Gustavo Duque

Summary

Affiliation: McGill University
Country: Canada

Publications

  1. ncbi Estrogens (E2) regulate expression and response of 1,25-dihydroxyvitamin D3 receptors in bone cells: changes with aging and hormone deprivation
    Gustavo Duque
    Calcium Research Laboratory, Department of Medicine, McGill University, Que, Montreal, Canada
    Biochem Biophys Res Commun 299:446-54. 2002
  2. ncbi Early clinical exposure to geriatric medicine in second-year medical school students--the McGill experience
    Gustavo Duque
    Division of Geriatric Medicine McGill University, Montreal, Quebec, Canada
    J Am Geriatr Soc 51:544-8. 2003
  3. ncbi Web-based evaluation of medical clerkships: a new approach to immediacy and efficacy of feedback and assessment
    Gustavo Duque
    Division of Geriatric Medicine, McGill University, Montreal, Canada
    Med Teach 25:510-4. 2003
  4. ncbi 1,25(OH)2D3 inhibits bone marrow adipogenesis in senescence accelerated mice (SAM-P/6) by decreasing the expression of peroxisome proliferator-activated receptor gamma 2 (PPARgamma2)
    Gustavo Duque
    Division of Geriatric Medicine, Department of Medicine, 3755, Cote Sainte Catherine, Montreal, Que, Canada H3T 1E2
    Exp Gerontol 39:333-8. 2004
  5. ncbi To treat or not to treat, that is the question: proceedings of the Quebec symposium for the treatment of osteoporosis in long-term care institutions, Saint-Hyacinthe, Quebec, November 5, 2004
    Gustavo Duque
    Division of Geriatric Medicine, McGill University, Montreal, Quebec, Canada
    J Am Med Dir Assoc 8:e67-73. 2007
  6. doi Autocrine regulation of interferon gamma in mesenchymal stem cells plays a role in early osteoblastogenesis
    Gustavo Duque
    Department of Medicine and Center for Bone and Periodontal Research, McGill University and McGill University Health Center, Montreal, Quebec, Canada
    Stem Cells 27:550-8. 2009
  7. doi Effect of lamin A/C knockdown on osteoblast differentiation and function
    Rahima Akter
    Division of Experimental Medicine, Department of Medicine, McGill University, Montreal, Quebec, Canada
    J Bone Miner Res 24:283-93. 2009
  8. pmc Inhibition of fatty acid biosynthesis prevents adipocyte lipotoxicity on human osteoblasts in vitro
    Alexandre Elbaz
    Lady Davis Institute for Medical Research, McGill University, Montreal, Quebec, Canada
    J Cell Mol Med 14:982-91. 2010
  9. ncbi Accelerated features of age-related bone loss in zmpste24 metalloproteinase-deficient mice
    Daniel Rivas
    Lady Davis Institute, McGill University, Montreal, Quebec, Canada
    J Gerontol A Biol Sci Med Sci 64:1015-24. 2009
  10. ncbi Vitamin D treatment of senescence accelerated mice (SAM-P/6) induces several regulators of stromal cell plasticity
    Gustavo Duque
    Division of Geriatric Medicine, McGill University, 3755, Cote Sainte Catherine, Montreal, QC, Canada H3T 1E2
    Biogerontology 5:421-9. 2004

