M Diksic

Summary

Affiliation: McGill University
Country: Canada

Publications

  1. ncbi request reprint Brain net unidirectional uptake of alpha-[14c]methyl-L-tryptophan (alpha-MTrp) and its correlation with regional serotonin synthesis, tryptophan incorporation into proteins, and permeability surface area products of tryptophan and alpha-MTrp
    M Diksic
    Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada
    Neurochem Res 25:1537-46. 2000
  2. ncbi request reprint Study of the brain serotonergic system with labeled alpha-methyl-L-tryptophan
    M Diksic
    Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada
    J Neurochem 78:1185-200. 2001
  3. pmc Labelled alpha-methyl-L-tryptophan as a tracer for the study of the brain serotonergic system
    M Diksic
    Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, 3801 University St, Montreal, QC H3A 2B4
    J Psychiatry Neurosci 26:293-303. 2001
  4. ncbi request reprint Brain Regional alpha-[11C]methyl-L-tryptophan trapping in impulsive subjects with borderline personality disorder
    M Leyton
    Department of Psychiatry, McGill University, , , Canada
    Am J Psychiatry 158:775-82. 2001
  5. doi request reprint Sumatriptan normalizes the migraine attack-related increase in brain serotonin synthesis
    Y Sakai
    Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada
    Neurology 70:431-9. 2008
  6. ncbi request reprint Cortical trapping of alpha-[(11)C]methyl-l-tryptophan, an index of serotonin synthesis, is lower in females than males
    Y Sakai
    Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, 3801 University St, Montreal, Canada QC H3A 2B4
    Neuroimage 33:815-24. 2006
  7. ncbi request reprint Localizing value of alpha-methyl-L-tryptophan PET in intractable epilepsy of neocortical origin
    M Fedi
    Department of Neurology, McGill University, Canada
    Neurology 57:1629-36. 2001
  8. doi request reprint Tryptophan hydroxylase(2) gene polymorphisms predict brain serotonin synthesis in the orbitofrontal cortex in humans
    L Booij
    Department of Psychiatry, McGill University, Montreal, QC, Canada
    Mol Psychiatry 17:809-17. 2012
  9. ncbi request reprint Acute prefrontal cortex TMS in healthy volunteers: effects on brain 11C-alphaMtrp trapping
    I Sibon
    Department of Psychiatry, Montreal Neurological Institute, McGill University, QC, Canada
    Neuroimage 34:1658-64. 2007
  10. ncbi request reprint Effects of selective 5-HT1A receptor antagonists on regional serotonin synthesis in the rat brain: an autoradiographic study with alpha-[14C]methyl-L-tryptophan
    Y Tohyama
    Cone Neurosurgical Research Laboratory, Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Quebec, Montreal, Canada
    Eur Neuropsychopharmacol 11:193-202. 2001

