A Cuello

Summary

Affiliation: McGill University
Country: Canada

Publications

  1. ncbi request reprint Long-lasting rescue of age-associated deficits in cognition and the CNS cholinergic phenotype by a partial agonist peptidomimetic ligand of TrkA
    Martin A Bruno
    Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, H3T 1E2 Canada
    J Neurosci 24:8009-18. 2004
  2. doi request reprint Cholinergic involvement in Alzheimer's disease. A link with NGF maturation and degradation
    A Claudio Cuello
    Department of Pharmacology and Therapeutics, McGill University, Montreal, QC, H3G 1Y6, Canada
    J Mol Neurosci 40:230-5. 2010
  3. doi request reprint Modeling Alzheimer's disease in transgenic rats
    Sonia Do Carmo
    Department of Pharmacology and Therapeutics, McGill University, 3655 Promenade Sir William Osler, Room 1325, Montreal, Quebec H3G 1Y6, Canada
    Mol Neurodegener 8:37. 2013
  4. doi request reprint Evidence for the accumulation of Abeta immunoreactive material in the human brain and in transgenic animal models
    A Claudio Cuello
    Department of Pharmacology and Therapeutics, McGill University, 3655 Sir William Osler Promenade, Room 1210, Montreal, Quebec, Canada
    Life Sci 91:1141-7. 2012
  5. doi request reprint Preplaque ('preclinical') Aβ-induced inflammation and nerve growth factor deregulation in transgenic models of Alzheimer's disease-like amyloid pathology
    A C Cuello
    Department of Pharmacology and Therapeutics, McGill University, Montreal, Que, Canada
    Neurodegener Dis 10:104-7. 2012
  6. pmc Minocycline corrects early, pre-plaque neuroinflammation and inhibits BACE-1 in a transgenic model of Alzheimer's disease-like amyloid pathology
    Maria Teresa Ferretti
    Department of Pharmacology and Therapeutics, McGill University, 3655 Promenade Sir William Osler, Montreal, QC H3G 1Y6, Canada
    J Neuroinflammation 9:62. 2012
  7. doi request reprint Gangliosides, NGF, brain aging and disease: a mini-review with personal reflections
    A Claudio Cuello
    Department of Pharmacology and Therapeutics, McGill University, Montreal, QC, Canada
    Neurochem Res 37:1256-60. 2012
  8. ncbi request reprint The failure in NGF maturation and its increased degradation as the probable cause for the vulnerability of cholinergic neurons in Alzheimer's disease
    A Claudio Cuello
    Departments of Pharmacology and Therapeutics, McGill University, 3655 Promenade Sir William Osler, Montreal, QC, Canada
    Neurochem Res 32:1041-5. 2007
  9. doi request reprint Impact of intracellular beta-amyloid in transgenic animals and cell models
    A Claudio Cuello
    Department of Pharmacology and Therapeutics, McGill University, Montreal, Que, Canada
    Neurodegener Dis 5:146-8. 2008
  10. ncbi request reprint Intracellular and extracellular Abeta, a tale of two neuropathologies
    A Claudio Cuello
    Department of Pharmacology and Therapeutics, McGill University, Montreal, Canada
    Brain Pathol 15:66-71. 2005

Research Grants

Collaborators

  • Valentina Echeverria
  • Karen E Duff
  • David A Bennett
  • M Szyf
  • Karim Nader
  • Falk Fahrenholz
  • H Uri Saragovi
  • WILLIAM KLEIN
  • Juhani Janne
  • ELLIOTT JAY MUFSON
  • J Avila
  • Mauro Costa-Mattioli
  • Martin A Bruno
  • Karen F S Bell
  • M T Ferretti
  • Alfredo Ribeiro-Da-Silva
  • Maria Teresa Ferretti
  • Adriana Ducatenzeiler
  • Sonia Do Carmo
  • Vanessa Partridge
  • Simon Allard
  • Maria Antonietta Casu
  • Wanda Carolina Leon
  • Leena Alhonen
  • Maryam Majdi
  • Tak Pan Wong
  • Freya G G Vercauteren
  • Yves De Koninck
  • Isabella Ruocco
  • F Vercauteren
  • D N Arvanitis
  • V Partridge
  • S Allard
  • C G Glabe
  • W C Leon
  • D Houle
  • A Ducatenzeiler
  • F Canneva
  • Fabio Canneva
  • Freya Vercauteren
  • Ramtin Atifeh
  • Arald DeWilde
  • Guillermina Almazan
  • Wanda C Leon
  • Walter E Mushynski
  • Joanne Wuu
  • Gabriela Fragoso
  • Luyu Zheng
  • Giorgio Marchese
  • Lut Arckens
  • Line Roy
  • Stefan Clerens
  • Nathalie Hamel
  • Kevin Burgess
  • Remi Quirion
  • Frans Vandesande
  • Paul B S Clarke
  • Alicia Seltzer
  • Andre Parent
  • T P Wong

