Research Topics
Genomes and Genes | Mauro Costa-MattioliSummaryAffiliation: McGill University Country: Canada Publications
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Publications
Translational control of the innate immune response through IRF-7Rodney Colina
Department of Biochemistry and McGill Cancer Center, McGill University, Montreal, Quebec H3G 1Y6, Canada
Nature 452:323-8. 2008..These findings highlight the role of 4E-BPs as negative regulators of type-I IFN production, via translational repression of Irf7 mRNA...- Translational control of gene expression: a molecular switch for memory storageMauro Costa-Mattioli
Department of Biochemistry and McGill Cancer Center, 3655 Promendde Sir William Osler, McGill University, Montreal, QC H3G 1Y6, Canada
Prog Brain Res 169:81-95. 2008..In this chapter, we provide an overview of the role of translational control by the eIF2alpha signaling pathway in long-term synaptic plasticity and memory consolidation... 
Genetic variability of hepatitis A virusMauro Costa-Mattioli
Department of Biochemistry, McGill University, McIntyre Medical Building, Montreal, Quebec, Canada H3G 1Y6
J Gen Virol 84:3191-201. 2003..Its evolutionary mechanisms are described with particular emphasis on genetic recombination and HAV mutation rate. Genotypic classification methods are also discussed...- Translational control of long-term synaptic plasticity and memory storage by eIF2alphaMauro Costa-Mattioli
Department of Biochemistry, McGill Cancer Centre, Montreal, Quebec, Canada
Crit Rev Neurobiol 18:187-95. 2006..In this review, we highlight the role of the eukaryotic initiation factor 2 alpha (eIF2alpha) signalling pathway in long-term synaptic plasticity and memory... - eIF2alpha phosphorylation bidirectionally regulates the switch from short- to long-term synaptic plasticity and memoryMauro Costa-Mattioli
Department of Biochemistry and McGill Cancer Center, McGill University, Montreal, Quebec, Canada
Cell 129:195-206. 2007..These findings highlight the importance of a single phosphorylation site in eIF2alpha as a key regulator of L-LTP and LTM formation... 
Translational control of hippocampal synaptic plasticity and memory by the eIF2alpha kinase GCN2Mauro Costa-Mattioli
Department of Biochemistry and McGill Cancer Center, Montreal, Quebec, Canada
Nature 436:1166-73. 2005..Our study provides genetic, physiological, behavioural and molecular evidence that GCN2 regulates synaptic plasticity, as well as learning and memory, through modulation of the ATF4/CREB pathway...- Postnatal deamidation of 4E-BP2 in brain enhances its association with raptor and alters kinetics of excitatory synaptic transmissionMichael Bidinosti
Department of Biochemistry and Goodman Cancer Centre, McGill University, Montreal, QC H3G 1Y6, Canada
Mol Cell 37:797-808. 2010..4E-BP2 deamidation may represent a compensatory mechanism for the developmental reduction of PI3K-Akt-mTOR signaling... - Translational control of the activation of transcription factor NF-κB and production of type I interferon by phosphorylation of the translation factor eIF4EBarbara Herdy
Department of Biochemistry, McGill University, Montreal, Quebec, Canada
Nat Immunol 13:543-50. 2012..Thus, regulated phosphorylation of eIF4E has a key role in antiviral host defense by selectively controlling the translation of an mRNA that encodes a critical suppressor of the innate antiviral response... - p53-dependent translational control of senescence and transformation via 4E-BPsEmmanuel Petroulakis
Department of Biochemistry and Goodman Cancer Center, McGill University, Montreal, Quebec, H3G 1Y6, Canada
Cancer Cell 16:439-46. 2009..Our data demonstrate a role for 4E-BPs in senescence and tumorigenesis and highlight a p53-mediated mechanism of senescence through a 4E-BP-dependent pathway... - Stimulation of picornavirus replication by the poly(A) tail in a cell-free extract is largely independent of the poly(A) binding protein (PABP)Yuri V Svitkin
Department of Biochemistry and McGill Cancer Centre, McGill University, Montreal, Quebec, Canada H3G 1Y6
RNA 13:2330-40. 2007..These results suggest that the poly(A) tail functions in picornavirus replication largely independent of PABP... - Leishmania repression of host translation through mTOR cleavage is required for parasite survival and infectionMaritza Jaramillo
Department of Biochemistry and Goodman Cancer Center, McGill University, Montreal, Quebec, Canada
Cell Host Microbe 9:331-41. 2011..This study demonstrates that Leishmania evolved a survival mechanism by activating 4E-BPs, which serve as major targets for host translational control... - Translational control of long-lasting synaptic plasticity and memoryMauro Costa-Mattioli
Department of Biochemistry and McGill Cancer Center, McGill University, Montreal QCH3G1Y6, Canada
Neuron 61:10-26. 2009..In this review, we summarize and discuss recent progress in the field and highlight the prospects for better understanding of long-lasting changes in synaptic strength, learning, and memory and implications for neurological diseases... - Eukaryotic translation initiation factor 4E availability controls the switch between cap-dependent and internal ribosomal entry site-mediated translationYuri V Svitkin
