Mauro Costa-Mattioli

Summary

Affiliation: McGill University
Country: Canada

Publications

  1. doi Translational control of the innate immune response through IRF-7
    Rodney Colina
    Department of Biochemistry and McGill Cancer Center, McGill University, Montreal, Quebec H3G 1Y6, Canada
    Nature 452:323-8. 2008
  2. doi Translational control of gene expression: a molecular switch for memory storage
    Mauro Costa-Mattioli
    Department of Biochemistry and McGill Cancer Center, 3655 Promendde Sir William Osler, McGill University, Montreal, QC H3G 1Y6, Canada
    Prog Brain Res 169:81-95. 2008
  3. ncbi Genetic variability of hepatitis A virus
    Mauro Costa-Mattioli
    Department of Biochemistry, McGill University, McIntyre Medical Building, Montreal, Quebec, Canada H3G 1Y6
    J Gen Virol 84:3191-201. 2003
  4. ncbi Translational control of long-term synaptic plasticity and memory storage by eIF2alpha
    Mauro Costa-Mattioli
    Department of Biochemistry, McGill Cancer Centre, Montreal, Quebec, Canada
    Crit Rev Neurobiol 18:187-95. 2006
  5. ncbi eIF2alpha phosphorylation bidirectionally regulates the switch from short- to long-term synaptic plasticity and memory
    Mauro Costa-Mattioli
    Department of Biochemistry and McGill Cancer Center, McGill University, Montreal, Quebec, Canada
    Cell 129:195-206. 2007
  6. pmc Postnatal deamidation of 4E-BP2 in brain enhances its association with raptor and alters kinetics of excitatory synaptic transmission
    Michael Bidinosti
    Department of Biochemistry and Goodman Cancer Centre, McGill University, Montreal, QC H3G 1Y6, Canada
    Mol Cell 37:797-808. 2010
  7. pmc Translational control of hippocampal synaptic plasticity and memory by the eIF2alpha kinase GCN2
    Mauro Costa-Mattioli
    Department of Biochemistry and McGill Cancer Center, Montreal, Quebec, Canada
    Nature 436:1166-73. 2005
  8. pmc Translational control of the activation of transcription factor NF-κB and production of type I interferon by phosphorylation of the translation factor eIF4E
    Barbara Herdy
    Department of Biochemistry, McGill University, Montreal, Quebec, Canada
    Nat Immunol 13:543-50. 2012
  9. doi Leishmania repression of host translation through mTOR cleavage is required for parasite survival and infection
    Maritza Jaramillo
    Department of Biochemistry and Goodman Cancer Center, McGill University, Montreal, Quebec, Canada
    Cell Host Microbe 9:331-41. 2011
  10. doi p53-dependent translational control of senescence and transformation via 4E-BPs
    Emmanuel Petroulakis
    Department of Biochemistry and Goodman Cancer Center, McGill University, Montreal, Quebec, H3G 1Y6, Canada
    Cancer Cell 16:439-46. 2009