Detail Information

Publications30

  1. ncbi request reprint Long-lasting rescue of age-associated deficits in cognition and the CNS cholinergic phenotype by a partial agonist peptidomimetic ligand of TrkA
    Martin A Bruno
    Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, H3T 1E2 Canada
    J Neurosci 24:8009-18. 2004
    ..Small, proteolytically stable ligands with selective agonistic activity at a growth factor receptor may have therapeutic potential for neurodegenerative disorders...
  2. doi request reprint Cholinergic involvement in Alzheimer's disease. A link with NGF maturation and degradation
    A Claudio Cuello
    Department of Pharmacology and Therapeutics, McGill University, Montreal, QC, H3G 1Y6, Canada
    J Mol Neurosci 40:230-5. 2010
    ....
  3. doi request reprint Modeling Alzheimer's disease in transgenic rats
    Sonia Do Carmo
    Department of Pharmacology and Therapeutics, McGill University, 3655 Promenade Sir William Osler, Room 1325, Montreal, Quebec H3G 1Y6, Canada
    Mol Neurodegener 8:37. 2013
    ..Consequently, rat models of AD should allow a more sophisticated and accurate assessment of the impact of pathology and novel therapeutics on cognitive outcomes. ..
  4. doi request reprint Evidence for the accumulation of Abeta immunoreactive material in the human brain and in transgenic animal models
    A Claudio Cuello
    Department of Pharmacology and Therapeutics, McGill University, 3655 Sir William Osler Promenade, Room 1210, Montreal, Quebec, Canada
    Life Sci 91:1141-7. 2012
    ..Finally, we discuss the possible pathological significance of these intracellular APP fragments and the expected future research directions regarding this thought-provoking problem...
  5. doi request reprint Preplaque ('preclinical') Aβ-induced inflammation and nerve growth factor deregulation in transgenic models of Alzheimer's disease-like amyloid pathology
    A C Cuello
    Department of Pharmacology and Therapeutics, McGill University, Montreal, Que, Canada
    Neurodegener Dis 10:104-7. 2012
    ..Our transgenic (tg) animal models are most suitable to study early AD pathological events, as the pathology evolves in a well-staged manner, starting with intracellular Aβ accumulation and ending with plaque deposition...
  6. pmc Minocycline corrects early, pre-plaque neuroinflammation and inhibits BACE-1 in a transgenic model of Alzheimer's disease-like amyloid pathology
    Maria Teresa Ferretti
    Department of Pharmacology and Therapeutics, McGill University, 3655 Promenade Sir William Osler, Montreal, QC H3G 1Y6, Canada
    J Neuroinflammation 9:62. 2012
    ..The role of such a pro-inflammatory process in the progression of the pathology remained to be elucidated...
  7. doi request reprint Gangliosides, NGF, brain aging and disease: a mini-review with personal reflections
    A Claudio Cuello
    Department of Pharmacology and Therapeutics, McGill University, Montreal, QC, Canada
    Neurochem Res 37:1256-60. 2012
    ....
  8. ncbi request reprint The failure in NGF maturation and its increased degradation as the probable cause for the vulnerability of cholinergic neurons in Alzheimer's disease
    A Claudio Cuello
    Departments of Pharmacology and Therapeutics, McGill University, 3655 Promenade Sir William Osler, Montreal, QC, Canada
    Neurochem Res 32:1041-5. 2007
    ..This metabolic scenario in Alzheimer's disease should result in the failure of NGF trophic support to forebrain cholinergic neurons and thus explaining the vulnerability of these neurons in this neurodegenerative condition...
  9. doi request reprint Impact of intracellular beta-amyloid in transgenic animals and cell models
    A Claudio Cuello
    Department of Pharmacology and Therapeutics, McGill University, Montreal, Que, Canada
    Neurodegener Dis 5:146-8. 2008
    ..Moreover, intracellular pathology would be independent and additive to the toxic effects of the extracellular Abeta burden...
  10. ncbi request reprint Intracellular and extracellular Abeta, a tale of two neuropathologies
    A Claudio Cuello
    Department of Pharmacology and Therapeutics, McGill University, Montreal, Canada
    Brain Pathol 15:66-71. 2005
    ....
  11. doi request reprint Early-stage inflammation and experimental therapy in transgenic models of the Alzheimer-like amyloid pathology