Collaborators

Detail Information

Publications38

  1. ncbi Estrogens (E2) regulate expression and response of 1,25-dihydroxyvitamin D3 receptors in bone cells: changes with aging and hormone deprivation
    Gustavo Duque
    Calcium Research Laboratory, Department of Medicine, McGill University, Que, Montreal, Canada
    Biochem Biophys Res Commun 299:446-54. 2002
    ..002). In summary, our results demonstrate that E(2) increases VDR expression in bone in vivo and potentiate the bioresponse of VDR in osteoblasts in vitro...
  2. ncbi Early clinical exposure to geriatric medicine in second-year medical school students--the McGill experience
    Gustavo Duque
    Division of Geriatric Medicine McGill University, Montreal, Quebec, Canada
    J Am Geriatr Soc 51:544-8. 2003
    ..The integrated week is a more-effective learning tool in the early clinical experience for medical students in geriatric medicine than 10 weekly sessions as the first introductory experience to the field of geriatric medicine...
  3. ncbi Web-based evaluation of medical clerkships: a new approach to immediacy and efficacy of feedback and assessment
    Gustavo Duque
    Division of Geriatric Medicine, McGill University, Montreal, Canada
    Med Teach 25:510-4. 2003
    ....
  4. ncbi 1,25(OH)2D3 inhibits bone marrow adipogenesis in senescence accelerated mice (SAM-P/6) by decreasing the expression of peroxisome proliferator-activated receptor gamma 2 (PPARgamma2)
    Gustavo Duque
    Division of Geriatric Medicine, Department of Medicine, 3755, Cote Sainte Catherine, Montreal, Que, Canada H3T 1E2
    Exp Gerontol 39:333-8. 2004
    ..01) In summary, this study shows that the administration of 1,25(OH)(2)D(3) in an in vivo model of senile osteoporosis is associated with reduction in PPARgamma2 a key transcription factor for the adipose differentiation of MSC...
  5. ncbi To treat or not to treat, that is the question: proceedings of the Quebec symposium for the treatment of osteoporosis in long-term care institutions, Saint-Hyacinthe, Quebec, November 5, 2004
    Gustavo Duque
    Division of Geriatric Medicine, McGill University, Montreal, Quebec, Canada
    J Am Med Dir Assoc 8:e67-73. 2007
    ..Management strategies include both nonpharmacological and pharmacological interventions for the prevention and treatment of osteoporotic fractures in very frail older subjects...
  6. doi Autocrine regulation of interferon gamma in mesenchymal stem cells plays a role in early osteoblastogenesis
    Gustavo Duque
    Department of Medicine and Center for Bone and Periodontal Research, McGill University and McGill University Health Center, Montreal, Quebec, Canada
    Stem Cells 27:550-8. 2009
    ..These data therefore support a new role for IFNgamma as an autocrine regulator of hMSC differentiation and as a potential new target of bone-forming cells in vivo...
  7. doi Effect of lamin A/C knockdown on osteoblast differentiation and function
    Rahima Akter
    Division of Experimental Medicine, Department of Medicine, McGill University, Montreal, Quebec, Canada
    J Bone Miner Res 24:283-93. 2009
    ..In summary, our results indicate that lamin A/C is a new factor needed for osteoblast differentiation that plays an important role in the cellular mechanisms of age-related bone loss...
  8. pmc Inhibition of fatty acid biosynthesis prevents adipocyte lipotoxicity on human osteoblasts in vitro
    Alexandre Elbaz
    Lady Davis Institute for Medical Research, McGill University, Montreal, Quebec, Canada
    J Cell Mol Med 14:982-91. 2010
    ..We conclude that the presence of FA within the marrow milieu can contribute to the age-related changes in bone mass and can be prevented by the inhibition of FA synthase...
  9. ncbi Accelerated features of age-related bone loss in zmpste24 metalloproteinase-deficient mice
    Daniel Rivas
    Lady Davis Institute, McGill University, Montreal, Quebec, Canada
    J Gerontol A Biol Sci Med Sci 64:1015-24. 2009
    ..In summary, processing of prelamin A could become a new approach to regulate osteoblastogenesis and bone turnover and thus for the prevention and treatment of senile osteoporosis...
  10. ncbi Vitamin D treatment of senescence accelerated mice (SAM-P/6) induces several regulators of stromal cell plasticity
    Gustavo Duque
    Division of Geriatric Medicine, McGill University, 3755, Cote Sainte Catherine, Montreal, QC, Canada H3T 1E2
    Biogerontology 5:421-9. 2004
    ..In summary, this study illustrates the anti-adipogenic effect of 1,25(OH)2D3 in bone cells and identifies some of the possible key signals involved in bone cell plasticity...
  11. ncbi 1,25(OH)2D3 acts as a bone-forming agent in the hormone-independent senescence-accelerated mouse (SAM-P/6)
    Gustavo Duque
    Calcium Research Laboratories, Department of Medicine, McGill University Health Centre, Quebec, Canada
    Am J Physiol Endocrinol Metab 288:E723-30. 2005
    ..Taken together, these findings demonstrate that 1,25(OH)2D3 acts simultaneously on bone formation and resorption to prevent the development of senile osteoporosis...
  12. ncbi Will reducing adopogenesis in bone increase bone mass?: PPARgamma2 as a key target in the treatment of age-related bone loss
    Gustavo Duque