Collaborators

Detail Information

Publications21

  1. ncbi request reprint Brain net unidirectional uptake of alpha-[14c]methyl-L-tryptophan (alpha-MTrp) and its correlation with regional serotonin synthesis, tryptophan incorporation into proteins, and permeability surface area products of tryptophan and alpha-MTrp
    M Diksic
    Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada
    Neurochem Res 25:1537-46. 2000
    ..From this also follows that labeled alpha-MTrp is a good tracer for in vivo evaluation of the brain 5-HT synthesis...
  2. ncbi request reprint Study of the brain serotonergic system with labeled alpha-methyl-L-tryptophan
    M Diksic
    Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada
    J Neurochem 78:1185-200. 2001
    ..We review studies in animals looking at the normal control of 5-HT synthesis and the way in which it is altered by drugs, as well as initial studies investigating healthy humans and patients with neuropsychiatric disorders...
  3. pmc Labelled alpha-methyl-L-tryptophan as a tracer for the study of the brain serotonergic system
    M Diksic
    Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, 3801 University St, Montreal, QC H3A 2B4
    J Psychiatry Neurosci 26:293-303. 2001
    ..However, as with all biological models, there is likely room for improvement in our approach...
  4. ncbi request reprint Brain Regional alpha-[11C]methyl-L-tryptophan trapping in impulsive subjects with borderline personality disorder
    M Leyton
    Department of Psychiatry, McGill University, , , Canada
    Am J Psychiatry 158:775-82. 2001
    ..CONCLUSIONS: Low 5-HT synthesis capacity in corticostriatal pathways may contribute to the development of impulsive behaviors in persons with borderline personality disorder...
  5. doi request reprint Sumatriptan normalizes the migraine attack-related increase in brain serotonin synthesis
    Y Sakai
    Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada
    Neurology 70:431-9. 2008
    ..Altered serotonin (5-HT) neurotransmission has been implicated in the pathophysiology of migraine headache...
  6. ncbi request reprint Cortical trapping of alpha-[(11)C]methyl-l-tryptophan, an index of serotonin synthesis, is lower in females than males
    Y Sakai
    Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, 3801 University St, Montreal, Canada QC H3A 2B4
    Neuroimage 33:815-24. 2006
    ..These differences may be related, at least in part, to previously suggested gender differences in affect, cognitive processes, and susceptibility to 5-HT-related neuropsychiatric and neurological disorders...
  7. ncbi request reprint Localizing value of alpha-methyl-L-tryptophan PET in intractable epilepsy of neocortical origin
    M Fedi
    Department of Neurology, McGill University, Canada
    Neurology 57:1629-36. 2001
    ..7, p < 0.05). CONCLUSIONS: alpha-MTrp-PET may be of value in the localization of the epileptogenic area not only in patients with visible dysplastic lesions, but also in those with cryptogenic partial epilepsy...
  8. doi request reprint Tryptophan hydroxylase(2) gene polymorphisms predict brain serotonin synthesis in the orbitofrontal cortex in humans
    L Booij
    Department of Psychiatry, McGill University, Montreal, QC, Canada
    Mol Psychiatry 17:809-17. 2012
    ..Associations in the OBFC remained statistically significant in a mixed larger sample of patients and controls. These results suggest that in humans, genetic factors might partly account for variations in serotonin synthesis in the OBFC...
  9. ncbi request reprint Acute prefrontal cortex TMS in healthy volunteers: effects on brain 11C-alphaMtrp trapping
    I Sibon
    Department of Psychiatry, Montreal Neurological Institute, McGill University, QC, Canada
    Neuroimage 34:1658-64. 2007
    ..Such adaptive changes may contribute to the mechanism of action of prefrontal rTMS in major depression...
  10. ncbi request reprint Effects of selective 5-HT1A receptor antagonists on regional serotonin synthesis in the rat brain: an autoradiographic study with alpha-[14C]methyl-L-tryptophan
    Y Tohyama
    Cone Neurosurgical Research Laboratory, Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Quebec, Montreal, Canada
    Eur Neuropsychopharmacol 11:193-202. 2001
    ..These treatments did not have any effect on the plasma free or total tryptophan...
  11. ncbi request reprint Effects of pentadecapeptide BPC157 on regional serotonin synthesis in the rat brain: alpha-methyl-L-tryptophan autoradiographic measurements
    Y Tohyama
    Cone Neurosurgical Research Laboratory, Department of Neurology and Neurosurgery, and Montreal Neurological Institute, McGill University, 3801 University Street, Montreal, Quebec, Canada H3A 2B4
    Life Sci 76:345-57. 2004
    ..This data suggests that BPC157, a gut peptide, influences brain 5-HT synthesis in rats, but we cannot determine, from this data, the mechanism of this action...