Department of Biochemistry, McGill University, 3655 Promenade Sir William Osler, Montreal, Quebec, Canada H3G 1Y6
Mol Cell Biol 25:10556-65. 2005..These data explain numerous reported observations where viral mRNAs are preferentially translated during infection... - Persistent transcription- and translation-dependent long-term potentiation induced by mGluR1 in hippocampal interneuronsIsraeli Ran
Groupe de Recherche sur le Système Nerveux Central and Département de Physiologie, Universite de Montreal, Montreal, Quebec H3C 3J7, Canada
J Neurosci 29:5605-15. 2009.... - A mechanism of translational repression by competition of Paip2 with eIF4G for poly(A) binding protein (PABP) bindingMuhammad M Karim
Department of Biochemistry and McGill Cancer Center, McGill University, Montreal, QC, Canada H3G 1Y6
Proc Natl Acad Sci U S A 103:9494-9. 2006..Thus, Paip2 can inhibit translation by a previously unrecognized mechanism, which is independent of its ability to disrupt PABP-poly(A) interaction... - Vesicular stomatitis virus oncolysis is potentiated by impairing mTORC1-dependent type I IFN productionTommy Alain
Department of Biochemistry and Goodman Cancer Center, McGill University, Montreal, QC H3G 1Y6, Canada
Proc Natl Acad Sci U S A 107:1576-81. 2010..These results demonstrate that reducing type I IFNs through inhibition of mTORC1 is an effective strategy to augment the therapeutic activity of VSV(DeltaM51)... - A nuclear translation-like factor eIF4AIII is recruited to the mRNA during splicing and functions in nonsense-mediated decayMaria A Ferraiuolo
Department of Biochemistry, McGill University, 3655 Promenade Sir William Osler, Montreal, Quebec, Canada H3G 1Y6
Proc Natl Acad Sci U S A 101:4118-23. 2004.... - Analysis of sequential hepatitis A virus strains reveals coexistence of distinct viral subpopulationsMauro Costa-Mattioli
Department of Biochemistry and McGill Cancer Center, McGill University, Montreal, Quebec, Canada
J Gen Virol 87:115-8. 2006.... - RAPping production of type I interferon in pDCs through mTORMauro Costa-Mattioli
Department of Biochemistry and the McGill Cancer Centre, McGill University, Montreal, Quebec, Canada
Nat Immunol 9:1097-9. 2008..The production of type I interferon -- the first line of defense against virus infection and critical for innate immunity -- in plasmacytoid dendritic cells relies on the mammalian target of rapamycin... - La autoantigen is necessary for optimal function of the poliovirus and hepatitis C virus internal ribosome entry site in vivo and in vitroMauro Costa-Mattioli
Department of Biochemistry and McGill Cancer Center, McGill University, McIntyre Medical Building, Montreal, Quebec, Canada H3G 1Y6
Mol Cell Biol 24:6861-70. 2004..These results provide strong evidence for a function of the La autoantigen in IRES-dependent translation and define the step of translation which is stimulated by La... - The fragile X syndrome protein represses activity-dependent translation through CYFIP1, a new 4E-BPIlaria Napoli
Department of Biology, University Tor Vergata, Rome, Italy
Cell 134:1042-54. 2008..Thus, the translational repression activity of FMRP in the brain is mediated, at least in part, by CYFIP1... - Prolonged hepatitis A infection in an HIV-1 seropositive patientMauro Costa-Mattioli
Laboratorie de Virologie, Institut de Biologie, CHU Nantes, Nantes, France
J Med Virol 68:7-11. 2002..As inactivated HAV vaccine is safe in HIV-positive subjects, it would be wise to establish a strategy of preventive vaccination in this high-risk group... - Molecular evolution of hepatitis A virus: a new classification based on the complete VP1 proteinMauro Costa-Mattioli
Laboratorie de Virologie UPRES-EA1156, Institut de Biologie, Centre Hospitalier Regional Universitaire de Nantes, 44093 Nantes, France
J Virol 76:9516-25. 2002..This could be the first antigenic variant of HAV so far identified... - Bayesian coalescent inference of hepatitis A virus populations: evolutionary rates and patternsGonzalo Moratorio
Laboratorio de Virologia Molecular, Centro de Investigaciones Nucleares, Facultad de Ciencias, Igua 4225, 11400 Montevideo, Uruguay
J Gen Virol 88:3039-42. 2007..Bayesian skyline plots revealed a sharp decline in the effective number of infections in 1996, coinciding with the introduction of HAV vaccine... - Evidence of recombination in natural populations of hepatitis A virusMauro Costa-Mattioli
Laboratorie de Virologie UPRES-EA1156, Institut de Biologie, Centre Hospitalier Regional Universitaire de Nantes, Rue Quai Moncousu, 9, 44093, Nantes, France
Virology 311:51-9. 2003..These findings indicate that capsid-recombination can play a significant role in shaping the genetic diversity of HAV and, as such, can have important implications for its evolution, biology, and control... - Genetic variability and molecular evolution of hepatitis A virusJuan Cristina
Laboratorio de Virologia Molecular, Centro de Investigaciones Nucleares, Facultad de Ciencias, Igua 4225, 11400 Montevideo, Uruguay
Virus Res 127:151-7. 2007..HAV mutation rate is significantly lower as compared to other members of the family Picornaviridae. The mode of evolution appears, at least in part, to contribute to the presence of only one known serotype...