    Division of Geriatric Medicine McGill University, Jewish General Hospital, 3599 Cote Sainte Catherine, Montreal, Quebec, Canada
    Drug News Perspect 16:341-6. 2003
    ....
  13. doi Effect of estrogens on bone marrow adipogenesis and Sirt1 in aging C57BL/6J mice
    Alexander Elbaz
    Lady Davis Institute for Medical Research, McGill University, Montreal, QC H3T 1E2, Canada
    Biogerontology 10:747-55. 2009
    ..In addition, this evidence suggests that old individuals may show a better response to E2 administration in terms of reverting the high levels of marrow fat seen in age-related bone loss...
  14. ncbi From the facts to the screen: a blended model of teaching basic hospital skills to 2nd year medical students
    Gustavo Duque
    Division of Geriatric Medicine, McGill University, 3755 Cote Sainte Catherine, Montreal, QC, Canada, H3T 1E2
    Med Teach 28:729-33. 2006
    ....
  15. ncbi Age-related changes in lamin A/C expression in the osteoarticular system: laminopathies as a potential new aging mechanism
    Gustavo Duque
    Division of Geriatric Medicine, Jewish General Hospital 3755, McGill University, Chemin de la Cote Sainte Catherine Montreal, Que, Canada H3T 1E2
    Mech Ageing Dev 127:378-83. 2006
    ..In this study we hypothesize that the expression of lamin A/C may play a role in the pathogenesis of age-related diseases in the osteoarticular system...
  16. doi Alendronate affects calcium dynamics in cardiomyocytes in vitro
    Naomi Kemeny-Suss
    Faculty of Dentistry, McGill University, Montreal, Quebec, Canada H3A 2B2
    Vascul Pharmacol 51:350-8. 2009
    ....
  17. doi Conjugated linoleic acid is related to bone mineral density but does not affect parathyroid hormone in men
    Jason R Deguire
    School of Dietetics and Human Nutrition, McGill University, Montreal, Quebec, Canada
    Nutr Res 32:911-20. 2012
    ..These findings indicate that RBC c9, t11 CLA status, a reflection of long-term (~4 months) dietary CLA intake, positively relates to BMD. However, c9, t11 CLA supplementation does not appear to affect PTH in healthy men...
  18. ncbi Differential expression of cytokines in subcutaneous and marrow fat of aging C57BL/6J mice
    Marco Gasparrini
    Lady Davis Institute for Medical Research, McGill University, Montreal, Quebec, Canada
    Exp Gerontol 44:613-8. 2009
    ..These cytokines, if secreted, could play a role in the pathogenesis of age-related bone loss by affecting other cells within the marrow milieu...
  19. ncbi Age-related bone loss: old bone, new facts
    George K Chan
    Division of Geriatric Medicine, McGill University, Montreal, Que, Canada
    Gerontology 48:62-71. 2002
    ..We also consider the mechanism of programmed cell death, apoptosis, as being an important determinant of aging in bone as well as describe possible future interventions to prolong the life span of osteoblasts...
  20. ncbi To treat or not to treat, that is the question: proceedings of the Quebec Symposium for the Treatment of Osteoporosis in Long-term Care Institutions, Saint-Hyacinthe, Quebec, November 5, 2004
    Gustavo Duque
    Division of Geriatric Medicine, McGill University Jewish General Hospital, 3755 Cote Sainte Catherine, Montreal, Quebec, Canada
    J Am Med Dir Assoc 7:435-41. 2006
    ..Management strategies include both nonpharmacological and pharmacological interventions for the prevention and treatment of osteoporotic fractures in very frail older subjects...
  21. ncbi [Osteoporosis in the elderly]
    Frederique Retornaz
    Division de gériatrie, Universite McGill, Hôpital général juif, Montreal, Quebec, Canada
    Presse Med 35:1547-56. 2006
    ..Strontium ranelate is a promising treatment in this population. Fall prevention is a major part of osteoporosis management. The potential benefit of hip protectors is questionable, even in institutionalized patients...
  22. pmc Learning while evaluating: the use of an electronic evaluation portfolio in a geriatric medicine clerkship
    Gustavo Duque
    Division of Geriatric Medicine, McGill University, Montreal, Quebec, Canada
    BMC Med Educ 6:4. 2006
    ..Electronic evaluation portfolios may play a role in learning and evaluation in clinical settings and may complement other traditional evaluation methods (bedside evaluations, written exams and tutor-led evaluations)...
  23. ncbi Vitamin D inhibits Fas ligand-induced apoptosis in human osteoblasts by regulating components of both the mitochondrial and Fas-related pathways
    Gustavo Duque
    Calcium Research Laboratory, McGill University, Montreal, Quebec, Canada H3A 1A1
    Bone 35:57-64. 2004
    ..In summary, these results demonstrate that the anti-apoptotic effect of 1,25(OH)2D3 in human osteoblasts after the activation of Fas-ligand is mediated by the regulation of components of both the mitochondrial and Fas-related pathways...
  24. ncbi Alendronate has an anabolic effect on bone through the differentiation of mesenchymal stem cells
    Gustavo Duque
    Division of Geriatric Medicine, Department of Medicine, McGill University, Montreal, Quebec, Canada
    J Bone Miner Res 22:1603-11. 2007
    ..ALN inhibited adipogenesis while promoting osteoblast differentiation and activity. Our results reveal a new anabolic effect of ALN in differentiating bone marrow cells...