Collaborators

Detail Information

Publications26

  1. doi Translational control of the innate immune response through IRF-7
    Rodney Colina
    Department of Biochemistry and McGill Cancer Center, McGill University, Montreal, Quebec H3G 1Y6, Canada
    Nature 452:323-8. 2008
    ..These findings highlight the role of 4E-BPs as negative regulators of type-I IFN production, via translational repression of Irf7 mRNA...
  2. doi Translational control of gene expression: a molecular switch for memory storage
    Mauro Costa-Mattioli
    Department of Biochemistry and McGill Cancer Center, 3655 Promendde Sir William Osler, McGill University, Montreal, QC H3G 1Y6, Canada
    Prog Brain Res 169:81-95. 2008
    ..In this chapter, we provide an overview of the role of translational control by the eIF2alpha signaling pathway in long-term synaptic plasticity and memory consolidation...
  3. ncbi Genetic variability of hepatitis A virus
    Mauro Costa-Mattioli
    Department of Biochemistry, McGill University, McIntyre Medical Building, Montreal, Quebec, Canada H3G 1Y6
    J Gen Virol 84:3191-201. 2003
    ..Its evolutionary mechanisms are described with particular emphasis on genetic recombination and HAV mutation rate. Genotypic classification methods are also discussed...
  4. ncbi Translational control of long-term synaptic plasticity and memory storage by eIF2alpha
    Mauro Costa-Mattioli
    Department of Biochemistry, McGill Cancer Centre, Montreal, Quebec, Canada
    Crit Rev Neurobiol 18:187-95. 2006
    ..In this review, we highlight the role of the eukaryotic initiation factor 2 alpha (eIF2alpha) signalling pathway in long-term synaptic plasticity and memory...
  5. ncbi eIF2alpha phosphorylation bidirectionally regulates the switch from short- to long-term synaptic plasticity and memory
    Mauro Costa-Mattioli
    Department of Biochemistry and McGill Cancer Center, McGill University, Montreal, Quebec, Canada
    Cell 129:195-206. 2007
    ..These findings highlight the importance of a single phosphorylation site in eIF2alpha as a key regulator of L-LTP and LTM formation...
  6. pmc Postnatal deamidation of 4E-BP2 in brain enhances its association with raptor and alters kinetics of excitatory synaptic transmission
    Michael Bidinosti
    Department of Biochemistry and Goodman Cancer Centre, McGill University, Montreal, QC H3G 1Y6, Canada
    Mol Cell 37:797-808. 2010
    ..4E-BP2 deamidation may represent a compensatory mechanism for the developmental reduction of PI3K-Akt-mTOR signaling...
  7. pmc Translational control of hippocampal synaptic plasticity and memory by the eIF2alpha kinase GCN2
    Mauro Costa-Mattioli
    Department of Biochemistry and McGill Cancer Center, Montreal, Quebec, Canada
    Nature 436:1166-73. 2005
    ..Our study provides genetic, physiological, behavioural and molecular evidence that GCN2 regulates synaptic plasticity, as well as learning and memory, through modulation of the ATF4/CREB pathway...
  8. pmc Translational control of the activation of transcription factor NF-κB and production of type I interferon by phosphorylation of the translation factor eIF4E
    Barbara Herdy
    Department of Biochemistry, McGill University, Montreal, Quebec, Canada
    Nat Immunol 13:543-50. 2012
    ..Thus, regulated phosphorylation of eIF4E has a key role in antiviral host defense by selectively controlling the translation of an mRNA that encodes a critical suppressor of the innate antiviral response...
  9. doi Leishmania repression of host translation through mTOR cleavage is required for parasite survival and infection
    Maritza Jaramillo
    Department of Biochemistry and Goodman Cancer Center, McGill University, Montreal, Quebec, Canada
    Cell Host Microbe 9:331-41. 2011
    ..This study demonstrates that Leishmania evolved a survival mechanism by activating 4E-BPs, which serve as major targets for host translational control...
  10. doi p53-dependent translational control of senescence and transformation via 4E-BPs
    Emmanuel Petroulakis
    Department of Biochemistry and Goodman Cancer Center, McGill University, Montreal, Quebec, H3G 1Y6, Canada
    Cancer Cell 16:439-46. 2009
    ..Our data demonstrate a role for 4E-BPs in senescence and tumorigenesis and highlight a p53-mediated mechanism of senescence through a 4E-BP-dependent pathway...
  11. pmc Stimulation of picornavirus replication by the poly(A) tail in a cell-free extract is largely independent of the poly(A) binding protein (PABP)
    Yuri V Svitkin
    Department of Biochemistry and McGill Cancer Centre, McGill University, Montreal, Quebec, Canada H3G 1Y6
    RNA 13:2330-40. 2007
    ..These results suggest that the poly(A) tail functions in picornavirus replication largely independent of PABP...
  12. doi Translational control of long-lasting synaptic plasticity and memory
    Mauro Costa-Mattioli
    Department of Biochemistry and McGill Cancer Center, McGill University, Montreal QCH3G1Y6, Canada
    Neuron 61:10-26. 2009
    ..In this review, we summarize and discuss recent progress in the field and highlight the prospects for better understanding of long-lasting changes in synaptic strength, learning, and memory and implications for neurological diseases...
  13. pmc Eukaryotic translation initiation factor 4E availability controls the switch between cap-dependent and internal ribosomal entry site-mediated translation
    Yuri V Svitkin
    Department of Biochemistry, McGill University, 3655 Promenade Sir William Osler, Montreal, Quebec, Canada H3G 1Y6