    A C Cuello
    Department of Pharmacology and Therapeutics, McGill University, Montreal, Que, Canada
    Neurodegener Dis 7:96-8. 2010
    ....
  12. ncbi request reprint Transgenic mice as a model of pre-clinical Alzheimer's disease
    M T Ferretti
    Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada
    Curr Alzheimer Res 8:4-23. 2011
    ..Similar neuronal alterations might occur prior to clinical diagnosis in AD, during a yet undefined 'latent' stage. A better understanding of such pre-clinical AD might yield novel therapeutic targets and or diagnostic tools...
  13. ncbi request reprint NGF-cholinergic dependency in brain aging, MCI and Alzheimer's disease
    A C Cuello
    Department of Pharmacology and Therapeutics, McGill University, Montreal, QC, Canada
    Curr Alzheimer Res 4:351-8. 2007
    ..Given that proNGF is known to be upregulated in AD patients a dysregulation in the maturation or degradation of mature NGF might explain the preferential vulnerability of the cholinergic system in the AD pathology...
  14. doi request reprint Amyloid beta-induced nerve growth factor dysmetabolism in Alzheimer disease
    Martin A Bruno
    Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada
    J Neuropathol Exp Neurol 68:857-69. 2009
    ..The effects of amyloid-beta amyloid CNS burden on NGF metabolism may explain the paradoxical upregulation of pro-NGF in AD accompanied by atrophy of forebrain cholinergic neurons...
  15. pmc Activity-dependent release of precursor nerve growth factor, conversion to mature nerve growth factor, and its degradation by a protease cascade
    Martin A Bruno
    Department of Pharmacology and Therapeutics, McGill University, Montreal, QC, Canada H3G 1Y6
    Proc Natl Acad Sci U S A 103:6735-40. 2006
    ....
  16. ncbi request reprint Paradoxical upregulation of glutamatergic presynaptic boutons during mild cognitive impairment
    Karen F S Bell
    Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada H3G 1Y6
    J Neurosci 27:10810-7. 2007
    ..This pattern of synaptic remodeling mirrors our previous findings in transgenic animal models and is of major relevance to current transmitter-based therapeutics...
  17. ncbi request reprint Intracellular A-beta amyloid, a sign for worse things to come?
    Valentina Echeverria
    Department of Pharmacology and Therapeutics, McGill University, Montreal, QC, Canada
    Mol Neurobiol 26:299-316. 2002
    ....
  18. ncbi request reprint Early dysregulation of hippocampal proteins in transgenic rats with Alzheimer's disease-linked mutations in amyloid precursor protein and presenilin 1
    Freya G G Vercauteren
    Department of Pharmacology and Therapeutics, McGill University, 3655 Promenade Sir William Osler, Montreal, Quebec, Canada H3G 1Y6
    Brain Res Mol Brain Res 132:241-59. 2004
    ..The implications of these findings on our understanding of the early stages of AD are discussed...
  19. ncbi request reprint The amyloid pathology progresses in a neurotransmitter-specific manner
    Karen F S Bell
    Department of Pharmacology and Therapeutics, McGill University, 3655 Sir William Osler Promenade, Montreal, Que, Canada, H3G 1Y6
    Neurobiol Aging 27:1644-57. 2006
    ..Subsequent staining in AD brain tissue revealed the novel presence of glutamatergic dystrophic neurites, to our knowledge the first evidence of a structural glutamatergic deficit in the AD pathology...
  20. ncbi request reprint Rat transgenic models with a phenotype of intracellular Abeta accumulation in hippocampus and cortex
    Valentina Echeverria
    Department of Pharmacology and Therapeutics, McGill University, Montreal, Canada
    J Alzheimers Dis 6:209-19. 2004
    ..A preliminary protein analysis of the hippocampus of the double transgenic rat (UKUR25) by mass spectrometry showed differences in the protein profile between this transgenic line and controls...
  21. pmc Increased matrix metalloproteinase 9 activity in mild cognitive impairment
    Martin A Bruno
    Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada
    J Neuropathol Exp Neurol 68:1309-18. 2009
    ..These findings suggest that a reduction in mNGF as a consequence of MMP-9-mediated degradation may in part underlie the pathogenesis of cognitive deficits in mild cognitive impairment and AD...
