Andrey V Cybulsky
Affiliation: McGill University
Cybulsky A, Takano T, Papillon J, Kitzler T, Bijian K. Endoplasmic reticulum stress in glomerular epithelial cell injury. Am J Physiol Renal Physiol. 2011;301:F496-508 pubmed publisher
..FSGS is associated with induction of ER stress. Enhancing protective aspects of the ER stress response may reduce apoptosis and possibly glomerulosclerosis. ..
Sareen Khanna K, Papillon J, Wing S, Cybulsky A. Role of the deubiquitinating enzyme ubiquitin-specific protease-14 in proteostasis in renal cells. Am J Physiol Renal Physiol. 2016;311:F1035-F1046 pubmed publisher
..In conclusion, Usp14 controls proteasomal degradation of some misfolded proteins. In addition, a Usp14-directed inhibitor reduces cytotoxicity in the context of global protein misfolding during certain types of renal cell injury. ..
Kaufman D, Papillon J, Larose L, Iwawaki T, Cybulsky A. Deletion of inositol-requiring enzyme-1? in podocytes disrupts glomerular capillary integrity and autophagy. Mol Biol Cell. 2017;28:1636-1651 pubmed publisher
..Thus IRE1? is essential for maintaining podocyte and glomerular integrity as mice age and in glomerulonephritis. The mechanism is related, at least in part, to the maintenance of autophagy in podocytes. ..
Cybulsky A, Papillon J, Guillemette J, Belkina N, Patino Lopez G, Torban E. Ste20-like Kinase, SLK, a Novel Mediator of Podocyte Integrity. Am J Physiol Renal Physiol. 2017;:ajprenal.00238.2017 pubmed publisher
..In summary, podocyte-specific deletion of SLK leads to albuminuria, loss of podocytes and morphologic evidence of podocyte injury. Thus, SLK is essential to the maintenance of podocyte integrity as mice age...
Cybulsky A, Takano T, Papillon J, Khadir A, Liu J, Peng H. Complement C5b-9 membrane attack complex increases expression of endoplasmic reticulum stress proteins in glomerular epithelial cells. J Biol Chem. 2002;277:41342-51 pubmed
..Thus, C5b-9 injures the ER and enhances ER stress protein expression, in part, via activation of cPLA(2). ER stress protein induction is a novel mechanism of protection from complement attack. ..
Cybulsky A, Takano T, Papillon J, Khadir A, Bijian K, Chien C, et al
. Renal expression and activity of the germinal center kinase SK2. Am J Physiol Renal Physiol. 2004;286:F16-25 pubmed
..The actions of SK2 appear to be antiproliferative and may facilitate cell injury. ..
Cybulsky A, Takano T, Papillon J, Bijian K, Guillemette J, Kennedy C. Glomerular epithelial cell injury associated with mutant alpha-actinin-4. Am J Physiol Renal Physiol. 2009;297:F987-95 pubmed publisher
..In addition, alpha-actinin-4 K256E exacerbated apoptosis in the context of mild proteasome inhibition. Thus alpha-actinin-4 K256E triggers several metabolic abnormalities, which may lead to GEC injury and glomerulosclerosis. ..
Cybulsky A, Takano T, Papillon J, Guillemette J, Herzenberg A, Kennedy C. Podocyte injury and albuminuria in mice with podocyte-specific overexpression of the Ste20-like kinase, SLK. Am J Pathol. 2010;177:2290-9 pubmed publisher
..Thus, podocyte SLK overexpression in vivo results in injury and podocyte loss, consistent with the effects of SLK in cultured cells. ..
Nezvitsky L, Tremblay M, Takano T, Papillon J, Cybulsky A. Complement-mediated glomerular injury is reduced by inhibition of protein-tyrosine phosphatase 1B. Am J Physiol Renal Physiol. 2014;307:F634-47 pubmed publisher
..The cytoprotective effects of PTP1B deletion in cultured cells and in anti-glomerular basement membrane nephritis suggest that PTP1B may potentially be a therapeutic target in complement-mediated diseases. ..