Anne Duffy

..A major aim of this longitudinal high-risk study is to identify reliable early indicators of emerging bipolar disorder (BD) among offspring from well-characterized parents...

..Some children manifest antecedent nonspecific psychopathology in early childhood. Therefore, as currently diagnosed, BD does not manifest as such typically until at least adolescence...

..The present study examines the relationship between temperament, recent and remote life events, and psychopathology among the offspring of parents with bipolar disorder and well comparisons...

..Long-term treatment studies of youth with BD are lacking. This paper provides longitudinal observations of response to mood stabilizers early in the course of illness in youth with BD...

..To address this question, we performed the first high-risk study of pituitary volumes in affected and unaffected relatives of bipolar subjects...

..We conducted volumetric high-risk study to investigate whether striatal volume changes represent primary biological risk factor for bipolar disorders...

..The objective of this study was to evaluate effectiveness of commonly used prophylactic treatments for bipolar disorder in a naturalistic setting and to explore factors associated with treatment response...

..The current study investigated whether or not deficits in early information processing were present before the onset and/or during the early stages of bipolar disorder...

..We tested the hypothesis that in high risk offspring, bipolar disorder evolves in a predictable clinical sequence from non-specific (non-mood) to specific (mood) psychopathology...

..In this review, we compare different methods of ascertainment and assessment, and their impact on study findings...

..Among the offspring of lithium-responsive bipolar parents, an early-onset subgroup with a classical episodic clinical course can be identified...

..CONCLUSIONS: These findings suggest that lithium- and lamotrigine-responsive patients differ with respect to course of illness, comorbidity and family history and may represent distinct subtypes of bipolar disorder...

..The purpose of the study was to determine the effectiveness and tolerability of quetiapine as a maintenance treatment preventing against relapse or recurrence of acute mood episodes in adolescent patients diagnosed with bipolar disorder...

..This is the first study of SGC volumes in affected and unaffected subjects at familial risk for mood disorders...

..However, this recommendation has not been adequately substantiated in the literature. We tested the hypothesis that response to long-term lithium treatment is a familial trait...

..The purpose of this study is to replicate findings of increased cortisol secretion during clinical remission in bipolar patients and in the offspring of bipolar parents, rigorously controlling for known confounders...

..These observations raise questions about the nature of the relationship between the neurobiological mechanisms of BD and suicide, namely whether they are shared or independent...

..Further, the nature of the residual symptoms as indicated by the abnormal MMPIs support the view of heterogeneity of the bipolar diagnosis. The relevance to treatment response is discussed...

..A high-risk paradigm would clarify the temporal relation of cognitive dysfunction to clinical course...

..We hypothesized that the free cortisol response to waking, believed to be genetically influenced, would be elevated in a significant percentage of cases, regardless of the afternoon Dexamethasone Suppression Test (DST) value...