Research Topics
| A CuelloSummaryAffiliation: McGill University Country: Canada Publications
Research Grants
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Detail Information
Publications
Long-lasting rescue of age-associated deficits in cognition and the CNS cholinergic phenotype by a partial agonist peptidomimetic ligand of TrkAMartin A Bruno
Department of Pharmacology and Therapeutics, McGill University, , Quebec, H3T 1E2 Canada
J Neurosci 24:8009-18. 2004..Small, proteolytically stable ligands with selective agonistic activity at a growth factor receptor may have therapeutic potential for neurodegenerative disorders...
Cholinergic involvement in Alzheimer's disease. A link with NGF maturation and degradationA Claudio Cuello
Department of Pharmacology and Therapeutics, McGill University, Montreal, QC, H3G 1Y6, Canada
J Mol Neurosci 40:230-5. 2010....- Evidence for the accumulation of Abeta immunoreactive material in the human brain and in transgenic animal modelsA Claudio Cuello
Department of Pharmacology and Therapeutics, McGill University, 3655 Sir William Osler Promenade, Room 1210, Montreal, Quebec, Canada
Life Sci 91:1141-7. 2012..Finally, we discuss the possible pathological significance of these intracellular APP fragments and the expected future research directions regarding this thought-provoking problem... - Preplaque ('preclinical') Aβ-induced inflammation and nerve growth factor deregulation in transgenic models of Alzheimer's disease-like amyloid pathologyA C Cuello
Department of Pharmacology and Therapeutics, McGill University, Montreal, Que, Canada
Neurodegener Dis 10:104-7. 2012..Our transgenic (tg) animal models are most suitable to study early AD pathological events, as the pathology evolves in a well-staged manner, starting with intracellular Aβ accumulation and ending with plaque deposition... 
Minocycline corrects early, pre-plaque neuroinflammation and inhibits BACE-1 in a transgenic model of Alzheimer's disease-like amyloid pathologyMaria Teresa Ferretti
Department of Pharmacology and Therapeutics, McGill University, 3655 Promenade Sir William Osler, Montreal, QC H3G 1Y6, Canada
J Neuroinflammation 9:62. 2012..The role of such a pro-inflammatory process in the progression of the pathology remained to be elucidated...- Gangliosides, NGF, brain aging and disease: a mini-review with personal reflectionsA Claudio Cuello
Department of Pharmacology and Therapeutics, McGill University, Montreal, QC, Canada
Neurochem Res 37:1256-60. 2012.... - NGF-cholinergic dependency in brain aging, MCI and Alzheimer's diseaseA C Cuello
Department of Pharmacology and Therapeutics, McGill University, Montreal, QC, Canada
Curr Alzheimer Res 4:351-8. 2007..Given that proNGF is known to be upregulated in AD patients a dysregulation in the maturation or degradation of mature NGF might explain the preferential vulnerability of the cholinergic system in the AD pathology... - Impact of intracellular beta-amyloid in transgenic animals and cell modelsA Claudio Cuello
Department of Pharmacology and Therapeutics, McGill University, Montreal, Que, Canada
Neurodegener Dis 5:146-8. 2008..Moreover, intracellular pathology would be independent and additive to the toxic effects of the extracellular Abeta burden... - Early-stage inflammation and experimental therapy in transgenic models of the Alzheimer-like amyloid pathologyA C Cuello
Department of Pharmacology and Therapeutics, McGill University, Montreal, Que, Canada
Neurodegener Dis 7:96-8. 2010.... - Transgenic mice as a model of pre-clinical Alzheimer's diseaseM T Ferretti
Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada
Curr Alzheimer Res 8:4-23. 2011..Similar neuronal alterations might occur prior to clinical diagnosis in AD, during a yet undefined 'latent' stage. A better understanding of such pre-clinical AD might yield novel therapeutic targets and or diagnostic tools... - The failure in NGF maturation and its increased degradation as the probable cause for the vulnerability of cholinergic neurons in Alzheimer's diseaseA Claudio Cuello
Departments of Pharmacology and Therapeutics, McGill University, 3655 Promenade Sir William Osler, Montreal, QC, Canada
Neurochem Res 32:1041-5. 2007..This metabolic scenario in Alzheimer's disease should result in the failure of NGF trophic support to forebrain cholinergic neurons and thus explaining the vulnerability of these neurons in this neurodegenerative condition... - Intracellular and extracellular Abeta, a tale of two neuropathologiesA Claudio Cuello
Department of Pharmacology and Therapeutics, McGill University, Montreal, Canada
Brain Pathol 15:66-71. 2005.... - Activity-dependent release of precursor nerve growth factor, conversion to mature nerve growth factor, and its degradation by a protease cascadeMartin A Bruno
Department of Pharmacology and Therapeutics, McGill University, Montreal, QC, Canada H3G 1Y6
Proc Natl Acad Sci U S A 103:6735-40. 2006.... - Amyloid beta-induced nerve growth factor dysmetabolism in Alzheimer diseaseMartin A Bruno
Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada
J Neuropathol Exp Neurol 68:857-69. 2009..The effects of amyloid-beta amyloid CNS burden on NGF metabolism may explain the paradoxical upregulation of pro-NGF in AD accompanied by atrophy of forebrain cholinergic neurons... - Intracellular A-beta amyloid, a sign for worse things to come?Valentina Echeverria
Department of Pharmacology and Therapeutics, McGill University, Montreal, QC, Canada
Mol Neurobiol 26:299-316. 2002.... - Paradoxical upregulation of glutamatergic presynaptic boutons during mild cognitive impairmentKaren F S Bell
Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada H3G 1Y6
