OSR1 allele which disturbs OSR1 mRNA expression in renal progenitor cells is associated with reduction of newborn kidney size and function
    Zhao Zhang
    McGill University Department of Human Genetics, Montreal Children s Hospital Research Institute, Montreal, Canada
    Hum Mol Genet 20:4167-74. 2011
    ..006) versus newborns with wild-type alleles. Although only two subjects had PAX2(rs11599825)(A) and OSR1(rs12329305)(T) alleles, kidney size was reduced by 27% and cystatin C was increased by 14% versus wild-types (P= NS)...
  16. ncbi request reprint Hypoxia promotes murine bone-marrow-derived stromal cell migration and tube formation
    Borhane Annabi
    Laboratoire de Médecine Moléculaire and Division of Hematology Oncology, Centre de cancérologie Charles Bruneau, Hôpital Sainte Justine and Université du Québec à Montréal, Montreal, Quebec, Canada
    Stem Cells 21:337-47. 2003
    ....
  17. pmc Stem cell microvesicles transfer cystinosin to human cystinotic cells and reduce cystine accumulation in vitro
    Diana M Iglesias
    Department of Pediatrics, Montreal Children s Hospital Research Institute, McGill University, Montreal, Quebec, Canada
    PLoS ONE 7:e42840. 2012
    ..Our observations suggest that exogenous stem cells may reprogram the biology of mutant tissues by direct microvesicle transfer of membrane-associated wildtype molecules...