Jean Paul Collet

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..We did a randomised trial to assess the efficacy and side-effects of this form of therapy in children with cerebral palsy...

..Through analyses such as this, new signals can be identified and investigated further...

..We investigated the effect of nonsteroidal anti-inflammatory drug (NSAID) use on stage of colon cancer and presence of distant metastases at diagnosis...

..There is emerging evidence that disease management with self-management education provided by a case manager might benefit COPD patients...

..Two methods are suggested for sample size planning based on a quantitative, rather than binary, exposure...

..In light of recent reviews, we examined the effect of individual and clinical factors, associated with lung transplantation (LTx), on health-related quality of life (HRQL)...

..Indirect evidence suggests that prolonged treatment with warfarin might be associated with a decreased incidence of urogenital cancer. We aimed to assess this association in a large population-based study...

..The evidence that breastfeeding protects against obesity and a variety of chronic diseases comes almost entirely from observational studies, which have a potential for bias due to confounding, selection bias, and selective publication...

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..5 y. Previous reports of protective effects against obesity may reflect uncontrolled bias caused by confounding and selection...

..Chronic neuropathic pain affects 1%-2% of the adult population and is often refractory to standard pharmacologic treatment. Patients with chronic pain have reported using smoked cannabis to relieve pain, improve sleep and improve mood...

..Despite the current World Health Organization recommendation that infants be exclusively breastfed for 6 mo, this practice remains unusual in both developed and developing countries...

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..We evaluated the effect of a continuum of self-management, specific to COPD, on the use of hospital services and health status among patients with moderate to severe disease...

..Efficacy requirements were studied for female stress urinary incontinence, where an experimental treatment (collagen injection) was compared to the standard therapy (surgery)...

..This evidence, however, is based on observational studies, which are unable to separate the effects of feeding mode per se from selection bias, reverse causality, and the confounding effects of maternal attitudinal factors...

..Potential sources of bias in such studies have led to doubts about the magnitude of these health benefits in industrialized countries...

..To compare, in a multicenter, randomized clinical trial, collagen injections versus surgery with regard to efficacy, quality of life, satisfaction, and complications...

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..Correlates of general and physical fatigue are disease-related, behavioural and psychosocial factors. Correlates of mental fatigue are psychosocial factors. Potentially modifiable factors account for a considerable portion of fatigue...

..Depression and anxiety are significant comorbid and potentially modifiable conditions in chronic obstructive pulmonary disease (COPD), but their effects on exacerbations are not clear...

..We examined the efficacy and safety of preemptive treatment with high-dose fluticasone in reducing the severity of recurrent virus-induced wheezing in children...

..To study health-related differences between hormone replacement therapy (HRT) users and nonusers among colorectal cases and women without diagnosed cancer...

..The intervention included increased emergency physician coverage, the designation of physician coordinators, and new hospital policies regarding laboratory, consultation, and admission procedures...

..The cause of PPS is unknown, but abnormal inflammatory responses have been implicated in several small studies...

..TCA use 2-5 years in the past was associated with a small dose-dependent increase in the risk of prostate cancer. Nevertheless, detection bias could have contributed to the observed association...

..25), and having > or = 3 tattoos and testing positive for at least one TTD (OR = 2.98). We suggest that non-professional tattoos and number of tattoos should be assessed as potential deferral criteria in screening blood donors...

..CONCLUSION: Short-term exposure to HBO2 at medium level pressure (1.75 atm abs) was responsible for a significant increase of middle ear barotrauma compared to children that received very low external pressure (1.3 atm abs)...

..Various methods used to define HRT exposure produce a range of estimated ORs that vary in magnitude similar to results reported in the literature from observational studies investigating the association between HRT and colorectal cancer...

..The implications of the results found lead us to carry out a separate case-control study, using the same source population, to validate the conclusions drawn from our previous study...

..We sought to investigate whether prenatal vitamin C and E supplementation reduces the incidence of gestational hypertension (GH) and its adverse conditions among high- and low-risk women...

..These results also showed that direct measurement of lipoprotein family of particles provides important information not only about the composition but also the type and number of apoA- and apoB-containing lipoprotein particles...

..61 (95% CI 0.09-9.13)). Development and evaluation of self-management programmes emphasising early recognition of exacerbations and consequent action appear to be warranted...

..The use of NSAIDs may retard the growth of breast cancers and prevent distant metastasis...

..Presence of tattoos has been a criterion for temporary deferral of blood donors. Scientific evidence remains equivocal regarding the association between tattooing and transfusion-transmitted diseases (TTDs)...

..33 (95% CI: 0.12-0.95), and for OE use were 0.90 (95% CI: 0.73-1.01) and 0.75 (95% CI: 0.60-0.93), respectively. The risk reduction for colorectal cancer with TDE may be greater in magnitude than that which has been reported for oral HRT...

..In most cases, PNDs involve the peripheral nerves. Treatment of PNDs is likely to use large health care resources. However, little is known about the economic burden of PNDs in Canada...

..The timing of NSAID use must be considered in planning intervention trials to prevent colorectal cancer. There may be a 10-year delay before any preventive effect will appear...

..Nucare, a short-term psychoeducational coping skills training intervention was evaluated in a randomized controlled clinical trial (RCT) of 225 newly diagnosed breast and colon cancer patients...

..However, our results may have been confounded by the effects of other determinants of breast cancer associated with tricyclic antidepressant use...

..It is therefore difficult to adequately evaluate the equivalence of this instrument in Chinese populations...

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