  22. ncbi request reprint Does a pro-inflammatory process precede Alzheimer's disease and mild cognitive impairment?
    M T Ferretti
    Department of Pharmacology and Therapeutics, McGill University, 3655 Promenade Sir William Osler, Room 1325, Montreal, Quebec, Canada
    Curr Alzheimer Res 8:164-74. 2011
    ..Finally, we propose MMP-9 as a promising biomarker for signalling early stages of an ongoing CNS inflammation...
  23. ncbi request reprint Skin blood vessels are simultaneously innervated by sensory, sympathetic, and parasympathetic fibers
    Isabella Ruocco
    Department of Pharmacology, McGill University, Montreal, Quebec, Canada H3G 1Y6
    J Comp Neurol 448:323-36. 2002
    ..Our findings suggest that the regulation of skin microcirculation might be the result of the coordinated functions of sensory and autonomic fibers...
  24. ncbi request reprint ADAM-10 over-expression increases cortical synaptogenesis
    Karen F S Bell
    Department of Pharmacology and Therapeutics, McGill University, Montreal, Canada
    Neurobiol Aging 29:554-65. 2008
    ..These results are the first to demonstrate an in vivo influence of ADAM-10 on neurotransmitter-specific cortical synaptic plasticity and further confirm the neurotrophic influence of sAPP alpha on cortical synaptogenesis...
  25. doi request reprint A novel transgenic rat model with a full Alzheimer's-like amyloid pathology displays pre-plaque intracellular amyloid-beta-associated cognitive impairment
    Wanda Carolina Leon
    Department of Pharmacology and Therapeutics, McGill University, Montreal, QC, Canada
    J Alzheimers Dis 20:113-26. 2010
    ..The spatial cognitive impairment becomes more prominent in older animals (13 months), where the behavioral performance of Tg rats positively correlates with the levels of soluble Abeta (trimers) measured in the cortex...
  26. pmc Translational control of hippocampal synaptic plasticity and memory by the eIF2alpha kinase GCN2
    Mauro Costa-Mattioli
    Department of Biochemistry and McGill Cancer Center, Montreal, Quebec, Canada
    Nature 436:1166-73. 2005
    ..Our study provides genetic, physiological, behavioural and molecular evidence that GCN2 regulates synaptic plasticity, as well as learning and memory, through modulation of the ATF4/CREB pathway...
  27. ncbi request reprint Imbalance towards inhibition as a substrate of aging-associated cognitive impairment
    Tak Pan Wong
    Department of Pharmacology and Therapeutics, McGill University, Montreal, Que, Canada H3G 1Y6
    Neurosci Lett 397:64-8. 2006
    ..Thus, cognitive impairment may be more related to an altered balance between different neurotransmitter systems than a mere reduction in synaptic structures...
  28. ncbi request reprint Cognitive impairment and transmitter-specific pre- and postsynaptic changes in the rat cerebral cortex during ageing
    Maryam Majdi
    Department of Pharmacology and Therapeutics, McGill University, 3655 Promenade Sir William Osler, Room 1325, Montreal, Quebec, Canada, H3G 1Y6
    Eur J Neurosci 26:3583-96. 2007
    ..Significant changes in the ratios of excitatory to inhibitory postsynaptic densities were observed only in AI compared to young rats...
  29. ncbi request reprint Tau function and dysfunction in neurons: its role in neurodegenerative disorders
    Jesus Avila
    Centro de Biologia Molecular CSIC UAM, Universidad Autónoa, Madrid, Spain
    Mol Neurobiol 25:213-31. 2002
    ..It is characterized by the presence of two main brain pathological hallmarks: senile plaques and neurofibrillary tangles (NFTs). NFTs are composed of fibrillar polymers of the abnormally phosphorylated cytoskeletal protein tau...
  30. ncbi request reprint Aging causes a preferential loss of cholinergic innervation of characterized neocortical pyramidal neurons
    Maria Antonietta Casu
    Departments of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada, H3G 1Y6
    Cereb Cortex 12:329-37. 2002
    ..Our results add important new evidence in support of the concept that the age-related learning and memory deficits are attributable, at least partially, to a decline in the functional integrity of the forebrain cholinergic systems...

Research Grants3

  1. Synaptic Alterations in the Cerebral Cortex during Aging
    A Cuello; Fiscal Year: 2005
    ..abstract_text> ..