Affiliation: McGill University
- The neurobiology of appetite: hunger as addictionA Dagher
Department of Neurology, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada
Int J Obes (Lond) 33:S30-3. 2009..In this overview and the associated reviews, the behavioral, genetic and neural factors that promote over-eating in animals and humans are discussed...
- From anticipation to action, the role of dopamine in perceptual decision making: an fMRI-tyrosine depletion studyAtsuko Nagano-Saito
Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada
J Neurophysiol 108:501-12. 2012....
- Functional brain imaging of appetiteAlain Dagher
Montreal Neurological Institute, McGill University, 3801 University Street, Montreal, Quebec, H3A 2B4, Canada
Trends Endocrinol Metab 23:250-60. 2012..This article reviews the recent use of functional brain imaging in humans to study the neural control of appetite, and how the neural systems involved may cause vulnerability to overeating in the obesogenic environment...
- An acute psychosocial stress enhances the neural response to smoking cuesAlain Dagher
Montreal Neurological Institute, McGill University, 3801 University St, Montreal QC, Canada H3A 2B4
Brain Res 1293:40-8. 2009..Stress-induced limbic deactivation predicted subsequent neural cue-reactivity. We suggest that stress increases the incentive salience of drug cues...
- Personality, addiction, dopamine: insights from Parkinson's diseaseAlain Dagher
Montreal Neurological Institute, McGill University, 3801 University Street, Montreal, QC H3A 2B4, Canada
Neuron 61:502-10. 2009..We describe the clinical phenomena and attempt to relate them to current models of learning and addiction. We conclude that persistently elevated dopaminergic stimulation promotes the development and maintenance of addictive behaviors...
- Neural substrates of cognitive skill learning in Parkinson's diseaseM H Beauchamp
Departement de Psychologie, Universite de Montreal, C P 6128 Succursale Centre Ville, Montreal, Que, Canada
Brain Cogn 68:134-43. 2008..These findings reflect a shift to the explicit memory system in PD patients, enabling them to learn this cognitive skill, which is normally acquired by control subjects using implicit learning strategies and frontostriatal circuitry...
- Stimulation of dopa decarboxylase activity in striatum of healthy human brain secondary to NMDA receptor antagonism with a low dose of amantadineP Deep
McConnell Brain Imaging Center, Montreal Neurological Institute, 3801 University St, Montreal, Quebec, Canada H3A 2B4
Synapse 34:313-8. 1999..Nonetheless, PET studies in parkinsonian patients using higher, clinically effective doses of amantadine may reveal more pronounced enhancements of cerebral DDC activity...
- A neural model of working memory processes in normal subjects, Parkinson's disease and schizophrenia for fMRI design and predictionsO Monchi
McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Que, Canada
Neural Netw 13:953-73. 2000..A specific event-related functional magnetic resonance imaging study was elaborated to test some of those predictions...
- Pharmacokinetics of radiotracers in human plasma during positron emission tomographyP Cumming
McConnell Brain Imaging Centre, Montreal Neurological Institute, Montreal, Canada
Synapse 34:124-34. 1999..Drug-drug interactions were revealed in subjects treated with specific pharmacological agents prior to tracer administration...
- Wisconsin Card Sorting revisited: distinct neural circuits participating in different stages of the task identified by event-related functional magnetic resonance imagingO Monchi
McConnell Brain Imaging Centre and Cognitive Neuroscience Unit, Montreal Neurological Institute, McGill University, , , H3A 2B4 Canada
J Neurosci 21:7733-41. 2001..The putamen exhibited increased activity while matching after negative feedback but not while matching after positive feedback, implying greater involvement during novel than routine actions...
- Mapping the network for planning: a correlational PET activation study with the Tower of London taskA Dagher
Medical Research Council Cyclotron Unit, Hammersmith Hospital, Montreal, Canada
Brain 122:1973-87. 1999..We propose that dorsolateral prefrontal, lateral premotor, anterior cingulate and caudate areas form a network for the planning of movement that interacts with brain areas primarily involved in visual processing and movement execution...
- Food and drug cues activate similar brain regions: a meta-analysis of functional MRI studiesD W Tang
Department of Psychology, McGill University, Montreal Neurological Institute, Montreal, QC, Canada
Physiol Behav 106:317-24. 2012..There is significant overlap in brain regions responding to conditioned cues associated with natural and drug rewards...
- Repetitive transcranial magnetic stimulation of the human prefrontal cortex induces dopamine release in the caudate nucleusA P Strafella
Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada H3A 2B4
J Neurosci 21:RC157. 2001..This finding has implications for the therapeutic and research use of rTMS in neurological and psychiatric disorders...
- The role of the striatum and hippocampus in planning: a PET activation study in Parkinson's diseaseA Dagher
MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, London, UK
Brain 124:1020-32. 2001..This could represent a shift to the declarative memory system in Parkinson's disease during performance of the TOL task, possibly resulting from insufficient working memory capacity within the frontostriatal system...
- Reduced dopamine D1 receptor binding in the ventral striatum of cigarette smokersA Dagher
McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, Canada
Synapse 42:48-53. 2001..Such a hypodopaminergic state may play an important role in sustaining nicotine-seeking behavior. Alternatively, an inherited reduction in dopamine receptors in the striatum may be associated with an increased risk of addictive behavior...
- Critical involvement of the thalamus and precuneus during restoration of consciousness with physostigmine in humans during propofol anaesthesia: a positron emission tomography studyG Xie
Department of Anesthesia, McGill University, Montreal, QC, Canada H3A 1A2
Br J Anaesth 106:548-57. 2011..However, functional imaging changes may result from drug effects unrelated to hypnosis. Establishing a causal link with loss of consciousness is thus difficult...
- Dynamic functional changes associated with cognitive skill learning of an adapted version of the Tower of London taskM H Beauchamp
, Montreal, Quebec, Canada
Neuroimage 20:1649-60. 2003..In sum, the results lend further support to the idea that the learning of cognitive skills requiring planning and working memory capacities is mediated through a fronto-striatal network...