    Mol Cell Biol 25:10556-65. 2005
    ..These data explain numerous reported observations where viral mRNAs are preferentially translated during infection...
  14. doi Persistent transcription- and translation-dependent long-term potentiation induced by mGluR1 in hippocampal interneurons
    Israeli Ran
    Groupe de Recherche sur le Système Nerveux Central and Département de Physiologie, Universite de Montreal, Montreal, Quebec H3C 3J7, Canada
    J Neurosci 29:5605-15. 2009
    ....
  15. pmc A mechanism of translational repression by competition of Paip2 with eIF4G for poly(A) binding protein (PABP) binding
    Muhammad M Karim
    Department of Biochemistry and McGill Cancer Center, McGill University, Montreal, QC, Canada H3G 1Y6
    Proc Natl Acad Sci U S A 103:9494-9. 2006
    ..Thus, Paip2 can inhibit translation by a previously unrecognized mechanism, which is independent of its ability to disrupt PABP-poly(A) interaction...
  16. pmc Vesicular stomatitis virus oncolysis is potentiated by impairing mTORC1-dependent type I IFN production
    Tommy Alain
    Department of Biochemistry and Goodman Cancer Center, McGill University, Montreal, QC H3G 1Y6, Canada
    Proc Natl Acad Sci U S A 107:1576-81. 2010
    ..These results demonstrate that reducing type I IFNs through inhibition of mTORC1 is an effective strategy to augment the therapeutic activity of VSV(DeltaM51)...
  17. pmc A nuclear translation-like factor eIF4AIII is recruited to the mRNA during splicing and functions in nonsense-mediated decay
    Maria A Ferraiuolo
    Department of Biochemistry, McGill University, 3655 Promenade Sir William Osler, Montreal, Quebec, Canada H3G 1Y6
    Proc Natl Acad Sci U S A 101:4118-23. 2004
    ....
  18. doi RAPping production of type I interferon in pDCs through mTOR
    Mauro Costa-Mattioli
    Department of Biochemistry and the McGill Cancer Centre, McGill University, Montreal, Quebec, Canada
    Nat Immunol 9:1097-9. 2008
    ..The production of type I interferon -- the first line of defense against virus infection and critical for innate immunity -- in plasmacytoid dendritic cells relies on the mammalian target of rapamycin...
  19. pmc La autoantigen is necessary for optimal function of the poliovirus and hepatitis C virus internal ribosome entry site in vivo and in vitro
    Mauro Costa-Mattioli
    Department of Biochemistry and McGill Cancer Center, McGill University, McIntyre Medical Building, Montreal, Quebec, Canada H3G 1Y6
    Mol Cell Biol 24:6861-70. 2004
    ..These results provide strong evidence for a function of the La autoantigen in IRES-dependent translation and define the step of translation which is stimulated by La...
  20. ncbi Analysis of sequential hepatitis A virus strains reveals coexistence of distinct viral subpopulations
    Mauro Costa-Mattioli
    Department of Biochemistry and McGill Cancer Center, McGill University, Montreal, Quebec, Canada
    J Gen Virol 87:115-8. 2006
    ....
  21. doi The fragile X syndrome protein represses activity-dependent translation through CYFIP1, a new 4E-BP
    Ilaria Napoli
    Department of Biology, University Tor Vergata, Rome, Italy
    Cell 134:1042-54. 2008
    ..Thus, the translational repression activity of FMRP in the brain is mediated, at least in part, by CYFIP1...
  22. ncbi Prolonged hepatitis A infection in an HIV-1 seropositive patient
    Mauro Costa-Mattioli
    Laboratorie de Virologie, Institut de Biologie, CHU Nantes, Nantes, France
    J Med Virol 68:7-11. 2002
    ..As inactivated HAV vaccine is safe in HIV-positive subjects, it would be wise to establish a strategy of preventive vaccination in this high-risk group...
  23. pmc Molecular evolution of hepatitis A virus: a new classification based on the complete VP1 protein
    Mauro Costa-Mattioli
    Laboratorie de Virologie UPRES EA1156, Institut de Biologie, Centre Hospitalier Regional Universitaire de Nantes, 44093 Nantes, France
    J Virol 76:9516-25. 2002
    ..This could be the first antigenic variant of HAV so far identified...
  24. ncbi Bayesian coalescent inference of hepatitis A virus populations: evolutionary rates and patterns
    Gonzalo Moratorio
    Laboratorio de Virologia Molecular, Centro de Investigaciones Nucleares, Facultad de Ciencias, Igua 4225, 11400 Montevideo, Uruguay
    J Gen Virol 88:3039-42. 2007
    ..Bayesian skyline plots revealed a sharp decline in the effective number of infections in 1996, coinciding with the introduction of HAV vaccine...
  25. ncbi Genetic variability and molecular evolution of hepatitis A virus
    Juan Cristina
    Laboratorio de Virologia Molecular, Centro de Investigaciones Nucleares, Facultad de Ciencias, Igua 4225, 11400 Montevideo, Uruguay
    Virus Res 127:151-7. 2007
    ..HAV mutation rate is significantly lower as compared to other members of the family Picornaviridae. The mode of evolution appears, at least in part, to contribute to the presence of only one known serotype...
  26. ncbi Evidence of recombination in natural populations of hepatitis A virus
    Mauro Costa-Mattioli
    Laboratorie de Virologie UPRES EA1156, Institut de Biologie, Centre Hospitalier Regional Universitaire de Nantes, Rue Quai Moncousu, 9, 44093, Nantes, France
    Virology 311:51-9. 2003
    ..These findings indicate that capsid-recombination can play a significant role in shaping the genetic diversity of HAV and, as such, can have important implications for its evolution, biology, and control...