  12. ncbi request reprint Increasing blood oxygen increases an index of 5-HT synthesis in human brain as measured using alpha-[(11)C]methyl-L-tryptophan and positron emission tomography
    M Nishikawa
    Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, 3801 University St Montreal, QC H3A2B4, Canada
    Neurochem Int 47:556-64. 2005
    ..1+/-7.7 mmHg) blood oxygen levels. This suggests that tryptophan hydroxylase is not saturated with oxygen in the living human brain and that increases in blood oxygen can elevate brain serotonin synthesis...
  13. ncbi request reprint Reduction in serotonin synthesis following acute and chronic treatments with paroxetine, a selective serotonin reuptake inhibitor, in rat brain: an autoradiographic study with alpha-[14C]methyl-L-tryptophan(2)
    F Yamane
    Cone Laboratory for Neurosurgical Research, Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, 3801 University St, H3A 2B4, Montreal, Quebec, Canada
    Biochem Pharmacol 62:1481-9. 2001
    ..In conclusion, the present data suggest that the effects of paroxetine on 5-HT synthesis in the cerebral cortex are different from its effects in the cell body area of the brainstem...
  14. ncbi request reprint The effects of the 5-HT3 antagonist, alosetron, on brain serotonin synthesis in patients with irritable bowel syndrome
    A Nakai
    McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, 3801 University Street, Montreal, QC, Canada H3A2B4
    Neurogastroenterol Motil 17:212-21. 2005
    ..The gender differences in the effect of alosetron on brain 5-HT synthesis may be related to the gender differences in the efficacy of alosetron...
  15. doi request reprint Time-efficient and convenient synthesis of [(18)F]altanserin for human PET imaging by a new work-up procedure
    G Massarweh
    McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada
    Appl Radiat Isot 67:2040-3. 2009
    ..The synthesis was performed semi-automatically in a modified GE TracerLab synthesis module using an in-house-developed program. The synthesized [(18)F]altanserin was used in our ongoing human and animal PET imaging studies...
  16. ncbi request reprint Measurement of cerebral blood flow and volume with positron emission tomography during isoflurane administration in the hypocapnic baboon
    D P Archer
    Department of Anesthesia, McGill University, Montreal, Canada
    Anesthesiology 72:1031-7. 1990
    ..05) and addition of isoflurane did not change CBV. From these results the authors conclude that in the normal hypocapnic baboon the addition of 1.3% isoflurane does not significantly change cerebral blood flow or volume...
  17. ncbi request reprint PET studies of potential chemotherapeutic agents--X. Synthesis of "no-carrier-added" (11C)-HECNU: the hydroxyethyl analog of the chemotherapeutic agent BCNU
    T Conway
    McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, Quebec, Canada
    Int J Rad Appl Instrum A 42:441-6. 1991
    ..This synthesis yielded (11C)-HECNU with an average radiochemical purity of 98% in an average radiochemical yield of 18% relative to the radioactivity measured at the end of the 11C-phosgene introduction...
  18. ncbi request reprint Effects of acute or chronic administration of anti-migraine drugs sumatriptan and zolmitriptan on serotonin synthesis in the rat brain
    C F Dobson
    Laboratory of Cerebrovascular Research, Montreal Neurological Institute, McGill University, 3801 University Street, Montreal, Quebec, Canada H3A 2B4
    Cephalalgia 24:2-11. 2004
    ..Overall, the present findings indicate that not only zolmitriptan but also sumatriptan affect brain serotonergic neurotransmission...
  19. ncbi request reprint Selective decrease in serotonin synthesis rate in rat brainstem raphe nuclei following chronic administration of low doses of amitriptyline: an effect compatible with an anti-migraine effect
    T Pringsheim
    Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada
    Cephalalgia 23:367-75. 2003
    ....
  20. ncbi request reprint Alpha-[11C] methyl-L-tryptophan and glucose metabolism in patients with temporal lobe epilepsy
    J Natsume
    Department of Neurology and Neurosurgery, Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada
    Neurology 60:756-61. 2003
    ..To determine whether metabolism in the brain serotonergic system, including the kynurenine pathway, is involved in temporal lobe epilepsy (TLE)...
  21. ncbi request reprint Synthesis, receptor binding and target-tissue uptake of carbon-11-labeled carbamate derivatives of estradiol and hexestrol
    H Ali
    MRC Group in the Radiation Sciences, Faculty of Medicine, University of Sherbrooke, Quebec, Canada
    Int J Rad Appl Instrum B 19:175-82. 1992
    ..In spite of this, affinity for the estrogen receptor was strongly impaired for all carbamate derivatives. Likewise, in vivo, the [11C]carbamate analogs failed to localize in receptor rich tissue via an estrogen receptor mediated process...