  25. ncbi Age-related changes in lamin A/C expression in cardiomyocytes
    Jonathan Afilalo
    Division of Internal Medicine, Department of Medicine, Sir Mortimer B Davis Jewish General Hospital, McGill University, Montreal, Quebec, Canada
    Am J Physiol Heart Circ Physiol 293:H1451-6. 2007
    ..This is the first study to show that normal aging is associated with reduced expression and altered distribution of lamin A/C in nuclei of cardiomyocytes...
  26. pmc Inhibition of Protein Farnesylation Arrests Adipogenesis and Affects PPARgamma Expression and Activation in Differentiating Mesenchymal Stem Cells
    Daniel Rivas
    Lady Davis, Institute for Medical Research, Montreal, Quebec, Canada QC H3T 1E2
    PPAR Res 2007:81654. 2007
    ..In summary, inhibition of protein farnesylation arrests the adipogenic differentiation of MSCs and affects PPARgamma expression and activity...
  27. doi Statins for secondary prevention in elderly patients: a hierarchical bayesian meta-analysis
    Jonathan Afilalo
    Department of Medicine, Sir Mortimer B Davis Jewish General Hospital, McGill University, Montreal, Canada
    J Am Coll Cardiol 51:37-45. 2008
    ..This study was designed to determine whether statins reduce all-cause mortality in elderly patients with coronary heart disease...
  28. ncbi Taking musculoskeletal aging out of the bench: do we finally understand frailty?
    Gustavo Duque
    Jewish General Hospital, Division of Geriatric Medicine, McGill University, 3755, chemin de la Côte, Sainte Catherine, Montreal, Quebec, Canada H3T 1E2
    Mol Aspects Med 26:141-3. 2005
  29. pmc Gait disorders are associated with non-cardiovascular falls in elderly people: a preliminary study
    Manuel Montero-Odasso
    Division of Geriatric Medicine, McGill University, Montreal, Canada
    BMC Geriatr 5:15. 2005
    ..A second objective is to test the sensitivity and specificity of a gait assessment approach for detecting non-cardiovascular causes when compared with intrinsic-extrinsic classification...
  30. ncbi Understanding the mechanisms of senile osteoporosis: new facts for a major geriatric syndrome
    Gustavo Duque
    Aging Bone Research Program, Nepean Clinical School, University of Sydney, Penrith, New South Wales, Australia
    J Am Geriatr Soc 56:935-41. 2008
    ..New potential treatments are also considered, including therapeutic approaches to osteoporosis in elderly people that focus on the pathophysiology and potential reversal of the adipogenic shift in bone...
  31. doi Bone and fat connection in aging bone
    Gustavo Duque
    Nepean Clinical School, University of Sydney, Penrith, New South Wales, Australia
    Curr Opin Rheumatol 20:429-34. 2008
    ..Additionally, bone marrow fat will be considered as a diagnostic and therapeutic approach to osteoporosis...
  32. ncbi Vitamin D in the aging musculoskeletal system: an authentic strength preserving hormone
    Manuel Montero-Odasso
    Geriatric Medicine Program, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina
    Mol Aspects Med 26:203-19. 2005
    ....
  33. ncbi Severe bone changes in a case of Hutchinson-Gilford syndrome
    Giselle Helena de Paula Rodrigues
    Division on Aging, Sorocaba Medical School, Pontifícia Universidade Católica de São Paulo, Brazil
    Ann Genet 45:151-5. 2002
    ..In summary, we report the case of an 8-year-old girl who meets the diagnostic criteria for HGPS with severe involvement of her bones and joints with a review of the current literature and a possible therapeutic approach...
  34. ncbi Role of endocrine-immune dysregulation in osteoporosis, sarcopenia, frailty and fracture risk
    Cherian Joseph
    UConn Center on Aging, University of Connecticut Health Center, MC 5215, 263 Farmington Ave, Farmington, CT 06030 5215, United States
    Mol Aspects Med 26:181-201. 2005
    ....
  35. ncbi Use of analgesics in elderly nursing home residents
    Gustavo Duque
    J Am Geriatr Soc 53:909; author reply 909-10. 2005
  36. ncbi Chronic hypercalcemia as a reversible cause of cognitive impairment: improvement after a single administration of pamidronate
    Gustavo Duque
    J Am Geriatr Soc 53:1633-4. 2005
  37. ncbi Learning while having fun: the use of video gaming to teach geriatric house calls to medical students
    Gustavo Duque
    Centre for Medical Education, Nepean Clinical School, University of Sydney, Penrith, New South Wales, Australia
    J Am Geriatr Soc 56:1328-32. 2008
    ..In summary, this method provides medical students with a fun and structured experience that has an effect not only on their learning, but also on their understanding of the particular needs of the elderly population...
  38. ncbi Seasonal variance in serum levels of vitamin d determines a compensatory response by parathyroid hormone: study in an ambulatory elderly population in Quebec
    Concepción Vecino-Vecino
    S de Geriatría y Unidad de Investigación Hospital Universitario de Getafe, Madrid, Spain
    Gerontology 52:33-9. 2006
    ..Although the seasonal variance in serum levels of vitamin D in the elderly is well known, its significance on parathyroid hormone (PTH) remains controversial...