J Neurosci 27:10810-7. 2007..This pattern of synaptic remodeling mirrors our previous findings in transgenic animal models and is of major relevance to current transmitter-based therapeutics... - Increased matrix metalloproteinase 9 activity in mild cognitive impairmentMartin A Bruno
Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada
J Neuropathol Exp Neurol 68:1309-18. 2009..These findings suggest that a reduction in mNGF as a consequence of MMP-9-mediated degradation may in part underlie the pathogenesis of cognitive deficits in mild cognitive impairment and AD... - Rat transgenic models with a phenotype of intracellular Abeta accumulation in hippocampus and cortexValentina Echeverria
Department of Pharmacology and Therapeutics, McGill University, Montreal, Canada
J Alzheimers Dis 6:209-19. 2004..A preliminary protein analysis of the hippocampus of the double transgenic rat (UKUR25) by mass spectrometry showed differences in the protein profile between this transgenic line and controls... - Early dysregulation of hippocampal proteins in transgenic rats with Alzheimer's disease-linked mutations in amyloid precursor protein and presenilin 1Freya G G Vercauteren
Department of Pharmacology and Therapeutics, McGill University, 3655 Promenade Sir-William-Osler, Montreal, Quebec, Canada H3G 1Y6
Brain Res Mol Brain Res 132:241-59. 2004..The implications of these findings on our understanding of the early stages of AD are discussed... - The amyloid pathology progresses in a neurotransmitter-specific mannerKaren F S Bell
Department of Pharmacology and Therapeutics, McGill University, 3655 Sir William Osler Promenade, Montreal, Que, Canada, H3G 1Y6
Neurobiol Aging 27:1644-57. 2006..Subsequent staining in AD brain tissue revealed the novel presence of glutamatergic dystrophic neurites, to our knowledge the first evidence of a structural glutamatergic deficit in the AD pathology... - Does a pro-inflammatory process precede Alzheimer's disease and mild cognitive impairment?M T Ferretti
Department of Pharmacology and Therapeutics, McGill University, 3655 Promenade Sir William Osler, Room 1325, Montreal, Quebec, Canada
Curr Alzheimer Res 8:164-74. 2011..Finally, we propose MMP-9 as a promising biomarker for signalling early stages of an ongoing CNS inflammation... - Skin blood vessels are simultaneously innervated by sensory, sympathetic, and parasympathetic fibersIsabella Ruocco
Department of Pharmacology, McGill University, Montreal, Quebec, Canada H3G 1Y6
J Comp Neurol 448:323-36. 2002..Our findings suggest that the regulation of skin microcirculation might be the result of the coordinated functions of sensory and autonomic fibers... - A novel transgenic rat model with a full Alzheimer's-like amyloid pathology displays pre-plaque intracellular amyloid-beta-associated cognitive impairmentWanda Carolina Leon
Department of Pharmacology and Therapeutics, McGill University, Montreal, QC, Canada
J Alzheimers Dis 20:113-26. 2010..The spatial cognitive impairment becomes more prominent in older animals (13 months), where the behavioral performance of Tg rats positively correlates with the levels of soluble Abeta (trimers) measured in the cortex... - Imbalance towards inhibition as a substrate of aging-associated cognitive impairmentTak Pan Wong
Department of Pharmacology and Therapeutics, McGill University, , Que, Canada H3G 1Y6
Neurosci Lett 397:64-8. 2006..Thus, cognitive impairment may be more related to an altered balance between different neurotransmitter systems than a mere reduction in synaptic structures... - Cognitive impairment and transmitter-specific pre- and postsynaptic changes in the rat cerebral cortex during ageingMaryam Majdi
Department of Pharmacology and Therapeutics, McGill University, 3655 Promenade Sir William Osler, Room 1325, Montreal, Quebec, Canada, H3G 1Y6
Eur J Neurosci 26:3583-96. 2007..Significant changes in the ratios of excitatory to inhibitory postsynaptic densities were observed only in AI compared to young rats... - Translational control of hippocampal synaptic plasticity and memory by the eIF2alpha kinase GCN2Mauro Costa-Mattioli
Department of Biochemistry and McGill Cancer Center, Montreal, Quebec, Canada
Nature 436:1166-73. 2005..Our study provides genetic, physiological, behavioural and molecular evidence that GCN2 regulates synaptic plasticity, as well as learning and memory, through modulation of the ATF4/CREB pathway... - ADAM-10 over-expression increases cortical synaptogenesisKaren F S Bell
Department of Pharmacology and Therapeutics, McGill University, Montreal, Canada
Neurobiol Aging 29:554-65. 2008..These results are the first to demonstrate an in vivo influence of ADAM-10 on neurotransmitter-specific cortical synaptic plasticity and further confirm the neurotrophic influence of sAPP alpha on cortical synaptogenesis... - Tau function and dysfunction in neurons: its role in neurodegenerative disordersJesus Avila
Centro de Biologia Molecular CSIC UAM, Universidad Autónoa, Madrid, Spain
Mol Neurobiol 25:213-31. 2002..It is characterized by the presence of two main brain pathological hallmarks: senile plaques and neurofibrillary tangles (NFTs). NFTs are composed of fibrillar polymers of the abnormally phosphorylated cytoskeletal protein tau... - Aging causes a preferential loss of cholinergic innervation of characterized neocortical pyramidal neuronsMaria Antonietta Casu
Departments of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada, H3G 1Y6
Cereb Cortex 12:329-37. 2002..Our results add important new evidence in support of the concept that the age-related learning and memory deficits are attributable, at least partially, to a decline in the functional integrity of the forebrain cholinergic systems...
Research Grants
- Synaptic Alterations in the Cerebral Cortex during AgingA Cuello; Fiscal Year: 2005..abstract_text> ..